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Q04487

- YM07_YEAST

UniProt

Q04487 - YM07_YEAST

Protein

Putative succinate dehydrogenase [ubiquinone] cytochrome b subunit, mitochondrial

Gene

YMR118C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Putative membrane-anchoring mono-heme cytochrome b subunit of succinate dehydrogenase (SDH) that is involved in system II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). The membrane dimer anchors the catalytic dimer formed by SDH1 and SDH2 to the matrix surface of the mitochondrial inner membrane. Electrons originating from the catalytic dimer enter the membrane dimer for ubiquinone reduction.

    Cofactori

    Heme group. The heme is bound between the two transmembrane subunits By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei91 – 911UbiquinoneBy similarity
    Binding sitei95 – 951UbiquinoneBy similarity
    Metal bindingi154 – 1541Iron (heme axial ligand); shared with second transmembrane subunitBy similarity

    GO - Molecular functioni

    1. electron carrier activity Source: InterPro
    2. metal ion binding Source: UniProtKB-KW
    3. quinone binding Source: UniProtKB-KW
    4. succinate dehydrogenase activity Source: InterPro

    GO - Biological processi

    1. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32813-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative succinate dehydrogenase [ubiquinone] cytochrome b subunit, mitochondrial
    Gene namesi
    Ordered Locus Names:YMR118C
    ORF Names:YM9718.17C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYMR118c.
    SGDiS000004724. YMR118C.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. succinate dehydrogenase complex Source: InterPro

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 196Putative succinate dehydrogenase [ubiquinone] cytochrome b subunit, mitochondrialPRO_0000003639
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Keywords - PTMi

    Quinone

    Expressioni

    Gene expression databases

    GenevestigatoriQ04487.

    Interactioni

    Subunit structurei

    Forms part of complex II containing four subunits: a flavoprotein (FP), an iron-sulfur protein (IP) and a cytochrome b composed of two integral membrane proteins.By similarity

    Protein-protein interaction databases

    BioGridi35294. 5 interactions.
    DIPiDIP-5316N.
    MINTiMINT-534886.
    STRINGi4932.YMR118C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04487.
    SMRiQ04487. Positions 64-167.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei98 – 11821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei138 – 16023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei175 – 19521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome b560 family.Curated

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2009.
    GeneTreeiENSGT00740000116167.
    HOGENOMiHOG000160253.
    KOiK00236.
    OMAiITILMIA.
    OrthoDBiEOG725DVZ.

    Family and domain databases

    InterProiIPR018495. Succ_DH_cyt_bsu_CS.
    IPR014314. Succ_DH_cytb556.
    IPR000701. Succ_DH_Fumarate_Rdtase_TM-su.
    [Graphical view]
    PfamiPF01127. Sdh_cyt. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02970. succ_dehyd_cytB. 1 hit.
    PROSITEiPS01000. SDH_CYT_1. 1 hit.
    PS01001. SDH_CYT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q04487-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKATIQRVTS VFGVPRASVF VPRISTPFIL HNYISNGRMD LFSKEFHNGR    50
    VSKSDLWSSN KEEELLVSQR KKRPISPHLT VYEPEMSWYL SSLHRISGVL 100
    LALGFYAFTI TLGVTTIMGM DTTFQDLNKW YHEKMPKWSQ WVAKGSAAYL 150
    FAFHFGNGIR HLIWDMGYEL TNRGVIKTGS IVLAGTLVLG TYLLAQ 196
    Length:196
    Mass (Da):22,309
    Last modified:November 1, 1997 - v1
    Checksum:i41413998B9B2B057
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49702 Genomic DNA. Translation: CAA89756.1.
    AY557968 Genomic DNA. Translation: AAS56294.1.
    BK006946 Genomic DNA. Translation: DAA10015.1.
    PIRiS54580.
    RefSeqiNP_013836.1. NM_001182618.1.

    Genome annotation databases

    EnsemblFungiiYMR118C; YMR118C; YMR118C.
    GeneIDi855145.
    KEGGisce:YMR118C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49702 Genomic DNA. Translation: CAA89756.1 .
    AY557968 Genomic DNA. Translation: AAS56294.1 .
    BK006946 Genomic DNA. Translation: DAA10015.1 .
    PIRi S54580.
    RefSeqi NP_013836.1. NM_001182618.1.

    3D structure databases

    ProteinModelPortali Q04487.
    SMRi Q04487. Positions 64-167.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35294. 5 interactions.
    DIPi DIP-5316N.
    MINTi MINT-534886.
    STRINGi 4932.YMR118C.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YMR118C ; YMR118C ; YMR118C .
    GeneIDi 855145.
    KEGGi sce:YMR118C.

    Organism-specific databases

    CYGDi YMR118c.
    SGDi S000004724. YMR118C.

    Phylogenomic databases

    eggNOGi COG2009.
    GeneTreei ENSGT00740000116167.
    HOGENOMi HOG000160253.
    KOi K00236.
    OMAi ITILMIA.
    OrthoDBi EOG725DVZ.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32813-MONOMER.

    Miscellaneous databases

    NextBioi 978543.
    PROi Q04487.

    Gene expression databases

    Genevestigatori Q04487.

    Family and domain databases

    InterProi IPR018495. Succ_DH_cyt_bsu_CS.
    IPR014314. Succ_DH_cytb556.
    IPR000701. Succ_DH_Fumarate_Rdtase_TM-su.
    [Graphical view ]
    Pfami PF01127. Sdh_cyt. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02970. succ_dehyd_cytB. 1 hit.
    PROSITEi PS01000. SDH_CYT_1. 1 hit.
    PS01001. SDH_CYT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "The Saccharomyces cerevisiae mitochondrial succinate:ubiquinone oxidoreductase."
      Lemire B.D., Oyedotun K.S.
      Biochim. Biophys. Acta 1553:102-116(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON SUCCINATE DEHYDROGENASE.

    Entry informationi

    Entry nameiYM07_YEAST
    AccessioniPrimary (citable) accession number: Q04487
    Secondary accession number(s): D6VZU1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3