Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q04452 (COX4_BACPE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 4B

EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 4B
Cytochrome c oxidase polypeptide IVB
Gene names
Name:ctaF
Ordered Locus Names:BpOF4_00900
OrganismBacillus pseudofirmus (strain OF4) [Complete proteome] [HAMAP]
Taxonomic identifier398511 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length114 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase bacterial subunit 4 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncytochrome-c oxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 114114Cytochrome c oxidase subunit 4B
PRO_0000183900

Regions

Transmembrane29 – 4921Helical; Potential
Transmembrane56 – 7621Helical; Potential
Transmembrane89 – 10921Helical; Potential

Experimental info

Sequence conflict321V → A in AAA22367. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q04452 [UniParc].

Last modified June 15, 2010. Version 2.
Checksum: FEE7A03352BF648D

FASTA11413,045
        10         20         30         40         50         60 
MADNLSQSFD KSAMTEEERR HIKKEIRKQI VVFALMIFLT LMSFMAVATD VIPRSFAIPF 

        70         80         90        100        110 
IFILAVIQFA LQLFFFMHMK DKDHGWANAF MISGIFITVP TIAALMLLLG VNKI 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of the cta operon from alkaliphilic Bacillus firmus OF4 and characterization of the pH-regulated cytochrome caa3 oxidase it encodes."
Quirk P.G., Hicks D.B., Krulwich T.A.
J. Biol. Chem. 268:678-685(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Genome of alkaliphilic Bacillus pseudofirmus OF4 reveals adaptations that support the ability to grow in an external pH range from 7.5 to 11.4."
Janto B., Ahmed A., Ito M., Liu J., Hicks D.B., Pagni S., Fackelmayer O.J., Smith T.A., Earl J., Elbourne L.D., Hassan K., Paulsen I.T., Kolsto A.B., Tourasse N.J., Ehrlich G.D., Boissy R., Ivey D.M., Li G. expand/collapse author list , Xue Y., Ma Y., Hu F.Z., Krulwich T.A.
Environ. Microbiol. 13:3289-3309(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: OF4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M94110 Genomic DNA. Translation: AAA22367.1.
CP001878 Genomic DNA. Translation: ADC48249.1.
RefSeqYP_003425141.1. NC_013791.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADC48249; ADC48249; BpOF4_00900.
GeneID8765152.
KEGGbpf:BpOF4_00900.
PATRIC31942826. VBIBacPse80461_0175.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000261855.
KOK02277.
ProtClustDBCLSK2459926.

Enzyme and pathway databases

BioCycBPSE398511:GJI9-2591-MONOMER.

Family and domain databases

InterProIPR005171. Cyt_c_oxidase_suIV_prok.
[Graphical view]
PfamPF03626. COX4_pro. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX4_BACPE
AccessionPrimary (citable) accession number: Q04452
Secondary accession number(s): D3FU47
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 15, 2010
Last modified: April 16, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families