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Q043A6

- PYRF_LACGA

UniProt

Q043A6 - PYRF_LACGA

Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Lactobacillus gasseri (strain ATCC 33323 / DSM 20243)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei10 – 101SubstrateUniRule annotation
    Binding sitei33 – 331SubstrateUniRule annotation
    Active sitei62 – 621Proton donorUniRule annotation
    Binding sitei123 – 1231SubstrateUniRule annotation
    Binding sitei185 – 1851SubstrateUniRule annotation
    Binding sitei194 – 1941SubstrateUniRule annotation
    Binding sitei214 – 2141Substrate; via amide nitrogenUniRule annotation
    Binding sitei215 – 2151SubstrateUniRule annotation

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    BioCyciLGAS324831:GHTY-1093-MONOMER.
    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
    Alternative name(s):
    OMP decarboxylaseUniRule annotation
    Short name:
    OMPDCaseUniRule annotation
    Short name:
    OMPdecaseUniRule annotation
    Gene namesi
    Name:pyrFUniRule annotation
    Ordered Locus Names:LGAS_1093
    OrganismiLactobacillus gasseri (strain ATCC 33323 / DSM 20243)
    Taxonomic identifieri324831 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000000664: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 235235Orotidine 5'-phosphate decarboxylasePRO_1000065914Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi324831.LGAS_1093.

    Structurei

    3D structure databases

    ProteinModelPortaliQ043A6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni60 – 6910Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0284.
    HOGENOMiHOG000226071.
    KOiK01591.
    OMAiRPITQSA.
    OrthoDBiEOG6N6815.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01200_B. OMPdecase_type1_B.
    InterProiIPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR01740. pyrF. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q043A6-1 [UniParc]FASTAAdd to Basket

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    MTRPVIVALD LDNEKKLNEL LPKLGKPENV FIKIGMELFF NEGPAIVRNL    50
    SRQGYQIFLD LKMSDIPNTV YNGAKALAQL GITYTTVHAL GGSQMIKAAK 100
    EGLIAGTPVG KNIPKLLAVT ELTSISDDIL HEEQNCNLSM NQQVLSLAET 150
    AKKAGADGVI CSPLEVKNLR QNVGDDFLYV TPGIRPAGNA KDDQSRVATP 200
    AQAKEWGSTA IVVGRPITLA TNPEAAYEAI KKEFN 235
    Length:235
    Mass (Da):25,370
    Last modified:November 14, 2006 - v1
    Checksum:i9628A8427BBFF626
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000413 Genomic DNA. Translation: ABJ60466.1.
    RefSeqiYP_814904.1. NC_008530.1.

    Genome annotation databases

    EnsemblBacteriaiABJ60466; ABJ60466; LGAS_1093.
    GeneIDi4439696.
    KEGGilga:LGAS_1093.
    PATRICi22230350. VBILacGas62225_1082.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000413 Genomic DNA. Translation: ABJ60466.1 .
    RefSeqi YP_814904.1. NC_008530.1.

    3D structure databases

    ProteinModelPortali Q043A6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 324831.LGAS_1093.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ60466 ; ABJ60466 ; LGAS_1093 .
    GeneIDi 4439696.
    KEGGi lga:LGAS_1093.
    PATRICi 22230350. VBILacGas62225_1082.

    Phylogenomic databases

    eggNOGi COG0284.
    HOGENOMi HOG000226071.
    KOi K01591.
    OMAi RPITQSA.
    OrthoDBi EOG6N6815.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .
    BioCyci LGAS324831:GHTY-1093-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01200_B. OMPdecase_type1_B.
    InterProi IPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR01740. pyrF. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33323 / DSM 20243.

    Entry informationi

    Entry nameiPYRF_LACGA
    AccessioniPrimary (citable) accession number: Q043A6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3