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Reviewed, UniProtKB/Swiss-Prot Q04573 (NPY1R_MOUSE)

Last modified June 16, 2009. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Neuropeptide Y receptor type 1
Alternative name(s):
    NPY1-R
Gene names
Name: Npy1r
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length382 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Receptor for neuropeptide Y and peptide YY.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

The alpha form is highly expressed in the brain, heart, kidney, spleen, skeletal muscle, and lung, whereas the beta receptor mRNA was not detected in these tissues. However, the beta form is expressed in mouse embryonic developmental stage (7 and 11 days), bone marrow cells and several hematopoietic cell lines.

Developmental stage

The beta form is expressed in embryonic developmental stage (7 and 11 days). The beta form is an embryonic and a bone marrow form of NPY1-R, which decreases in the expression during development and differentiation.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

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Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform NPY1-R alpha (identifier: Q04573-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform NPY1-R beta (identifier: Q04573-2)

The sequence of this isoform differs from the canonical sequence as follows:
     304-307: CHLT → LNMN
     308-382: Missing.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 382382Neuropeptide Y receptor type 1
PRO_0000069921

Regions

Topological domain1 – 3333Extracellular Potential
Transmembrane34 – 54211 Potential
Topological domain55 – 7521Cytoplasmic Potential
Transmembrane76 – 96212 Potential
Topological domain97 – 11519Extracellular Potential
Transmembrane116 – 136213 Potential
Topological domain137 – 15317Cytoplasmic Potential
Transmembrane154 – 174214 Potential
Topological domain175 – 21036Extracellular Potential
Transmembrane211 – 231215 Potential
Topological domain232 – 25928Cytoplasmic Potential
Transmembrane260 – 280216 Potential
Topological domain281 – 29818Extracellular Potential
Transmembrane299 – 319217 Potential
Topological domain320 – 38263Cytoplasmic Potential

Amino acid modifications

Lipidation3371S-palmitoyl cysteine By similarity
Glycosylation21N-linked (GlcNAc...) Potential
Glycosylation111N-linked (GlcNAc...) Potential
Glycosylation171N-linked (GlcNAc...) Potential
Disulfide bond112 ↔ 197 By similarity

Natural variations

Alternative sequence304 – 3074CHLT → LNMN in isoform NPY1-R beta.
VSP_001912
Alternative sequence308 – 38275Missing in isoform NPY1-R beta.
VSP_001913

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Sequences

Sequence LengthMass (Da)Tools
Isoform NPY1-R alpha [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: CDCCF93E3ABB4D70

FASTA38244,015
        10         20         30         40         50         60 
MNSTLFSKVE NHSIHYNASE NSPLLAFEND DCHLPLAVIF TLALAYGAVI ILGVSGNLAL 

        70         80         90        100        110        120 
IIIILKQKEM RNVTNILIVN LSFSDLLVAV MCLPFTFVYT LMDHWVFGET MCKLNPFVQC 

       130        140        150        160        170        180 
VSITVSIFSL VLIAVERHQL IINPRGWRPN NRHAYIGITV IWVLAVASSL PFVIYQILTD 

       190        200        210        220        230        240 
EPFQNVSLAA FKDKYVCFDK FPSDSHRLSY TTLLLVLQYF GPLCFIFICY FKIYIRLKRR 

       250        260        270        280        290        300 
NNMMDKIRDS KYRSSETKRI NIMLLSIVVA FAVCWLPLTI FNTVFDWNHQ IIATCNHNLL 

       310        320        330        340        350        360 
FLLCHLTAMI STCVNPIFYG FLNKNFQRDL QFFFNFCDFR SRDDDYETIA MSTMHTDVSK 

       370        380 
TSLKQASPVA FKKISMNDNE KV

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Isoform NPY1-R beta.

Checksum: 7F8B733BAA2A387F
Show »

FASTA30735,304

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References

« Hide 'large scale' references
[1]"The murine NPY-1 receptor gene. Structure and delineation of tissue-specific expression."
Eva C., Oberto A., Sprengel R., Genazzani E.
FEBS Lett. 314:285-288(1992) [PubMed: 1468559] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Liver.
[2]"Identification of two isoforms of mouse neuropeptide Y-Y1 receptor generated by alternative splicing. Isolation, genomic structure, and functional expression of the receptors."
Nakamura M., Sakanaka C., Aoki Y., Ogasawara H., Tsuji T., Kodama H., Matsumoto T., Shimizu T., Noma M.
J. Biol. Chem. 270:30102-30110(1995) [PubMed: 8530415] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM NPY1-R ALPHA).
Tissue: Eye.
+Additional computationally mapped references.

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Cross-references

Sequence databases

Z18280 Genomic DNA. Translation: CAA79157.1.
Z18281 Genomic DNA. No translation available.
D63818 mRNA. Translation: BAA09887.1.
D63819 mRNA. Translation: BAA09888.1.
BC051420 mRNA. Translation: AAH51420.1.
IPIIPI00138130.
IPI00227890.
PIRS27388.
RefSeqNP_035064.1.
UniGeneMm.5112

3D structure databases

ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ04573.

Genome annotation databases

EnsemblENSMUSG00000036437. Mus musculus. [Contig view]
GeneID18166.
KEGGmmu:18166.

Organism-specific databases

MGIMGI:104963. Npy1r.

Phylogenomic databases

HOGENOMQ04573.
HOVERGENQ04573.
OMAQ04573. DAFKDKY.

Gene expression databases

ArrayExpressQ04573.
BgeeQ04573.
CleanExMM_NPY1R.
GermOnlineENSMUSG00000036437. Mus musculus.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
IPR000351. NPY1_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01013. NRPEPTIDEY1R.
PR01012. NRPEPTIDEYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio293450.
SOURCESearch...

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Entry information

Entry nameNPY1R_MOUSE
AccessionPrimary (citable) accession number: Q04573
Secondary accession number(s): Q61993
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 16, 2009
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents