Q04564 (TR2M_AGRVS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tryptophan 2-monooxygenase
EC=1.13.12.3

Gene names

Name:	iaaM
Synonyms:	tms1
Ordered Locus Names:	Avi_8288

Encoded on

Plasmid pTiS4

Organism

Agrobacterium vitis (strain S4 / ATCC BAA-846) (Rhizobium vitis (strain S4)) [Complete proteome] [HAMAP]

Taxonomic identifier

311402 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium

Protein attributes

Sequence length	723 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-tryptophan + O2 = (indol-3-yl)acetamide + CO2 + H2O.
Pathway	Plant hormone metabolism; auxin biosynthesis.
Sequence similarities	Belongs to the tryptophan 2-monooxygenase family.

Ontologies

Keywords
Biological process	Auxin biosynthesis
Disease	Crown gall tumor
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Plasmid
Gene Ontology (GO)
Biological process	auxin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	nucleic acid binding Inferred from electronic annotation. Source: InterPro tryptophan 2-monooxygenase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 723	723	Tryptophan 2-monooxygenase		PRO_0000065588

Sequences

	Sequence		Length	Mass (Da)
	Q04564 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: ABA9CEA94B6B4E36	FASTA	723	80,803
	10 20 30 40 50 60 MANFFYSRIT NRSYSTKNLL NIEDKGRLKD ELEKTRQTNI CEICLHPRGH RASVCRQILM 70 80 90 100 110 120 GFAYTSKTVL EGLLSTMPHD DAPLGKIFVT DLPPYDEQVP QVLLMQAAAL VTSYEYSFED 130 140 150 160 170 180 LAYFLVLPLQ MALMQKSPSL GKDFPVISGY SITKDSVHSP VAFGRNLMPR GVSCEFPQID 190 200 210 220 230 240 VLYDYRGFLE GGAFSEGVTS FPKETKKPKV AVIGAGISGL VSATLLLRNG IDDVTIFEAK 250 260 270 280 290 300 NVVGGRAHTH FFKGEPSVCA ELGAMRFPRS QACLFYLLEY LGINAMTKFP NPGTVDTGLY 310 320 330 340 350 360 YRGRSYNWKA HSLPPAIFNR VHKGWRTFLH AGFVDGVAAF ASPFTLTECL RLRNYEFASS 370 380 390 400 410 420 LWQKWLDAFS SETFSSGIER IFRGAHPPGG EKWTRDVDME LFKELGVGSG GFGPVFGCGF 430 440 450 460 470 480 IEILRLIVNG YEDNVMLLLD GIEEIPRRLS QQKVGSYSIR DRIIHKEVKE IIRTESGISL 490 500 510 520 530 540 AIGEGMHATF DRVIVTSGFT NIQLRHLLTN DDSFFSYDVN QAIENSHMTG SSKLFVLTQN 550 560 570 580 590 600 KFWKAEELPS CILTTGVAKA VYCLDYEPDK PSGKGLVLLS YTWEDDSHKL LTFDKGERFQ 610 620 630 640 650 660 ILKRDLAKSY PRFADLLEPA DGDYDNNIIQ HDWILDPYAG GAFKLNRRCE DVYSKRLFFQ 670 680 690 700 710 720 PLRLNGEPDG RVCLAGCSCS FSGGWVEGAI QTACNAAMAT IRDAGGLISG DNPLTNEFVN YHY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Organization and functional analysis of three T-DNAs from the vitopine Ti plasmid pTiS4." Canaday J., Gerard J.-C., Crouzet P., Otten L. Mol. Gen. Genet. 235:292-303(1992) [PubMed: 1465104] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Genome sequences of three Agrobacterium biovars help elucidate the evolution of multichromosome genomes in bacteria." Slater S.C., Goldman B.S., Goodner B., Setubal J.C., Farrand S.K., Nester E.W., Burr T.J., Banta L., Dickerman A.W., Paulsen I., Otten L., Suen G., Welch R., Almeida N.F., Arnold F., Burton O.T., Du Z., Ewing A. , Godsy E., Heisel S., Houmiel K.L., Jhaveri J., Lu J., Miller N.M., Norton S., Chen Q., Phoolcharoen W., Ohlin V., Ondrusek D., Pride N., Stricklin S.L., Sun J., Wheeler C., Wilson L., Zhu H., Wood D.W. J. Bacteriol. 191:2501-2511(2009) [PubMed: 19251847] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: S4 / ATCC BAA-846.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M91609 Genomic DNA. Translation: AAA98149.1. CP000637 Genomic DNA. Translation: ACM39708.1.
PIR	S30105.
RefSeq	YP_002540148.1. NC_011982.1.
3D structure databases
ProteinModelPortal	Q04564.
ModBase	Search...
Protein-protein interaction databases
STRING	Q04564.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7365245.
GenomeReviews	Gene locus Avi_8288 in contig CP000637_GR.
KEGG	avi:Avi_8288.
PATRIC	20822172. VBIAgrVit37146_0791.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	RAINDTH.
ProtClustDB	CLSK687392.
Family and domain databases
InterPro	IPR002937. Amino_oxidase. IPR006064. Glycosidase. IPR012142. Trp_2-mOase. IPR001878. Znf_CCHC. [Graphical view]
KO	K00466.
Pfam	PF01593. Amino_oxidase. 1 hit. PF02027. RolB_RolC. 1 hit. [Graphical view]
PIRSF	PIRSF000319. Trp_2-mono_O2ase. 1 hit.
SMART	SM00343. ZnF_C2HC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TR2M_AGRVS

Accession

Primary (citable) accession number: Q04564
Secondary accession number(s): B9K454

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program