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Protein

Prefoldin subunit 5

Gene

GIM5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

Miscellaneous

Present with 2900 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • tubulin binding Source: SGD
  • unfolded protein binding Source: InterPro

GO - Biological processi

  • positive regulation of transcription elongation from RNA polymerase II promoter Source: SGD
  • protein folding Source: InterPro
  • tubulin complex assembly Source: SGD

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-32679-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 5
Alternative name(s):
Genes involved in microtubule biogenesis protein 5
Gim complex subunit 5
Short name:
GimC subunit 5
Gene namesi
Name:GIM5
Synonyms:PFD5
Ordered Locus Names:YML094W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YML094W
SGDiS000004559 GIM5

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001536681 – 163Prefoldin subunit 5Add BLAST163

Proteomic databases

MaxQBiQ04493
PaxDbiQ04493
PRIDEiQ04493
TopDownProteomicsiQ04493

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • tubulin binding Source: SGD
  • unfolded protein binding Source: InterPro

Protein-protein interaction databases

BioGridi35049595 interactors.
DIPiDIP-1332N
IntActiQ04493 83 interactors.
MINTiQ04493
STRINGi4932.YML094W

Structurei

3D structure databases

ProteinModelPortaliQ04493
SMRiQ04493
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit alpha family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000008783
HOGENOMiHOG000207562
InParanoidiQ04493
KOiK04797
OMAiFQPDWEN
OrthoDBiEOG092C5AQ0

Family and domain databases

Gene3Di1.10.287.3701 hit
InterProiView protein in InterPro
IPR011599 PFD_alpha_archaea
IPR009053 Prefoldin
IPR004127 Prefoldin_subunit_alpha
PfamiView protein in Pfam
PF02996 Prefoldin, 1 hit
TIGRFAMsiTIGR00293 TIGR00293, 1 hit

Sequencei

Sequence statusi: Complete.

Q04493-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSQKIDLTK LNPEQLNAVK QQFDQELQHF TQSLQALTMA KGKFTECIDD
60 70 80 90 100
IKTVSQAGNE GQKLLVPASA SLYIPGKIVD NKKFMVDIGT GYYVEKSAEA
110 120 130 140 150
AIAFYQKKVD KLNKESVQIQ DIIKEKTQYS LSIEAQIRQA AIRQHEAMSK
160
QQQQQQKKES STA
Length:163
Mass (Da):18,356
Last modified:November 1, 1997 - v1
Checksum:i24C71A33885CEE63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46660 Genomic DNA Translation: CAA86644.1
BK006946 Genomic DNA Translation: DAA09805.1
PIRiS49633
RefSeqiNP_013616.1, NM_001182453.1

Genome annotation databases

EnsemblFungiiYML094W; YML094W; YML094W
GeneIDi854879
KEGGisce:YML094W

Similar proteinsi

Entry informationi

Entry nameiPFD5_YEAST
AccessioniPrimary (citable) accession number: Q04493
Secondary accession number(s): D6W0J1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome