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Protein

Zyxin

Gene

ZYX

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adhesion plaque protein. Binds alpha-actinin and the CRP protein. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression.1 Publication

GO - Molecular functioni

  • alpha-actinin binding Source: AgBase
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zyxin
Gene namesi
Name:ZYX
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000759151 – 542ZyxinAdd BLAST542

Proteomic databases

PaxDbiQ04584

Expressioni

Gene expression databases

BgeeiENSGALG00000014688

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ACTN1P05094-24EBI-6222189,EBI-6049246

GO - Molecular functioni

  • alpha-actinin binding Source: AgBase

Protein-protein interaction databases

ELMiQ04584
IntActiQ04584, 1 interactor
STRINGi9031.ENSGALP00000023626

Structurei

3D structure databases

ProteinModelPortaliQ04584
SMRiQ04584
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini352 – 411LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST60
Domaini412 – 471LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST60
Domaini472 – 538LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi83 – 90Pro-rich8
Compositional biasi103 – 108Pro-rich6
Compositional biasi112 – 117Pro-rich6
Compositional biasi124 – 130Pro-rich7

Sequence similaritiesi

Belongs to the zyxin/ajuba family.Curated

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG1701 Eukaryota
ENOG410Y3GP LUCA
GeneTreeiENSGT00760000119039
HOGENOMiHOG000220910
InParanoidiQ04584
KOiK06273
OMAiEADENGC
OrthoDBiEOG091G085F
PhylomeDBiQ04584
TreeFamiTF320310

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 3 hits
SMARTiView protein in SMART
SM00132 LIM, 3 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q04584-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPGTPGTR MTTTVSINIS TPSFYNPQKK FAPVVAPKPK VNPFKTGGTS
60 70 80 90 100
ESSQPQPPGT GAQRAQIGRV GEIPVSVTAE ELPLPPPPPP GEELSFSSNC
110 120 130 140 150
AFPPPPPPFE EPFPPAPDEA FPSPPPPPPP MFDEGPALQI PPGSTGSVEK
160 170 180 190 200
PLAPKAHVEI SSAPRDPTPP FPSKFTPKPS GTLSSKPPGL DSTPAPAPWA
210 220 230 240 250
APQQRKEPLA SVPPPPSLPS QPTAKFTPPP VASSPGSKPG ATVPMAPSNS
260 270 280 290 300
TRYPTSLQTQ FTAPSPSGPL SRPQPPNFTY AQQWERPQVQ EKPVPTEKSA
310 320 330 340 350
AVKDMRRPTA DPPKGNSPLT MKEVEELELL TQKLMKDMDH PPPVEAATSE
360 370 380 390 400
LCGFCRKPLS RTQPAVRALD CLFHVECFTC FKCEKQLQGQ QFYNVDEKPF
410 420 430 440 450
CEDCYAGTLE KCSVCKQTIT DRMLKATGNS YHPQCFTCVM CHTPLEGASF
460 470 480 490 500
IVDQANQPHC VDDYHRKYAP RCSVCSEPIM PEPGKDETVR VVALEKNFHM
510 520 530 540
KCYKCEDCGR PLSIEADENG CFPLDGHVLC MKCHTVRAKT AC
Length:542
Mass (Da):58,538
Last modified:October 1, 1993 - v1
Checksum:i9D898AC180C680FC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti463D → V. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69190 mRNA Translation: CAA48936.1
PIRiA44358
RefSeqiNP_001004386.1, NM_001004386.1
UniGeneiGga.4325

Genome annotation databases

EnsembliENSGALT00000023672; ENSGALP00000023626; ENSGALG00000014688
GeneIDi418300
KEGGigga:418300

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZYX_CHICK
AccessioniPrimary (citable) accession number: Q04584
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: February 28, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health