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Q04512

- HEM1_RHOS4

UniProt

Q04512 - HEM1_RHOS4

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Protein

5-aminolevulinate synthase 1

Gene
hemA, RHOS4_15770, RSP_2984
Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

Cofactori

Pyridoxal phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei21 – 211Substrate By similarity
Binding sitei137 – 1371Substrate By similarity
Binding sitei156 – 1561Substrate By similarity
Binding sitei189 – 1891Pyridoxal phosphate By similarity
Binding sitei217 – 2171Pyridoxal phosphate By similarity
Binding sitei245 – 2451Pyridoxal phosphate By similarity
Active sitei248 – 2481 By similarity
Binding sitei277 – 2771Pyridoxal phosphate By similarity
Binding sitei278 – 2781Pyridoxal phosphate By similarity
Binding sitei363 – 3631Substrate By similarity

GO - Molecular functioni

  1. 5-aminolevulinate synthase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Heme biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciRSPH272943:GJAS-1613-MONOMER.
UniPathwayiUPA00251; UER00375.

Names & Taxonomyi

Protein namesi
Recommended name:
5-aminolevulinate synthase 1 (EC:2.3.1.37)
Alternative name(s):
5-aminolevulinic acid synthase
Delta-ALA synthase
Delta-aminolevulinate synthase
Gene namesi
Name:hemA
Ordered Locus Names:RHOS4_15770
ORF Names:RSP_2984
OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Taxonomic identifieri272943 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
ProteomesiUP000002703: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4074075-aminolevulinate synthase 1PRO_0000163829Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei248 – 2481N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Protein-protein interaction databases

STRINGi272943.RSP_2984.

Structurei

3D structure databases

ProteinModelPortaliQ04512.
SMRiQ04512. Positions 1-395.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0156.
HOGENOMiHOG000221020.
KOiK00643.
OMAiTEGRYRT.
OrthoDBiEOG6Q8HZD.
PhylomeDBiQ04512.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04512-1 [UniParc]FASTAAdd to Basket

« Hide

MDYNLALDTA LNRLHTEGRY RTFIDIERRK GAFPKAMWRK PDGSEKEITV    50
WCGNDYLGMG QHPVVLGAMH EALDSTGAGS GGTRNISGTT LYHKRLEAEL 100
ADLHGKEAAL VFSSAYIAND ATLSTLPQLI PGLVIVSDKL NHASMIEGIR 150
RSGTEKHIFK HNDLDDLRRI LTSIGKDRPI LVAFESVYSM DGDFGRIEEI 200
CDIADEFGAL KYIDEVHAVG MYGPRGGGVA ERDGLMDRID IINGTLGKAY 250
GVFGGYIAAS SKMCDAVRSY APGFIFSTSL PPVVAAGAAA SVRHLKGDVE 300
LREKHQTQAR ILKMRLKGLG LPIIDHGSHI VPVHVGDPVH CKMISDMLLE 350
HFGIYVQPIN FPTVPRGTER LRFTPSPVHD SGMIDHLVKA MDVLWQHCAL 400
NRAEVVA 407
Length:407
Mass (Da):44,616
Last modified:October 1, 1993 - v1
Checksum:iDCDE2484BFACC7F0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L07490 Genomic DNA. Translation: AAA72325.1.
CP000143 Genomic DNA. Translation: ABA79145.1.
RefSeqiWP_011337894.1. NZ_AKVW01000001.1.
YP_353046.1. NC_007493.2.

Genome annotation databases

EnsemblBacteriaiABA79145; ABA79145; RSP_2984.
GeneIDi3720398.
KEGGirsp:RSP_2984.
PATRICi23153077. VBIRhoSph57909_1924.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L07490 Genomic DNA. Translation: AAA72325.1 .
CP000143 Genomic DNA. Translation: ABA79145.1 .
RefSeqi WP_011337894.1. NZ_AKVW01000001.1.
YP_353046.1. NC_007493.2.

3D structure databases

ProteinModelPortali Q04512.
SMRi Q04512. Positions 1-395.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272943.RSP_2984.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA79145 ; ABA79145 ; RSP_2984 .
GeneIDi 3720398.
KEGGi rsp:RSP_2984.
PATRICi 23153077. VBIRhoSph57909_1924.

Phylogenomic databases

eggNOGi COG0156.
HOGENOMi HOG000221020.
KOi K00643.
OMAi TEGRYRT.
OrthoDBi EOG6Q8HZD.
PhylomeDBi Q04512.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00375 .
BioCyci RSPH272943:GJAS-1613-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of the Rhodobacter sphaeroides hemA and hemT genes, encoding two 5-aminolevulinic acid synthase isozymes."
    Neidle E.L., Kaplan S.
    J. Bacteriol. 175:2292-2303(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158.

Entry informationi

Entry nameiHEM1_RHOS4
AccessioniPrimary (citable) accession number: Q04512
Secondary accession number(s): Q3J239
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: September 3, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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