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Protein

Uracil catabolism protein 2

Gene

URC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable transcriptional activator involved in uracil catabolism.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi72 – 10130Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Cytosine metabolism, Nucleotide metabolism, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-30037-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil catabolism protein 2
Gene namesi
Name:URC2
Ordered Locus Names:YDR520C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR520C.
SGDiS000002928. URC2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 772772Uracil catabolism protein 2PRO_0000253827Add
BLAST

Proteomic databases

MaxQBiQ04411.

Interactioni

Protein-protein interaction databases

BioGridi32571. 36 interactions.
DIPiDIP-4849N.
IntActiQ04411. 10 interactions.
MINTiMINT-502232.

Structurei

3D structure databases

ProteinModelPortaliQ04411.
SMRiQ04411. Positions 70-105.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the URC2 family.Curated
Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000001072.
InParanoidiQ04411.
OMAiTRCDFEP.
OrthoDBiEOG092C2ADS.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04411-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDINSNASVS PRPDGLPMTA GYNSASGKVR NSIRSIINHP EDSARAKERS
60 70 80 90 100
ETNSPKNNGN KKPRKKRKTF SCDTCRRVKT RCDFEPFIGK CYRCNVLQLD
110 120 130 140 150
CSLARNKDNE ILNTLREDGL LKKINSINHN LGSFSHLNAD SPNESQSSFE
160 170 180 190 200
KNGTVNFDNY MIDKRLSSLE EHIKSLHQKM DLIITTAKMS YNSDIKGPGD
210 220 230 240 250
DIQNVDFSSN KTYDSRLTSG SETIRKTGEY RKENLFLNGF KLKESPLKLL
260 270 280 290 300
HDIDERLFPS KATSKAAKLA GQQRPYAVAR VNFLHFYENN QELCHKLAKE
310 320 330 340 350
FLVRSHFWII PGGRKEIDVE YAHSHLFITS VFTIIAMSFA DNDKYAAEQE
360 370 380 390 400
ILYPLVERLL TNTLTMFEKL TAFDIEAILY CCMFHISRKA KRYRQLKFNS
410 420 430 440 450
LVLSNFALNS LLHVIDFYQI KDRVLVKEVY NPEDLYHLRI LNSLTACYLE
460 470 480 490 500
YSISYGDIRE QDDMLKEFNK LVAKFPQANF GDDIKISEIN LGDIVNGIFI
510 520 530 540 550
NLKNYFAQCL DDFNNDRYGG NADTFIFVFP ELNYWLKNWE ELLAKDGAGV
560 570 580 590 600
LLFTFDFYHI MICRTFITEF SSTLKSNQRF LKLILNTMKE HSFSLLNGFL
610 620 630 640 650
RLPPTLIRGA PIFTCHQLVY ACLTLCDYLY WFDSSERQRV LSLCTKVYWH
660 670 680 690 700
LSTIGEKMNE ATDNVGKIIK SIIDTSKTRI NFGSLSKENS DNDKMSTNAN
710 720 730 740 750
NYTGAGNLHA AKPATSPTNV GTLHENLSSS HFMIPDVDQF NSFEDFFQDF
760 770
FDSLKPNSQK MFTSDKKTEQ TT
Length:772
Mass (Da):88,648
Last modified:November 1, 1996 - v1
Checksum:iA31A93A4B4561DB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33057 Genomic DNA. Translation: AAB64961.1.
AY692719 Genomic DNA. Translation: AAT92738.1.
BK006938 Genomic DNA. Translation: DAA12351.1.
PIRiS69577.
RefSeqiNP_010808.3. NM_001180828.3.

Genome annotation databases

EnsemblFungiiYDR520C; YDR520C; YDR520C.
GeneIDi852133.
KEGGisce:YDR520C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33057 Genomic DNA. Translation: AAB64961.1.
AY692719 Genomic DNA. Translation: AAT92738.1.
BK006938 Genomic DNA. Translation: DAA12351.1.
PIRiS69577.
RefSeqiNP_010808.3. NM_001180828.3.

3D structure databases

ProteinModelPortaliQ04411.
SMRiQ04411. Positions 70-105.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32571. 36 interactions.
DIPiDIP-4849N.
IntActiQ04411. 10 interactions.
MINTiMINT-502232.

Proteomic databases

MaxQBiQ04411.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR520C; YDR520C; YDR520C.
GeneIDi852133.
KEGGisce:YDR520C.

Organism-specific databases

EuPathDBiFungiDB:YDR520C.
SGDiS000002928. URC2.

Phylogenomic databases

HOGENOMiHOG000001072.
InParanoidiQ04411.
OMAiTRCDFEP.
OrthoDBiEOG092C2ADS.

Enzyme and pathway databases

BioCyciYEAST:G3O-30037-MONOMER.

Miscellaneous databases

PROiQ04411.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiURC2_YEAST
AccessioniPrimary (citable) accession number: Q04411
Secondary accession number(s): D6VTE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 937 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.