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UniProtKB - Q04500 (UTP14_YEAST)

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Protein

U3 small nucleolar RNA-associated protein 14

Gene

UTP14

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in nucleolar processing of pre-18S ribosomal RNA.1 Publication

Miscellaneous

Present with 1470 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi260 – 267ATPSequence analysis8

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionRibonucleoprotein
Biological processRibosome biogenesis, rRNA processing
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32678-MONOMER.
ReactomeiR-SCE-6790901. rRNA modification in the nucleus and cytosol.
R-SCE-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 14
Short name:
U3 snoRNA-associated protein 14
Alternative name(s):
U three protein 14
Gene namesi
Name:UTP14
Ordered Locus Names:YML093W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YML093W.
SGDiS000004558. UTP14.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: SGD
  • nucleoplasm Source: Reactome
  • small-subunit processome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000657421 – 899U3 small nucleolar RNA-associated protein 14Add BLAST899

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphoserineCombined sources1
Modified residuei35PhosphoserineCombined sources1
Modified residuei151PhosphoserineCombined sources1
Modified residuei423PhosphoserineCombined sources1
Modified residuei424PhosphoserineCombined sources1
Modified residuei488PhosphoserineCombined sources1
Modified residuei500PhosphoserineCombined sources1
Modified residuei562PhosphoserineCombined sources1
Modified residuei668PhosphoserineCombined sources1
Modified residuei738PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ04500.
PRIDEiQ04500.

PTM databases

iPTMnetiQ04500.

Interactioni

Subunit structurei

Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.1 Publication

Protein-protein interaction databases

BioGridi35050. 99 interactors.
DIPiDIP-6410N.
IntActiQ04500. 5 interactors.
MINTiMINT-8285383.

Structurei

3D structure databases

ProteinModelPortaliQ04500.
SMRiQ04500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi162 – 168Poly-Ser7
Compositional biasi179 – 182Poly-Glu4
Compositional biasi704 – 712Poly-Lys9

Sequence similaritiesi

Belongs to the UTP14 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000008142.
HOGENOMiHOG000074497.
InParanoidiQ04500.
KOiK14567.
OMAiTTLPGWG.
OrthoDBiEOG092C1VSC.

Family and domain databases

InterProiView protein in InterPro
IPR006709. SSU_processome_Utp14.
PANTHERiPTHR14150. PTHR14150. 1 hit.
PfamiView protein in Pfam
PF04615. Utp14. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04500-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKKKSKSRS KSSRRVLDAL QLAEREINGE FDNSSDNDKR HDARRNGTVV 
        60         70         80         90        100
NLLKRSKGDT NSDEDDIDSE SFEDEELNSD EALGSDDDYD ILNSKFSQTI 
       110        120        130        140        150
RDKKENANYQ EEEDEGGYTS IDEEDLMPLS QVWDMDEKTA QSNGNDDEDA 
       160        170        180        190        200
SPQLKLQDTD ISSESSSSEE SESESEDDEE EEDPFDEISE DEEDIELNTI 
       210        220        230        240        250
TSKLIDETKS KAPKRLDTYG SGEANEYVLP SANAASGASG KLSLTDMMNV 
       260        270        280        290        300
IDDRQVIENA NLLKGKSSTY EVPLPQRIQQ RHDRKAAYEI SRQEVSKWND 
       310        320        330        340        350
IVQQNRRADH LIFPLNKPTE HNHASAFTRT QDVPQTELQE KVDQVLQESN 
       360        370        380        390        400
LANPEKDSKF EELSTAKMTP EEMRKRTTEM RLMRELMFRE ERKARRLKKI 
       410        420        430        440        450
KSKTYRKIKK KELMKNRELA AVSSDEDNED HDIARAKERM TLKHKTNSKW 
       460        470        480        490        500
AKDMIKHGMT NDAETREEME EMLRQGERLK AKMLDRNSDD EEDGRVQTLS 
       510        520        530        540        550
DVENEEKENI DSEALKSKLG KTGVMNMAFM KNGEAREREA NKETLRQLRA 
       560        570        580        590        600
VENGDDIKLF ESDEEETNGE NIQINKGRRI YTPGSLESNK DMNELNDHTR 
       610        620        630        640        650
KENKVDESRS LENRLRAKNS GQSKNARTNA EGAIIVEEES DGEPLQDGQN 
       660        670        680        690        700
NQQDEEAKDV NPWLANESDE EHTVKKQSSK VNVIDKDSSK NVKAMNKMEK 
       710        720        730        740        750
AELKQKKKKK GKSNDDEDLL LTADDSTRLK IVDPYGGSDD EQGDNVFMFK 
       760        770        780        790        800
QQDVIAEAFA GDDVVAEFQE EKKRVIDDED DKEVDTTLPG WGEWAGAGSK 
       810        820        830        840        850
PKNKKRKFIK KVKGVVNKDK RRDKNLQNVI INEKVNKKNL KYQSSAVPFP 
       860        870        880        890 
FENREQYERS LRMPIGQEWT SRASHQELIK PRIMTKPGQV IDPLKAPFK
Length:899
Mass (Da):103,023
Last modified:November 1, 1997 - v1
Checksum:i0D4FC90D1CB3CFF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46660 Genomic DNA. Translation: CAA86645.1.
BK006946 Genomic DNA. Translation: DAA09806.1.
PIRiS49634.
RefSeqiNP_013617.1. NM_001182452.1.

Genome annotation databases

EnsemblFungiiYML093W; YML093W; YML093W.
GeneIDi854881.
KEGGisce:YML093W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46660 Genomic DNA. Translation: CAA86645.1.
BK006946 Genomic DNA. Translation: DAA09806.1.
PIRiS49634.
RefSeqiNP_013617.1. NM_001182452.1.

3D structure databases

ProteinModelPortaliQ04500.
SMRiQ04500.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35050. 99 interactors.
DIPiDIP-6410N.
IntActiQ04500. 5 interactors.
MINTiMINT-8285383.

PTM databases

iPTMnetiQ04500.

Proteomic databases

MaxQBiQ04500.
PRIDEiQ04500.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYML093W; YML093W; YML093W.
GeneIDi854881.
KEGGisce:YML093W.

Organism-specific databases

EuPathDBiFungiDB:YML093W.
SGDiS000004558. UTP14.

Phylogenomic databases

GeneTreeiENSGT00390000008142.
HOGENOMiHOG000074497.
InParanoidiQ04500.
KOiK14567.
OMAiTTLPGWG.
OrthoDBiEOG092C1VSC.

Enzyme and pathway databases

BioCyciYEAST:G3O-32678-MONOMER.
ReactomeiR-SCE-6790901. rRNA modification in the nucleus and cytosol.
R-SCE-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Miscellaneous databases

PROiPR:Q04500.

Family and domain databases

InterProiView protein in InterPro
IPR006709. SSU_processome_Utp14.
PANTHERiPTHR14150. PTHR14150. 1 hit.
PfamiView protein in Pfam
PF04615. Utp14. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUTP14_YEAST
AccessioniPrimary (citable) accession number: Q04500
Secondary accession number(s): D6W0J2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 7, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.