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Protein

Type 2A phosphatase-associated protein 42

Gene

TAP42

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in negative regulation of the TOR signaling pathway in response to type of available nitrogen source. Inhibitor of PP2A phosphatase SIT4, which results in inhibition of nuclear export of MSN2, due to lack of dephosphorylation by SIT4. Also required for rapamycin induced activation of expression of many nitrogen discrimination pathway (NDP) genes. In complex with PPH21, required for organization of the actin cytoskeletom during the cell cycle via a Rho GTPase-dependent mechanism.4 Publications

GO - Molecular functioni

GO - Biological processi

  • negative regulation of signal transduction Source: UniProtKB-KW
  • positive regulation of transcription by RNA polymerase I Source: SGD
  • regulation of dephosphorylation Source: GO_Central
  • TOR signaling Source: SGD

Keywordsi

Molecular functionSignal transduction inhibitor

Enzyme and pathway databases

BioCyciYEAST:G3O-32733-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Type 2A phosphatase-associated protein 42
Gene namesi
Name:TAP42
Ordered Locus Names:YMR028W
ORF Names:YM9711.18, YM9973.01C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR028W
SGDiS000004630 TAP42

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002186231 – 366Type 2A phosphatase-associated protein 42Add BLAST366

Post-translational modificationi

Phosphorylated by TOR kinases. Dephosphorylated by CDC55, TPD3 and SIT4.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ04372
PaxDbiQ04372
PRIDEiQ04372

PTM databases

iPTMnetiQ04372

Interactioni

Subunit structurei

Associates with the PP2a (PPH21 and PPH22) and SIT4 protein phosphatase catalytic subunits. Interacts with PPG1, PPH3 and TIP41.5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi35200, 313 interactors
DIPiDIP-6380N
IntActiQ04372, 15 interactors
MINTiQ04372
STRINGi4932.YMR028W

Structurei

Secondary structure

1366
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 18Combined sources15
Helixi29 – 50Combined sources22
Helixi62 – 64Combined sources3
Helixi67 – 74Combined sources8
Helixi75 – 83Combined sources9
Helixi93 – 120Combined sources28
Helixi126 – 133Combined sources8
Helixi143 – 146Combined sources4
Helixi156 – 186Combined sources31
Helixi199 – 231Combined sources33

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2V0PX-ray1.80A/B1-234[»]
ProteinModelPortaliQ04372
SMRiQ04372
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ04372

Family & Domainsi

Sequence similaritiesi

Belongs to the IGBP1/TAP42 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000002414
HOGENOMiHOG000176034
InParanoidiQ04372
KOiK17606
OMAiFRPGHNL
OrthoDBiEOG092C4C1Q

Family and domain databases

Gene3Di1.25.40.540, 1 hit
InterProiView protein in InterPro
IPR007304 TAP42-like
IPR038511 TAP42/TAP46-like_sf
PANTHERiPTHR10933 PTHR10933, 1 hit
PfamiView protein in Pfam
PF04177 TAP42, 1 hit

Sequencei

Sequence statusi: Complete.

Q04372-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVTEQFND IISLYSTKLE HTSLRQDSPE YQGLLLSTIK KLLNLKTAIF
60 70 80 90 100
DRLALFSTNE TIDDVSTASI KFLAVDYYLG LLISRRQSND SDVAQRQSMK
110 120 130 140 150
LIYLKKSVES FINFLTLLQD YKLLDPLVGE KLGNFKDRYN PQLSELYAQP
160 170 180 190 200
KNNKDLSGAQ LKRKEKIELF QRNKEISTKL HCLELELKNN DEDHDHDELL
210 220 230 240 250
RELYLMRLHH FSLDTINNIE QNLFECEMLS NFLKNSVHEV KSSGTQIRKE
260 270 280 290 300
SNDDDSTGFT DKLENINKPL IDKKGQVLRN FTLVDKRQQL QQKVRGYGQY
310 320 330 340 350
GPTMSVEEFL DKEFEEGRVL QGGEEPEQAP DEENMDWQDR ETYKAREWDE
360
FKESHAKGSG NTMNRG
Length:366
Mass (Da):42,568
Last modified:November 1, 1997 - v1
Checksum:i16F1E236BEC696DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43890 Genomic DNA Translation: AAC49396.1
Z49211 Genomic DNA Translation: CAA89131.1
Z49213 Genomic DNA Translation: CAA89143.1
AY558399 Genomic DNA Translation: AAS56725.1
BK006946 Genomic DNA Translation: DAA09926.1
PIRiS54030
RefSeqiNP_013741.1, NM_001182524.1

Genome annotation databases

EnsemblFungiiYMR028W; YMR028W; YMR028W
GeneIDi855043
KEGGisce:YMR028W

Similar proteinsi

Entry informationi

Entry nameiTAP42_YEAST
AccessioniPrimary (citable) accession number: Q04372
Secondary accession number(s): D6VZK2, Q05039
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health