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Q04430

- PANK_YEAST

UniProt

Q04430 - PANK_YEAST

Protein

Pantothenate kinase CAB1

Gene

CAB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Plays a role in the physiological regulation of the intracellular CoA concentration.1 Publication

    Catalytic activityi

    ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.

    Enzyme regulationi

    Regulated by feedback inhibition by malonyl-CoA.By similarity

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. pantothenate kinase activity Source: SGD

    GO - Biological processi

    1. coenzyme A biosynthetic process Source: SGD

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Coenzyme A biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER3O-268.
    YEAST:MONOMER3O-268.
    UniPathwayiUPA00241; UER00352.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantothenate kinase CAB1 (EC:2.7.1.33)
    Alternative name(s):
    Coenzyme A biosynthesis protein 1
    Pantothenic acid kinase CAB1
    Gene namesi
    Name:CAB1
    Ordered Locus Names:YDR531W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IV

    Organism-specific databases

    CYGDiYDR531w.
    SGDiS000002939. CAB1.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi351 – 3511G → S: Leads to thermo-sensitivity. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 367367Pantothenate kinase CAB1PRO_0000253828Add
    BLAST

    Proteomic databases

    MaxQBiQ04430.
    PaxDbiQ04430.

    Expressioni

    Gene expression databases

    GenevestigatoriQ04430.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SSA2P105921EBI-35891,EBI-8603
    YHR080CP388001EBI-35891,EBI-24597

    Protein-protein interaction databases

    BioGridi32580. 74 interactions.
    DIPiDIP-5375N.
    IntActiQ04430. 10 interactions.
    MINTiMINT-567996.
    STRINGi4932.YDR531W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04430.
    SMRiQ04430. Positions 72-354.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the type II pantothenate kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG5146.
    GeneTreeiENSGT00390000020719.
    HOGENOMiHOG000194691.
    KOiK09680.
    OMAiESFTYHH.
    OrthoDBiEOG74N5S8.

    Family and domain databases

    InterProiIPR004567. Type_II_PanK.
    [Graphical view]
    PfamiPF03630. Fumble. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00555. panK_eukar. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q04430-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRITQEISY NCDYGDNTFN LAIDIGGTLA KVVFSPIHSN RLMFYTIETE    50
    KIDKFMELLH SIIKEHNNGC YRMTHIIATG GGAFKFYDLL YENFPQIKGI 100
    SRFEEMEGLI HGLDFFIHEI PDEVFTYNDQ DGERIIPTSS GTMDSKAIYP 150
    YLLVNIGSGV SILKVTEPNN FSRVGGSSLG GGTLWGLLSL ITGAQTYDQM 200
    LDWAQEGDNS SVDMLVGDIY GTDYNKIGLK SSAIASSFGK VFQNRMTSNK 250
    SLENNENKLY SSHESIEKNN GQMFKNPDIC KSLLFAISNN IGQIAYLQAK 300
    INNIQNIYFG GSYTRGHLTT MNTLSYAINF WSQGSKQAFF LKHEGYLGAM 350
    GAFLSASRHS STKKTST 367
    Length:367
    Mass (Da):40,903
    Last modified:November 1, 1996 - v1
    Checksum:iE87F23FFAA08E2AA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U33057 Genomic DNA. Translation: AAB64970.1.
    BK006938 Genomic DNA. Translation: DAA12362.1.
    PIRiS69586.
    RefSeqiNP_010820.3. NM_001180839.3.

    Genome annotation databases

    EnsemblFungiiYDR531W; YDR531W; YDR531W.
    GeneIDi852144.
    KEGGisce:YDR531W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U33057 Genomic DNA. Translation: AAB64970.1 .
    BK006938 Genomic DNA. Translation: DAA12362.1 .
    PIRi S69586.
    RefSeqi NP_010820.3. NM_001180839.3.

    3D structure databases

    ProteinModelPortali Q04430.
    SMRi Q04430. Positions 72-354.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32580. 74 interactions.
    DIPi DIP-5375N.
    IntActi Q04430. 10 interactions.
    MINTi MINT-567996.
    STRINGi 4932.YDR531W.

    Proteomic databases

    MaxQBi Q04430.
    PaxDbi Q04430.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YDR531W ; YDR531W ; YDR531W .
    GeneIDi 852144.
    KEGGi sce:YDR531W.

    Organism-specific databases

    CYGDi YDR531w.
    SGDi S000002939. CAB1.

    Phylogenomic databases

    eggNOGi COG5146.
    GeneTreei ENSGT00390000020719.
    HOGENOMi HOG000194691.
    KOi K09680.
    OMAi ESFTYHH.
    OrthoDBi EOG74N5S8.

    Enzyme and pathway databases

    UniPathwayi UPA00241 ; UER00352 .
    BioCyci MetaCyc:MONOMER3O-268.
    YEAST:MONOMER3O-268.

    Miscellaneous databases

    NextBioi 970561.
    PROi Q04430.

    Gene expression databases

    Genevestigatori Q04430.

    Family and domain databases

    InterProi IPR004567. Type_II_PanK.
    [Graphical view ]
    Pfami PF03630. Fumble. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00555. panK_eukar. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
      Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
      , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
      Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    6. "Genetic analysis of coenzyme A biosynthesis in the yeast Saccharomyces cerevisiae: identification of a conditional mutation in the pantothenate kinase gene CAB1."
      Olzhausen J., Schuebbe S., Schueller H.-J.
      Curr. Genet. 55:163-173(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF GLY-351.

    Entry informationi

    Entry nameiPANK_YEAST
    AccessioniPrimary (citable) accession number: Q04430
    Secondary accession number(s): D6VTF2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 6190 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome IV
      Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

    External Data

    Dasty 3