Cytochrome c oxidase subunit 2 precursor - Bacillus pseudofirmus (strain OF4)

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Q04441 (COX2_BACPE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 111. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Oxidase aa(3) subunit 2

Gene names

Name:	ctaC
Ordered Locus Names:	BpOF4_00915

Organism

Bacillus pseudofirmus (strain OF4) [Complete proteome] [HAMAP]

Taxonomic identifier

398511 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus ›

Protein attributes

Sequence length	342 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).
Catalytic activity	4 ferrocytochrome c + O₂ + 4 H⁺ = 4 ferricytochrome c + 2 H₂O.
Cofactor	Copper A. Heme group.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family. Contains 1 cytochrome c domain.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Cell membrane Membrane
Domain	Signal Transmembrane Transmembrane helix
Ligand	Copper Heme Iron Metal-binding
Molecular function	Oxidoreductase
PTM	Lipoprotein Palmitate
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 22

Ref.1

Chain

23 – 342

320

Cytochrome c oxidase subunit 2

PRO_0000006049

Regions

Topological domain

23 – 50

Extracellular Potential

Transmembrane

51 – 69

Helical; Potential

Topological domain

70 – 89

Cytoplasmic Potential

Transmembrane

90 – 108

Helical; Potential

Topological domain

109 – 342

234

Extracellular Potential

Domain

250 – 342

Cytochrome c

Region

23 – 249

227

Cytochrome c oxidase subunit II

Sites

Metal binding

175

Copper A Probable

Metal binding

210

Copper A Probable

Metal binding

214

Copper A Probable

Metal binding

218

Copper A Probable

Metal binding

268

Iron (heme axial ligand) Probable

Metal binding

317

Iron (heme axial ligand) Probable

Binding site

264

Heme (covalent) Probable

Binding site

267

Heme (covalent) Probable

Amino acid modifications

Lipidation

N-palmitoyl cysteine Potential

Lipidation

S-diacylglycerol cysteine Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q04441 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: F777C7D1FE44A429
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FASTA

342

38,142

        10         20         30         40         50         60 
MKLWKTASRF LPLSFLTLFL TGCLGEENLT ALDPKGPQAQ WIYDNMILSI IVMALVSIVV 

        70         80         90        100        110        120 
FAIFFIILAK YRRKPGDDEI PKQVHGNTAL EITWTVIPII LLVILAVPTI TGTFMFADKD 

       130        140        150        160        170        180 
PDPEVGDNTV YIKVTGHQFW WQFDYENEGF TAGQDVYIPV GEKVIFELHA QDVLHSFWVP 

       190        200        210        220        230        240 
ALGGKIDTVP GITNHMWLEA DEPGVFKGKC AELCGPSHAL MDFKLIALER DEYDAWVEGM 

       250        260        270        280        290        300 
SAEVEEPTET LANQGRQVFE ENSCIGCHAV GGTGTAAGPA FTNFGEREVI AGYLENNDEN 

       310        320        330        340 
LEAWIRDPQS LKQGNVMPAY PDMSEEDMEA LIAYLRSLKV ME

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of the cta operon from alkaliphilic Bacillus firmus OF4 and characterization of the pH-regulated cytochrome caa3 oxidase it encodes." Quirk P.G., Hicks D.B., Krulwich T.A. J. Biol. Chem. 268:678-685(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 23-48.
[2]	"Genome of alkaliphilic Bacillus pseudofirmus OF4 reveals adaptations that support the ability to grow in an external pH range from 7.5 to 11.4." Janto B., Ahmed A., Ito M., Liu J., Hicks D.B., Pagni S., Fackelmayer O.J., Smith T.A., Earl J., Elbourne L.D., Hassan K., Paulsen I.T., Kolsto A.B., Tourasse N.J., Ehrlich G.D., Boissy R., Ivey D.M., Li G. , Xue Y., Ma Y., Hu F.Z., Krulwich T.A. Environ. Microbiol. 13:3289-3309(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: OF4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M94110 Genomic DNA. Translation: AAA22364.1. CP001878 Genomic DNA. Translation: ADC48252.1.
RefSeq	YP_003425144.1. NC_013791.2.
3D structure databases
ProteinModelPortal	Q04441.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADC48252; ADC48252; BpOF4_00915.
GeneID	8765155.
KEGG	bpf:BpOF4_00915.
PATRIC	31942832. VBIBacPse80461_0178.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000268576.
KO	K02275.
ProtClustDB	CLSK247864.
Enzyme and pathway databases
BioCyc	BPSE398511:GJI9-2594-MONOMER.
Family and domain databases
Gene3D	1.10.287.90. 1 hit. 2.60.40.420. 1 hit.
InterPro	IPR001505. Copper_CuA. IPR008972. Cupredoxin. IPR009056. Cyt_c_dom. IPR003088. Cyt_c_I. IPR014222. Cyt_c_oxidase_su2. IPR002429. Cyt_c_oxidase_su2_C. IPR011759. Cyt_c_oxidase_su2_TM_dom. [Graphical view]
Pfam	PF00116. COX2. 1 hit. PF02790. COX2_TM. 1 hit. PF00034. Cytochrom_C. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit. SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit. SSF46626. Cytochrome_c. 1 hit.
TIGRFAMs	TIGR02866. CoxB. 1 hit.
PROSITE	PS00078. COX2. 1 hit. PS50857. COX2_CUA. 1 hit. PS50999. COX2_TM. 1 hit. PS51007. CYTC. 1 hit. PS51257. PROKAR_LIPOPROTEIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_BACPE

Accession

Primary (citable) accession number: Q04441
Secondary accession number(s): D3FU50

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	May 1, 2013
This is version 111 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents