Q04452 (COX4_BACPE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 4B
EC=1.9.3.1

Alternative name(s):
Cytochrome aa3 subunit 4B
Cytochrome c oxidase polypeptide IVB

Gene names

Name:	ctaF
Ordered Locus Names:	BpOF4_00900

Organism

Bacillus pseudofirmus (strain OF4) [Complete proteome] [HAMAP]

Taxonomic identifier

398511 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus pseudofirmus

Protein attributes

Sequence length	114 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cytochrome c oxidase bacterial subunit 4 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 114	114	Cytochrome c oxidase subunit 4B		PRO_0000183900
Regions
	Transmembrane	29 – 49	21	Helical; Potential
	Transmembrane	56 – 76	21	Helical; Potential
	Transmembrane	89 – 109	21	Helical; Potential
Experimental info
	Sequence conflict	32	1	V → A in AAA22367. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q04452 [UniParc]. Last modified June 15, 2010. Version 2. Checksum: FEE7A03352BF648D	FASTA	114	13,045
	10 20 30 40 50 60 MADNLSQSFD KSAMTEEERR HIKKEIRKQI VVFALMIFLT LMSFMAVATD VIPRSFAIPF 70 80 90 100 110 IFILAVIQFA LQLFFFMHMK DKDHGWANAF MISGIFITVP TIAALMLLLG VNKI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of the cta operon from alkaliphilic Bacillus firmus OF4 and characterization of the pH-regulated cytochrome caa3 oxidase it encodes." Quirk P.G., Hicks D.B., Krulwich T.A. J. Biol. Chem. 268:678-685(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Genome of alkaliphilic Bacillus pseudofirmus OF4 reveals adaptations that support the ability to grow in an external pH range from 7.5 to 11.4." Janto B., Ahmed A., Ito M., Liu J., Hicks D.B., Pagni S., Fackelmayer O.J., Smith T.A., Earl J., Elbourne L.D., Hassan K., Paulsen I.T., Kolsto A.B., Tourasse N.J., Ehrlich G.D., Boissy R., Ivey D.M., Li G. , Xue Y., Ma Y., Hu F.Z., Krulwich T.A. Environ. Microbiol. 13:3289-3309(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: OF4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M94110 Genomic DNA. Translation: AAA22367.1. CP001878 Genomic DNA. Translation: ADC48249.1.
RefSeq	YP_003425141.1. NC_013791.2.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADC48249; ADC48249; BpOF4_00900.
GeneID	8765152.
KEGG	bpf:BpOF4_00900.
PATRIC	31942826. VBIBacPse80461_0175.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000261855.
KO	K02277.
ProtClustDB	CLSK2459926.
Enzyme and pathway databases
BioCyc	BPSE398511:GJI9-2591-MONOMER.
Family and domain databases
InterPro	IPR005171. Cyt_c_oxidase_suIV_prok. [Graphical view]
Pfam	PF03626. COX4_pro. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX4_BACPE

Accession

Primary (citable) accession number: Q04452
Secondary accession number(s): D3FU47

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	June 15, 2010
Last modified:	May 1, 2013
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program