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Protein

Cytochrome c oxidase subunit 1

Gene

ctaD

Organism
Bacillus pseudofirmus (strain OF4)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi69Iron (heme A axial ligand)Curated1
Metal bindingi246Copper BCurated1
Metal bindingi250Copper BCurated1
Metal bindingi295Copper BCurated1
Metal bindingi296Copper BCurated1
Metal bindingi381Iron (heme A3 axial ligand)Curated1
Metal bindingi383Iron (heme A axial ligand)Curated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene namesi
Name:ctaD
Ordered Locus Names:BpOF4_00910
OrganismiBacillus pseudofirmus (strain OF4)
Taxonomic identifieri398511 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001544 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Transmembranei272 – 292HelicalSequence analysisAdd BLAST21
Transmembranei309 – 329HelicalSequence analysisAdd BLAST21
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Transmembranei382 – 402HelicalSequence analysisAdd BLAST21
Transmembranei417 – 437HelicalSequence analysisAdd BLAST21
Transmembranei460 – 480HelicalSequence analysisAdd BLAST21
Transmembranei551 – 571HelicalSequence analysisAdd BLAST21
Transmembranei577 – 597HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001834342 – 625Cytochrome c oxidase subunit 1Add BLAST624

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki246 ↔ 2501'-histidyl-3'-tyrosine (His-Tyr)By similarity

Expressioni

Inductioni

Elevated expression at high pH.

Interactioni

Protein-protein interaction databases

STRINGi398511.BpOF4_00910

Structurei

3D structure databases

ProteinModelPortaliQ04440
SMRiQ04440
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ9 Bacteria
COG0843 LUCA
HOGENOMiHOG000085275
KOiK02274
OMAiPVDFQYH
OrthoDBiPOG091H042R

Family and domain databases

Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
IPR023615 Cyt_c_Oxase_su1_BS
IPR014241 Cyt_c_oxidase_su1_bac
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
TIGRFAMsiTIGR02891 CtaD_CoxA, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit
PS00077 COX1_CUB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04440-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATQKQEKSV IWDWLTTVDH KKIAIMYLIA GTLFFVKAGV MALFMRIQLM
60 70 80 90 100
YPEMNFLSGQ TFNEFITMHG TIMLFLAATP LLFAFMNYVI PLQIGARDVA
110 120 130 140 150
FPFVNALGFW IFFFGGLLLS LSWFFGGGPD AGWTAYVPLS SRDYGGLGID
160 170 180 190 200
FYVLGLQVSG IGTLISAINF LVTIVNMRAP GMTMMRLPLF VWTSFISSTL
210 220 230 240 250
ILFAFTPLAA GLALLMLDRL FEAQYFIPSM GGNVVLWQHI FWIFGHPEVY
260 270 280 290 300
ILVLPAFGII SEVIPAFSRK RLFGYTAMVF ATMIIAFLGF MVWAHHMFTV
310 320 330 340 350
GMGPVANSIF AVATMTIAVP TGIKIFNWLF TMWGGKITFN TAMLFASSFV
360 370 380 390 400
PTFVLGGVTG VMLAMAPVDY LYHDTYFVVA HFHYIIVGGI VLSLFAGLFY
410 420 430 440 450
WYPKMFGHML NETLGKLFFW VFYIGFHLTF FVQHLLGLMG MPRRVYTYLG
460 470 480 490 500
DQGLDAFNFI STIGTFFMSA GVILLVINVI YSAFKGERVT VADPWDARTL
510 520 530 540 550
EWATPTPVPE YNFAQTPQVR SLDPLFYEKI HGDGTMKPAE PVTDIHMPNG
560 570 580 590 600
SILPFIMSIG LFFAGFGLIM LNMDNPIINP WIVAIGGLAL TFGCMFVRSI
610 620
KEDHGYHIPA EQVKADLAEL KKGGN
Length:625
Mass (Da):69,871
Last modified:June 15, 2010 - v3
Checksum:i6D8058522B7C54A4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti575N → K in AAA22365 (PubMed:7678007).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94110 Genomic DNA Translation: AAA22365.1
CP001878 Genomic DNA Translation: ADC48251.1
RefSeqiWP_012959533.1, NC_013791.2

Genome annotation databases

EnsemblBacteriaiADC48251; ADC48251; BpOF4_00910
KEGGibpf:BpOF4_00910

Similar proteinsi

Entry informationi

Entry nameiCOX1_BACPE
AccessioniPrimary (citable) accession number: Q04440
Secondary accession number(s): D3FU49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 15, 2010
Last modified: May 23, 2018
This is version 123 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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