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Q04522 (GSTF_SILVU) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase

EC=2.5.1.18
Alternative name(s):
GST class-phi
Gene names
Name:GST
OrganismSilene vulgaris (Bladder campion) (Silene cucubalus)
Taxonomic identifier42043 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeCaryophyllalesCaryophyllaceaeSilene

Protein attributes

Sequence length217 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the GST superfamily. Phi family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1
Chain2 – 217216Glutathione S-transferase
PRO_0000185855

Regions

Domain2 – 8281GST N-terminal
Domain91 – 217127GST C-terminal
Region40 – 412Glutathione binding By similarity
Region53 – 542Glutathione binding By similarity
Region66 – 672Glutathione binding By similarity

Sites

Binding site111Glutathione By similarity

Sequences

Sequence LengthMass (Da)Tools
Q04522 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 51ABE9DA2FE23D67

FASTA21724,599
        10         20         30         40         50         60 
MTIKVHGNPR STATQRVLVA LYEKHLEFEF VPIDMGAGGH KQPSYLALNP FGQVPALEDG 

        70         80         90        100        110        120 
EIKLFESRAI TKYLAYTHDH QNEGTSLIHK EKHEMAAQLV WEEVEAHQFD PVASKLAWEL 

       130        140        150        160        170        180 
VFKGIFGMQT DTTVVEENEA KLAKVLDVYE ARLTESEYLG ANDSFTLVDL HHLPLLGYLM 

       190        200        210 
GTQVKKLFEE RAHVSAWCKK ILARPSWEKT LALQKQA 

« Hide

References

[1]"Nucleotide sequence of a cDNA encoding a constitutively expressed glutathione-S-transferase from cell suspension cultures of Silene cucubalus."
Kutchan T.M., Hochberger A.
Plant Physiol. 99:789-790(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-40; 124-141 AND 146-153.
[2]"Nucleotide sequence of the gene for a glutathione-S-transferase from cell suspension cultures of Silene cucubalus."
Praendl R., Kutchan T.M.
Plant Physiol. 99:1729-1731(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M84968 mRNA. Translation: AAA33930.1.
M84969 Genomic DNA. Translation: AAA33931.1.

3D structure databases

ProteinModelPortalQ04522.
SMRQ04522. Positions 3-210.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ04522.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSTF_SILVU
AccessionPrimary (citable) accession number: Q04522
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 64 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families