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Q04500

- UTP14_YEAST

UniProt

Q04500 - UTP14_YEAST

Protein

U3 small nucleolar RNA-associated protein 14

Gene

UTP14

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Involved in nucleolar processing of pre-18S ribosomal RNA.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi260 – 2678ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
    2. endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
    3. endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    Ribosome biogenesis, rRNA processing

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32678-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    U3 small nucleolar RNA-associated protein 14
    Short name:
    U3 snoRNA-associated protein 14
    Alternative name(s):
    U three protein 14
    Gene namesi
    Name:UTP14
    Ordered Locus Names:YML093W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYML093w.
    SGDiS000004558. UTP14.

    Subcellular locationi

    Nucleusnucleolus 1 Publication

    GO - Cellular componenti

    1. nucleolus Source: SGD
    2. small-subunit processome Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 899899U3 small nucleolar RNA-associated protein 14PRO_0000065742Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei34 – 341Phosphoserine3 Publications
    Modified residuei35 – 351Phosphoserine2 Publications
    Modified residuei151 – 1511Phosphoserine3 Publications
    Modified residuei423 – 4231Phosphoserine3 Publications
    Modified residuei424 – 4241Phosphoserine2 Publications
    Modified residuei488 – 4881Phosphoserine2 Publications
    Modified residuei500 – 5001Phosphoserine2 Publications
    Modified residuei562 – 5621Phosphoserine3 Publications
    Modified residuei668 – 6681Phosphoserine2 Publications
    Modified residuei738 – 7381Phosphoserine4 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ04500.
    PaxDbiQ04500.

    Expressioni

    Gene expression databases

    GenevestigatoriQ04500.

    Interactioni

    Subunit structurei

    Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.1 Publication

    Protein-protein interaction databases

    BioGridi35050. 34 interactions.
    DIPiDIP-6410N.
    IntActiQ04500. 3 interactions.
    MINTiMINT-8285383.
    STRINGi4932.YML093W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04500.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi162 – 1687Poly-Ser
    Compositional biasi179 – 1824Poly-Glu
    Compositional biasi704 – 7129Poly-Lys

    Sequence similaritiesi

    Belongs to the UTP14 family.Curated

    Phylogenomic databases

    eggNOGiCOG5644.
    GeneTreeiENSGT00390000008142.
    HOGENOMiHOG000074497.
    KOiK14567.
    OMAiKANDAMV.
    OrthoDBiEOG7HQNJB.

    Family and domain databases

    InterProiIPR006709. SSU_processome_Utp14.
    [Graphical view]
    PANTHERiPTHR14150. PTHR14150. 1 hit.
    PfamiPF04615. Utp14. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04500-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKKKSKSRS KSSRRVLDAL QLAEREINGE FDNSSDNDKR HDARRNGTVV    50
    NLLKRSKGDT NSDEDDIDSE SFEDEELNSD EALGSDDDYD ILNSKFSQTI 100
    RDKKENANYQ EEEDEGGYTS IDEEDLMPLS QVWDMDEKTA QSNGNDDEDA 150
    SPQLKLQDTD ISSESSSSEE SESESEDDEE EEDPFDEISE DEEDIELNTI 200
    TSKLIDETKS KAPKRLDTYG SGEANEYVLP SANAASGASG KLSLTDMMNV 250
    IDDRQVIENA NLLKGKSSTY EVPLPQRIQQ RHDRKAAYEI SRQEVSKWND 300
    IVQQNRRADH LIFPLNKPTE HNHASAFTRT QDVPQTELQE KVDQVLQESN 350
    LANPEKDSKF EELSTAKMTP EEMRKRTTEM RLMRELMFRE ERKARRLKKI 400
    KSKTYRKIKK KELMKNRELA AVSSDEDNED HDIARAKERM TLKHKTNSKW 450
    AKDMIKHGMT NDAETREEME EMLRQGERLK AKMLDRNSDD EEDGRVQTLS 500
    DVENEEKENI DSEALKSKLG KTGVMNMAFM KNGEAREREA NKETLRQLRA 550
    VENGDDIKLF ESDEEETNGE NIQINKGRRI YTPGSLESNK DMNELNDHTR 600
    KENKVDESRS LENRLRAKNS GQSKNARTNA EGAIIVEEES DGEPLQDGQN 650
    NQQDEEAKDV NPWLANESDE EHTVKKQSSK VNVIDKDSSK NVKAMNKMEK 700
    AELKQKKKKK GKSNDDEDLL LTADDSTRLK IVDPYGGSDD EQGDNVFMFK 750
    QQDVIAEAFA GDDVVAEFQE EKKRVIDDED DKEVDTTLPG WGEWAGAGSK 800
    PKNKKRKFIK KVKGVVNKDK RRDKNLQNVI INEKVNKKNL KYQSSAVPFP 850
    FENREQYERS LRMPIGQEWT SRASHQELIK PRIMTKPGQV IDPLKAPFK 899
    Length:899
    Mass (Da):103,023
    Last modified:November 1, 1997 - v1
    Checksum:i0D4FC90D1CB3CFF1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46660 Genomic DNA. Translation: CAA86645.1.
    BK006946 Genomic DNA. Translation: DAA09806.1.
    PIRiS49634.
    RefSeqiNP_013617.1. NM_001182452.1.

    Genome annotation databases

    EnsemblFungiiYML093W; YML093W; YML093W.
    GeneIDi854881.
    KEGGisce:YML093W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46660 Genomic DNA. Translation: CAA86645.1 .
    BK006946 Genomic DNA. Translation: DAA09806.1 .
    PIRi S49634.
    RefSeqi NP_013617.1. NM_001182452.1.

    3D structure databases

    ProteinModelPortali Q04500.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35050. 34 interactions.
    DIPi DIP-6410N.
    IntActi Q04500. 3 interactions.
    MINTi MINT-8285383.
    STRINGi 4932.YML093W.

    Proteomic databases

    MaxQBi Q04500.
    PaxDbi Q04500.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YML093W ; YML093W ; YML093W .
    GeneIDi 854881.
    KEGGi sce:YML093W.

    Organism-specific databases

    CYGDi YML093w.
    SGDi S000004558. UTP14.

    Phylogenomic databases

    eggNOGi COG5644.
    GeneTreei ENSGT00390000008142.
    HOGENOMi HOG000074497.
    KOi K14567.
    OMAi KANDAMV.
    OrthoDBi EOG7HQNJB.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32678-MONOMER.

    Miscellaneous databases

    NextBioi 977828.
    PROi Q04500.

    Gene expression databases

    Genevestigatori Q04500.

    Family and domain databases

    InterProi IPR006709. SSU_processome_Utp14.
    [Graphical view ]
    PANTHERi PTHR14150. PTHR14150. 1 hit.
    Pfami PF04615. Utp14. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: FUNCTION, INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU PROCESSOME BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34; SER-35; SER-151; SER-423; SER-424; SER-562 AND SER-738, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    6. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
      Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
      Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-668 AND SER-738, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34; SER-35; SER-151; SER-423; SER-424; SER-488; SER-500; SER-562; SER-668 AND SER-738, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34; SER-151; SER-423; SER-488; SER-500; SER-562 AND SER-738, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiUTP14_YEAST
    AccessioniPrimary (citable) accession number: Q04500
    Secondary accession number(s): D6W0J2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1470 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3