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Protein

Beta-2-microglobulin

Gene

b2m

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiR-DRE-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-2-microglobulin
Gene namesi
Name:b2m
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 4

Organism-specific databases

ZFINiZDB-GENE-980526-88. b2m.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

MHC I, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 11697Beta-2-microglobulinPRO_0000018807Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi44 ↔ 99PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ04475.

Expressioni

Gene expression databases

BgeeiQ04475.
ExpressionAtlasiQ04475. differential.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000069612.

Structurei

Secondary structure

1
116
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi25 – 328Combined sources
Beta strandi40 – 489Combined sources
Beta strandi50 – 523Combined sources
Beta strandi55 – 606Combined sources
Beta strandi74 – 763Combined sources
Turni77 – 793Combined sources
Beta strandi80 – 8910Combined sources
Beta strandi97 – 1037Combined sources
Beta strandi106 – 1116Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4M9OX-ray2.14A19-116[»]
ProteinModelPortaliQ04475.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 11188Ig-like C1-typeAdd
BLAST

Sequence similaritiesi

Belongs to the beta-2-microglobulin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410J15A. Eukaryota.
ENOG410YTDG. LUCA.
GeneTreeiENSGT00690000102227.
HOGENOMiHOG000043084.
HOVERGENiHBG006197.
InParanoidiQ04475.
KOiK08055.
OMAiITIDLLC.
OrthoDBiEOG7RFTKJ.
PhylomeDBiQ04475.
TreeFamiTF334167.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015707. B2Microglobulin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PANTHERiPTHR19944:SF62. PTHR19944:SF62. 1 hit.
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04475-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALITFALL CLLYITVQGK VSTPKVHVYS HFPGEYGKPN TLICYVSSFH
60 70 80 90 100
PPDISIELLK NGQVMSDTKQ TDLAFEKGWQ FHLTKSVAFT PEKGDEYTCS
110
VRHMKETKKF SWEPNM
Length:116
Mass (Da):13,289
Last modified:October 1, 1993 - v1
Checksum:iD2F3766C9A2BDBEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05383 mRNA. Translation: AAA50022.1.
L05384 Genomic DNA. Translation: AAA50023.1.
BC062841 mRNA. Translation: AAH62841.1.
PIRiI51732. I51733.
RefSeqiNP_001153240.1. NM_001159768.1.
NP_571238.1. NM_131163.2.
UniGeneiDr.51646.

Genome annotation databases

EnsembliENSDART00000075127; ENSDARP00000069612; ENSDARG00000053136.
ENSDART00000131026; ENSDARP00000110049; ENSDARG00000053136.
GeneIDi30400.
KEGGidre:30400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05383 mRNA. Translation: AAA50022.1.
L05384 Genomic DNA. Translation: AAA50023.1.
BC062841 mRNA. Translation: AAH62841.1.
PIRiI51732. I51733.
RefSeqiNP_001153240.1. NM_001159768.1.
NP_571238.1. NM_131163.2.
UniGeneiDr.51646.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4M9OX-ray2.14A19-116[»]
ProteinModelPortaliQ04475.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000069612.

Proteomic databases

PaxDbiQ04475.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000075127; ENSDARP00000069612; ENSDARG00000053136.
ENSDART00000131026; ENSDARP00000110049; ENSDARG00000053136.
GeneIDi30400.
KEGGidre:30400.

Organism-specific databases

CTDi567.
ZFINiZDB-GENE-980526-88. b2m.

Phylogenomic databases

eggNOGiENOG410J15A. Eukaryota.
ENOG410YTDG. LUCA.
GeneTreeiENSGT00690000102227.
HOGENOMiHOG000043084.
HOVERGENiHBG006197.
InParanoidiQ04475.
KOiK08055.
OMAiITIDLLC.
OrthoDBiEOG7RFTKJ.
PhylomeDBiQ04475.
TreeFamiTF334167.

Enzyme and pathway databases

ReactomeiR-DRE-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

PROiQ04475.

Gene expression databases

BgeeiQ04475.
ExpressionAtlasiQ04475. differential.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015707. B2Microglobulin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PANTHERiPTHR19944:SF62. PTHR19944:SF62. 1 hit.
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the beta 2-microglobulin gene in the zebrafish."
    Ono H., Figueroa F., O'Huigin C., Klein K.A.
    Immunogenetics 38:1-10(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiB2MG_DANRE
AccessioniPrimary (citable) accession number: Q04475
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 8, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.