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Q04539

- RPEP_CUPNH

UniProt

Q04539 - RPEP_CUPNH

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Protein
Ribulose-phosphate 3-epimerase, plasmid
Gene
cbbEP, cfxE, PHG423
Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate By similarity.

Catalytic activityi

D-ribulose 5-phosphate = D-xylulose 5-phosphate.

Cofactori

Binds 1 divalent metal cation per subunit. Active with Co2+, Fe2+, Mn2+ and Zn2+ By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei21 – 211Substrate By similarity
Metal bindingi46 – 461Divalent metal cation By similarity
Active sitei48 – 481Proton acceptor By similarity
Metal bindingi48 – 481Divalent metal cation By similarity
Metal bindingi79 – 791Divalent metal cation By similarity
Binding sitei79 – 791Substrate By similarity
Active sitei192 – 1921Proton donor By similarity
Metal bindingi192 – 1921Divalent metal cation By similarity
Binding sitei194 – 1941Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribulose-phosphate 3-epimerase activity Source: UniProtKB-EC

GO - Biological processi

  1. pentose-phosphate shunt Source: InterPro
  2. reductive pentose-phosphate cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Calvin cycle, Carbohydrate metabolism

Keywords - Ligandi

Cobalt, Iron, Manganese, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciCNEC381666:GJUJ-6697-MONOMER.
UniPathwayiUPA00116.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose-phosphate 3-epimerase, plasmid (EC:5.1.3.1)
Alternative name(s):
Pentose-5-phosphate 3-epimerase
Short name:
PPE
R5P3E
Gene namesi
Name:cbbEP
Synonyms:cfxE
Ordered Locus Names:PHG423
Encoded oniPlasmid megaplasmid pHG10 Publication
OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Taxonomic identifieri381666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000008210: Plasmid megaplasmid pHG1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Ribulose-phosphate 3-epimerase, plasmid
PRO_0000171557Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi381666.PHG423.

Structurei

3D structure databases

ProteinModelPortaliQ04539.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni155 – 1584Substrate binding By similarity
Regioni214 – 2152Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0036.
HOGENOMiHOG000259347.
KOiK01783.
OMAiHATEPNT.
OrthoDBiEOG67HK17.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR026019. Ribul_P_3_epim.
IPR000056. Ribul_P_3_epim-like.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PANTHERiPTHR11749. PTHR11749. 1 hit.
PfamiPF00834. Ribul_P_3_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF001461. RPE. 1 hit.
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01163. rpe. 1 hit.
PROSITEiPS01085. RIBUL_P_3_EPIMER_1. 1 hit.
PS01086. RIBUL_P_3_EPIMER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04539-1 [UniParc]FASTAAdd to Basket

« Hide

MHATEPNTGH GSQRAIRLAP SILSADFARL GEEVCAIEAG GADLVHFDVM    50
DNHYVSNLTI GPLVCEAIRP LVSIPIDVHL MVEPVDALIP MFAKAGANLI 100
SFHPEASRHV DRTIGLIRDH GCKAGLVLNP ATPLSWLDHT LDKLDLVLLM 150
SVNPGFGGQA FIPGVLDKVR QARARIDRQV AAGGRPVWLE IDGGVKADNI 200
TEIARAGADT FVAGSAVFGA PDADGGYRGI LHRLREAATI T 241
Length:241
Mass (Da):25,594
Last modified:February 1, 1995 - v1
Checksum:i6FACA5B81D6734CD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64172 Genomic DNA. Translation: AAA98231.1.
AY305378 Genomic DNA. Translation: AAP86172.1.
RefSeqiNP_943058.1. NC_005241.1.

Genome annotation databases

EnsemblBacteriaiAAP86172; AAP86172; PHG423.
GeneIDi2656542.
KEGGireh:PHG423.
PATRICi35229358. VBIRalEut6770_0351.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64172 Genomic DNA. Translation: AAA98231.1 .
AY305378 Genomic DNA. Translation: AAP86172.1 .
RefSeqi NP_943058.1. NC_005241.1.

3D structure databases

ProteinModelPortali Q04539.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 381666.PHG423.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP86172 ; AAP86172 ; PHG423 .
GeneIDi 2656542.
KEGGi reh:PHG423.
PATRICi 35229358. VBIRalEut6770_0351.

Phylogenomic databases

eggNOGi COG0036.
HOGENOMi HOG000259347.
KOi K01783.
OMAi HATEPNT.
OrthoDBi EOG67HK17.

Enzyme and pathway databases

UniPathwayi UPA00116 .
BioCyci CNEC381666:GJUJ-6697-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR026019. Ribul_P_3_epim.
IPR000056. Ribul_P_3_epim-like.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
PANTHERi PTHR11749. PTHR11749. 1 hit.
Pfami PF00834. Ribul_P_3_epim. 1 hit.
[Graphical view ]
PIRSFi PIRSF001461. RPE. 1 hit.
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01163. rpe. 1 hit.
PROSITEi PS01085. RIBUL_P_3_EPIMER_1. 1 hit.
PS01086. RIBUL_P_3_EPIMER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Calvin cycle enzyme pentose-5-phosphate 3-epimerase is encoded within the cfx operons of the chemoautotroph Alcaligenes eutrophus."
    Kusian B., Yoo J.-G., Bednarski R., Bowien B.
    J. Bacteriol. 174:7337-7344(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete nucleotide sequence of pHG1: a Ralstonia eutropha H16 megaplasmid encoding key enzymes of H(2)-based lithoautotrophy and anaerobiosis."
    Schwartz E., Henne A., Cramm R., Eitinger T., Friedrich B., Gottschalk G.
    J. Mol. Biol. 332:369-383(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.

Entry informationi

Entry nameiRPEP_CUPNH
AccessioniPrimary (citable) accession number: Q04539
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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