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Protein

Cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Bacillus pseudofirmus (strain OF4)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi175Copper ACurated1
Metal bindingi210Copper ACurated1
Metal bindingi214Copper ACurated1
Metal bindingi218Copper ACurated1
Binding sitei264Heme (covalent)Curated1
Binding sitei267Heme (covalent)Curated1
Metal bindingi268Iron (heme axial ligand)Curated1
Metal bindingi317Iron (heme axial ligand)Curated1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Oxidase aa(3) subunit 2
Gene namesi
Name:ctaC
Ordered Locus Names:BpOF4_00915
OrganismiBacillus pseudofirmus (strain OF4)
Taxonomic identifieri398511 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001544 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 50ExtracellularSequence analysisAdd BLAST28
Transmembranei51 – 69HelicalSequence analysisAdd BLAST19
Topological domaini70 – 89CytoplasmicSequence analysisAdd BLAST20
Transmembranei90 – 108HelicalSequence analysisAdd BLAST19
Topological domaini109 – 342ExtracellularSequence analysisAdd BLAST234

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22PROSITE-ProRule annotation1 PublicationAdd BLAST22
ChainiPRO_000000604923 – 342Cytochrome c oxidase subunit 2Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi23N-palmitoyl cysteinePROSITE-ProRule annotation1
Lipidationi23S-diacylglycerol cysteinePROSITE-ProRule annotation1

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

STRINGi398511.BpOF4_00915.

Structurei

3D structure databases

ProteinModelPortaliQ04441.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini250 – 342Cytochrome cPROSITE-ProRule annotationAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni23 – 249Cytochrome c oxidase subunit IIAdd BLAST227

Sequence similaritiesi

Contains 1 cytochrome c domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CV4. Bacteria.
COG1622. LUCA.
COG2857. LUCA.
HOGENOMiHOG000268576.
KOiK02275.
OMAiKMTGTYP.
OrthoDBiPOG091H05L4.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
1.10.760.10. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR009056. Cyt_c-like_dom.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
PF00034. Cytochrom_C. 1 hit.
[Graphical view]
SUPFAMiSSF46626. SSF46626. 1 hit.
SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
PS51007. CYTC. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04441-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLWKTASRF LPLSFLTLFL TGCLGEENLT ALDPKGPQAQ WIYDNMILSI
60 70 80 90 100
IVMALVSIVV FAIFFIILAK YRRKPGDDEI PKQVHGNTAL EITWTVIPII
110 120 130 140 150
LLVILAVPTI TGTFMFADKD PDPEVGDNTV YIKVTGHQFW WQFDYENEGF
160 170 180 190 200
TAGQDVYIPV GEKVIFELHA QDVLHSFWVP ALGGKIDTVP GITNHMWLEA
210 220 230 240 250
DEPGVFKGKC AELCGPSHAL MDFKLIALER DEYDAWVEGM SAEVEEPTET
260 270 280 290 300
LANQGRQVFE ENSCIGCHAV GGTGTAAGPA FTNFGEREVI AGYLENNDEN
310 320 330 340
LEAWIRDPQS LKQGNVMPAY PDMSEEDMEA LIAYLRSLKV ME
Length:342
Mass (Da):38,142
Last modified:February 1, 1994 - v1
Checksum:iF777C7D1FE44A429
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94110 Genomic DNA. Translation: AAA22364.1.
CP001878 Genomic DNA. Translation: ADC48252.1.
RefSeqiWP_012959534.1. NC_013791.2.

Genome annotation databases

EnsemblBacteriaiADC48252; ADC48252; BpOF4_00915.
KEGGibpf:BpOF4_00915.
PATRICi31942832. VBIBacPse80461_0178.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94110 Genomic DNA. Translation: AAA22364.1.
CP001878 Genomic DNA. Translation: ADC48252.1.
RefSeqiWP_012959534.1. NC_013791.2.

3D structure databases

ProteinModelPortaliQ04441.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi398511.BpOF4_00915.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADC48252; ADC48252; BpOF4_00915.
KEGGibpf:BpOF4_00915.
PATRICi31942832. VBIBacPse80461_0178.

Phylogenomic databases

eggNOGiENOG4105CV4. Bacteria.
COG1622. LUCA.
COG2857. LUCA.
HOGENOMiHOG000268576.
KOiK02275.
OMAiKMTGTYP.
OrthoDBiPOG091H05L4.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
1.10.760.10. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR009056. Cyt_c-like_dom.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
PF00034. Cytochrom_C. 1 hit.
[Graphical view]
SUPFAMiSSF46626. SSF46626. 1 hit.
SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
PS51007. CYTC. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX2_BACPE
AccessioniPrimary (citable) accession number: Q04441
Secondary accession number(s): D3FU50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.