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Q04522

- GSTF_SILVU

UniProt

Q04522 - GSTF_SILVU

Protein

Glutathione S-transferase

Gene

GST

Organism
Silene vulgaris (Bladder campion) (Silene cucubalus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei11 – 111GlutathioneBy similarity

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase (EC:2.5.1.18)
    Alternative name(s):
    GST class-phi
    Gene namesi
    Name:GST
    OrganismiSilene vulgaris (Bladder campion) (Silene cucubalus)
    Taxonomic identifieri42043 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeCaryophyllalesCaryophyllaceaeSilene

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 217216Glutathione S-transferasePRO_0000185855Add
    BLAST

    Proteomic databases

    PRIDEiQ04522.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04522.
    SMRiQ04522. Positions 3-210.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 8281GST N-terminalAdd
    BLAST
    Domaini91 – 217127GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni40 – 412Glutathione bindingBy similarity
    Regioni53 – 542Glutathione bindingBy similarity
    Regioni66 – 672Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Phi family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q04522-1 [UniParc]FASTAAdd to Basket

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    MTIKVHGNPR STATQRVLVA LYEKHLEFEF VPIDMGAGGH KQPSYLALNP    50
    FGQVPALEDG EIKLFESRAI TKYLAYTHDH QNEGTSLIHK EKHEMAAQLV 100
    WEEVEAHQFD PVASKLAWEL VFKGIFGMQT DTTVVEENEA KLAKVLDVYE 150
    ARLTESEYLG ANDSFTLVDL HHLPLLGYLM GTQVKKLFEE RAHVSAWCKK 200
    ILARPSWEKT LALQKQA 217
    Length:217
    Mass (Da):24,599
    Last modified:January 23, 2007 - v3
    Checksum:i51ABE9DA2FE23D67
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M84968 mRNA. Translation: AAA33930.1.
    M84969 Genomic DNA. Translation: AAA33931.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M84968 mRNA. Translation: AAA33930.1 .
    M84969 Genomic DNA. Translation: AAA33931.1 .

    3D structure databases

    ProteinModelPortali Q04522.
    SMRi Q04522. Positions 3-210.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q04522.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a cDNA encoding a constitutively expressed glutathione-S-transferase from cell suspension cultures of Silene cucubalus."
      Kutchan T.M., Hochberger A.
      Plant Physiol. 99:789-790(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-40; 124-141 AND 146-153.
    2. "Nucleotide sequence of the gene for a glutathione-S-transferase from cell suspension cultures of Silene cucubalus."
      Praendl R., Kutchan T.M.
      Plant Physiol. 99:1729-1731(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiGSTF_SILVU
    AccessioniPrimary (citable) accession number: Q04522
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 65 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3