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Protein

Gut esterase 1

Gene

ges-1

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A carboxylic ester + H2O = an alcohol + a carboxylate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei199 – 1991Acyl-ester intermediatePROSITE-ProRule annotation
Active sitei320 – 3201Charge relay systemBy similarity
Active sitei451 – 4511Charge relay systemBy similarity

GO - Molecular functioni

  1. carboxylic ester hydrolase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Names & Taxonomyi

Protein namesi
Recommended name:
Gut esterase 1 (EC:3.1.1.1)
Alternative name(s):
Non-specific carboxylesterase
Gene namesi
Name:ges-1
ORF Names:CBG06418
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome V, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG06418; CBP15596; WBGene00028697; Cbr-ges-1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Add
BLAST
Chaini17 – 562546Gut esterase 1PRO_0000008550Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi75 ↔ 93By similarity
Disulfide bondi251 ↔ 259By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed only in the intestine.

Developmental stagei

Appears in mid-proliferation phase when the developing gut has four to eight cells.

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG06418.

Structurei

3D structure databases

ProteinModelPortaliQ04456.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi559 – 5624Prevents secretion from ER

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2272.
InParanoidiQ04456.
OMAiKGSPHAN.
OrthoDBiEOG793B7B.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
PS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04456-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLLASLLI FGACWAGPVV NTNYGKVEGF EYGAAEVFLA IPFAKPPVDN
60 70 80 90 100
LRFEKPEAPE PWEDVYQATQ FRNDCTPHYR LVAQFSSYSG EDCLTLNVIK
110 120 130 140 150
PKTIEKKLPV LFWVHGGGYE IGSGSQHGYE FFADRYTSQG VIVVTIQYRL
160 170 180 190 200
GFMGFFSEGT SDAPGNYGLF DQAAALRFVK ENIGNFGGDP DDITIWGYSA
210 220 230 240 250
GAASVSQLTM SPYTHDLYSK AIIMSASSFV GWATGPNVID TSKQLAEILG
260 270 280 290 300
CPWPGAKECM KKKTLHEIFD AVETQGWTTG TIDILRWSPV IDGDYLPKNP
310 320 330 340 350
ENLINDAPIK PTLIGMSNKE GSYFATMNMG RVIADFGLSP EEIPKVDEDF
360 370 380 390 400
ISEIIDRKLL YNNRYGENRQ KVWDQILDYY TKQGKPERDL NGFYVDRYAE
410 420 430 440 450
LLSDITFNVP ILREITARVE RKTPVWTYRF DHYNEQIWKK YIPEQAKGSP
460 470 480 490 500
HANEYHYLFN MPVMAQIDFK KEPESWLQRD LIDMVVSFAK TGVPHIQDVE
510 520 530 540 550
WRPVSDPDDV NFLNFQSSGV SVKHGLFQEP LDFWNNLRER EGFDLVDPAY
560
SKTTSNSEKD EL
Length:562
Mass (Da):63,819
Last modified:October 1, 1993 - v1
Checksum:i7FA312F3B2587E53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96144 Genomic DNA. Translation: AAA28056.1.
HE601320 Genomic DNA. Translation: CAP26727.1.
PIRiS27782.
RefSeqiXP_002647363.1. XM_002647317.1.

Genome annotation databases

EnsemblMetazoaiCBG06418; CBG06418; CBG06418.
GeneIDi8589362.
KEGGicbr:CBG06418.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96144 Genomic DNA. Translation: AAA28056.1.
HE601320 Genomic DNA. Translation: CAP26727.1.
PIRiS27782.
RefSeqiXP_002647363.1. XM_002647317.1.

3D structure databases

ProteinModelPortaliQ04456.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6238.CBG06418.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCBG06418; CBG06418; CBG06418.
GeneIDi8589362.
KEGGicbr:CBG06418.

Organism-specific databases

CTDi8589362.
WormBaseiCBG06418; CBP15596; WBGene00028697; Cbr-ges-1.

Phylogenomic databases

eggNOGiCOG2272.
InParanoidiQ04456.
OMAiKGSPHAN.
OrthoDBiEOG793B7B.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
PS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The gut esterase gene (ges-1) from the nematodes Caenorhabditis elegans and Caenorhabditis briggsae."
    Kennedy B.P., Aamodt E.J., Allen F.L., Chung M.A., Heschl M.F.P., McGhee J.D.
    J. Mol. Biol. 229:890-908(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiEST1_CAEBR
AccessioniPrimary (citable) accession number: Q04456
Secondary accession number(s): A8X267
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: March 4, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.