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Q04487

- YM07_YEAST

UniProt

Q04487 - YM07_YEAST

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Protein
Putative succinate dehydrogenase [ubiquinone] cytochrome b subunit, mitochondrial
Gene
YMR118C, YM9718.17C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Putative membrane-anchoring mono-heme cytochrome b subunit of succinate dehydrogenase (SDH) that is involved in system II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). The membrane dimer anchors the catalytic dimer formed by SDH1 and SDH2 to the matrix surface of the mitochondrial inner membrane. Electrons originating from the catalytic dimer enter the membrane dimer for ubiquinone reduction.

Cofactori

Heme group. The heme is bound between the two transmembrane subunits By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei91 – 911Ubiquinone By similarity
Binding sitei95 – 951Ubiquinone By similarity
Metal bindingi154 – 1541Iron (heme axial ligand); shared with second transmembrane subunit By similarity

GO - Molecular functioni

  1. electron carrier activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
  3. quinone binding Source: UniProtKB-KW
  4. succinate dehydrogenase activity Source: InterPro

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32813-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative succinate dehydrogenase [ubiquinone] cytochrome b subunit, mitochondrial
Gene namesi
Ordered Locus Names:YMR118C
ORF Names:YM9718.17C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR118c.
SGDiS000004724. YMR118C.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei98 – 11821Helical; Reviewed prediction
Add
BLAST
Transmembranei138 – 16023Helical; Reviewed prediction
Add
BLAST
Transmembranei175 – 19521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. succinate dehydrogenase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 196Putative succinate dehydrogenase [ubiquinone] cytochrome b subunit, mitochondrialPRO_0000003639
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Keywords - PTMi

Quinone

Expressioni

Gene expression databases

GenevestigatoriQ04487.

Interactioni

Subunit structurei

Forms part of complex II containing four subunits: a flavoprotein (FP), an iron-sulfur protein (IP) and a cytochrome b composed of two integral membrane proteins By similarity.

Protein-protein interaction databases

BioGridi35294. 5 interactions.
DIPiDIP-5316N.
MINTiMINT-534886.
STRINGi4932.YMR118C.

Structurei

3D structure databases

ProteinModelPortaliQ04487.
SMRiQ04487. Positions 64-167.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome b560 family.

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2009.
GeneTreeiENSGT00740000116167.
HOGENOMiHOG000160253.
KOiK00236.
OMAiITILMIA.
OrthoDBiEOG725DVZ.

Family and domain databases

InterProiIPR018495. Succ_DH_cyt_bsu_CS.
IPR014314. Succ_DH_cytb556.
IPR000701. Succ_DH_Fumarate_Rdtase_TM-su.
[Graphical view]
PfamiPF01127. Sdh_cyt. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02970. succ_dehyd_cytB. 1 hit.
PROSITEiPS01000. SDH_CYT_1. 1 hit.
PS01001. SDH_CYT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04487-1 [UniParc]FASTAAdd to Basket

« Hide

MKATIQRVTS VFGVPRASVF VPRISTPFIL HNYISNGRMD LFSKEFHNGR    50
VSKSDLWSSN KEEELLVSQR KKRPISPHLT VYEPEMSWYL SSLHRISGVL 100
LALGFYAFTI TLGVTTIMGM DTTFQDLNKW YHEKMPKWSQ WVAKGSAAYL 150
FAFHFGNGIR HLIWDMGYEL TNRGVIKTGS IVLAGTLVLG TYLLAQ 196
Length:196
Mass (Da):22,309
Last modified:November 1, 1997 - v1
Checksum:i41413998B9B2B057
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49702 Genomic DNA. Translation: CAA89756.1.
AY557968 Genomic DNA. Translation: AAS56294.1.
BK006946 Genomic DNA. Translation: DAA10015.1.
PIRiS54580.
RefSeqiNP_013836.1. NM_001182618.1.

Genome annotation databases

EnsemblFungiiYMR118C; YMR118C; YMR118C.
GeneIDi855145.
KEGGisce:YMR118C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49702 Genomic DNA. Translation: CAA89756.1 .
AY557968 Genomic DNA. Translation: AAS56294.1 .
BK006946 Genomic DNA. Translation: DAA10015.1 .
PIRi S54580.
RefSeqi NP_013836.1. NM_001182618.1.

3D structure databases

ProteinModelPortali Q04487.
SMRi Q04487. Positions 64-167.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35294. 5 interactions.
DIPi DIP-5316N.
MINTi MINT-534886.
STRINGi 4932.YMR118C.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR118C ; YMR118C ; YMR118C .
GeneIDi 855145.
KEGGi sce:YMR118C.

Organism-specific databases

CYGDi YMR118c.
SGDi S000004724. YMR118C.

Phylogenomic databases

eggNOGi COG2009.
GeneTreei ENSGT00740000116167.
HOGENOMi HOG000160253.
KOi K00236.
OMAi ITILMIA.
OrthoDBi EOG725DVZ.

Enzyme and pathway databases

BioCyci YEAST:G3O-32813-MONOMER.

Miscellaneous databases

NextBioi 978543.
PROi Q04487.

Gene expression databases

Genevestigatori Q04487.

Family and domain databases

InterProi IPR018495. Succ_DH_cyt_bsu_CS.
IPR014314. Succ_DH_cytb556.
IPR000701. Succ_DH_Fumarate_Rdtase_TM-su.
[Graphical view ]
Pfami PF01127. Sdh_cyt. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02970. succ_dehyd_cytB. 1 hit.
PROSITEi PS01000. SDH_CYT_1. 1 hit.
PS01001. SDH_CYT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "The Saccharomyces cerevisiae mitochondrial succinate:ubiquinone oxidoreductase."
    Lemire B.D., Oyedotun K.S.
    Biochim. Biophys. Acta 1553:102-116(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON SUCCINATE DEHYDROGENASE.

Entry informationi

Entry nameiYM07_YEAST
AccessioniPrimary (citable) accession number: Q04487
Secondary accession number(s): D6VZU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

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