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Protein

Zyxin

Gene

ZYX

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adhesion plaque protein. Binds alpha-actinin and the CRP protein. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression.1 Publication

GO - Molecular functioni

  • alpha-actinin binding Source: AgBase
  • RNA binding Source: Ensembl
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zyxin
Gene namesi
Name:ZYX
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  • cell Source: AgBase
  • cell-cell adherens junction Source: Ensembl
  • cytoplasm Source: AgBase
  • cytosol Source: Ensembl
  • focal adhesion Source: AgBase
  • nucleus Source: UniProtKB-SubCell
  • stress fiber Source: AgBase

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000759151 – 542ZyxinAdd BLAST542

Proteomic databases

PaxDbiQ04584.

Expressioni

Gene expression databases

BgeeiENSGALG00000014688.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ACTN1P05094-24EBI-6222189,EBI-6049246

GO - Molecular functioni

  • alpha-actinin binding Source: AgBase

Protein-protein interaction databases

IntActiQ04584. 1 interactor.
STRINGi9031.ENSGALP00000023626.

Structurei

3D structure databases

ProteinModelPortaliQ04584.
SMRiQ04584.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini352 – 411LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST60
Domaini412 – 471LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST60
Domaini472 – 538LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi83 – 90Pro-rich8
Compositional biasi103 – 108Pro-rich6
Compositional biasi112 – 117Pro-rich6
Compositional biasi124 – 130Pro-rich7

Sequence similaritiesi

Belongs to the zyxin/ajuba family.Curated

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG1701. Eukaryota.
ENOG410Y3GP. LUCA.
GeneTreeiENSGT00760000119039.
HOGENOMiHOG000220910.
InParanoidiQ04584.
KOiK06273.
OMAiEADENGC.
OrthoDBiEOG091G085F.
PhylomeDBiQ04584.
TreeFamiTF320310.

Family and domain databases

InterProiView protein in InterPro
IPR001781. Znf_LIM.
PfamiView protein in Pfam
PF00412. LIM. 3 hits.
SMARTiView protein in SMART
SM00132. LIM. 3 hits.
PROSITEiView protein in PROSITE
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 3 hits.

Sequencei

Sequence statusi: Complete.

Q04584-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPGTPGTR MTTTVSINIS TPSFYNPQKK FAPVVAPKPK VNPFKTGGTS
60 70 80 90 100
ESSQPQPPGT GAQRAQIGRV GEIPVSVTAE ELPLPPPPPP GEELSFSSNC
110 120 130 140 150
AFPPPPPPFE EPFPPAPDEA FPSPPPPPPP MFDEGPALQI PPGSTGSVEK
160 170 180 190 200
PLAPKAHVEI SSAPRDPTPP FPSKFTPKPS GTLSSKPPGL DSTPAPAPWA
210 220 230 240 250
APQQRKEPLA SVPPPPSLPS QPTAKFTPPP VASSPGSKPG ATVPMAPSNS
260 270 280 290 300
TRYPTSLQTQ FTAPSPSGPL SRPQPPNFTY AQQWERPQVQ EKPVPTEKSA
310 320 330 340 350
AVKDMRRPTA DPPKGNSPLT MKEVEELELL TQKLMKDMDH PPPVEAATSE
360 370 380 390 400
LCGFCRKPLS RTQPAVRALD CLFHVECFTC FKCEKQLQGQ QFYNVDEKPF
410 420 430 440 450
CEDCYAGTLE KCSVCKQTIT DRMLKATGNS YHPQCFTCVM CHTPLEGASF
460 470 480 490 500
IVDQANQPHC VDDYHRKYAP RCSVCSEPIM PEPGKDETVR VVALEKNFHM
510 520 530 540
KCYKCEDCGR PLSIEADENG CFPLDGHVLC MKCHTVRAKT AC
Length:542
Mass (Da):58,538
Last modified:October 1, 1993 - v1
Checksum:i9D898AC180C680FC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti463D → V. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69190 mRNA. Translation: CAA48936.1.
PIRiA44358.
RefSeqiNP_001004386.1. NM_001004386.1.
UniGeneiGga.4325.

Genome annotation databases

EnsembliENSGALT00000023672; ENSGALP00000023626; ENSGALG00000014688.
GeneIDi418300.
KEGGigga:418300.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69190 mRNA. Translation: CAA48936.1.
PIRiA44358.
RefSeqiNP_001004386.1. NM_001004386.1.
UniGeneiGga.4325.

3D structure databases

ProteinModelPortaliQ04584.
SMRiQ04584.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ04584. 1 interactor.
STRINGi9031.ENSGALP00000023626.

Proteomic databases

PaxDbiQ04584.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000023672; ENSGALP00000023626; ENSGALG00000014688.
GeneIDi418300.
KEGGigga:418300.

Organism-specific databases

CTDi7791.

Phylogenomic databases

eggNOGiKOG1701. Eukaryota.
ENOG410Y3GP. LUCA.
GeneTreeiENSGT00760000119039.
HOGENOMiHOG000220910.
InParanoidiQ04584.
KOiK06273.
OMAiEADENGC.
OrthoDBiEOG091G085F.
PhylomeDBiQ04584.
TreeFamiTF320310.

Miscellaneous databases

PROiPR:Q04584.

Gene expression databases

BgeeiENSGALG00000014688.

Family and domain databases

InterProiView protein in InterPro
IPR001781. Znf_LIM.
PfamiView protein in Pfam
PF00412. LIM. 3 hits.
SMARTiView protein in SMART
SM00132. LIM. 3 hits.
PROSITEiView protein in PROSITE
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiZYX_CHICK
AccessioniPrimary (citable) accession number: Q04584
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 7, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.