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Protein

Neuropeptide Y receptor type 1

Gene

Npy1r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for neuropeptide Y and peptide YY.

GO - Molecular functioni

  • neuropeptide Y receptor activity Source: MGI
  • pancreatic polypeptide receptor activity Source: MGI
  • peptide YY receptor activity Source: MGI

GO - Biological processi

  • feeding behavior Source: MGI
  • glucose metabolic process Source: MGI
  • locomotory behavior Source: MGI
  • negative regulation of cytosolic calcium ion concentration Source: Ensembl
  • negative regulation of hormone secretion Source: Ensembl
  • neuropeptide signaling pathway Source: GOC
  • outflow tract morphogenesis Source: MGI
  • peristalsis Source: Ensembl
  • positive regulation of vasoconstriction Source: Ensembl
  • regulation of blood pressure Source: MGI
  • regulation of multicellular organism growth Source: MGI
  • response to estradiol Source: Ensembl
  • sensory perception of pain Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide Y receptor type 1
Short name:
NPY1-R
Gene namesi
Name:Npy1r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:104963. Npy1r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333ExtracellularSequence analysisAdd
BLAST
Transmembranei34 – 5421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini55 – 7521CytoplasmicSequence analysisAdd
BLAST
Transmembranei76 – 9621Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini97 – 11519ExtracellularSequence analysisAdd
BLAST
Transmembranei116 – 13621Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini137 – 15317CytoplasmicSequence analysisAdd
BLAST
Transmembranei154 – 17421Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini175 – 21036ExtracellularSequence analysisAdd
BLAST
Transmembranei211 – 23121Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini232 – 25928CytoplasmicSequence analysisAdd
BLAST
Transmembranei260 – 28021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini281 – 29818ExtracellularSequence analysisAdd
BLAST
Transmembranei299 – 31921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini320 – 38263CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

GuidetoPHARMACOLOGYi305.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Neuropeptide Y receptor type 1PRO_0000069921Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence analysis
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence analysis
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence analysis
Disulfide bondi112 ↔ 197PROSITE-ProRule annotation
Lipidationi337 – 3371S-palmitoyl cysteineBy similarity
Modified residuei375 – 3751PhosphoserineCombined sources

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ04573.
PRIDEiQ04573.

PTM databases

PhosphoSiteiQ04573.

Expressioni

Tissue specificityi

The alpha form is highly expressed in the brain, heart, kidney, spleen, skeletal muscle, and lung, whereas the beta receptor mRNA was not detected in these tissues. However, the beta form is expressed in mouse embryonic developmental stage (7 and 11 days), bone marrow cells and several hematopoietic cell lines.

Developmental stagei

The beta form is expressed in embryonic developmental stage (7 and 11 days). The beta form is an embryonic and a bone marrow form of NPY1-R, which decreases in the expression during development and differentiation.

Gene expression databases

BgeeiQ04573.
CleanExiMM_NPY1R.
ExpressionAtlasiQ04573. baseline and differential.
GenevisibleiQ04573. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045530.

Structurei

3D structure databases

ProteinModelPortaliQ04573.
SMRiQ04573. Positions 35-367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000050229.
HOVERGENiHBG105676.
InParanoidiQ04573.
KOiK04204.
OMAiQVENHSI.
OrthoDBiEOG7C2R16.
PhylomeDBiQ04573.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000351. NPY1_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01013. NRPEPTIDEY1R.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform NPY1-R alpha (identifier: Q04573-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSTLFSKVE NHSIHYNASE NSPLLAFEND DCHLPLAVIF TLALAYGAVI
60 70 80 90 100
ILGVSGNLAL IIIILKQKEM RNVTNILIVN LSFSDLLVAV MCLPFTFVYT
110 120 130 140 150
LMDHWVFGET MCKLNPFVQC VSITVSIFSL VLIAVERHQL IINPRGWRPN
160 170 180 190 200
NRHAYIGITV IWVLAVASSL PFVIYQILTD EPFQNVSLAA FKDKYVCFDK
210 220 230 240 250
FPSDSHRLSY TTLLLVLQYF GPLCFIFICY FKIYIRLKRR NNMMDKIRDS
260 270 280 290 300
KYRSSETKRI NIMLLSIVVA FAVCWLPLTI FNTVFDWNHQ IIATCNHNLL
310 320 330 340 350
FLLCHLTAMI STCVNPIFYG FLNKNFQRDL QFFFNFCDFR SRDDDYETIA
360 370 380
MSTMHTDVSK TSLKQASPVA FKKISMNDNE KV
Length:382
Mass (Da):44,015
Last modified:October 1, 1993 - v1
Checksum:iCDCCF93E3ABB4D70
GO
Isoform NPY1-R beta (identifier: Q04573-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     304-307: CHLT → LNMN
     308-382: Missing.

Show »
Length:307
Mass (Da):35,304
Checksum:i7F8B733BAA2A387F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei304 – 3074CHLT → LNMN in isoform NPY1-R beta. CuratedVSP_001912
Alternative sequencei308 – 38275Missing in isoform NPY1-R beta. CuratedVSP_001913Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18280 Genomic DNA. Translation: CAA79157.1.
Z18281 Genomic DNA. No translation available.
D63818 mRNA. Translation: BAA09887.1.
D63819 mRNA. Translation: BAA09888.1.
BC051420 mRNA. Translation: AAH51420.1.
CCDSiCCDS22336.1. [Q04573-1]
PIRiS27388.
RefSeqiNP_035064.1. NM_010934.4. [Q04573-1]
XP_006509657.1. XM_006509594.2. [Q04573-1]
XP_006509658.1. XM_006509595.2. [Q04573-1]
XP_006509659.1. XM_006509596.2. [Q04573-1]
UniGeneiMm.5112.

Genome annotation databases

EnsembliENSMUST00000039303; ENSMUSP00000045530; ENSMUSG00000036437. [Q04573-1]
GeneIDi18166.
KEGGimmu:18166.
UCSCiuc009lvt.2. mouse. [Q04573-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18280 Genomic DNA. Translation: CAA79157.1.
Z18281 Genomic DNA. No translation available.
D63818 mRNA. Translation: BAA09887.1.
D63819 mRNA. Translation: BAA09888.1.
BC051420 mRNA. Translation: AAH51420.1.
CCDSiCCDS22336.1. [Q04573-1]
PIRiS27388.
RefSeqiNP_035064.1. NM_010934.4. [Q04573-1]
XP_006509657.1. XM_006509594.2. [Q04573-1]
XP_006509658.1. XM_006509595.2. [Q04573-1]
XP_006509659.1. XM_006509596.2. [Q04573-1]
UniGeneiMm.5112.

3D structure databases

ProteinModelPortaliQ04573.
SMRiQ04573. Positions 35-367.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045530.

Chemistry

GuidetoPHARMACOLOGYi305.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ04573.

Proteomic databases

PaxDbiQ04573.
PRIDEiQ04573.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039303; ENSMUSP00000045530; ENSMUSG00000036437. [Q04573-1]
GeneIDi18166.
KEGGimmu:18166.
UCSCiuc009lvt.2. mouse. [Q04573-1]

Organism-specific databases

CTDi4886.
MGIiMGI:104963. Npy1r.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000050229.
HOVERGENiHBG105676.
InParanoidiQ04573.
KOiK04204.
OMAiQVENHSI.
OrthoDBiEOG7C2R16.
PhylomeDBiQ04573.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSiNpy1r. mouse.
NextBioi293450.
PROiQ04573.
SOURCEiSearch...

Gene expression databases

BgeeiQ04573.
CleanExiMM_NPY1R.
ExpressionAtlasiQ04573. baseline and differential.
GenevisibleiQ04573. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000351. NPY1_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01013. NRPEPTIDEY1R.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The murine NPY-1 receptor gene. Structure and delineation of tissue-specific expression."
    Eva C., Oberto A., Sprengel R., Genazzani E.
    FEBS Lett. 314:285-288(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.
  2. "Identification of two isoforms of mouse neuropeptide Y-Y1 receptor generated by alternative splicing. Isolation, genomic structure, and functional expression of the receptors."
    Nakamura M., Sakanaka C., Aoki Y., Ogasawara H., Tsuji T., Kodama H., Matsumoto T., Shimizu T., Noma M.
    J. Biol. Chem. 270:30102-30110(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM NPY1-R ALPHA).
    Tissue: Eye.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-375, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney.

Entry informationi

Entry nameiNPY1R_MOUSE
AccessioniPrimary (citable) accession number: Q04573
Secondary accession number(s): Q61993
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 11, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.