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Protein

Putative multicopper oxidase GMC1

Gene

GMC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Could be a iron transport multicopper oxidase, which is required for Fe2+ high affinity uptake. May be required to oxidize Fe2+ and release it from the transporter. Essential component of copper-dependent iron transport (By similarity). Involved in meiotic prophase and synaptonemal complex (SC) assembly.By similarity1 Publication

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi100 – 1001Copper 1; type 2By similarity
Metal bindingi102 – 1021Copper 2; type 3By similarity
Metal bindingi145 – 1451Copper 2; type 3By similarity
Metal bindingi147 – 1471Copper 3; type 3By similarity
Metal bindingi452 – 4521Copper 4; type 1By similarity
Metal bindingi455 – 4551Copper 1; type 2By similarity
Metal bindingi457 – 4571Copper 3; type 3By similarity
Metal bindingi530 – 5301Copper 3; type 3By similarity
Metal bindingi531 – 5311Copper 4; type 1By similarity
Metal bindingi532 – 5321Copper 2; type 3By similarity
Metal bindingi536 – 5361Copper 4; type 1By similarity

GO - Molecular functioni

GO - Biological processi

  • ion transport Source: UniProtKB-KW
  • iron ion homeostasis Source: UniProtKB-KW
  • meiotic nuclear division Source: SGD
  • synaptonemal complex organization Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Ion transport, Iron transport, Meiosis, Transport

Keywords - Ligandi

Copper, Iron, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30027-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative multicopper oxidase GMC1 (EC:1.-.-.-)
Alternative name(s):
Grand meiotic recombination cluster protein 1
Gene namesi
Name:GMC1
Ordered Locus Names:YDR506C
ORF Names:D9719.12
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR506C.
SGDiS000002914. GMC1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 608608Putative multicopper oxidase GMC1PRO_0000085585Add
BLAST

Proteomic databases

MaxQBiQ04399.

Interactioni

Protein-protein interaction databases

BioGridi32557. 20 interactions.
DIPiDIP-5270N.
IntActiQ04399. 2 interactions.
MINTiMINT-544571.

Structurei

3D structure databases

ProteinModelPortaliQ04399.
SMRiQ04399. Positions 43-561.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 163113Plastocyanin-like 1Add
BLAST
Domaini243 – 374132Plastocyanin-like 2Add
BLAST
Domaini421 – 548128Plastocyanin-like 3Add
BLAST

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00530000064508.
HOGENOMiHOG000057101.
InParanoidiQ04399.
OrthoDBiEOG7Q5HQB.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 2 hits.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04399-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVILLKPVQ LPMLLLILLK FIMAAKEGKI HVLEFNASSE YTLDKRRVIS
60 70 80 90 100
INGYSATFGP EIRVKSGDTL NLKLTNWICS EEEASKDSDV WKDYCSTALH
110 120 130 140 150
FHGVVPLANE FDGIPGLTQP TIGYGESYWY NFTIDQSTCG TFWYHSHSSV
160 170 180 190 200
QYGDGMRGVL IVECDDYDNH VANTINSVRD IETLDDGVVT MKKDKHTKEL
210 220 230 240 250
TDYEVQERII TLSDWYTNWN LDILNDKVLS STGGTDPKFD GSLINGKSSD
260 270 280 290 300
GETIKIGFNT EYLLLRIVNS GMSGTQVFHL DGFQLIVLEA DGIMIKPFIV
310 320 330 340 350
QTINLAVGQR YTILVKLKSD TSFIRMINGC NKMMGYITKQ WWFYKEGAHL
360 370 380 390 400
DLPKNPNDVS IEHLPGFTKA ELYRDIEPTQ EENKKLRTKA DPVAVFEFDY
410 420 430 440 450
AYYKDESTKQ KYGTGMYKVN ERTFSEYVKD PVRFGFNETY DIVINSLDHM
460 470 480 490 500
RHPWHMHGHH FQIISLGNKG DGPFHKDVQE GKAWSRYQND LRHLARTGKA
510 520 530 540 550
PMVRDSINIA GNSYAVLRIN TEMPGKWLLH CHVEWHMMKG LGIVFEVPTT
560 570 580 590 600
TEDSTKQATT AVLSYPTKEP DPNTVVHTAA LEQNKSKVIA VYILIMCAVD

AIFYWLLM
Length:608
Mass (Da):69,281
Last modified:November 1, 1996 - v1
Checksum:iD51B830F15E704AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33057 Genomic DNA. Translation: AAB64948.1.
BK006938 Genomic DNA. Translation: DAA12338.1.
PIRiS69564.
RefSeqiNP_010794.3. NM_001180814.3.

Genome annotation databases

EnsemblFungiiYDR506C; YDR506C; YDR506C.
GeneIDi852117.
KEGGisce:YDR506C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33057 Genomic DNA. Translation: AAB64948.1.
BK006938 Genomic DNA. Translation: DAA12338.1.
PIRiS69564.
RefSeqiNP_010794.3. NM_001180814.3.

3D structure databases

ProteinModelPortaliQ04399.
SMRiQ04399. Positions 43-561.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32557. 20 interactions.
DIPiDIP-5270N.
IntActiQ04399. 2 interactions.
MINTiMINT-544571.

Proteomic databases

MaxQBiQ04399.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR506C; YDR506C; YDR506C.
GeneIDi852117.
KEGGisce:YDR506C.

Organism-specific databases

EuPathDBiFungiDB:YDR506C.
SGDiS000002914. GMC1.

Phylogenomic databases

GeneTreeiENSGT00530000064508.
HOGENOMiHOG000057101.
InParanoidiQ04399.
OrthoDBiEOG7Q5HQB.

Enzyme and pathway databases

BioCyciYEAST:G3O-30027-MONOMER.

Miscellaneous databases

PROiQ04399.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 2 hits.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  4. "High-resolution view of the yeast meiotic program revealed by ribosome profiling."
    Brar G.A., Yassour M., Friedman N., Regev A., Ingolia N.T., Weissman J.S.
    Science 335:552-557(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiGMC1_YEAST
AccessioniPrimary (citable) accession number: Q04399
Secondary accession number(s): D6VTC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 589 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.