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Q04539

- RPEP_CUPNH

UniProt

Q04539 - RPEP_CUPNH

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Protein

Ribulose-phosphate 3-epimerase, plasmid

Gene

cbbEP

Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.By similarity

Catalytic activityi

D-ribulose 5-phosphate = D-xylulose 5-phosphate.

Cofactori

Co2+By similarity, Fe2+By similarity, Mn2+By similarity, Zn2+By similarityNote: Binds 1 divalent metal cation per subunit. Active with Co(2+), Fe(2+), Mn(2+) and Zn(2+).By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei21 – 211SubstrateBy similarity
Metal bindingi46 – 461Divalent metal cationBy similarity
Active sitei48 – 481Proton acceptorBy similarity
Metal bindingi48 – 481Divalent metal cationBy similarity
Metal bindingi79 – 791Divalent metal cationBy similarity
Binding sitei79 – 791SubstrateBy similarity
Active sitei192 – 1921Proton donorBy similarity
Metal bindingi192 – 1921Divalent metal cationBy similarity
Binding sitei194 – 1941Substrate; via amide nitrogenBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribulose-phosphate 3-epimerase activity Source: UniProtKB-EC

GO - Biological processi

  1. pentose-phosphate shunt Source: InterPro
  2. reductive pentose-phosphate cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Calvin cycle, Carbohydrate metabolism

Keywords - Ligandi

Cobalt, Iron, Manganese, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciCNEC381666:GJUJ-6697-MONOMER.
UniPathwayiUPA00116.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose-phosphate 3-epimerase, plasmid (EC:5.1.3.1)
Alternative name(s):
Pentose-5-phosphate 3-epimerase
Short name:
PPE
R5P3E
Gene namesi
Name:cbbEP
Synonyms:cfxE
Ordered Locus Names:PHG423
Encoded oniPlasmid megaplasmid pHG10 Publication
OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Taxonomic identifieri381666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000008210: Plasmid megaplasmid pHG1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Ribulose-phosphate 3-epimerase, plasmidPRO_0000171557Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi381666.PHG423.

Structurei

3D structure databases

ProteinModelPortaliQ04539.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni155 – 1584Substrate bindingBy similarity
Regioni214 – 2152Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0036.
HOGENOMiHOG000259347.
KOiK01783.
OMAiHATEPNT.
OrthoDBiEOG67HK17.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR026019. Ribul_P_3_epim.
IPR000056. Ribul_P_3_epim-like.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PANTHERiPTHR11749. PTHR11749. 1 hit.
PfamiPF00834. Ribul_P_3_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF001461. RPE. 1 hit.
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01163. rpe. 1 hit.
PROSITEiPS01085. RIBUL_P_3_EPIMER_1. 1 hit.
PS01086. RIBUL_P_3_EPIMER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04539-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHATEPNTGH GSQRAIRLAP SILSADFARL GEEVCAIEAG GADLVHFDVM
60 70 80 90 100
DNHYVSNLTI GPLVCEAIRP LVSIPIDVHL MVEPVDALIP MFAKAGANLI
110 120 130 140 150
SFHPEASRHV DRTIGLIRDH GCKAGLVLNP ATPLSWLDHT LDKLDLVLLM
160 170 180 190 200
SVNPGFGGQA FIPGVLDKVR QARARIDRQV AAGGRPVWLE IDGGVKADNI
210 220 230 240
TEIARAGADT FVAGSAVFGA PDADGGYRGI LHRLREAATI T
Length:241
Mass (Da):25,594
Last modified:February 1, 1995 - v1
Checksum:i6FACA5B81D6734CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64172 Genomic DNA. Translation: AAA98231.1.
AY305378 Genomic DNA. Translation: AAP86172.1.
RefSeqiNP_943058.1. NC_005241.1.
WP_011154335.1. NC_005241.1.

Genome annotation databases

EnsemblBacteriaiAAP86172; AAP86172; PHG423.
GeneIDi2656542.
KEGGireh:PHG423.
PATRICi35229358. VBIRalEut6770_0351.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64172 Genomic DNA. Translation: AAA98231.1 .
AY305378 Genomic DNA. Translation: AAP86172.1 .
RefSeqi NP_943058.1. NC_005241.1.
WP_011154335.1. NC_005241.1.

3D structure databases

ProteinModelPortali Q04539.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 381666.PHG423.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAP86172 ; AAP86172 ; PHG423 .
GeneIDi 2656542.
KEGGi reh:PHG423.
PATRICi 35229358. VBIRalEut6770_0351.

Phylogenomic databases

eggNOGi COG0036.
HOGENOMi HOG000259347.
KOi K01783.
OMAi HATEPNT.
OrthoDBi EOG67HK17.

Enzyme and pathway databases

UniPathwayi UPA00116 .
BioCyci CNEC381666:GJUJ-6697-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR026019. Ribul_P_3_epim.
IPR000056. Ribul_P_3_epim-like.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
PANTHERi PTHR11749. PTHR11749. 1 hit.
Pfami PF00834. Ribul_P_3_epim. 1 hit.
[Graphical view ]
PIRSFi PIRSF001461. RPE. 1 hit.
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01163. rpe. 1 hit.
PROSITEi PS01085. RIBUL_P_3_EPIMER_1. 1 hit.
PS01086. RIBUL_P_3_EPIMER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Calvin cycle enzyme pentose-5-phosphate 3-epimerase is encoded within the cfx operons of the chemoautotroph Alcaligenes eutrophus."
    Kusian B., Yoo J.-G., Bednarski R., Bowien B.
    J. Bacteriol. 174:7337-7344(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete nucleotide sequence of pHG1: a Ralstonia eutropha H16 megaplasmid encoding key enzymes of H(2)-based lithoautotrophy and anaerobiosis."
    Schwartz E., Henne A., Cramm R., Eitinger T., Friedrich B., Gottschalk G.
    J. Mol. Biol. 332:369-383(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.

Entry informationi

Entry nameiRPEP_CUPNH
AccessioniPrimary (citable) accession number: Q04539
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: November 26, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3