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Q044H0 (FMT_LACGA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Methionyl-tRNA formyltransferase

EC=2.1.2.9
Gene names
Name:fmt
Ordered Locus Names:LGAS_0761
OrganismLactobacillus gasseri (strain ATCC 33323 / DSM 20243) [Complete proteome] [HAMAP]
Taxonomic identifier324831 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP By similarity. HAMAP-Rule MF_00182

Catalytic activity

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet). HAMAP-Rule MF_00182

Sequence similarities

Belongs to the Fmt family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionmethionyl-tRNA formyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Methionyl-tRNA formyltransferase HAMAP-Rule MF_00182
PRO_1000020086

Regions

Region110 – 1134Tetrahydrofolate (THF) binding By similarity

Sequences

Sequence LengthMass (Da)Tools
Q044H0 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 49D74D0F566F355D

FASTA31434,423
        10         20         30         40         50         60 
MSSVIFLGTP NFGSVVLQGL IDQGYDVKAV VTQPDKRVGR KQVVHQSAVK QTALKHNLPV 

        70         80         90        100        110        120 
YQPAKLSGSD ELAELMKIEP DFIVTAAYGQ FLPTKFLKSA KIAPVNVHGS LLPKYRGGAP 

       130        140        150        160        170        180 
IQYSVLNGDK ETGVTIMEMV KKMDAGDIFS QKALPIEDDD TSGTLFDKLS ILGRDLLLET 

       190        200        210        220        230        240 
LPKFIDGTVT RTPQNEDKVV FSPNISKEQE QIKLTMTAEQ ANNLIRALNP DPGAYVMLDG 

       250        260        270        280        290        300 
KRFKIWKAKP LAEKTSFPAG TLVTNKKKFV ISMAGGSELE LLEVQPTGKK KMNIKDYLNG 

       310 
QGSHFTSGEK IIDE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000413 Genomic DNA. Translation: ABJ60152.1.
RefSeqYP_814590.1. NC_008530.1.

3D structure databases

ProteinModelPortalQ044H0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING324831.LGAS_0761.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ60152; ABJ60152; LGAS_0761.
GeneID4440045.
KEGGlga:LGAS_0761.
PATRIC22229669. VBILacGas62225_0743.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0223.
HOGENOMHOG000261177.
KOK00604.
OMAFDKITPK.
OrthoDBEOG6B09WV.
ProtClustDBCLSK925380.

Enzyme and pathway databases

BioCycLGAS324831:GHTY-761-MONOMER.

Family and domain databases

Gene3D3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPMF_00182. Formyl_trans.
InterProIPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR015518. Met_tRNA_Form_TA-like.
[Graphical view]
PANTHERPTHR11138. PTHR11138. 1 hit.
PfamPF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
SUPFAMSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsTIGR00460. fmt. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFMT_LACGA
AccessionPrimary (citable) accession number: Q044H0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: April 16, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families