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Protein

Protein VP2

Gene

ORF3

Organism
Southampton virus (strain GI/Human/United Kingdom/Southampton/1991) (SHV) (Hu/NV/SHV/1991/UK)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Minor structural protein present in one or two copies per virion. Stabilizes capsid protein VP1 by protecting it from disassembly and degradation. May play a role in RNA genome packaging (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Protein VP2
Alternative name(s):
Minor capsid protein
Gene namesi
ORF Names:ORF3
OrganismiSouthampton virus (strain GI/Human/United Kingdom/Southampton/1991) (SHV) (Hu/NV/SHV/1991/UK)
Taxonomic identifieri37129 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageCaliciviridaeNorovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000007226 Componenti: Genome

Subcellular locationi

Virion. Host cytoplasm By similarity

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-SubCell
  2. virion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211Protein VP2PRO_0000100131Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the norovirus VP2 family.Curated

Family and domain databases

InterProiIPR004278. RNA_pol/capsid.
[Graphical view]
PfamiPF03035. RNA_capsid. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04550-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQAIIGAIA ASAAGSALGA GIQAGAEAAL QSQRYQQDLA LQRNTFEHDK
60 70 80 90 100
DMLSYQVQAS NALLAKNLNT RYSMLIAGGL SSADASRAVA GAPVTRLIDW
110 120 130 140 150
NGTRVAAPRS SATTLRSGGF MAVPMPVQPK SKTPQSSGFS NPAYDMSTVS
160 170 180 190 200
SRTSSWVQSQ NSLRSVSPFH RQALQTVWVT PPGSTSSSSV SSTPYGVFNT
210
DRMPLFANLR R
Length:211
Mass (Da):22,257
Last modified:September 30, 1994 - v1
Checksum:i3D6D1B51CC3C27B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07418 Genomic RNA. Translation: AAA92985.1.
PIRiC37491.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07418 Genomic RNA. Translation: AAA92985.1.
PIRiC37491.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR004278. RNA_pol/capsid.
[Graphical view]
PfamiPF03035. RNA_capsid. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence and genome organization of a human small round-structured (Norwalk-like) virus."
    Lambden P.R., Caul E.O., Ashley C.R., Clarke I.N.
    Science 259:516-519(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiVP2_SOUV3
AccessioniPrimary (citable) accession number: Q04550
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 30, 1994
Last sequence update: September 30, 1994
Last modified: January 6, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Translated by a ribosomal termination-reinitiation process from the bicistronic mRNA coding for VP1 and VP2.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.