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Protein

Facilitator of iron transport 1

Gene

FIT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the uptake of non-siderophore sources of iron and the siderophores ferrioxamine B and ferrichrome. Has a role in the retention of iron in the cell wall and periplasmic space.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi488 – 4958ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

  • ion transport Source: UniProtKB-KW
  • iron ion homeostasis Source: UniProtKB-KW
  • siderophore transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

ATP-binding, Iron, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30045-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Facilitator of iron transport 1
Gene namesi
Name:FIT1
Ordered Locus Names:YDR534C
ORF Names:D9719.37
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR534C.
SGDiS000002942. FIT1.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • extracellular region Source: UniProtKB-KW
  • fungal-type cell wall Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 506488Facilitator of iron transport 1PRO_0000021265Add
BLAST
Propeptidei507 – 52822Removed in mature formSequence analysisPRO_0000021266Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi412 – 4121N-linked (GlcNAc...)Sequence analysis
Glycosylationi464 – 4641N-linked (GlcNAc...)Sequence analysis
Glycosylationi503 – 5031N-linked (GlcNAc...)Sequence analysis
Lipidationi506 – 5061GPI-anchor amidated glycineSequence analysis

Post-translational modificationi

The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Expressioni

Inductioni

By iron.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi32583. 12 interactions.
DIPiDIP-5274N.
MINTiMINT-493183.

Structurei

3D structure databases

ProteinModelPortaliQ04433.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati20 – 98791-11 PublicationAdd
BLAST
Repeati99 – 168701-21 PublicationAdd
BLAST
Repeati169 – 233651-31 PublicationAdd
BLAST
Repeati234 – 274411-4; truncated1 PublicationAdd
BLAST
Repeati289 – 29462-11 Publication
Repeati295 – 30062-21 Publication
Repeati301 – 30662-31 Publication
Repeati307 – 31262-41 Publication
Repeati313 – 31862-51 Publication
Repeati319 – 32462-61 Publication
Repeati325 – 33062-71 Publication
Repeati331 – 33662-81 Publication
Repeati337 – 34262-91 Publication
Repeati343 – 34862-101 Publication
Repeati349 – 35352-111 Publication
Repeati354 – 35962-121 Publication

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 2742554 X approximate tandem repeatsAdd
BLAST
Regioni289 – 3597112 X 6 AA approximate tandem repeats, Ser/Thr-richAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi22 – 498477Thr-richAdd
BLAST
Compositional biasi275 – 478204Ser-richAdd
BLAST

Domaini

The number of the intragenic tandem repeats varies between different S.cerevisiae strains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

GeneTreeiENSGT00720000109434.
InParanoidiQ04433.
OMAiTTEYETK.
OrthoDBiEOG092C4YSD.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04433-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLSSAFVLS AITVAALGES ITTTITATKN GHVYTKTVTQ DATFVWAGEG
60 70 80 90 100
AAVTSAVTEA STVAATSAAA ETSVAAETSI VEPSTSAQGT SADEGSGSSI
110 120 130 140 150
TTTITATKNG HVYTKTVTQD ATFVWTGEGE RAPASTVATV ETSVAAETSV
160 170 180 190 200
AEPSTSAQGT SADEGSGSSI TTTITATKNG HVYTKTVTQD ATFVWTGEGE
210 220 230 240 250
RAPVSTVATV ETAASPVTSV AEPSASTDEG SGSSITTTIT ATKNGHVYTK
260 270 280 290 300
TVTQDATFVW TGEGERAPAS TVATSSISAI EIPSTTEASI VEASSAVETS
310 320 330 340 350
SAAETSSAVE TSSAVETSSA VETSSAAETS SAAETSSAVE TSSAVEISSA
360 370 380 390 400
VETSAVETSS SSSTIETTSV KSLSPTQTSL SSSVQASSPI ETSSAAKTSS
410 420 430 440 450
VVPTFSSTTT ENSSNSKSTS AVVASTTTSS ESSATIVTPT RIGQAYTESS
460 470 480 490 500
SRDAQSVRTH ESNNWSSSSS ASTKMVSSIT RVQTTTAGIF TNGKSSTTPQ
510 520
IVNYTGAADS IAAGTGLMGA ALAAVIFL
Length:528
Mass (Da):52,490
Last modified:November 1, 1996 - v1
Checksum:i42A31EF67E416E0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33057 Genomic DNA. Translation: AAB64973.1.
BK006938 Genomic DNA. Translation: DAA12365.1.
PIRiS69589.
RefSeqiNP_010823.1. NM_001180842.1.

Genome annotation databases

EnsemblFungiiYDR534C; YDR534C; YDR534C.
GeneIDi852147.
KEGGisce:YDR534C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33057 Genomic DNA. Translation: AAB64973.1.
BK006938 Genomic DNA. Translation: DAA12365.1.
PIRiS69589.
RefSeqiNP_010823.1. NM_001180842.1.

3D structure databases

ProteinModelPortaliQ04433.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32583. 12 interactions.
DIPiDIP-5274N.
MINTiMINT-493183.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR534C; YDR534C; YDR534C.
GeneIDi852147.
KEGGisce:YDR534C.

Organism-specific databases

EuPathDBiFungiDB:YDR534C.
SGDiS000002942. FIT1.

Phylogenomic databases

GeneTreeiENSGT00720000109434.
InParanoidiQ04433.
OMAiTTEYETK.
OrthoDBiEOG092C4YSD.

Enzyme and pathway databases

BioCyciYEAST:G3O-30045-MONOMER.

Miscellaneous databases

PROiQ04433.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiFIT1_YEAST
AccessioniPrimary (citable) accession number: Q04433
Secondary accession number(s): D6VTF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.