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Q043I0

- FTHS_LACGA

UniProt

Q043I0 - FTHS_LACGA

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Lactobacillus gasseri (strain ATCC 33323 / DSM 20243)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi68 – 758ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLGAS324831:GHTY-1016-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:LGAS_1016
    OrganismiLactobacillus gasseri (strain ATCC 33323 / DSM 20243)
    Taxonomic identifieri324831 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000000664: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 559559Formate--tetrahydrofolate ligasePRO_0000293041Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi324831.LGAS_1016.

    Structurei

    3D structure databases

    ProteinModelPortaliQ043I0.
    SMRiQ043I0. Positions 6-557.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiGIEHEAS.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q043I0-1 [UniParc]FASTAAdd to Basket

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    MNLKSDIEIA QNTKELPIKE IAQKIDLRPE EIELYGNDKA KISWKGINCI    50
    KKNQKLGKLI LVTSISPTPA GEGKSTITIG LGDAIRNQLH KNTLIALREP 100
    SMGPVFGLKG GATGGGYAQI IPMEDINLHF TGDMHALTSA IDTLAALVDN 150
    YIYQDNSLEL DPNRILLKRG IDVNDRTLRK ITIGQGSRFN GIEHEASFAI 200
    TVANELMAIL CLATDINDLK KRIGNILVGF SVKDEPVYVK DLGFEGAIAA 250
    LLSTALKPNL VQTLEHTPAI VHGGPFANIA HGANSVIATN TALHLSDYVL 300
    TEAGFGADLG GQKFMDFVSN HLDKRPDAVV VVATVRALKY QAEESTDHLD 350
    EENIPALEKG FANLKRHMEN MAHYGVPVIV LINKFASDTD QELNKLKELV 400
    QDDGFECEIV SYHDEGSKGG IQAAEKVVEL TGKASDFKPV YKPEDSVEDK 450
    IAKIAHKIYH AKDIEYSDTA KKQLAEIKKM GKDELPVIIA KTQYSFTDKK 500
    KILGAPEDFI LHVKDLALKN GAGFIVVATG SILDMPGLPK HPAALDIDVD 550
    NNGKISGLF 559
    Length:559
    Mass (Da):60,837
    Last modified:November 14, 2006 - v1
    Checksum:i56620F6B9F29B750
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000413 Genomic DNA. Translation: ABJ60392.1.
    RefSeqiYP_814830.1. NC_008530.1.

    Genome annotation databases

    EnsemblBacteriaiABJ60392; ABJ60392; LGAS_1016.
    GeneIDi4439761.
    KEGGilga:LGAS_1016.
    PATRICi22230196. VBILacGas62225_1005.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000413 Genomic DNA. Translation: ABJ60392.1 .
    RefSeqi YP_814830.1. NC_008530.1.

    3D structure databases

    ProteinModelPortali Q043I0.
    SMRi Q043I0. Positions 6-557.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 324831.LGAS_1016.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ60392 ; ABJ60392 ; LGAS_1016 .
    GeneIDi 4439761.
    KEGGi lga:LGAS_1016.
    PATRICi 22230196. VBILacGas62225_1005.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi GIEHEAS.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci LGAS324831:GHTY-1016-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33323 / DSM 20243.

    Entry informationi

    Entry nameiFTHS_LACGA
    AccessioniPrimary (citable) accession number: Q043I0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3