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Protein

Putative multicopper oxidase GMC1

Gene

GMC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could be a iron transport multicopper oxidase, which is required for Fe2+ high affinity uptake. May be required to oxidize Fe2+ and release it from the transporter. Essential component of copper-dependent iron transport (By similarity). Involved in meiotic prophase and synaptonemal complex (SC) assembly.By similarity1 Publication

Miscellaneous

Present with 589 molecules/cell in log phase SD medium.1 Publication

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi100Copper 1; type 2By similarity1
Metal bindingi102Copper 2; type 3By similarity1
Metal bindingi145Copper 2; type 3By similarity1
Metal bindingi147Copper 3; type 3By similarity1
Metal bindingi452Copper 4; type 1By similarity1
Metal bindingi455Copper 1; type 2By similarity1
Metal bindingi457Copper 3; type 3By similarity1
Metal bindingi530Copper 3; type 3By similarity1
Metal bindingi531Copper 4; type 1By similarity1
Metal bindingi532Copper 2; type 3By similarity1
Metal bindingi536Copper 4; type 1By similarity1

GO - Molecular functioni

GO - Biological processi

  • ion transport Source: UniProtKB-KW
  • iron ion homeostasis Source: UniProtKB-KW
  • meiotic cell cycle Source: SGD
  • synaptonemal complex organization Source: SGD

Keywordsi

Molecular functionOxidoreductase
Biological processIon transport, Iron transport, Meiosis, Transport
LigandCopper, Iron, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30027-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative multicopper oxidase GMC1 (EC:1.-.-.-)
Alternative name(s):
Grand meiotic recombination cluster protein 1
Gene namesi
Name:GMC1
Ordered Locus Names:YDR506C
ORF Names:D9719.12
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR506C
SGDiS000002914 GMC1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000855851 – 608Putative multicopper oxidase GMC1Add BLAST608

Proteomic databases

MaxQBiQ04399
PaxDbiQ04399
PRIDEiQ04399

Interactioni

Protein-protein interaction databases

BioGridi32557, 52 interactors
DIPiDIP-5270N
IntActiQ04399, 3 interactors
MINTiQ04399
STRINGi4932.YDR506C

Structurei

3D structure databases

ProteinModelPortaliQ04399
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 163Plastocyanin-like 1Add BLAST113
Domaini243 – 374Plastocyanin-like 2Add BLAST132
Domaini421 – 548Plastocyanin-like 3Add BLAST128

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00530000064508
HOGENOMiHOG000057101
InParanoidiQ04399
OMAiCHTAWHA
OrthoDBiEOG092C3JWR

Family and domain databases

Gene3Di2.60.40.420, 3 hits
InterProiView protein in InterPro
IPR001117 Cu-oxidase
IPR011706 Cu-oxidase_2
IPR011707 Cu-oxidase_3
IPR033138 Cu_oxidase_CS
IPR002355 Cu_oxidase_Cu_BS
IPR008972 Cupredoxin
PfamiView protein in Pfam
PF00394 Cu-oxidase, 1 hit
PF07731 Cu-oxidase_2, 1 hit
PF07732 Cu-oxidase_3, 1 hit
SUPFAMiSSF49503 SSF49503, 3 hits
PROSITEiView protein in PROSITE
PS00079 MULTICOPPER_OXIDASE1, 2 hits
PS00080 MULTICOPPER_OXIDASE2, 1 hit

Sequencei

Sequence statusi: Complete.

Q04399-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVILLKPVQ LPMLLLILLK FIMAAKEGKI HVLEFNASSE YTLDKRRVIS
60 70 80 90 100
INGYSATFGP EIRVKSGDTL NLKLTNWICS EEEASKDSDV WKDYCSTALH
110 120 130 140 150
FHGVVPLANE FDGIPGLTQP TIGYGESYWY NFTIDQSTCG TFWYHSHSSV
160 170 180 190 200
QYGDGMRGVL IVECDDYDNH VANTINSVRD IETLDDGVVT MKKDKHTKEL
210 220 230 240 250
TDYEVQERII TLSDWYTNWN LDILNDKVLS STGGTDPKFD GSLINGKSSD
260 270 280 290 300
GETIKIGFNT EYLLLRIVNS GMSGTQVFHL DGFQLIVLEA DGIMIKPFIV
310 320 330 340 350
QTINLAVGQR YTILVKLKSD TSFIRMINGC NKMMGYITKQ WWFYKEGAHL
360 370 380 390 400
DLPKNPNDVS IEHLPGFTKA ELYRDIEPTQ EENKKLRTKA DPVAVFEFDY
410 420 430 440 450
AYYKDESTKQ KYGTGMYKVN ERTFSEYVKD PVRFGFNETY DIVINSLDHM
460 470 480 490 500
RHPWHMHGHH FQIISLGNKG DGPFHKDVQE GKAWSRYQND LRHLARTGKA
510 520 530 540 550
PMVRDSINIA GNSYAVLRIN TEMPGKWLLH CHVEWHMMKG LGIVFEVPTT
560 570 580 590 600
TEDSTKQATT AVLSYPTKEP DPNTVVHTAA LEQNKSKVIA VYILIMCAVD

AIFYWLLM
Length:608
Mass (Da):69,281
Last modified:November 1, 1996 - v1
Checksum:iD51B830F15E704AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33057 Genomic DNA Translation: AAB64948.1
BK006938 Genomic DNA Translation: DAA12338.1
PIRiS69564
RefSeqiNP_010794.3, NM_001180814.3

Genome annotation databases

EnsemblFungiiYDR506C; YDR506C; YDR506C
GeneIDi852117
KEGGisce:YDR506C

Similar proteinsi

Entry informationi

Entry nameiGMC1_YEAST
AccessioniPrimary (citable) accession number: Q04399
Secondary accession number(s): D6VTC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health