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Q04512

- HEM1_RHOS4

UniProt

Q04512 - HEM1_RHOS4

Protein

5-aminolevulinate synthase 1

Gene

hemA

Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

    Cofactori

    Pyridoxal phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei21 – 211SubstrateBy similarity
    Binding sitei137 – 1371SubstrateBy similarity
    Binding sitei156 – 1561SubstrateBy similarity
    Binding sitei189 – 1891Pyridoxal phosphateBy similarity
    Binding sitei217 – 2171Pyridoxal phosphateBy similarity
    Binding sitei245 – 2451Pyridoxal phosphateBy similarity
    Active sitei248 – 2481By similarity
    Binding sitei277 – 2771Pyridoxal phosphateBy similarity
    Binding sitei278 – 2781Pyridoxal phosphateBy similarity
    Binding sitei363 – 3631SubstrateBy similarity

    GO - Molecular functioni

    1. 5-aminolevulinate synthase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Heme biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciRSPH272943:GJAS-1613-MONOMER.
    UniPathwayiUPA00251; UER00375.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-aminolevulinate synthase 1 (EC:2.3.1.37)
    Alternative name(s):
    5-aminolevulinic acid synthase
    Delta-ALA synthase
    Delta-aminolevulinate synthase
    Gene namesi
    Name:hemA
    Ordered Locus Names:RHOS4_15770
    ORF Names:RSP_2984
    OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
    Taxonomic identifieri272943 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
    ProteomesiUP000002703: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4074075-aminolevulinate synthase 1PRO_0000163829Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei248 – 2481N6-(pyridoxal phosphate)lysineBy similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi272943.RSP_2984.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04512.
    SMRiQ04512. Positions 1-395.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0156.
    HOGENOMiHOG000221020.
    KOiK00643.
    OMAiTEGRYRT.
    OrthoDBiEOG6Q8HZD.
    PhylomeDBiQ04512.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
    PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04512-1 [UniParc]FASTAAdd to Basket

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    MDYNLALDTA LNRLHTEGRY RTFIDIERRK GAFPKAMWRK PDGSEKEITV    50
    WCGNDYLGMG QHPVVLGAMH EALDSTGAGS GGTRNISGTT LYHKRLEAEL 100
    ADLHGKEAAL VFSSAYIAND ATLSTLPQLI PGLVIVSDKL NHASMIEGIR 150
    RSGTEKHIFK HNDLDDLRRI LTSIGKDRPI LVAFESVYSM DGDFGRIEEI 200
    CDIADEFGAL KYIDEVHAVG MYGPRGGGVA ERDGLMDRID IINGTLGKAY 250
    GVFGGYIAAS SKMCDAVRSY APGFIFSTSL PPVVAAGAAA SVRHLKGDVE 300
    LREKHQTQAR ILKMRLKGLG LPIIDHGSHI VPVHVGDPVH CKMISDMLLE 350
    HFGIYVQPIN FPTVPRGTER LRFTPSPVHD SGMIDHLVKA MDVLWQHCAL 400
    NRAEVVA 407
    Length:407
    Mass (Da):44,616
    Last modified:October 1, 1993 - v1
    Checksum:iDCDE2484BFACC7F0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07490 Genomic DNA. Translation: AAA72325.1.
    CP000143 Genomic DNA. Translation: ABA79145.1.
    RefSeqiWP_011337894.1. NZ_AKVW01000001.1.
    YP_353046.1. NC_007493.2.

    Genome annotation databases

    EnsemblBacteriaiABA79145; ABA79145; RSP_2984.
    GeneIDi3720398.
    KEGGirsp:RSP_2984.
    PATRICi23153077. VBIRhoSph57909_1924.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07490 Genomic DNA. Translation: AAA72325.1 .
    CP000143 Genomic DNA. Translation: ABA79145.1 .
    RefSeqi WP_011337894.1. NZ_AKVW01000001.1.
    YP_353046.1. NC_007493.2.

    3D structure databases

    ProteinModelPortali Q04512.
    SMRi Q04512. Positions 1-395.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272943.RSP_2984.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA79145 ; ABA79145 ; RSP_2984 .
    GeneIDi 3720398.
    KEGGi rsp:RSP_2984.
    PATRICi 23153077. VBIRhoSph57909_1924.

    Phylogenomic databases

    eggNOGi COG0156.
    HOGENOMi HOG000221020.
    KOi K00643.
    OMAi TEGRYRT.
    OrthoDBi EOG6Q8HZD.
    PhylomeDBi Q04512.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00375 .
    BioCyci RSPH272943:GJAS-1613-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
    PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of the Rhodobacter sphaeroides hemA and hemT genes, encoding two 5-aminolevulinic acid synthase isozymes."
      Neidle E.L., Kaplan S.
      J. Bacteriol. 175:2292-2303(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158.

    Entry informationi

    Entry nameiHEM1_RHOS4
    AccessioniPrimary (citable) accession number: Q04512
    Secondary accession number(s): Q3J239
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3