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Q04522

- GSTF_SILVU

UniProt

Q04522 - GSTF_SILVU

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Protein

Glutathione S-transferase

Gene

GST

Organism
Silene vulgaris (Bladder campion) (Silene cucubalus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111GlutathioneBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase (EC:2.5.1.18)
Alternative name(s):
GST class-phi
Gene namesi
Name:GST
OrganismiSilene vulgaris (Bladder campion) (Silene cucubalus)
Taxonomic identifieri42043 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeCaryophyllalesCaryophyllaceaeSilene

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 217216Glutathione S-transferasePRO_0000185855Add
BLAST

Proteomic databases

PRIDEiQ04522.

Structurei

3D structure databases

ProteinModelPortaliQ04522.
SMRiQ04522. Positions 3-210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8281GST N-terminalAdd
BLAST
Domaini91 – 217127GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni40 – 412Glutathione bindingBy similarity
Regioni53 – 542Glutathione bindingBy similarity
Regioni66 – 672Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Phi family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04522-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTIKVHGNPR STATQRVLVA LYEKHLEFEF VPIDMGAGGH KQPSYLALNP
60 70 80 90 100
FGQVPALEDG EIKLFESRAI TKYLAYTHDH QNEGTSLIHK EKHEMAAQLV
110 120 130 140 150
WEEVEAHQFD PVASKLAWEL VFKGIFGMQT DTTVVEENEA KLAKVLDVYE
160 170 180 190 200
ARLTESEYLG ANDSFTLVDL HHLPLLGYLM GTQVKKLFEE RAHVSAWCKK
210
ILARPSWEKT LALQKQA
Length:217
Mass (Da):24,599
Last modified:January 23, 2007 - v3
Checksum:i51ABE9DA2FE23D67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84968 mRNA. Translation: AAA33930.1.
M84969 Genomic DNA. Translation: AAA33931.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84968 mRNA. Translation: AAA33930.1 .
M84969 Genomic DNA. Translation: AAA33931.1 .

3D structure databases

ProteinModelPortali Q04522.
SMRi Q04522. Positions 3-210.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q04522.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of a cDNA encoding a constitutively expressed glutathione-S-transferase from cell suspension cultures of Silene cucubalus."
    Kutchan T.M., Hochberger A.
    Plant Physiol. 99:789-790(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-40; 124-141 AND 146-153.
  2. "Nucleotide sequence of the gene for a glutathione-S-transferase from cell suspension cultures of Silene cucubalus."
    Praendl R., Kutchan T.M.
    Plant Physiol. 99:1729-1731(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiGSTF_SILVU
AccessioniPrimary (citable) accession number: Q04522
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 66 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3