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Q04456

- EST1_CAEBR

UniProt

Q04456 - EST1_CAEBR

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Protein
Gut esterase 1
Gene
ges-1, CBG06418
Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A carboxylic ester + H2O = an alcohol + a carboxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei199 – 1991Acyl-ester intermediate By similarity
Active sitei320 – 3201Charge relay system By similarity
Active sitei451 – 4511Charge relay system By similarity

GO - Molecular functioni

  1. carboxylic ester hydrolase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Protein family/group databases

MEROPSiS09.979.

Names & Taxonomyi

Protein namesi
Recommended name:
Gut esterase 1 (EC:3.1.1.1)
Alternative name(s):
Non-specific carboxylesterase
Gene namesi
Name:ges-1
ORF Names:CBG06418
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome V, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG06418; CBP15596; WBGene00028697; Cbr-ges-1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616
Add
BLAST
Chaini17 – 562546Gut esterase 1
PRO_0000008550Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi75 ↔ 93 By similarity
Disulfide bondi251 ↔ 259 By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed only in the intestine.

Developmental stagei

Appears in mid-proliferation phase when the developing gut has four to eight cells.

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG06418.

Structurei

3D structure databases

ProteinModelPortaliQ04456.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi559 – 5624Prevents secretion from ER

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2272.
OMAiAIPFAKP.
OrthoDBiEOG793B7B.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
PS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04456-1 [UniParc]FASTAAdd to Basket

« Hide

MRVLLASLLI FGACWAGPVV NTNYGKVEGF EYGAAEVFLA IPFAKPPVDN    50
LRFEKPEAPE PWEDVYQATQ FRNDCTPHYR LVAQFSSYSG EDCLTLNVIK 100
PKTIEKKLPV LFWVHGGGYE IGSGSQHGYE FFADRYTSQG VIVVTIQYRL 150
GFMGFFSEGT SDAPGNYGLF DQAAALRFVK ENIGNFGGDP DDITIWGYSA 200
GAASVSQLTM SPYTHDLYSK AIIMSASSFV GWATGPNVID TSKQLAEILG 250
CPWPGAKECM KKKTLHEIFD AVETQGWTTG TIDILRWSPV IDGDYLPKNP 300
ENLINDAPIK PTLIGMSNKE GSYFATMNMG RVIADFGLSP EEIPKVDEDF 350
ISEIIDRKLL YNNRYGENRQ KVWDQILDYY TKQGKPERDL NGFYVDRYAE 400
LLSDITFNVP ILREITARVE RKTPVWTYRF DHYNEQIWKK YIPEQAKGSP 450
HANEYHYLFN MPVMAQIDFK KEPESWLQRD LIDMVVSFAK TGVPHIQDVE 500
WRPVSDPDDV NFLNFQSSGV SVKHGLFQEP LDFWNNLRER EGFDLVDPAY 550
SKTTSNSEKD EL 562
Length:562
Mass (Da):63,819
Last modified:October 1, 1993 - v1
Checksum:i7FA312F3B2587E53
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M96144 Genomic DNA. Translation: AAA28056.1.
HE601320 Genomic DNA. Translation: CAP26727.1.
PIRiS27782.
RefSeqiXP_002647363.1. XM_002647317.1.

Genome annotation databases

EnsemblMetazoaiCBG06418; CBG06418; CBG06418.
GeneIDi8589362.
KEGGicbr:CBG06418.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M96144 Genomic DNA. Translation: AAA28056.1 .
HE601320 Genomic DNA. Translation: CAP26727.1 .
PIRi S27782.
RefSeqi XP_002647363.1. XM_002647317.1.

3D structure databases

ProteinModelPortali Q04456.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG06418.

Protein family/group databases

MEROPSi S09.979.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG06418 ; CBG06418 ; CBG06418 .
GeneIDi 8589362.
KEGGi cbr:CBG06418.

Organism-specific databases

CTDi 8589362.
WormBasei CBG06418 ; CBP15596 ; WBGene00028697 ; Cbr-ges-1.

Phylogenomic databases

eggNOGi COG2272.
OMAi AIPFAKP.
OrthoDBi EOG793B7B.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view ]
Pfami PF00135. COesterase. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The gut esterase gene (ges-1) from the nematodes Caenorhabditis elegans and Caenorhabditis briggsae."
    Kennedy B.P., Aamodt E.J., Allen F.L., Chung M.A., Heschl M.F.P., McGhee J.D.
    J. Mol. Biol. 229:890-908(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiEST1_CAEBR
AccessioniPrimary (citable) accession number: Q04456
Secondary accession number(s): A8X267
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 11, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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