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Q04472

- MGR3_YEAST

UniProt

Q04472 - MGR3_YEAST

Protein

Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR3

Gene

MGR3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Component of the mitochondrial inner membrane i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins. Together with MGR1, functions in an adapter complex that targets substrates to the i-AAA protease for degradation. Required for growth of cells lacking the mitochondrial genome.1 Publication

    GO - Molecular functioni

    1. misfolded protein binding Source: SGD

    GO - Biological processi

    1. misfolded or incompletely synthesized protein catabolic process Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32810-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR3
    Alternative name(s):
    Mitochondrial genome-required protein 3
    Gene namesi
    Name:MGR3
    Synonyms:FMP24
    Ordered Locus Names:YMR115W
    ORF Names:YM9718.14
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYMR115w.
    SGDiS000004721. MGR3.

    Subcellular locationi

    GO - Cellular componenti

    1. i-AAA complex Source: SGD
    2. integral component of membrane Source: UniProtKB-KW
    3. mitochondrial inner membrane Source: SGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Disruption phenotypei

    Reduces proteolysis by YME1.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 501501Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR3PRO_0000203293Add
    BLAST

    Proteomic databases

    MaxQBiQ04472.
    PaxDbiQ04472.

    Expressioni

    Gene expression databases

    GenevestigatoriQ04472.

    Interactioni

    Subunit structurei

    Component of the mitochondrial inner membrane i-AAA protease supercomplex composed of MGR1, MGR3 and YME1. With MGR1, forms a subcomplex that binds to YME1 and to substrates to facilitate proteolysis.1 Publication

    Protein-protein interaction databases

    BioGridi35291. 89 interactions.
    IntActiQ04472. 1 interaction.
    MINTiMINT-4497955.
    STRINGi4932.YMR115W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04472.
    SMRiQ04472. Positions 405-489.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7777Mitochondrial matrix1 PublicationAdd
    BLAST
    Topological domaini96 – 501406Mitochondrial intermembrane1 PublicationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei78 – 9518HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati109 – 14436TPR 1Add
    BLAST
    Repeati154 – 18734TPR 2Add
    BLAST
    Repeati386 – 42035TPR 3Add
    BLAST
    Repeati440 – 47334TPR 4Add
    BLAST

    Sequence similaritiesi

    Belongs to the MGR3 family.Curated
    Contains 4 TPR repeats.Curated

    Keywords - Domaini

    Repeat, TPR repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG275821.
    GeneTreeiENSGT00530000067630.
    HOGENOMiHOG000248851.
    OMAiRKGLWAE.
    OrthoDBiEOG7712HV.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    InterProiIPR011990. TPR-like_helical.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04472-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLQGMRLSQ RLHKRHLFAS KILTWTTNPA HIRHLHDIRP PASNFNTQES    50
    APIPESPANS PTRPQMAPKP NLKKKNRSLM YSIIGVSIVG LYFWFKSNSR 100
    KQKLPLSAQK VWKEAIWQES DKMDFNYKEA LRRYIEALDE CDRSHVDLLS 150
    DDYTRIELKI AEMYEKLNML EEAQNLYQEL LSRFFEALNV PGKVDESERG 200
    EVLRKDLRIL IKSLEINKDI ESGKRKLLQH LLLAQEEILS KSPELKEFFE 250
    NRKKKLSMVK DINRDPNDDF KTFVSEENIK FDEQGYMILD LEKNSSAWEP 300
    FKEEFFTARD LYTAYCLSSK DIAAALSCKI TSVEWMVMAD MPPGQILLSQ 350
    ANLGSLFYLQ AEKLEADLNQ LEQKKSKESN QELDMGTYIK AVRFVRKNRD 400
    LCLERAQKCY DSVIAFAKRN RKIRFHVKDQ LDPSIAQSIA LSTYGMGVLS 450
    LHEGVLAKAE KLFKDSITMA KETEFNELLA EAEKELEKTT VLKAAKKEGL 500
    N 501
    Length:501
    Mass (Da):58,004
    Last modified:November 1, 1997 - v1
    Checksum:i994613B288C8DB7C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49702 Genomic DNA. Translation: CAA89752.1.
    BK006946 Genomic DNA. Translation: DAA10012.1.
    PIRiS54576.
    RefSeqiNP_013833.1. NM_001182615.1.

    Genome annotation databases

    EnsemblFungiiYMR115W; YMR115W; YMR115W.
    GeneIDi855142.
    KEGGisce:YMR115W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49702 Genomic DNA. Translation: CAA89752.1 .
    BK006946 Genomic DNA. Translation: DAA10012.1 .
    PIRi S54576.
    RefSeqi NP_013833.1. NM_001182615.1.

    3D structure databases

    ProteinModelPortali Q04472.
    SMRi Q04472. Positions 405-489.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35291. 89 interactions.
    IntActi Q04472. 1 interaction.
    MINTi MINT-4497955.
    STRINGi 4932.YMR115W.

    Proteomic databases

    MaxQBi Q04472.
    PaxDbi Q04472.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YMR115W ; YMR115W ; YMR115W .
    GeneIDi 855142.
    KEGGi sce:YMR115W.

    Organism-specific databases

    CYGDi YMR115w.
    SGDi S000004721. MGR3.

    Phylogenomic databases

    eggNOGi NOG275821.
    GeneTreei ENSGT00530000067630.
    HOGENOMi HOG000248851.
    OMAi RKGLWAE.
    OrthoDBi EOG7712HV.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32810-MONOMER.

    Miscellaneous databases

    NextBioi 978534.

    Gene expression databases

    Genevestigatori Q04472.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    InterProi IPR011990. TPR-like_helical.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Strain: ATCC 76625 / YPH499.
    6. "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics."
      Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.
      J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    7. "Mgr3p and Mgr1p are adaptors for the mitochondrial i-AAA protease complex."
      Dunn C.D., Tamura Y., Sesaki H., Jensen R.E.
      Mol. Biol. Cell 19:5387-5397(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, TOPOLOGY.

    Entry informationi

    Entry nameiMGR3_YEAST
    AccessioniPrimary (citable) accession number: Q04472
    Secondary accession number(s): D6VZT8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 8970 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3