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Q044A1

- TYSY_LACGA

UniProt

Q044A1 - TYSY_LACGA

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Protein

Thymidylate synthase

Gene

thyA

Organism
Lactobacillus gasseri (strain ATCC 33323 / DSM 20243)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Provides the sole de novo source of dTMP for DNA biosynthesis.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei200 – 2001UniRule annotation

GO - Molecular functioni

  1. thymidylate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dTMP biosynthetic process Source: UniProtKB-HAMAP
  2. dTTP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Enzyme and pathway databases

BioCyciLGAS324831:GHTY-830-MONOMER.
UniPathwayiUPA00575.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthaseUniRule annotation (EC:2.1.1.45UniRule annotation)
Short name:
TSUniRule annotation
Short name:
TSaseUniRule annotation
Gene namesi
Name:thyAUniRule annotation
Ordered Locus Names:LGAS_0830
OrganismiLactobacillus gasseri (strain ATCC 33323 / DSM 20243)
Taxonomic identifieri324831 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000664: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Thymidylate synthasePRO_1000000616Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi324831.LGAS_0830.

Structurei

3D structure databases

ProteinModelPortaliQ044A1.
SMRiQ044A1. Positions 4-318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0207.
HOGENOMiHOG000257899.
KOiK00560.
OMAiDVHLYSN.
OrthoDBiEOG6K6V53.

Family and domain databases

Gene3Di3.30.572.10. 2 hits.
HAMAPiMF_00008. Thymidy_synth_bact.
InterProiIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamiPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSiPR00108. THYMDSNTHASE.
SUPFAMiSSF55831. SSF55831. 1 hit.
TIGRFAMsiTIGR03284. thym_sym. 1 hit.
PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q044A1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATLEQPYLD LLNKIMIEGH DKEDRTGTGT RSIFGAQMRF NLSEGFPILT
60 70 80 90 100
TKRVPFGLIK SELLWFLRGD TNIRFLLEHN NHIWDEWAFK NWVESDEYHG
110 120 130 140 150
PDMTNFGLRS QEDAKFKQVY QEEMKKFDER ILADRDFAVK FGNLGDVYGA
160 170 180 190 200
QWRHWQKREG GFIDQIQNVI DQIKKTPYSR RLIVSAWNPE DVPNSALPPC
210 220 230 240 250
HVLFQFYVND GRLSVQLYQR SGDMFLGVPF NIASYSLLVN LIAQETGLKP
260 270 280 290 300
GEFIHTLGDA HIYRNHFDQV KELLTRKPYD SPKLWLNPDK KKIEDFEMSD
310
IKLVDYKHHG TIKAPVAV
Length:318
Mass (Da):37,111
Last modified:November 14, 2006 - v1
Checksum:i60443555046EC252
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000413 Genomic DNA. Translation: ABJ60221.1.
RefSeqiYP_814659.1. NC_008530.1.

Genome annotation databases

EnsemblBacteriaiABJ60221; ABJ60221; LGAS_0830.
GeneIDi4439975.
KEGGilga:LGAS_0830.
PATRICi22229807. VBILacGas62225_0812.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000413 Genomic DNA. Translation: ABJ60221.1 .
RefSeqi YP_814659.1. NC_008530.1.

3D structure databases

ProteinModelPortali Q044A1.
SMRi Q044A1. Positions 4-318.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 324831.LGAS_0830.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ60221 ; ABJ60221 ; LGAS_0830 .
GeneIDi 4439975.
KEGGi lga:LGAS_0830.
PATRICi 22229807. VBILacGas62225_0812.

Phylogenomic databases

eggNOGi COG0207.
HOGENOMi HOG000257899.
KOi K00560.
OMAi DVHLYSN.
OrthoDBi EOG6K6V53.

Enzyme and pathway databases

UniPathwayi UPA00575 .
BioCyci LGAS324831:GHTY-830-MONOMER.

Family and domain databases

Gene3Di 3.30.572.10. 2 hits.
HAMAPi MF_00008. Thymidy_synth_bact.
InterProi IPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view ]
Pfami PF00303. Thymidylat_synt. 1 hit.
[Graphical view ]
PRINTSi PR00108. THYMDSNTHASE.
SUPFAMi SSF55831. SSF55831. 1 hit.
TIGRFAMsi TIGR03284. thym_sym. 1 hit.
PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33323 / DSM 20243.

Entry informationi

Entry nameiTYSY_LACGA
AccessioniPrimary (citable) accession number: Q044A1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3