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Protein

Cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Bacillus pseudofirmus (strain OF4)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi175Copper ACurated1
Metal bindingi210Copper ACurated1
Metal bindingi214Copper ACurated1
Metal bindingi218Copper ACurated1
Binding sitei264Heme (covalent)Curated1
Binding sitei267Heme (covalent)Curated1
Metal bindingi268Iron (heme axial ligand)Curated1
Metal bindingi317Iron (heme axial ligand)Curated1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Oxidase aa(3) subunit 2
Gene namesi
Name:ctaC
Ordered Locus Names:BpOF4_00915
OrganismiBacillus pseudofirmus (strain OF4)
Taxonomic identifieri398511 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001544 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 50ExtracellularSequence analysisAdd BLAST28
Transmembranei51 – 69HelicalSequence analysisAdd BLAST19
Topological domaini70 – 89CytoplasmicSequence analysisAdd BLAST20
Transmembranei90 – 108HelicalSequence analysisAdd BLAST19
Topological domaini109 – 342ExtracellularSequence analysisAdd BLAST234

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22PROSITE-ProRule annotation1 PublicationAdd BLAST22
ChainiPRO_000000604923 – 342Cytochrome c oxidase subunit 2Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi23N-palmitoyl cysteinePROSITE-ProRule annotation1
Lipidationi23S-diacylglycerol cysteinePROSITE-ProRule annotation1

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

STRINGi398511.BpOF4_00915

Structurei

3D structure databases

ProteinModelPortaliQ04441
SMRiQ04441
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini250 – 342Cytochrome cPROSITE-ProRule annotationAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni23 – 249Cytochrome c oxidase subunit IIAdd BLAST227

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CV4 Bacteria
COG1622 LUCA
COG2857 LUCA
HOGENOMiHOG000268576
KOiK02275
OMAiKMTGTYP
OrthoDBiPOG091H05L4

Family and domain databases

CDDicd04213 CuRO_CcO_Caa3_II, 1 hit
Gene3Di1.10.287.90, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR034236 CuRO_CcO_Caa3_II
IPR009056 Cyt_c-like_dom
IPR036909 Cyt_c-like_dom_sf
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
PF00034 Cytochrom_C, 1 hit
SUPFAMiSSF46626 SSF46626, 1 hit
SSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit
PS51007 CYTC, 1 hit
PS51257 PROKAR_LIPOPROTEIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04441-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLWKTASRF LPLSFLTLFL TGCLGEENLT ALDPKGPQAQ WIYDNMILSI
60 70 80 90 100
IVMALVSIVV FAIFFIILAK YRRKPGDDEI PKQVHGNTAL EITWTVIPII
110 120 130 140 150
LLVILAVPTI TGTFMFADKD PDPEVGDNTV YIKVTGHQFW WQFDYENEGF
160 170 180 190 200
TAGQDVYIPV GEKVIFELHA QDVLHSFWVP ALGGKIDTVP GITNHMWLEA
210 220 230 240 250
DEPGVFKGKC AELCGPSHAL MDFKLIALER DEYDAWVEGM SAEVEEPTET
260 270 280 290 300
LANQGRQVFE ENSCIGCHAV GGTGTAAGPA FTNFGEREVI AGYLENNDEN
310 320 330 340
LEAWIRDPQS LKQGNVMPAY PDMSEEDMEA LIAYLRSLKV ME
Length:342
Mass (Da):38,142
Last modified:February 1, 1994 - v1
Checksum:iF777C7D1FE44A429
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94110 Genomic DNA Translation: AAA22364.1
CP001878 Genomic DNA Translation: ADC48252.1
RefSeqiWP_012959534.1, NC_013791.2

Genome annotation databases

EnsemblBacteriaiADC48252; ADC48252; BpOF4_00915
KEGGibpf:BpOF4_00915

Similar proteinsi

Entry informationi

Entry nameiCOX2_BACPE
AccessioniPrimary (citable) accession number: Q04441
Secondary accession number(s): D3FU50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: March 28, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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