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Q04469

- GUN1_CRYFL

UniProt

Q04469 - GUN1_CRYFL

Protein

Endoglucanase 1

Gene

CMC1

Organism
Cryptococcus flavus
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    • Comment

    Functioni

    Has endoglucanase activity on carboxymethyl-cellulose (CMC).

    Catalytic activityi

    Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei166 – 1661Proton donorBy similarity
    Active sitei275 – 2751NucleophileBy similarity

    GO - Molecular functioni

    1. cellulase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Protein family/group databases

    CAZyiGH5. Glycoside Hydrolase Family 5.
    mycoCLAPiEGL5A_CRYFL.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endoglucanase 1 (EC:3.2.1.4)
    Alternative name(s):
    Carboxymethyl-cellulase 1
    Short name:
    CMCase 1
    Short name:
    Cellulase 1
    Endo-1,4-beta-glucanase 1
    Gene namesi
    Name:CMC1
    OrganismiCryptococcus flavus
    Taxonomic identifieri5416 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesmitosporic TremellalesCryptococcus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Propeptidei17 – 3014Sequence AnalysisPRO_0000007855Add
    BLAST
    Chaini31 – 341311Endoglucanase 1PRO_0000007856Add
    BLAST

    Keywords - PTMi

    Cleavage on pair of basic residues

    Structurei

    3D structure databases

    ProteinModelPortaliQ04469.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR001547. Glyco_hydro_5.
    IPR018087. Glyco_hydro_5_CS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF00150. Cellulase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.
    PROSITEiPS00659. GLYCOSYL_HYDROL_F5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q04469-1 [UniParc]FASTAAdd to Basket

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    MKTATLLAAL SVLAGALAAP LAGDSALHRR SLPRLGGVNL AGCDFGIDIY    50
    GNSGTPACPG TEQVGHFIAD GANLFRLPAG WQYLVGNNQA STSLAPDFFA 100
    QYDALVQAVI SKGAYAIIDV HNYARWNGAI IGQGGPSNQD FANLWTLLAT 150
    KVTSNDPNVI FGLMNEPHDL DVSTWAGSVQ AAVNAIRAAG ATSQYILIPG 200
    TGFTNANAWF QGQDNALLGV TDPVGGTDKL LLDVHRYNDV DFSGTHAECT 250
    TNSLDVLSSL DSWLKGNGRK AIVSETGGGH TTSCETDLGE FLNGIKEDYP 300
    SVLGFAVWAA GSFDPSYVLS ITPTNGVDNQ LFDIAVKPNL P 341
    Length:341
    Mass (Da):35,717
    Last modified:October 1, 1996 - v1
    Checksum:i4A62E45C952DD120
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D13967 mRNA. Translation: BAA03070.1.
    S45137 Genomic DNA. Translation: AAC60541.1.
    PIRiJC1201.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D13967 mRNA. Translation: BAA03070.1 .
    S45137 Genomic DNA. Translation: AAC60541.1 .
    PIRi JC1201.

    3D structure databases

    ProteinModelPortali Q04469.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH5. Glycoside Hydrolase Family 5.
    mycoCLAPi EGL5A_CRYFL.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR001547. Glyco_hydro_5.
    IPR018087. Glyco_hydro_5_CS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF00150. Cellulase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    PROSITEi PS00659. GLYCOSYL_HYDROL_F5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and molecular analysis of cDNA encoding a carboxymethylcellulase of the yeast Cryptococcus flavus."
      Cui Z., Mochizuki D., Matsuno Y., Nakamura T., Liu Y., Hatano T., Fukui S., Miyakawa T.
      Biosci. Biotechnol. Biochem. 56:1230-1235(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiGUN1_CRYFL
    AccessioniPrimary (citable) accession number: Q04469
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3