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Q04430

- PANK_YEAST

UniProt

Q04430 - PANK_YEAST

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Protein

Pantothenate kinase CAB1

Gene

CAB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in the physiological regulation of the intracellular CoA concentration.1 Publication

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.

Enzyme regulationi

Regulated by feedback inhibition by malonyl-CoA.By similarity

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantothenate kinase activity Source: SGD

GO - Biological processi

  1. coenzyme A biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER3O-268.
YEAST:MONOMER3O-268.
UniPathwayiUPA00241; UER00352.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate kinase CAB1 (EC:2.7.1.33)
Alternative name(s):
Coenzyme A biosynthesis protein 1
Pantothenic acid kinase CAB1
Gene namesi
Name:CAB1
Ordered Locus Names:YDR531W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

CYGDiYDR531w.
SGDiS000002939. CAB1.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi351 – 3511G → S: Leads to thermo-sensitivity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367Pantothenate kinase CAB1PRO_0000253828Add
BLAST

Proteomic databases

MaxQBiQ04430.
PaxDbiQ04430.

Expressioni

Gene expression databases

GenevestigatoriQ04430.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SSA2P105921EBI-35891,EBI-8603
YHR080CP388001EBI-35891,EBI-24597

Protein-protein interaction databases

BioGridi32580. 75 interactions.
DIPiDIP-5375N.
IntActiQ04430. 10 interactions.
MINTiMINT-567996.
STRINGi4932.YDR531W.

Structurei

3D structure databases

ProteinModelPortaliQ04430.
SMRiQ04430. Positions 72-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type II pantothenate kinase family.Curated

Phylogenomic databases

eggNOGiCOG5146.
GeneTreeiENSGT00390000020719.
HOGENOMiHOG000194691.
InParanoidiQ04430.
KOiK09680.
OMAiESFTYHH.
OrthoDBiEOG74N5S8.

Family and domain databases

InterProiIPR004567. Type_II_PanK.
[Graphical view]
PfamiPF03630. Fumble. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00555. panK_eukar. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04430-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRITQEISY NCDYGDNTFN LAIDIGGTLA KVVFSPIHSN RLMFYTIETE
60 70 80 90 100
KIDKFMELLH SIIKEHNNGC YRMTHIIATG GGAFKFYDLL YENFPQIKGI
110 120 130 140 150
SRFEEMEGLI HGLDFFIHEI PDEVFTYNDQ DGERIIPTSS GTMDSKAIYP
160 170 180 190 200
YLLVNIGSGV SILKVTEPNN FSRVGGSSLG GGTLWGLLSL ITGAQTYDQM
210 220 230 240 250
LDWAQEGDNS SVDMLVGDIY GTDYNKIGLK SSAIASSFGK VFQNRMTSNK
260 270 280 290 300
SLENNENKLY SSHESIEKNN GQMFKNPDIC KSLLFAISNN IGQIAYLQAK
310 320 330 340 350
INNIQNIYFG GSYTRGHLTT MNTLSYAINF WSQGSKQAFF LKHEGYLGAM
360
GAFLSASRHS STKKTST
Length:367
Mass (Da):40,903
Last modified:November 1, 1996 - v1
Checksum:iE87F23FFAA08E2AA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U33057 Genomic DNA. Translation: AAB64970.1.
BK006938 Genomic DNA. Translation: DAA12362.1.
PIRiS69586.
RefSeqiNP_010820.3. NM_001180839.3.

Genome annotation databases

EnsemblFungiiYDR531W; YDR531W; YDR531W.
GeneIDi852144.
KEGGisce:YDR531W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U33057 Genomic DNA. Translation: AAB64970.1 .
BK006938 Genomic DNA. Translation: DAA12362.1 .
PIRi S69586.
RefSeqi NP_010820.3. NM_001180839.3.

3D structure databases

ProteinModelPortali Q04430.
SMRi Q04430. Positions 72-354.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32580. 75 interactions.
DIPi DIP-5375N.
IntActi Q04430. 10 interactions.
MINTi MINT-567996.
STRINGi 4932.YDR531W.

Proteomic databases

MaxQBi Q04430.
PaxDbi Q04430.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YDR531W ; YDR531W ; YDR531W .
GeneIDi 852144.
KEGGi sce:YDR531W.

Organism-specific databases

CYGDi YDR531w.
SGDi S000002939. CAB1.

Phylogenomic databases

eggNOGi COG5146.
GeneTreei ENSGT00390000020719.
HOGENOMi HOG000194691.
InParanoidi Q04430.
KOi K09680.
OMAi ESFTYHH.
OrthoDBi EOG74N5S8.

Enzyme and pathway databases

UniPathwayi UPA00241 ; UER00352 .
BioCyci MetaCyc:MONOMER3O-268.
YEAST:MONOMER3O-268.

Miscellaneous databases

NextBioi 970561.
PROi Q04430.

Gene expression databases

Genevestigatori Q04430.

Family and domain databases

InterProi IPR004567. Type_II_PanK.
[Graphical view ]
Pfami PF03630. Fumble. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00555. panK_eukar. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  6. "Genetic analysis of coenzyme A biosynthesis in the yeast Saccharomyces cerevisiae: identification of a conditional mutation in the pantothenate kinase gene CAB1."
    Olzhausen J., Schuebbe S., Schueller H.-J.
    Curr. Genet. 55:163-173(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF GLY-351.

Entry informationi

Entry nameiPANK_YEAST
AccessioniPrimary (citable) accession number: Q04430
Secondary accession number(s): D6VTF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6190 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3