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Protein

ATP-dependent helicase/deoxyribonuclease subunit B

Gene

rexB

Organism
Lactobacillus gasseri (strain ATCC 33323 / DSM 20243 / JCM 1131 / NCIMB 11718 / AM63)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLGAS324831:GHTY-1032-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent helicase/deoxyribonuclease subunit BUniRule annotation (EC:3.1.-.-UniRule annotation, EC:3.6.4.12UniRule annotation)
Alternative name(s):
ATP-dependent helicase/nuclease RexBUniRule annotation
Gene namesi
Name:rexBUniRule annotation
Ordered Locus Names:LGAS_1032
OrganismiLactobacillus gasseri (strain ATCC 33323 / DSM 20243 / JCM 1131 / NCIMB 11718 / AM63)
Taxonomic identifieri324831 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11581158ATP-dependent helicase/deoxyribonuclease subunit BPRO_0000379372Add
BLAST

Interactioni

Subunit structurei

Heterodimer of AddA and RexB.UniRule annotation

Protein-protein interaction databases

STRINGi324831.LGAS_1032.

Structurei

3D structure databases

ProteinModelPortaliQ043G5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the helicase family. AddB/RexB type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C5N. Bacteria.
COG3857. LUCA.
HOGENOMiHOG000033807.
KOiK16899.
OMAiDYKSSAK.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01453. AddB_type2. 1 hit.
InterProiIPR014141. DNA_helicase_suRexB.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q043G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINVITGRQV DNLQNEIIDQ AVKSYYQDKT HDVFIIVPNH IKFTTEVRAL
60 70 80 90 100
SKLSVLTNKK QVAVNKLHIL SFSRLAWYFL KDEAIKLPQI LDDAASVMLL
110 120 130 140 150
EQIVKDHQDE LKLFQNKNQI TSGALRQMYE AILSVRAGNI DLENIDNEKL
160 170 180 190 200
NEETSYKVHD LQIIYDDFID RLSEKFATKD EMQLLLNEFL AKSDSLSTMV
210 220 230 240 250
FYFSDFSHFS LQELTSVRLI SKKAKNTTLA FKTKIGKIDS KAEQGDYDYV
260 270 280 290 300
VQRTIRQLEH FWQNQQLNYQ TTEFPLTKTN PSSLLNGVWT KTNGFDESLS
310 320 330 340 350
KFLQPVKADS RYAEAYFVAR TIYQQVALNN YRYQDFLVLA PNLNEYETYL
360 370 380 390 400
TPILRQNNIP FFNDLQKEMK YHPLVVAVEN LQQIFKRGFQ TDNVIALMKT
410 420 430 440 450
QLFIPEWYKS VARYQNDVDL LENFVLAHGI KGELWKKPLK SFVDAEVIAL
460 470 480 490 500
DKSEQEVEEL DRLRKYFISI LSEFFEDIET EKDPQAGVTI FWNFLIKNRV
510 520 530 540 550
AKRLEAWRKE ANDAGDLQLA QQPEQVWSTL NDLLKDYLLV AKEFSLEQFF
560 570 580 590 600
DLLISGFSEA NFSQIPSTLD AVNISEMGMV QGQGYKQVFI IGATSSNLPQ
610 620 630 640 650
IEKIPGFFSS ENLEQLNDGN NASGYLEDQQ KINNLDQNYQ FGNALSLASD
660 670 680 690 700
KIYISYPVIN TANEQLEPSI FYKQLLRLTQ ANEFSQHDLP SSAGDLLTFM
710 720 730 740 750
TNPEASLGYL TYLKGKQEVN VDSILELTEQ EIGEVAQNVL EGSNFKNVPE
760 770 780 790 800
NLPPKLAQEL YGDRIETSVS QLETYYQNSF EYFLNYGLHL KKRFENELDV
810 820 830 840 850
IQAGNYYHET FDYLVKKIKE KNLDFADLTD SKLNQLLIEV REELKEKGRY
860 870 880 890 900
RQLLNDPFNK YLFHKLDQTT SNVAHYWHSN VNKTTFRPQY SELSFGKNQK
910 920 930 940 950
VTGLSYSWKD ENNQKKIVDL RGKMDRVDLA KVNDRVLGEV IDYKSSAKKF
960 970 980 990 1000
DLGLFANGIS MQMISYLEVL KKNNKFFAQG KNLDVLGAFY QNITSSLERL
1010 1020 1030 1040 1050
SSDKMILSNY QIKDLLKEST KKLMYNGILV ADEEILDLIE PGMEKDRATS
1060 1070 1080 1090 1100
EIYSSIKRKV NGDISWPRNQ SFTPDQLELL LAYNSYLIKN AGSEILSGKI
1110 1120 1130 1140 1150
KLDPYTYGQQ SSLTYSDFKD IFFFDAMLKE NNYHKIKAID KKTLLNLIKE

KLDLDGDE
Length:1,158
Mass (Da):133,949
Last modified:November 14, 2006 - v1
Checksum:iA9C26B4CE688B3FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000413 Genomic DNA. Translation: ABJ60407.1.
RefSeqiWP_003647272.1. NZ_BALQ01000002.1.

Genome annotation databases

EnsemblBacteriaiABJ60407; ABJ60407; LGAS_1032.
KEGGilga:LGAS_1032.
PATRICi22230226. VBILacGas62225_1020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000413 Genomic DNA. Translation: ABJ60407.1.
RefSeqiWP_003647272.1. NZ_BALQ01000002.1.

3D structure databases

ProteinModelPortaliQ043G5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi324831.LGAS_1032.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ60407; ABJ60407; LGAS_1032.
KEGGilga:LGAS_1032.
PATRICi22230226. VBILacGas62225_1020.

Phylogenomic databases

eggNOGiENOG4105C5N. Bacteria.
COG3857. LUCA.
HOGENOMiHOG000033807.
KOiK16899.
OMAiDYKSSAK.

Enzyme and pathway databases

BioCyciLGAS324831:GHTY-1032-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01453. AddB_type2. 1 hit.
InterProiIPR014141. DNA_helicase_suRexB.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADDB_LACGA
AccessioniPrimary (citable) accession number: Q043G5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: November 14, 2006
Last modified: September 7, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.