Q04550 (VP2_SOUV3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein VP2

Alternative name(s):
Minor capsid protein

Gene names

ORF Names:

ORF3

Organism

Southampton virus (strain GI/Human/United Kingdom/Southampton/1991) (SHV) (Hu/NV/SHV/1991/UK) [Complete proteome]

Taxonomic identifier

37129 [NCBI]

Taxonomic lineage

Viruses › ssRNA viruses › ssRNA positive-strand viruses, no DNA stage › Caliciviridae › Norovirus › Norwalk virus › Norovirus genogroup I › Southampton virus

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	211 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Minor structural protein present in one or two copies per virion. Stabilizes capsid protein VP1 by protecting it from disassembly and degradation. May play a role in RNA genome packaging By similarity.
Subcellular location	Virion. Host cytoplasm By similarity.
Miscellaneous	Translated by a ribosomal termination-reinitiation process from the bicistronic mRNA encoding for VP1 and VP2.
Sequence similarities	Belongs to the norovirus VP2 family.

Ontologies

Keywords
Cellular component	Host cytoplasm Virion
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	host cell cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell virion Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 211	211	Protein VP2		PRO_0000100131

Sequences

	Sequence		Length	Mass (Da)
	Q04550 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 3D6D1B51CC3C27B4	FASTA	211	22,257
	10 20 30 40 50 60 MAQAIIGAIA ASAAGSALGA GIQAGAEAAL QSQRYQQDLA LQRNTFEHDK DMLSYQVQAS 70 80 90 100 110 120 NALLAKNLNT RYSMLIAGGL SSADASRAVA GAPVTRLIDW NGTRVAAPRS SATTLRSGGF 130 140 150 160 170 180 MAVPMPVQPK SKTPQSSGFS NPAYDMSTVS SRTSSWVQSQ NSLRSVSPFH RQALQTVWVT 190 200 210 PPGSTSSSSV SSTPYGVFNT DRMPLFANLR R

References

[1]	"Sequence and genome organization of a human small round-structured (Norwalk-like) virus." Lambden P.R., Caul E.O., Ashley C.R., Clarke I.N. Science 259:516-519(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	L07418 Genomic RNA. Translation: AAA92985.1.
PIR	C37491.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR004278. RNA_pol/capsid. [Graphical view]
Pfam	PF03035. RNA_capsid. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VP2_SOUV3

Accession

Primary (citable) accession number: Q04550

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	April 3, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program