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Protein

Uracil catabolism protein 2

Gene

URC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable transcriptional activator involved in uracil catabolism.By similarity1 Publication

Miscellaneous

Present with 937 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi72 – 101Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processCytosine metabolism, Nucleotide metabolism, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-30037-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil catabolism protein 2
Gene namesi
Name:URC2
Ordered Locus Names:YDR520C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR520C
SGDiS000002928 URC2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002538271 – 772Uracil catabolism protein 2Add BLAST772

Proteomic databases

MaxQBiQ04411
PaxDbiQ04411
PRIDEiQ04411

Interactioni

Protein-protein interaction databases

BioGridi32571, 111 interactors
DIPiDIP-4849N
IntActiQ04411, 10 interactors
MINTiQ04411
STRINGi4932.YDR520C

Structurei

3D structure databases

ProteinModelPortaliQ04411
SMRiQ04411
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the URC2 family.Curated

Phylogenomic databases

HOGENOMiHOG000001072
InParanoidiQ04411
OMAiFWIIPGG
OrthoDBiEOG092C2ADS

Family and domain databases

CDDicd00067 GAL4, 1 hit
Gene3Di4.10.240.10, 1 hit
InterProiView protein in InterPro
IPR001138 Zn2-C6_fun-type_DNA-bd
IPR036864 Zn2-C6_fun-type_DNA-bd_sf
PfamiView protein in Pfam
PF00172 Zn_clus, 1 hit
SMARTiView protein in SMART
SM00066 GAL4, 1 hit
SUPFAMiSSF57701 SSF57701, 1 hit
PROSITEiView protein in PROSITE
PS00463 ZN2_CY6_FUNGAL_1, 1 hit
PS50048 ZN2_CY6_FUNGAL_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q04411-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDINSNASVS PRPDGLPMTA GYNSASGKVR NSIRSIINHP EDSARAKERS
60 70 80 90 100
ETNSPKNNGN KKPRKKRKTF SCDTCRRVKT RCDFEPFIGK CYRCNVLQLD
110 120 130 140 150
CSLARNKDNE ILNTLREDGL LKKINSINHN LGSFSHLNAD SPNESQSSFE
160 170 180 190 200
KNGTVNFDNY MIDKRLSSLE EHIKSLHQKM DLIITTAKMS YNSDIKGPGD
210 220 230 240 250
DIQNVDFSSN KTYDSRLTSG SETIRKTGEY RKENLFLNGF KLKESPLKLL
260 270 280 290 300
HDIDERLFPS KATSKAAKLA GQQRPYAVAR VNFLHFYENN QELCHKLAKE
310 320 330 340 350
FLVRSHFWII PGGRKEIDVE YAHSHLFITS VFTIIAMSFA DNDKYAAEQE
360 370 380 390 400
ILYPLVERLL TNTLTMFEKL TAFDIEAILY CCMFHISRKA KRYRQLKFNS
410 420 430 440 450
LVLSNFALNS LLHVIDFYQI KDRVLVKEVY NPEDLYHLRI LNSLTACYLE
460 470 480 490 500
YSISYGDIRE QDDMLKEFNK LVAKFPQANF GDDIKISEIN LGDIVNGIFI
510 520 530 540 550
NLKNYFAQCL DDFNNDRYGG NADTFIFVFP ELNYWLKNWE ELLAKDGAGV
560 570 580 590 600
LLFTFDFYHI MICRTFITEF SSTLKSNQRF LKLILNTMKE HSFSLLNGFL
610 620 630 640 650
RLPPTLIRGA PIFTCHQLVY ACLTLCDYLY WFDSSERQRV LSLCTKVYWH
660 670 680 690 700
LSTIGEKMNE ATDNVGKIIK SIIDTSKTRI NFGSLSKENS DNDKMSTNAN
710 720 730 740 750
NYTGAGNLHA AKPATSPTNV GTLHENLSSS HFMIPDVDQF NSFEDFFQDF
760 770
FDSLKPNSQK MFTSDKKTEQ TT
Length:772
Mass (Da):88,648
Last modified:November 1, 1996 - v1
Checksum:iA31A93A4B4561DB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33057 Genomic DNA Translation: AAB64961.1
AY692719 Genomic DNA Translation: AAT92738.1
BK006938 Genomic DNA Translation: DAA12351.1
PIRiS69577
RefSeqiNP_010808.3, NM_001180828.3

Genome annotation databases

EnsemblFungiiYDR520C; YDR520C; YDR520C
GeneIDi852133
KEGGisce:YDR520C

Similar proteinsi

Entry informationi

Entry nameiURC2_YEAST
AccessioniPrimary (citable) accession number: Q04411
Secondary accession number(s): D6VTE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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