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Q04430 (PANK_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pantothenate kinase CAB1
EC=2.7.1.33
Alternative name(s):
Coenzyme A biosynthesis protein 1
Pantothenic acid kinase CAB1
Gene names
Name:CAB1
Ordered Locus Names:YDR531W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in the physiological regulation of the intracellular CoA concentration. Ref.5

Catalytic activity

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.

Enzyme regulation

Regulated by feedback inhibition by malonyl-CoA By similarity.

Pathway

Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.

Subcellular location

Cytoplasm. Nucleus Ref.3.

Miscellaneous

Present with 6190 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the type II pantothenate kinase family.

Ontologies

Keywords
   Biological processCoenzyme A biosynthesis
   Cellular componentCytoplasm
Nucleus
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcoenzyme A biosynthetic process

Inferred from genetic interaction Ref.5. Source: SGD

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 14690591. Source: SGD

nucleus

Inferred from direct assay PubMed 14690591. Source: SGD

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

pantothenate kinase activity

Inferred from mutant phenotype Ref.5. Source: SGD

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SSA2P105921EBI-35891,EBI-8603
YHR080CP388001EBI-35891,EBI-24597

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367Pantothenate kinase CAB1
PRO_0000253828

Experimental info

Mutagenesis3511G → S: Leads to thermo-sensitivity. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q04430 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: E87F23FFAA08E2AA

FASTA36740,903
        10         20         30         40         50         60 
MPRITQEISY NCDYGDNTFN LAIDIGGTLA KVVFSPIHSN RLMFYTIETE KIDKFMELLH 

        70         80         90        100        110        120 
SIIKEHNNGC YRMTHIIATG GGAFKFYDLL YENFPQIKGI SRFEEMEGLI HGLDFFIHEI 

       130        140        150        160        170        180 
PDEVFTYNDQ DGERIIPTSS GTMDSKAIYP YLLVNIGSGV SILKVTEPNN FSRVGGSSLG 

       190        200        210        220        230        240 
GGTLWGLLSL ITGAQTYDQM LDWAQEGDNS SVDMLVGDIY GTDYNKIGLK SSAIASSFGK 

       250        260        270        280        290        300 
VFQNRMTSNK SLENNENKLY SSHESIEKNN GQMFKNPDIC KSLLFAISNN IGQIAYLQAK 

       310        320        330        340        350        360 
INNIQNIYFG GSYTRGHLTT MNTLSYAINF WSQGSKQAFF LKHEGYLGAM GAFLSASRHS 


STKKTST

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. expand/collapse author list , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"Genetic analysis of coenzyme A biosynthesis in the yeast Saccharomyces cerevisiae: identification of a conditional mutation in the pantothenate kinase gene CAB1."
Olzhausen J., Schuebbe S., Schueller H.-J.
Curr. Genet. 55:163-173(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, MUTAGENESIS OF GLY-351.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U33057 Genomic DNA. Translation: AAB64970.1.
BK006938 Genomic DNA. Translation: DAA12362.1.
PIRS69586.
RefSeqNP_010820.3. NM_001180839.3.

3D structure databases

ProteinModelPortalQ04430.
SMRQ04430. Positions 72-354.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-5375N.
IntActQ04430. 10 interactions.
MINTMINT-567996.
STRING4932.YDR531W.

Proteomic databases

PaxDbQ04430.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYDR531W; YDR531W; YDR531W.
GeneID852144.
KEGGsce:YDR531W.
sce:YDR536W.

Organism-specific databases

CYGDYDR531w.
SGDS000002939. CAB1.

Phylogenomic databases

eggNOGCOG5146.
GeneTreeENSGT00390000020719.
HOGENOMHOG000194691.
KOK09680.
OMAESFTYHH.
OrthoDBEOG47M56V.

Enzyme and pathway databases

UniPathwayUPA00241; UER00352.

Gene expression databases

GenevestigatorQ04430.
GermOnlineYDR531W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR004567. Type_II_PanK.
[Graphical view]
PfamPF03630. Fumble. 1 hit.
[Graphical view]
TIGRFAMsTIGR00555. panK_eukar. 1 hit.
ProtoNetSearch...

Other

NextBio970561.

Entry information

Entry namePANK_YEAST
AccessionPrimary (citable) accession number: Q04430
Secondary accession number(s): D6VTF2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: November 1, 1996
Last modified: May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome IV

Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents