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Q04522

- GSTF_SILVU

UniProt

Q04522 - GSTF_SILVU

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Protein
Glutathione S-transferase
Gene
GST
Organism
Silene vulgaris (Bladder campion) (Silene cucubalus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111Glutathione By similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase (EC:2.5.1.18)
Alternative name(s):
GST class-phi
Gene namesi
Name:GST
OrganismiSilene vulgaris (Bladder campion) (Silene cucubalus)
Taxonomic identifieri42043 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeCaryophyllalesCaryophyllaceaeSilene

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 217216Glutathione S-transferase
PRO_0000185855Add
BLAST

Proteomic databases

PRIDEiQ04522.

Structurei

3D structure databases

ProteinModelPortaliQ04522.
SMRiQ04522. Positions 3-210.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8281GST N-terminal
Add
BLAST
Domaini91 – 217127GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni40 – 412Glutathione binding By similarity
Regioni53 – 542Glutathione binding By similarity
Regioni66 – 672Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Phi family.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04522-1 [UniParc]FASTAAdd to Basket

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MTIKVHGNPR STATQRVLVA LYEKHLEFEF VPIDMGAGGH KQPSYLALNP    50
FGQVPALEDG EIKLFESRAI TKYLAYTHDH QNEGTSLIHK EKHEMAAQLV 100
WEEVEAHQFD PVASKLAWEL VFKGIFGMQT DTTVVEENEA KLAKVLDVYE 150
ARLTESEYLG ANDSFTLVDL HHLPLLGYLM GTQVKKLFEE RAHVSAWCKK 200
ILARPSWEKT LALQKQA 217
Length:217
Mass (Da):24,599
Last modified:January 23, 2007 - v3
Checksum:i51ABE9DA2FE23D67
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M84968 mRNA. Translation: AAA33930.1.
M84969 Genomic DNA. Translation: AAA33931.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M84968 mRNA. Translation: AAA33930.1 .
M84969 Genomic DNA. Translation: AAA33931.1 .

3D structure databases

ProteinModelPortali Q04522.
SMRi Q04522. Positions 3-210.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q04522.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of a cDNA encoding a constitutively expressed glutathione-S-transferase from cell suspension cultures of Silene cucubalus."
    Kutchan T.M., Hochberger A.
    Plant Physiol. 99:789-790(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-40; 124-141 AND 146-153.
  2. "Nucleotide sequence of the gene for a glutathione-S-transferase from cell suspension cultures of Silene cucubalus."
    Praendl R., Kutchan T.M.
    Plant Physiol. 99:1729-1731(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiGSTF_SILVU
AccessioniPrimary (citable) accession number: Q04522
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 64 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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