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Q04441 (COX2_BACPE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Oxidase aa(3) subunit 2
Gene names
Name:ctaC
Ordered Locus Names:BpOF4_00915
OrganismBacillus pseudofirmus (strain OF4) [Complete proteome] [HAMAP]
Taxonomic identifier398511 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Heme group.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Contains 1 cytochrome c domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Ref.1
Chain23 – 342320Cytochrome c oxidase subunit 2
PRO_0000006049

Regions

Topological domain23 – 5028Extracellular Potential
Transmembrane51 – 6919Helical; Potential
Topological domain70 – 8920Cytoplasmic Potential
Transmembrane90 – 10819Helical; Potential
Topological domain109 – 342234Extracellular Potential
Domain250 – 34293Cytochrome c
Region23 – 249227Cytochrome c oxidase subunit II

Sites

Metal binding1751Copper A Probable
Metal binding2101Copper A Probable
Metal binding2141Copper A Probable
Metal binding2181Copper A Probable
Metal binding2681Iron (heme axial ligand) Probable
Metal binding3171Iron (heme axial ligand) Probable
Binding site2641Heme (covalent) Probable
Binding site2671Heme (covalent) Probable

Amino acid modifications

Lipidation231N-palmitoyl cysteine Potential
Lipidation231S-diacylglycerol cysteine Potential

Sequences

Sequence LengthMass (Da)Tools
Q04441 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: F777C7D1FE44A429

FASTA34238,142
        10         20         30         40         50         60 
MKLWKTASRF LPLSFLTLFL TGCLGEENLT ALDPKGPQAQ WIYDNMILSI IVMALVSIVV 

        70         80         90        100        110        120 
FAIFFIILAK YRRKPGDDEI PKQVHGNTAL EITWTVIPII LLVILAVPTI TGTFMFADKD 

       130        140        150        160        170        180 
PDPEVGDNTV YIKVTGHQFW WQFDYENEGF TAGQDVYIPV GEKVIFELHA QDVLHSFWVP 

       190        200        210        220        230        240 
ALGGKIDTVP GITNHMWLEA DEPGVFKGKC AELCGPSHAL MDFKLIALER DEYDAWVEGM 

       250        260        270        280        290        300 
SAEVEEPTET LANQGRQVFE ENSCIGCHAV GGTGTAAGPA FTNFGEREVI AGYLENNDEN 

       310        320        330        340 
LEAWIRDPQS LKQGNVMPAY PDMSEEDMEA LIAYLRSLKV ME 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of the cta operon from alkaliphilic Bacillus firmus OF4 and characterization of the pH-regulated cytochrome caa3 oxidase it encodes."
Quirk P.G., Hicks D.B., Krulwich T.A.
J. Biol. Chem. 268:678-685(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 23-48.
[2]"Genome of alkaliphilic Bacillus pseudofirmus OF4 reveals adaptations that support the ability to grow in an external pH range from 7.5 to 11.4."
Janto B., Ahmed A., Ito M., Liu J., Hicks D.B., Pagni S., Fackelmayer O.J., Smith T.A., Earl J., Elbourne L.D., Hassan K., Paulsen I.T., Kolsto A.B., Tourasse N.J., Ehrlich G.D., Boissy R., Ivey D.M., Li G. expand/collapse author list , Xue Y., Ma Y., Hu F.Z., Krulwich T.A.
Environ. Microbiol. 13:3289-3309(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: OF4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M94110 Genomic DNA. Translation: AAA22364.1.
CP001878 Genomic DNA. Translation: ADC48252.1.
RefSeqYP_003425144.1. NC_013791.2.

3D structure databases

ProteinModelPortalQ04441.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADC48252; ADC48252; BpOF4_00915.
GeneID8765155.
KEGGbpf:BpOF4_00915.
PATRIC31942832. VBIBacPse80461_0178.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000268576.
KOK02275.

Enzyme and pathway databases

BioCycBPSE398511:GJI9-2594-MONOMER.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
1.10.760.10. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR009056. Cyt_c-like_dom.
IPR003088. Cyt_c_dom.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
PF00034. Cytochrom_C. 1 hit.
[Graphical view]
SUPFAMSSF46626. SSF46626. 1 hit.
SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
PS51007. CYTC. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_BACPE
AccessionPrimary (citable) accession number: Q04441
Secondary accession number(s): D3FU50
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 14, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families