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Protein

Mitochondrial inner membrane protein SHH3

Gene

SHH3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Homolog of SDH3, but seems not to be a stoichiometric subunit of either the succinate dehydrogenase (SDH) complex or the mitochondrial inner membrane translocase TIM22 complex.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei91 – 911UbiquinoneBy similarity
Binding sitei95 – 951UbiquinoneBy similarity
Metal bindingi154 – 1541Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. electron carrier activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
  3. quinone binding Source: UniProtKB-KW
  4. succinate dehydrogenase activity Source: InterPro

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32813-MONOMER.
ReactomeiREACT_278278. Citric acid cycle (TCA cycle).
REACT_346640. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial inner membrane protein SHH3Curated
Alternative name(s):
SDH3 homolog1 Publication
Gene namesi
Name:SHH31 Publication
Ordered Locus Names:YMR118CImported
ORF Names:YM9718.17C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome XIII

Organism-specific databases

CYGDiYMR118c.
EuPathDBiFungiDB:YMR118C.
SGDiS000004724. SHH3.

Subcellular locationi

  1. Mitochondrion inner membrane By similarity; Multi-pass membrane protein Sequence Analysis

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini54 – 9744Mitochondrial matrixBy similarityAdd
BLAST
Transmembranei98 – 11821HelicalSequence AnalysisAdd
BLAST
Topological domaini119 – 13719Mitochondrial intermembraneBy similarityAdd
BLAST
Transmembranei138 – 16023HelicalSequence AnalysisAdd
BLAST
Topological domaini161 – 17414Mitochondrial matrixBy similarityAdd
BLAST
Transmembranei175 – 19521HelicalSequence AnalysisAdd
BLAST
Topological domaini196 – 1961Mitochondrial intermembraneBy similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. succinate dehydrogenase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Does not affect SDH or TIM22 complex formation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5353MitochondrionSequence AnalysisAdd
BLAST
Chaini54 – 196143Mitochondrial inner membrane protein SHH3PRO_0000003639Add
BLAST

Keywords - PTMi

Quinone

Expressioni

Gene expression databases

GenevestigatoriQ04487.

Interactioni

Protein-protein interaction databases

BioGridi35294. 6 interactions.
DIPiDIP-5316N.
MINTiMINT-534886.
STRINGi4932.YMR118C.

Structurei

3D structure databases

ProteinModelPortaliQ04487.
SMRiQ04487. Positions 64-167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome b560 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2009.
GeneTreeiENSGT00740000116167.
HOGENOMiHOG000160253.
InParanoidiQ04487.
KOiK00236.
OrthoDBiEOG725DVZ.

Family and domain databases

InterProiIPR018495. Succ_DH_cyt_bsu_CS.
IPR014314. Succ_DH_cytb556.
IPR000701. Succ_DH_Fumarate_Rdtase_TM-su.
[Graphical view]
PfamiPF01127. Sdh_cyt. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02970. succ_dehyd_cytB. 1 hit.
PROSITEiPS01000. SDH_CYT_1. 1 hit.
PS01001. SDH_CYT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04487-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKATIQRVTS VFGVPRASVF VPRISTPFIL HNYISNGRMD LFSKEFHNGR
60 70 80 90 100
VSKSDLWSSN KEEELLVSQR KKRPISPHLT VYEPEMSWYL SSLHRISGVL
110 120 130 140 150
LALGFYAFTI TLGVTTIMGM DTTFQDLNKW YHEKMPKWSQ WVAKGSAAYL
160 170 180 190
FAFHFGNGIR HLIWDMGYEL TNRGVIKTGS IVLAGTLVLG TYLLAQ
Length:196
Mass (Da):22,309
Last modified:November 1, 1997 - v1
Checksum:i41413998B9B2B057
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49702 Genomic DNA. Translation: CAA89756.1.
AY557968 Genomic DNA. Translation: AAS56294.1.
BK006946 Genomic DNA. Translation: DAA10015.1.
PIRiS54580.
RefSeqiNP_013836.1. NM_001182618.1.

Genome annotation databases

EnsemblFungiiYMR118C; YMR118C; YMR118C.
GeneIDi855145.
KEGGisce:YMR118C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49702 Genomic DNA. Translation: CAA89756.1.
AY557968 Genomic DNA. Translation: AAS56294.1.
BK006946 Genomic DNA. Translation: DAA10015.1.
PIRiS54580.
RefSeqiNP_013836.1. NM_001182618.1.

3D structure databases

ProteinModelPortaliQ04487.
SMRiQ04487. Positions 64-167.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35294. 6 interactions.
DIPiDIP-5316N.
MINTiMINT-534886.
STRINGi4932.YMR118C.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR118C; YMR118C; YMR118C.
GeneIDi855145.
KEGGisce:YMR118C.

Organism-specific databases

CYGDiYMR118c.
EuPathDBiFungiDB:YMR118C.
SGDiS000004724. SHH3.

Phylogenomic databases

eggNOGiCOG2009.
GeneTreeiENSGT00740000116167.
HOGENOMiHOG000160253.
InParanoidiQ04487.
KOiK00236.
OrthoDBiEOG725DVZ.

Enzyme and pathway databases

BioCyciYEAST:G3O-32813-MONOMER.
ReactomeiREACT_278278. Citric acid cycle (TCA cycle).
REACT_346640. Respiratory electron transport.

Miscellaneous databases

NextBioi978543.
PROiQ04487.

Gene expression databases

GenevestigatoriQ04487.

Family and domain databases

InterProiIPR018495. Succ_DH_cyt_bsu_CS.
IPR014314. Succ_DH_cytb556.
IPR000701. Succ_DH_Fumarate_Rdtase_TM-su.
[Graphical view]
PfamiPF01127. Sdh_cyt. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02970. succ_dehyd_cytB. 1 hit.
PROSITEiPS01000. SDH_CYT_1. 1 hit.
PS01001. SDH_CYT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiSHH3_YEAST
AccessioniPrimary (citable) accession number: Q04487
Secondary accession number(s): D6VZU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 29, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.