true1997-11-012023-05-03102DYR10_ECOLXA new trimethoprim resistance gene, dhfrX, in the In7 integron of plasmid pDGO100.Parsons Y.Hall R.M.Stokes H.W.doi:10.1128/aac.35.11.24361991Antimicrob. Agents Chemother.352436-2439NUCLEOTIDE SEQUENCE [GENOMIC DNA]VA292The partial 3'-conserved segment duplications in the integrons In6 from pSa and In7 from pDGO100 have a common origin.Stokes H.W.Tomaras C.Parsons Y.Hall R.M.doi:10.1006/plas.1993.10321993Plasmid3039-50NUCLEOTIDE SEQUENCE [GENOMIC DNA]In34, a complex In5 family class 1 integron containing orf513 and dfrA10.Partridge S.R.Hall R.M.doi:10.1128/aac.47.1.342-349.20032003Antimicrob. Agents Chemother.47342-349NUCLEOTIDE SEQUENCE [GENOMIC DNA]DHFRDihydrofolate Reductase, subunit ADHFRDHFR-like_dom_sfDHFR_CSDHFR_domDIHYDROFOLATE REDUCTASEDIHYDROFOLATE REDUCTASEDHFR_1DHFRDihydrofolate reductase-likeDHFR_1DHFR_2Dihydrofolate reductase type A101.5.1.3Dihydrofolate reductase type XDHFRXpDGO100dfrA10dfr10Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).Homodimer.Confers trimethoprim resistance.Belongs to the dihydrofolate reductase family.Dihydrofolate reductase type A10212201187DHFR21741996-11-0112122079367d0d3ebadac8d6ae30786e7cdfb8MNISLIFANELITRAFGNQGKLPWQFIKEDMQFFQKTTENSVVVMGLNTWRSLPKMKKLGRDFIVISSTITEHEVLNNNIQIFKSFESFLEAFRDTTKPINVIGGVGLLSEAIEHASTVYMSSIHMVKPVHADVYVPVELMNKLYSDFKYPENILWVGDPIDSVYSLSIDKFVRPASLVGVPNDINTtruetruetrue