UniProtKB - Q04500 (UTP14_YEAST)
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Protein
U3 small nucleolar RNA-associated protein 14
Gene
UTP14
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Involved in nucleolar processing of pre-18S ribosomal RNA.1 Publication
Miscellaneous
Present with 1470 molecules/cell in log phase SD medium.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 260 – 267 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
- endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
- endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
- rRNA methylation Source: Reactome
Keywordsi
Molecular function | Ribonucleoprotein |
Biological process | Ribosome biogenesis, rRNA processing |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | YEAST:G3O-32678-MONOMER. |
Reactomei | R-SCE-6791226. Major pathway of rRNA processing in the nucleolus and cytosol. |
Names & Taxonomyi
Protein namesi | Recommended name: U3 small nucleolar RNA-associated protein 14Short name: U3 snoRNA-associated protein 14 Alternative name(s): U three protein 14 |
Gene namesi | Name:UTP14 Ordered Locus Names:YML093W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YML093W. |
SGDi | S000004558. UTP14. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000065742 | 1 – 899 | U3 small nucleolar RNA-associated protein 14Add BLAST | 899 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 34 | PhosphoserineCombined sources | 1 | |
Modified residuei | 35 | PhosphoserineCombined sources | 1 | |
Modified residuei | 151 | PhosphoserineCombined sources | 1 | |
Modified residuei | 423 | PhosphoserineCombined sources | 1 | |
Modified residuei | 424 | PhosphoserineCombined sources | 1 | |
Modified residuei | 488 | PhosphoserineCombined sources | 1 | |
Modified residuei | 500 | PhosphoserineCombined sources | 1 | |
Modified residuei | 562 | PhosphoserineCombined sources | 1 | |
Modified residuei | 668 | PhosphoserineCombined sources | 1 | |
Modified residuei | 738 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q04500. |
PaxDbi | Q04500. |
PRIDEi | Q04500. |
PTM databases
iPTMneti | Q04500. |
Interactioni
Subunit structurei
Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.1 Publication
Binary interactionsi
Protein-protein interaction databases
BioGridi | 35050. 102 interactors. |
DIPi | DIP-6410N. |
IntActi | Q04500. 34 interactors. |
MINTi | Q04500. |
STRINGi | 4932.YML093W. |
Structurei
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5WLC | electron microscopy | 3.80 | SS | 1-899 | [»] | |
ProteinModelPortali | Q04500. | |||||
SMRi | Q04500. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 162 – 168 | Poly-Ser | 7 | |
Compositional biasi | 179 – 182 | Poly-Glu | 4 | |
Compositional biasi | 704 – 712 | Poly-Lys | 9 |
Sequence similaritiesi
Belongs to the UTP14 family.Curated
Phylogenomic databases
GeneTreei | ENSGT00390000008142. |
HOGENOMi | HOG000074497. |
InParanoidi | Q04500. |
KOi | K14567. |
OMAi | TTLPGWG. |
OrthoDBi | EOG092C1VSC. |
Family and domain databases
InterProi | View protein in InterPro IPR006709. SSU_processome_Utp14. |
PANTHERi | PTHR14150. PTHR14150. 1 hit. |
Pfami | View protein in Pfam PF04615. Utp14. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q04500-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAKKKSKSRS KSSRRVLDAL QLAEREINGE FDNSSDNDKR HDARRNGTVV
60 70 80 90 100
NLLKRSKGDT NSDEDDIDSE SFEDEELNSD EALGSDDDYD ILNSKFSQTI
110 120 130 140 150
RDKKENANYQ EEEDEGGYTS IDEEDLMPLS QVWDMDEKTA QSNGNDDEDA
160 170 180 190 200
SPQLKLQDTD ISSESSSSEE SESESEDDEE EEDPFDEISE DEEDIELNTI
210 220 230 240 250
TSKLIDETKS KAPKRLDTYG SGEANEYVLP SANAASGASG KLSLTDMMNV
260 270 280 290 300
IDDRQVIENA NLLKGKSSTY EVPLPQRIQQ RHDRKAAYEI SRQEVSKWND
310 320 330 340 350
IVQQNRRADH LIFPLNKPTE HNHASAFTRT QDVPQTELQE KVDQVLQESN
360 370 380 390 400
LANPEKDSKF EELSTAKMTP EEMRKRTTEM RLMRELMFRE ERKARRLKKI
410 420 430 440 450
KSKTYRKIKK KELMKNRELA AVSSDEDNED HDIARAKERM TLKHKTNSKW
460 470 480 490 500
AKDMIKHGMT NDAETREEME EMLRQGERLK AKMLDRNSDD EEDGRVQTLS
510 520 530 540 550
DVENEEKENI DSEALKSKLG KTGVMNMAFM KNGEAREREA NKETLRQLRA
560 570 580 590 600
VENGDDIKLF ESDEEETNGE NIQINKGRRI YTPGSLESNK DMNELNDHTR
610 620 630 640 650
KENKVDESRS LENRLRAKNS GQSKNARTNA EGAIIVEEES DGEPLQDGQN
660 670 680 690 700
NQQDEEAKDV NPWLANESDE EHTVKKQSSK VNVIDKDSSK NVKAMNKMEK
710 720 730 740 750
AELKQKKKKK GKSNDDEDLL LTADDSTRLK IVDPYGGSDD EQGDNVFMFK
760 770 780 790 800
QQDVIAEAFA GDDVVAEFQE EKKRVIDDED DKEVDTTLPG WGEWAGAGSK
810 820 830 840 850
PKNKKRKFIK KVKGVVNKDK RRDKNLQNVI INEKVNKKNL KYQSSAVPFP
860 870 880 890
FENREQYERS LRMPIGQEWT SRASHQELIK PRIMTKPGQV IDPLKAPFK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z46660 Genomic DNA. Translation: CAA86645.1. BK006946 Genomic DNA. Translation: DAA09806.1. |
PIRi | S49634. |
RefSeqi | NP_013617.1. NM_001182452.1. |
Genome annotation databases
EnsemblFungii | YML093W; YML093W; YML093W. |
GeneIDi | 854881. |
KEGGi | sce:YML093W. |
Similar proteinsi
Entry informationi
Entry namei | UTP14_YEAST | |
Accessioni | Q04500Primary (citable) accession number: Q04500 Secondary accession number(s): D6W0J2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | March 28, 2018 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |