Q04487 (YM07_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative succinate dehydrogenase [ubiquinone] cytochrome b subunit, mitochondrial

Gene names

Ordered Locus Names:	YMR118C
ORF Names:	YM9718.17C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Putative membrane-anchoring mono-heme cytochrome b subunit of succinate dehydrogenase (SDH) that is involved in system II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). The membrane dimer anchors the catalytic dimer formed by SDH1 and SDH2 to the matrix surface of the mitochondrial inner membrane. Electrons originating from the catalytic dimer enter the membrane dimer for ubiquinone reduction.
Cofactor	Heme group. The heme is bound between the two transmembrane subunits By similarity.
Subunit structure	Forms part of complex II containing four subunits: a flavoprotein (FP), an iron-sulfur protein (IP) and a cytochrome b composed of two integral membrane proteins By similarity.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome b560 family.

Ontologies

Keywords
Biological process	Electron transport Transport Tricarboxylic acid cycle
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide Transmembrane Transmembrane helix
Ligand	Heme Iron Metal-binding
PTM	Quinone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from sequence model PubMed 12192589. Source: SGD mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell succinate dehydrogenase complex Inferred from electronic annotation. Source: InterPro
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW quinone binding Inferred from electronic annotation. Source: UniProtKB-KW succinate dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 196		Putative succinate dehydrogenase [ubiquinone] cytochrome b subunit, mitochondrial		PRO_0000003639
Regions
	Transmembrane	98 – 118	21	Helical; Potential
	Transmembrane	138 – 160	23	Helical; Potential
	Transmembrane	175 – 195	21	Helical; Potential
Sites
	Metal binding	154	1	Iron (heme axial ligand); shared with second transmembrane subunit By similarity
	Binding site	91	1	Ubiquinone By similarity
	Binding site	95	1	Ubiquinone By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q04487 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 41413998B9B2B057	FASTA	196	22,309
	10 20 30 40 50 60 MKATIQRVTS VFGVPRASVF VPRISTPFIL HNYISNGRMD LFSKEFHNGR VSKSDLWSSN 70 80 90 100 110 120 KEEELLVSQR KKRPISPHLT VYEPEMSWYL SSLHRISGVL LALGFYAFTI TLGVTTIMGM 130 140 150 160 170 180 DTTFQDLNKW YHEKMPKWSQ WVAKGSAAYL FAFHFGNGIR HLIWDMGYEL TNRGVIKTGS 190 IVLAGTLVLG TYLLAQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. , Skelton J., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"The Saccharomyces cerevisiae mitochondrial succinate:ubiquinone oxidoreductase." Lemire B.D., Oyedotun K.S. Biochim. Biophys. Acta 1553:102-116(2002) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW ON SUCCINATE DEHYDROGENASE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z49702 Genomic DNA. Translation: CAA89756.1. AY557968 Genomic DNA. Translation: AAS56294.1. BK006946 Genomic DNA. Translation: DAA10015.1.
PIR	S54580.
RefSeq	NP_013836.1. NM_001182618.1.
3D structure databases
ProteinModelPortal	Q04487.
SMR	Q04487. Positions 64-167.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5316N.
MINT	MINT-534886.
STRING	4932.YMR118C.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YMR118C; YMR118C; YMR118C.
GeneID	855145.
KEGG	sce:YMR118C.
Organism-specific databases
CYGD	YMR118c.
SGD	S000004724. YMR118C.
Phylogenomic databases
eggNOG	COG2009.
GeneTree	ENSGT00510000053031.
HOGENOM	HOG000160253.
KO	K00236.
OMA	FVPRIST.
OrthoDB	EOG4TXG2C.
Gene expression databases
Genevestigator	Q04487.
GermOnline	YMR118C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR018495. Succ_DH_cyt_bsu_CS. IPR014314. Succ_DH_cytb556. IPR000701. Succ_DH_Fumarate_Rdtase_TM-su. [Graphical view]
Pfam	PF01127. Sdh_cyt. 1 hit. [Graphical view]
TIGRFAMs	TIGR02970. succ_dehyd_cytB. 1 hit.
PROSITE	PS01000. SDH_CYT_1. 1 hit. PS01001. SDH_CYT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	978543.

Entry information

Entry name

YM07_YEAST

Accession

Primary (citable) accession number: Q04487
Secondary accession number(s): D6VZU1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program