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Q043I0

- FTHS_LACGA

UniProt

Q043I0 - FTHS_LACGA

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Lactobacillus gasseri (strain ATCC 33323 / DSM 20243)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 758ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLGAS324831:GHTY-1016-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:LGAS_1016
OrganismiLactobacillus gasseri (strain ATCC 33323 / DSM 20243)
Taxonomic identifieri324831 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000664: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Formate--tetrahydrofolate ligasePRO_0000293041Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi324831.LGAS_1016.

Structurei

3D structure databases

ProteinModelPortaliQ043I0.
SMRiQ043I0. Positions 6-557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiGIEHEAS.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q043I0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNLKSDIEIA QNTKELPIKE IAQKIDLRPE EIELYGNDKA KISWKGINCI
60 70 80 90 100
KKNQKLGKLI LVTSISPTPA GEGKSTITIG LGDAIRNQLH KNTLIALREP
110 120 130 140 150
SMGPVFGLKG GATGGGYAQI IPMEDINLHF TGDMHALTSA IDTLAALVDN
160 170 180 190 200
YIYQDNSLEL DPNRILLKRG IDVNDRTLRK ITIGQGSRFN GIEHEASFAI
210 220 230 240 250
TVANELMAIL CLATDINDLK KRIGNILVGF SVKDEPVYVK DLGFEGAIAA
260 270 280 290 300
LLSTALKPNL VQTLEHTPAI VHGGPFANIA HGANSVIATN TALHLSDYVL
310 320 330 340 350
TEAGFGADLG GQKFMDFVSN HLDKRPDAVV VVATVRALKY QAEESTDHLD
360 370 380 390 400
EENIPALEKG FANLKRHMEN MAHYGVPVIV LINKFASDTD QELNKLKELV
410 420 430 440 450
QDDGFECEIV SYHDEGSKGG IQAAEKVVEL TGKASDFKPV YKPEDSVEDK
460 470 480 490 500
IAKIAHKIYH AKDIEYSDTA KKQLAEIKKM GKDELPVIIA KTQYSFTDKK
510 520 530 540 550
KILGAPEDFI LHVKDLALKN GAGFIVVATG SILDMPGLPK HPAALDIDVD

NNGKISGLF
Length:559
Mass (Da):60,837
Last modified:November 14, 2006 - v1
Checksum:i56620F6B9F29B750
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000413 Genomic DNA. Translation: ABJ60392.1.
RefSeqiYP_814830.1. NC_008530.1.

Genome annotation databases

EnsemblBacteriaiABJ60392; ABJ60392; LGAS_1016.
GeneIDi4439761.
KEGGilga:LGAS_1016.
PATRICi22230196. VBILacGas62225_1005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000413 Genomic DNA. Translation: ABJ60392.1 .
RefSeqi YP_814830.1. NC_008530.1.

3D structure databases

ProteinModelPortali Q043I0.
SMRi Q043I0. Positions 6-557.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 324831.LGAS_1016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ60392 ; ABJ60392 ; LGAS_1016 .
GeneIDi 4439761.
KEGGi lga:LGAS_1016.
PATRICi 22230196. VBILacGas62225_1005.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi GIEHEAS.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci LGAS324831:GHTY-1016-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33323 / DSM 20243.

Entry informationi

Entry nameiFTHS_LACGA
AccessioniPrimary (citable) accession number: Q043I0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: November 14, 2006
Last modified: October 1, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3