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Protein

Mitochondrial inner membrane protein SHH3

Gene

SHH3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Homolog of SDH3, but seems not to be a stoichiometric subunit of either the succinate dehydrogenase (SDH) complex or the mitochondrial inner membrane translocase TIM22 complex.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei91UbiquinoneBy similarity1
Binding sitei95UbiquinoneBy similarity1
Metal bindingi154Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32813-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial inner membrane protein SHH3Curated
Alternative name(s):
SDH3 homolog1 Publication
Gene namesi
Name:SHH31 Publication
Ordered Locus Names:YMR118CImported
ORF Names:YM9718.17C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR118C.
SGDiS000004724. SHH3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini54 – 97Mitochondrial matrixBy similarityAdd BLAST44
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Topological domaini119 – 137Mitochondrial intermembraneBy similarityAdd BLAST19
Transmembranei138 – 160HelicalSequence analysisAdd BLAST23
Topological domaini161 – 174Mitochondrial matrixBy similarityAdd BLAST14
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196Mitochondrial intermembraneBy similarity1

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Does not affect SDH or TIM22 complex formation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 53MitochondrionSequence analysisAdd BLAST53
ChainiPRO_000000363954 – 196Mitochondrial inner membrane protein SHH3Add BLAST143

Keywords - PTMi

Quinone

Proteomic databases

PRIDEiQ04487.

Interactioni

Protein-protein interaction databases

BioGridi35294. 7 interactors.
DIPiDIP-5316N.
MINTiMINT-534886.

Structurei

3D structure databases

ProteinModelPortaliQ04487.
SMRiQ04487.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome b560 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00860000134690.
HOGENOMiHOG000160253.
InParanoidiQ04487.
KOiK00236.
OMAiAYAKSER.
OrthoDBiEOG092C5NHG.

Family and domain databases

InterProiIPR018495. Succ_DH_cyt_bsu_CS.
IPR014314. Succ_DH_cytb556.
IPR000701. Succ_DH_Fumarate_Rdtase_TM-su.
[Graphical view]
PfamiPF01127. Sdh_cyt. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02970. succ_dehyd_cytB. 1 hit.
PROSITEiPS01000. SDH_CYT_1. 1 hit.
PS01001. SDH_CYT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04487-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKATIQRVTS VFGVPRASVF VPRISTPFIL HNYISNGRMD LFSKEFHNGR
60 70 80 90 100
VSKSDLWSSN KEEELLVSQR KKRPISPHLT VYEPEMSWYL SSLHRISGVL
110 120 130 140 150
LALGFYAFTI TLGVTTIMGM DTTFQDLNKW YHEKMPKWSQ WVAKGSAAYL
160 170 180 190
FAFHFGNGIR HLIWDMGYEL TNRGVIKTGS IVLAGTLVLG TYLLAQ
Length:196
Mass (Da):22,309
Last modified:November 1, 1997 - v1
Checksum:i41413998B9B2B057
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49702 Genomic DNA. Translation: CAA89756.1.
AY557968 Genomic DNA. Translation: AAS56294.1.
BK006946 Genomic DNA. Translation: DAA10015.1.
PIRiS54580.
RefSeqiNP_013836.1. NM_001182618.1.

Genome annotation databases

EnsemblFungiiYMR118C; YMR118C; YMR118C.
GeneIDi855145.
KEGGisce:YMR118C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49702 Genomic DNA. Translation: CAA89756.1.
AY557968 Genomic DNA. Translation: AAS56294.1.
BK006946 Genomic DNA. Translation: DAA10015.1.
PIRiS54580.
RefSeqiNP_013836.1. NM_001182618.1.

3D structure databases

ProteinModelPortaliQ04487.
SMRiQ04487.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35294. 7 interactors.
DIPiDIP-5316N.
MINTiMINT-534886.

Proteomic databases

PRIDEiQ04487.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR118C; YMR118C; YMR118C.
GeneIDi855145.
KEGGisce:YMR118C.

Organism-specific databases

EuPathDBiFungiDB:YMR118C.
SGDiS000004724. SHH3.

Phylogenomic databases

GeneTreeiENSGT00860000134690.
HOGENOMiHOG000160253.
InParanoidiQ04487.
KOiK00236.
OMAiAYAKSER.
OrthoDBiEOG092C5NHG.

Enzyme and pathway databases

BioCyciYEAST:G3O-32813-MONOMER.

Miscellaneous databases

PROiQ04487.

Family and domain databases

InterProiIPR018495. Succ_DH_cyt_bsu_CS.
IPR014314. Succ_DH_cytb556.
IPR000701. Succ_DH_Fumarate_Rdtase_TM-su.
[Graphical view]
PfamiPF01127. Sdh_cyt. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02970. succ_dehyd_cytB. 1 hit.
PROSITEiPS01000. SDH_CYT_1. 1 hit.
PS01001. SDH_CYT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSHH3_YEAST
AccessioniPrimary (citable) accession number: Q04487
Secondary accession number(s): D6VZU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.