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Q04456

- EST1_CAEBR

UniProt

Q04456 - EST1_CAEBR

Protein

Gut esterase 1

Gene

ges-1

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A carboxylic ester + H2O = an alcohol + a carboxylate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei199 – 1991Acyl-ester intermediatePROSITE-ProRule annotation
    Active sitei320 – 3201Charge relay systemBy similarity
    Active sitei451 – 4511Charge relay systemBy similarity

    GO - Molecular functioni

    1. carboxylic ester hydrolase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase, Serine esterase

    Protein family/group databases

    MEROPSiS09.979.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gut esterase 1 (EC:3.1.1.1)
    Alternative name(s):
    Non-specific carboxylesterase
    Gene namesi
    Name:ges-1
    ORF Names:CBG06418
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome V, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG06418; CBP15596; WBGene00028697; Cbr-ges-1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Add
    BLAST
    Chaini17 – 562546Gut esterase 1PRO_0000008550Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi75 ↔ 93By similarity
    Disulfide bondi251 ↔ 259By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed only in the intestine.

    Developmental stagei

    Appears in mid-proliferation phase when the developing gut has four to eight cells.

    Interactioni

    Protein-protein interaction databases

    STRINGi6238.CBG06418.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04456.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi559 – 5624Prevents secretion from ER

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2272.
    OMAiAIPFAKP.
    OrthoDBiEOG793B7B.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR002018. CarbesteraseB.
    IPR019826. Carboxylesterase_B_AS.
    IPR019819. Carboxylesterase_B_CS.
    [Graphical view]
    PfamiPF00135. COesterase. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
    PS00941. CARBOXYLESTERASE_B_2. 1 hit.
    PS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q04456-1 [UniParc]FASTAAdd to Basket

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    MRVLLASLLI FGACWAGPVV NTNYGKVEGF EYGAAEVFLA IPFAKPPVDN    50
    LRFEKPEAPE PWEDVYQATQ FRNDCTPHYR LVAQFSSYSG EDCLTLNVIK 100
    PKTIEKKLPV LFWVHGGGYE IGSGSQHGYE FFADRYTSQG VIVVTIQYRL 150
    GFMGFFSEGT SDAPGNYGLF DQAAALRFVK ENIGNFGGDP DDITIWGYSA 200
    GAASVSQLTM SPYTHDLYSK AIIMSASSFV GWATGPNVID TSKQLAEILG 250
    CPWPGAKECM KKKTLHEIFD AVETQGWTTG TIDILRWSPV IDGDYLPKNP 300
    ENLINDAPIK PTLIGMSNKE GSYFATMNMG RVIADFGLSP EEIPKVDEDF 350
    ISEIIDRKLL YNNRYGENRQ KVWDQILDYY TKQGKPERDL NGFYVDRYAE 400
    LLSDITFNVP ILREITARVE RKTPVWTYRF DHYNEQIWKK YIPEQAKGSP 450
    HANEYHYLFN MPVMAQIDFK KEPESWLQRD LIDMVVSFAK TGVPHIQDVE 500
    WRPVSDPDDV NFLNFQSSGV SVKHGLFQEP LDFWNNLRER EGFDLVDPAY 550
    SKTTSNSEKD EL 562
    Length:562
    Mass (Da):63,819
    Last modified:October 1, 1993 - v1
    Checksum:i7FA312F3B2587E53
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M96144 Genomic DNA. Translation: AAA28056.1.
    HE601320 Genomic DNA. Translation: CAP26727.1.
    PIRiS27782.
    RefSeqiXP_002647363.1. XM_002647317.1.

    Genome annotation databases

    EnsemblMetazoaiCBG06418; CBG06418; CBG06418.
    GeneIDi8589362.
    KEGGicbr:CBG06418.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M96144 Genomic DNA. Translation: AAA28056.1 .
    HE601320 Genomic DNA. Translation: CAP26727.1 .
    PIRi S27782.
    RefSeqi XP_002647363.1. XM_002647317.1.

    3D structure databases

    ProteinModelPortali Q04456.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6238.CBG06418.

    Protein family/group databases

    MEROPSi S09.979.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG06418 ; CBG06418 ; CBG06418 .
    GeneIDi 8589362.
    KEGGi cbr:CBG06418.

    Organism-specific databases

    CTDi 8589362.
    WormBasei CBG06418 ; CBP15596 ; WBGene00028697 ; Cbr-ges-1.

    Phylogenomic databases

    eggNOGi COG2272.
    OMAi AIPFAKP.
    OrthoDBi EOG793B7B.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR002018. CarbesteraseB.
    IPR019826. Carboxylesterase_B_AS.
    IPR019819. Carboxylesterase_B_CS.
    [Graphical view ]
    Pfami PF00135. COesterase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00122. CARBOXYLESTERASE_B_1. 1 hit.
    PS00941. CARBOXYLESTERASE_B_2. 1 hit.
    PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The gut esterase gene (ges-1) from the nematodes Caenorhabditis elegans and Caenorhabditis briggsae."
      Kennedy B.P., Aamodt E.J., Allen F.L., Chung M.A., Heschl M.F.P., McGhee J.D.
      J. Mol. Biol. 229:890-908(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16.

    Entry informationi

    Entry nameiEST1_CAEBR
    AccessioniPrimary (citable) accession number: Q04456
    Secondary accession number(s): A8X267
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3