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Q04456 (EST1_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gut esterase 1

EC=3.1.1.1
Alternative name(s):
Non-specific carboxylesterase
Gene names
Name:ges-1
ORF Names:CBG06418
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length562 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

A carboxylic ester + H2O = an alcohol + a carboxylate.

Subcellular location

Endoplasmic reticulum lumen.

Tissue specificity

Expressed only in the intestine.

Developmental stage

Appears in mid-proliferation phase when the developing gut has four to eight cells.

Sequence similarities

Belongs to the type-B carboxylesterase/lipase family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainSignal
   Molecular functionHydrolase
Serine esterase
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncarboxylic ester hydrolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616
Chain17 – 562546Gut esterase 1
PRO_0000008550

Regions

Motif559 – 5624Prevents secretion from ER

Sites

Active site1991Acyl-ester intermediate By similarity
Active site3201Charge relay system By similarity
Active site4511Charge relay system By similarity

Amino acid modifications

Disulfide bond75 ↔ 93 By similarity
Disulfide bond251 ↔ 259 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q04456 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: 7FA312F3B2587E53

FASTA56263,819
        10         20         30         40         50         60 
MRVLLASLLI FGACWAGPVV NTNYGKVEGF EYGAAEVFLA IPFAKPPVDN LRFEKPEAPE 

        70         80         90        100        110        120 
PWEDVYQATQ FRNDCTPHYR LVAQFSSYSG EDCLTLNVIK PKTIEKKLPV LFWVHGGGYE 

       130        140        150        160        170        180 
IGSGSQHGYE FFADRYTSQG VIVVTIQYRL GFMGFFSEGT SDAPGNYGLF DQAAALRFVK 

       190        200        210        220        230        240 
ENIGNFGGDP DDITIWGYSA GAASVSQLTM SPYTHDLYSK AIIMSASSFV GWATGPNVID 

       250        260        270        280        290        300 
TSKQLAEILG CPWPGAKECM KKKTLHEIFD AVETQGWTTG TIDILRWSPV IDGDYLPKNP 

       310        320        330        340        350        360 
ENLINDAPIK PTLIGMSNKE GSYFATMNMG RVIADFGLSP EEIPKVDEDF ISEIIDRKLL 

       370        380        390        400        410        420 
YNNRYGENRQ KVWDQILDYY TKQGKPERDL NGFYVDRYAE LLSDITFNVP ILREITARVE 

       430        440        450        460        470        480 
RKTPVWTYRF DHYNEQIWKK YIPEQAKGSP HANEYHYLFN MPVMAQIDFK KEPESWLQRD 

       490        500        510        520        530        540 
LIDMVVSFAK TGVPHIQDVE WRPVSDPDDV NFLNFQSSGV SVKHGLFQEP LDFWNNLRER 

       550        560 
EGFDLVDPAY SKTTSNSEKD EL 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M96144 Genomic DNA. Translation: AAA28056.1.
HE601320 Genomic DNA. Translation: CAP26727.1.
PIRS27782.
RefSeqXP_002647363.1. XM_002647317.1.

3D structure databases

ProteinModelPortalQ04456.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6238.CBG06418.

Protein family/group databases

MEROPSS09.979.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG06418; CBG06418; CBG06418.
GeneID8589362.
KEGGcbr:CBG06418.

Organism-specific databases

CTD8589362.
WormBaseCBG06418; CBP15596; WBGene00028697; Cbr-ges-1.

Phylogenomic databases

eggNOGCOG2272.
OMAAIPFAKP.
OrthoDBEOG793B7B.

Family and domain databases

InterProIPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamPF00135. COesterase. 1 hit.
[Graphical view]
PROSITEPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
PS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEST1_CAEBR
AccessionPrimary (citable) accession number: Q04456
Secondary accession number(s): A8X267
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families