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Protein

Cytochrome c oxidase subunit 4B

Gene

ctaF

Organism
Bacillus pseudofirmus (strain OF4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciBPSE398511:GJI9-2591-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 4B (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 4B
Cytochrome c oxidase polypeptide IVB
Gene namesi
Name:ctaF
Ordered Locus Names:BpOF4_00900
OrganismiBacillus pseudofirmus (strain OF4)
Taxonomic identifieri398511 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001544 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei29 – 4921HelicalSequence AnalysisAdd
BLAST
Transmembranei56 – 7621HelicalSequence AnalysisAdd
BLAST
Transmembranei89 – 10921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 114114Cytochrome c oxidase subunit 4BPRO_0000183900Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi398511.BpOF4_00900.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000261855.
KOiK02277.

Family and domain databases

InterProiIPR005171. Cyt_c_oxidase_su4_prok.
[Graphical view]
PfamiPF03626. COX4_pro. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04452-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADNLSQSFD KSAMTEEERR HIKKEIRKQI VVFALMIFLT LMSFMAVATD
60 70 80 90 100
VIPRSFAIPF IFILAVIQFA LQLFFFMHMK DKDHGWANAF MISGIFITVP
110
TIAALMLLLG VNKI
Length:114
Mass (Da):13,045
Last modified:June 15, 2010 - v2
Checksum:iFEE7A03352BF648D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321V → A in AAA22367 (PubMed:7678007).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94110 Genomic DNA. Translation: AAA22367.1.
CP001878 Genomic DNA. Translation: ADC48249.1.
RefSeqiWP_012959531.1. NC_013791.2.
YP_003425141.1. NC_013791.2.

Genome annotation databases

EnsemblBacteriaiADC48249; ADC48249; BpOF4_00900.
KEGGibpf:BpOF4_00900.
PATRICi31942826. VBIBacPse80461_0175.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94110 Genomic DNA. Translation: AAA22367.1.
CP001878 Genomic DNA. Translation: ADC48249.1.
RefSeqiWP_012959531.1. NC_013791.2.
YP_003425141.1. NC_013791.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi398511.BpOF4_00900.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADC48249; ADC48249; BpOF4_00900.
KEGGibpf:BpOF4_00900.
PATRICi31942826. VBIBacPse80461_0175.

Phylogenomic databases

HOGENOMiHOG000261855.
KOiK02277.

Enzyme and pathway databases

BioCyciBPSE398511:GJI9-2591-MONOMER.

Family and domain databases

InterProiIPR005171. Cyt_c_oxidase_su4_prok.
[Graphical view]
PfamiPF03626. COX4_pro. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the cta operon from alkaliphilic Bacillus firmus OF4 and characterization of the pH-regulated cytochrome caa3 oxidase it encodes."
    Quirk P.G., Hicks D.B., Krulwich T.A.
    J. Biol. Chem. 268:678-685(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Genome of alkaliphilic Bacillus pseudofirmus OF4 reveals adaptations that support the ability to grow in an external pH range from 7.5 to 11.4."
    Janto B., Ahmed A., Ito M., Liu J., Hicks D.B., Pagni S., Fackelmayer O.J., Smith T.A., Earl J., Elbourne L.D., Hassan K., Paulsen I.T., Kolsto A.B., Tourasse N.J., Ehrlich G.D., Boissy R., Ivey D.M., Li G.
    , Xue Y., Ma Y., Hu F.Z., Krulwich T.A.
    Environ. Microbiol. 13:3289-3309(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OF4.

Entry informationi

Entry nameiCOX4_BACPE
AccessioniPrimary (citable) accession number: Q04452
Secondary accession number(s): D3FU47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 15, 2010
Last modified: June 24, 2015
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.