Q04520 (BUDC_RAOTE) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 63.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Diacetyl reductase [(S)-acetoin forming] EC=1.1.1.304 Alternative name(s): Acetoin(diacetyl) reductase Short name=AR Meso-2,3-butanediol dehydrogenase | ||
| Gene names |
| ||
| Organism | Raoultella terrigena (Klebsiella terrigena) | ||
| Taxonomic identifier | 577 [NCBI] | ||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Raoultella |
Protein attributes
| Sequence length | 241 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the irreversible reduction of 2,3-butanediol to (S)-acetoin in the presence of NADH. |
| Catalytic activity | (S)-acetoin + NAD+ = diacetyl + NADH. |
| Subunit structure | Homotetramer. |
| Sequence similarities | Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | acetoin catabolic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | diacetyl reductase ((S)-acetoin forming) activity Inferred from electronic annotation. Source: EC nucleotide bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 241 | 241 | Diacetyl reductase [(S)-acetoin forming] | PRO_0000054538 | |||||
Regions | |||||||||
| Nucleotide binding | 6 – 30 | 25 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 152 | 1 | Proton acceptor By similarity | ||||||
| Active site | 156 | 1 | By similarity | ||||||
| Binding site | 139 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "Characterization of the genes of the 2,3-butanediol operons from Klebsiella terrigena and Enterobacter aerogenes." Blomqvist K., Nikkola M., Lehtovaara P., Suihko M.-L., Airaksinen U., Straby K.B., Knowles J.K.C., Penttilae M.E. J. Bacteriol. 175:1392-1404(1993) [PubMed: 8444801] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: VTT-E-74023. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | L04507 Genomic DNA. Translation: AAA25056.1. |
| PIR | E47069. |
3D structure databases | |
| ProteinModelPortal | Q04520. |
| SMR | Q04520. Positions 1-228. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Family and domain databases | |
| InterPro | IPR014007. 23BDH. IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| Pfam | PF00106. adh_short. 1 hit. [Graphical view] |
| PRINTS | PR00081. GDHRDH. PR00080. SDRFAMILY. |
| TIGRFAMs | TIGR02415. 23BDH. 1 hit. |
| PROSITE | PS00061. ADH_SHORT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | BUDC_RAOTE | ||||||||
| Accession | Primary (citable) accession number: Q04520 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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