Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q04458

- HFD1_YEAST

UniProt

Q04458 - HFD1_YEAST

Protein

Fatty aldehyde dehydrogenase HFD1

Gene

HFD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid.1 Publication

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei236 – 2361PROSITE-ProRule annotation
    Active sitei273 – 2731PROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi214 – 2196NADSequence Analysis

    GO - Molecular functioni

    1. 3-chloroallyl aldehyde dehydrogenase activity Source: SGD
    2. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC
    3. aldehyde dehydrogenase [NAD(P)+] activity Source: InterPro
    4. carboxylate reductase activity Source: SGD

    GO - Biological processi

    1. cellular aldehyde metabolic process Source: SGD

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32806-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fatty aldehyde dehydrogenase HFD1 (EC:1.2.1.3)
    Gene namesi
    Name:HFD1
    Ordered Locus Names:YMR110C
    ORF Names:YM9718.09C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYMR110c.
    SGDiS000004716. HFD1.

    Subcellular locationi

    GO - Cellular componenti

    1. endosome membrane Source: UniProtKB-SubCell
    2. integral component of mitochondrial outer membrane Source: SGD
    3. lipid particle Source: SGD

    Keywords - Cellular componenti

    Endosome, Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 532532Fatty aldehyde dehydrogenase HFD1PRO_0000056597Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei111 – 1111Phosphoserine4 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ04458.
    PaxDbiQ04458.
    PeptideAtlasiQ04458.
    PRIDEiQ04458.

    Expressioni

    Gene expression databases

    GenevestigatoriQ04458.

    Interactioni

    Protein-protein interaction databases

    BioGridi35286. 32 interactions.
    DIPiDIP-4437N.
    IntActiQ04458. 8 interactions.
    MINTiMINT-570953.
    STRINGi4932.YMR110C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04458.
    SMRiQ04458. Positions 15-484.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei134 – 15219HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1012.
    GeneTreeiENSGT00390000002825.
    HOGENOMiHOG000271515.
    OMAiNTFSHER.
    OrthoDBiEOG7SFJ6D.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR012394. Aldehyde_DH_NAD(P).
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036492. ALDH. 1 hit.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04458-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNDGSKILN YTPVSKIDEI VEISRNFFFE KQLKLSHENN PRKKDLEFRQ    50
    LQLKKLYYAV KDHEEELIDA MYKDFHRNKI ESVLNETTKL MNDILHLIEI 100
    LPKLIKPRRV SDSSPPFMFG KTIVEKISRG SVLIIAPFNF PLLLAFAPLA 150
    AALAAGNTIV LKPSELTPHT AVVMENLLTT AGFPDGLIQV VQGAIDETTR 200
    LLDCGKFDLI FYTGSPRVGS IVAEKAAKSL TPCVLELGGK SPTFITENFK 250
    ASNIKIALKR IFFGAFGNSG QICVSPDYLL VHKSIYPKVI KECESVLNEF 300
    YPSFDEQTDF TRMIHEPAYK KAVASINSTN GSKIVPSKIS INSDTEDLCL 350
    VPPTIVYNIG WDDPLMKQEN FAPVLPIIEY EDLDETINKI IEEHDTPLVQ 400
    YIFSDSQTEI NRILTRLRSG DCVVGDTVIH VGITDAPFGG IGTSGYGNYG 450
    GYYGFNTFSH ERTIFKQPYW NDFTLFMRYP PNSAQKEKLV RFAMERKPWF 500
    DRNGNNKWGL RQYFSLSAAV ILISTIYAHC SS 532
    Length:532
    Mass (Da):59,979
    Last modified:November 1, 1997 - v1
    Checksum:i6CAF4BFCF963AF88
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49702 Genomic DNA. Translation: CAA89746.1.
    BK006946 Genomic DNA. Translation: DAA10007.1.
    PIRiS54571.
    RefSeqiNP_013828.1. NM_001182610.1.

    Genome annotation databases

    EnsemblFungiiYMR110C; YMR110C; YMR110C.
    GeneIDi855137.
    KEGGisce:YMR110C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49702 Genomic DNA. Translation: CAA89746.1 .
    BK006946 Genomic DNA. Translation: DAA10007.1 .
    PIRi S54571.
    RefSeqi NP_013828.1. NM_001182610.1.

    3D structure databases

    ProteinModelPortali Q04458.
    SMRi Q04458. Positions 15-484.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35286. 32 interactions.
    DIPi DIP-4437N.
    IntActi Q04458. 8 interactions.
    MINTi MINT-570953.
    STRINGi 4932.YMR110C.

    Proteomic databases

    MaxQBi Q04458.
    PaxDbi Q04458.
    PeptideAtlasi Q04458.
    PRIDEi Q04458.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YMR110C ; YMR110C ; YMR110C .
    GeneIDi 855137.
    KEGGi sce:YMR110C.

    Organism-specific databases

    CYGDi YMR110c.
    SGDi S000004716. HFD1.

    Phylogenomic databases

    eggNOGi COG1012.
    GeneTreei ENSGT00390000002825.
    HOGENOMi HOG000271515.
    OMAi NTFSHER.
    OrthoDBi EOG7SFJ6D.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32806-MONOMER.

    Miscellaneous databases

    NextBioi 978519.

    Gene expression databases

    Genevestigatori Q04458.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR012394. Aldehyde_DH_NAD(P).
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036492. ALDH. 1 hit.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Strain: ATCC 76625 / YPH499.
    6. "Integral membrane proteins in the mitochondrial outer membrane of Saccharomyces cerevisiae."
      Burri L., Vascotto K., Gentle I.E., Chan N.C., Beilharz T., Stapleton D.I., Ramage L., Lithgow T.
      FEBS J. 273:1507-1515(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
    7. "Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins."
      Zahedi R.P., Sickmann A., Boehm A.M., Winkler C., Zufall N., Schoenfisch B., Guiard B., Pfanner N., Meisinger C.
      Mol. Biol. Cell 17:1436-1450(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
    8. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-111, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    9. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
      Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
      Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-111, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-111, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-111, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "The Sjogren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway."
      Nakahara K., Ohkuni A., Kitamura T., Abe K., Naganuma T., Ohno Y., Zoeller R.A., Kihara A.
      Mol. Cell 46:461-471(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiHFD1_YEAST
    AccessioniPrimary (citable) accession number: Q04458
    Secondary accession number(s): D6VZT3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 2930 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3