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Protein

Prefoldin subunit 5

Gene

GIM5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

GO - Molecular functioni

  • tubulin binding Source: SGD

GO - Biological processi

  • positive regulation of transcription elongation from RNA polymerase II promoter Source: SGD
  • protein folding Source: InterPro
  • tubulin complex assembly Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-32679-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 5
Alternative name(s):
Genes involved in microtubule biogenesis protein 5
Gim complex subunit 5
Short name:
GimC subunit 5
Gene namesi
Name:GIM5
Synonyms:PFD5
Ordered Locus Names:YML094W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YML094W.
SGDiS000004559. GIM5.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
  • prefoldin complex Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 163163Prefoldin subunit 5PRO_0000153668Add
BLAST

Proteomic databases

MaxQBiQ04493.
TopDownProteomicsiQ04493.

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PAC10P483636EBI-13253,EBI-13239
YKE2P525534EBI-13253,EBI-13260

GO - Molecular functioni

  • tubulin binding Source: SGD

Protein-protein interaction databases

BioGridi35049. 533 interactions.
DIPiDIP-1332N.
IntActiQ04493. 12 interactions.
MINTiMINT-406816.

Structurei

3D structure databases

ProteinModelPortaliQ04493.
SMRiQ04493. Positions 14-157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit alpha family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000008783.
HOGENOMiHOG000207562.
InParanoidiQ04493.
KOiK04797.
OMAiFYVEKTT.
OrthoDBiEOG092C5AQ0.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR011599. PFD_alpha_archaea.
IPR009053. Prefoldin.
IPR004127. Prefoldin_subunit_alpha.
[Graphical view]
PfamiPF02996. Prefoldin. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
TIGRFAMsiTIGR00293. TIGR00293. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04493-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSQKIDLTK LNPEQLNAVK QQFDQELQHF TQSLQALTMA KGKFTECIDD
60 70 80 90 100
IKTVSQAGNE GQKLLVPASA SLYIPGKIVD NKKFMVDIGT GYYVEKSAEA
110 120 130 140 150
AIAFYQKKVD KLNKESVQIQ DIIKEKTQYS LSIEAQIRQA AIRQHEAMSK
160
QQQQQQKKES STA
Length:163
Mass (Da):18,356
Last modified:November 1, 1997 - v1
Checksum:i24C71A33885CEE63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46660 Genomic DNA. Translation: CAA86644.1.
BK006946 Genomic DNA. Translation: DAA09805.1.
PIRiS49633.
RefSeqiNP_013616.1. NM_001182453.1.

Genome annotation databases

EnsemblFungiiYML094W; YML094W; YML094W.
GeneIDi854879.
KEGGisce:YML094W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46660 Genomic DNA. Translation: CAA86644.1.
BK006946 Genomic DNA. Translation: DAA09805.1.
PIRiS49633.
RefSeqiNP_013616.1. NM_001182453.1.

3D structure databases

ProteinModelPortaliQ04493.
SMRiQ04493. Positions 14-157.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35049. 533 interactions.
DIPiDIP-1332N.
IntActiQ04493. 12 interactions.
MINTiMINT-406816.

Proteomic databases

MaxQBiQ04493.
TopDownProteomicsiQ04493.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYML094W; YML094W; YML094W.
GeneIDi854879.
KEGGisce:YML094W.

Organism-specific databases

EuPathDBiFungiDB:YML094W.
SGDiS000004559. GIM5.

Phylogenomic databases

GeneTreeiENSGT00390000008783.
HOGENOMiHOG000207562.
InParanoidiQ04493.
KOiK04797.
OMAiFYVEKTT.
OrthoDBiEOG092C5AQ0.

Enzyme and pathway databases

BioCyciYEAST:G3O-32679-MONOMER.

Miscellaneous databases

PROiQ04493.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR011599. PFD_alpha_archaea.
IPR009053. Prefoldin.
IPR004127. Prefoldin_subunit_alpha.
[Graphical view]
PfamiPF02996. Prefoldin. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
TIGRFAMsiTIGR00293. TIGR00293. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPFD5_YEAST
AccessioniPrimary (citable) accession number: Q04493
Secondary accession number(s): D6W0J1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2900 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.