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Q04472

- MGR3_YEAST

UniProt

Q04472 - MGR3_YEAST

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Protein
Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR3
Gene
MGR3, FMP24, YMR115W, YM9718.14
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the mitochondrial inner membrane i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins. Together with MGR1, functions in an adapter complex that targets substrates to the i-AAA protease for degradation. Required for growth of cells lacking the mitochondrial genome.1 Publication

GO - Molecular functioni

  1. misfolded protein binding Source: SGD
Complete GO annotation...

GO - Biological processi

  1. misfolded or incompletely synthesized protein catabolic process Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-32810-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR3
Alternative name(s):
Mitochondrial genome-required protein 3
Gene namesi
Name:MGR3
Synonyms:FMP24
Ordered Locus Names:YMR115W
ORF Names:YM9718.14
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR115w.
SGDiS000004721. MGR3.

Subcellular locationi

Mitochondrion inner membrane; Single-pass membrane protein Reviewed prediction 4 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7777Mitochondrial matrix1 Publication
Add
BLAST
Transmembranei78 – 9518Helical; Reviewed prediction
Add
BLAST
Topological domaini96 – 501406Mitochondrial intermembrane1 Publication
Add
BLAST

GO - Cellular componenti

  1. i-AAA complex Source: SGD
  2. integral component of membrane Source: UniProtKB-KW
  3. mitochondrial inner membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Reduces proteolysis by YME1.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR3
PRO_0000203293Add
BLAST

Proteomic databases

MaxQBiQ04472.
PaxDbiQ04472.

Expressioni

Gene expression databases

GenevestigatoriQ04472.

Interactioni

Subunit structurei

Component of the mitochondrial inner membrane i-AAA protease supercomplex composed of MGR1, MGR3 and YME1. With MGR1, forms a subcomplex that binds to YME1 and to substrates to facilitate proteolysis.1 Publication

Protein-protein interaction databases

BioGridi35291. 89 interactions.
IntActiQ04472. 1 interaction.
MINTiMINT-4497955.
STRINGi4932.YMR115W.

Structurei

3D structure databases

ProteinModelPortaliQ04472.
SMRiQ04472. Positions 405-489.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati109 – 14436TPR 1
Add
BLAST
Repeati154 – 18734TPR 2
Add
BLAST
Repeati386 – 42035TPR 3
Add
BLAST
Repeati440 – 47334TPR 4
Add
BLAST

Sequence similaritiesi

Belongs to the MGR3 family.
Contains 4 TPR repeats.

Keywords - Domaini

Repeat, TPR repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG275821.
GeneTreeiENSGT00530000067630.
HOGENOMiHOG000248851.
OMAiRKGLWAE.
OrthoDBiEOG7712HV.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR011990. TPR-like_helical.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04472-1 [UniParc]FASTAAdd to Basket

« Hide

MLLQGMRLSQ RLHKRHLFAS KILTWTTNPA HIRHLHDIRP PASNFNTQES    50
APIPESPANS PTRPQMAPKP NLKKKNRSLM YSIIGVSIVG LYFWFKSNSR 100
KQKLPLSAQK VWKEAIWQES DKMDFNYKEA LRRYIEALDE CDRSHVDLLS 150
DDYTRIELKI AEMYEKLNML EEAQNLYQEL LSRFFEALNV PGKVDESERG 200
EVLRKDLRIL IKSLEINKDI ESGKRKLLQH LLLAQEEILS KSPELKEFFE 250
NRKKKLSMVK DINRDPNDDF KTFVSEENIK FDEQGYMILD LEKNSSAWEP 300
FKEEFFTARD LYTAYCLSSK DIAAALSCKI TSVEWMVMAD MPPGQILLSQ 350
ANLGSLFYLQ AEKLEADLNQ LEQKKSKESN QELDMGTYIK AVRFVRKNRD 400
LCLERAQKCY DSVIAFAKRN RKIRFHVKDQ LDPSIAQSIA LSTYGMGVLS 450
LHEGVLAKAE KLFKDSITMA KETEFNELLA EAEKELEKTT VLKAAKKEGL 500
N 501
Length:501
Mass (Da):58,004
Last modified:November 1, 1997 - v1
Checksum:i994613B288C8DB7C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49702 Genomic DNA. Translation: CAA89752.1.
BK006946 Genomic DNA. Translation: DAA10012.1.
PIRiS54576.
RefSeqiNP_013833.1. NM_001182615.1.

Genome annotation databases

EnsemblFungiiYMR115W; YMR115W; YMR115W.
GeneIDi855142.
KEGGisce:YMR115W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49702 Genomic DNA. Translation: CAA89752.1 .
BK006946 Genomic DNA. Translation: DAA10012.1 .
PIRi S54576.
RefSeqi NP_013833.1. NM_001182615.1.

3D structure databases

ProteinModelPortali Q04472.
SMRi Q04472. Positions 405-489.
ModBasei Search...

Protein-protein interaction databases

BioGridi 35291. 89 interactions.
IntActi Q04472. 1 interaction.
MINTi MINT-4497955.
STRINGi 4932.YMR115W.

Proteomic databases

MaxQBi Q04472.
PaxDbi Q04472.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR115W ; YMR115W ; YMR115W .
GeneIDi 855142.
KEGGi sce:YMR115W.

Organism-specific databases

CYGDi YMR115w.
SGDi S000004721. MGR3.

Phylogenomic databases

eggNOGi NOG275821.
GeneTreei ENSGT00530000067630.
HOGENOMi HOG000248851.
OMAi RKGLWAE.
OrthoDBi EOG7712HV.

Enzyme and pathway databases

BioCyci YEAST:G3O-32810-MONOMER.

Miscellaneous databases

NextBioi 978534.

Gene expression databases

Genevestigatori Q04472.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
InterProi IPR011990. TPR-like_helical.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: ATCC 76625 / YPH499.
  6. "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics."
    Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.
    J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  7. "Mgr3p and Mgr1p are adaptors for the mitochondrial i-AAA protease complex."
    Dunn C.D., Tamura Y., Sesaki H., Jensen R.E.
    Mol. Biol. Cell 19:5387-5397(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, TOPOLOGY.

Entry informationi

Entry nameiMGR3_YEAST
AccessioniPrimary (citable) accession number: Q04472
Secondary accession number(s): D6VZT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 14, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 8970 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

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