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Q04440 (COX1_BACPE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene names
Name:ctaD
Ordered Locus Names:BpOF4_00910
OrganismBacillus pseudofirmus (strain OF4) [Complete proteome] [HAMAP]
Taxonomic identifier398511 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length625 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Induction

Elevated expression at high pH.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1
Chain2 – 625624Cytochrome c oxidase subunit 1
PRO_0000183434

Regions

Transmembrane23 – 4321Helical; Potential
Transmembrane72 – 9221Helical; Potential
Transmembrane99 – 11921Helical; Potential
Transmembrane151 – 17121Helical; Potential
Transmembrane195 – 21521Helical; Potential
Transmembrane240 – 26021Helical; Potential
Transmembrane272 – 29221Helical; Potential
Transmembrane309 – 32921Helical; Potential
Transmembrane343 – 36321Helical; Potential
Transmembrane382 – 40221Helical; Potential
Transmembrane417 – 43721Helical; Potential
Transmembrane460 – 48021Helical; Potential
Transmembrane551 – 57121Helical; Potential
Transmembrane577 – 59721Helical; Potential

Sites

Metal binding691Iron (heme A axial ligand) Probable
Metal binding2461Copper B Probable
Metal binding2501Copper B Probable
Metal binding2951Copper B Probable
Metal binding2961Copper B Probable
Metal binding3811Iron (heme A3 axial ligand) Probable
Metal binding3831Iron (heme A axial ligand) Probable

Amino acid modifications

Cross-link246 ↔ 2501'-histidyl-3'-tyrosine (His-Tyr) By similarity

Experimental info

Sequence conflict5751N → K in AAA22365. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q04440 [UniParc].

Last modified June 15, 2010. Version 3.
Checksum: 6D8058522B7C54A4

FASTA62569,871
        10         20         30         40         50         60 
MATQKQEKSV IWDWLTTVDH KKIAIMYLIA GTLFFVKAGV MALFMRIQLM YPEMNFLSGQ 

        70         80         90        100        110        120 
TFNEFITMHG TIMLFLAATP LLFAFMNYVI PLQIGARDVA FPFVNALGFW IFFFGGLLLS 

       130        140        150        160        170        180 
LSWFFGGGPD AGWTAYVPLS SRDYGGLGID FYVLGLQVSG IGTLISAINF LVTIVNMRAP 

       190        200        210        220        230        240 
GMTMMRLPLF VWTSFISSTL ILFAFTPLAA GLALLMLDRL FEAQYFIPSM GGNVVLWQHI 

       250        260        270        280        290        300 
FWIFGHPEVY ILVLPAFGII SEVIPAFSRK RLFGYTAMVF ATMIIAFLGF MVWAHHMFTV 

       310        320        330        340        350        360 
GMGPVANSIF AVATMTIAVP TGIKIFNWLF TMWGGKITFN TAMLFASSFV PTFVLGGVTG 

       370        380        390        400        410        420 
VMLAMAPVDY LYHDTYFVVA HFHYIIVGGI VLSLFAGLFY WYPKMFGHML NETLGKLFFW 

       430        440        450        460        470        480 
VFYIGFHLTF FVQHLLGLMG MPRRVYTYLG DQGLDAFNFI STIGTFFMSA GVILLVINVI 

       490        500        510        520        530        540 
YSAFKGERVT VADPWDARTL EWATPTPVPE YNFAQTPQVR SLDPLFYEKI HGDGTMKPAE 

       550        560        570        580        590        600 
PVTDIHMPNG SILPFIMSIG LFFAGFGLIM LNMDNPIINP WIVAIGGLAL TFGCMFVRSI 

       610        620 
KEDHGYHIPA EQVKADLAEL KKGGN 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of the cta operon from alkaliphilic Bacillus firmus OF4 and characterization of the pH-regulated cytochrome caa3 oxidase it encodes."
Quirk P.G., Hicks D.B., Krulwich T.A.
J. Biol. Chem. 268:678-685(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-13.
[2]"Genome of alkaliphilic Bacillus pseudofirmus OF4 reveals adaptations that support the ability to grow in an external pH range from 7.5 to 11.4."
Janto B., Ahmed A., Ito M., Liu J., Hicks D.B., Pagni S., Fackelmayer O.J., Smith T.A., Earl J., Elbourne L.D., Hassan K., Paulsen I.T., Kolsto A.B., Tourasse N.J., Ehrlich G.D., Boissy R., Ivey D.M., Li G. expand/collapse author list , Xue Y., Ma Y., Hu F.Z., Krulwich T.A.
Environ. Microbiol. 13:3289-3309(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: OF4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M94110 Genomic DNA. Translation: AAA22365.1.
CP001878 Genomic DNA. Translation: ADC48251.1.
RefSeqYP_003425143.1. NC_013791.2.

3D structure databases

ProteinModelPortalQ04440.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADC48251; ADC48251; BpOF4_00910.
GeneID8765154.
KEGGbpf:BpOF4_00910.
PATRIC31942830. VBIBacPse80461_0177.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000085275.
KOK02274.
ProtClustDBCLSK873366.

Enzyme and pathway databases

BioCycBPSE398511:GJI9-2593-MONOMER.
UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
TIGRFAMsTIGR02891. CtaD_CoxA. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_BACPE
AccessionPrimary (citable) accession number: Q04440
Secondary accession number(s): D3FU49
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 15, 2010
Last modified: April 16, 2014
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways