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Protein

Protein-glutamate O-methyltransferase

Gene

YMR027W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

O-methyltransferase that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues.By similarity

Catalytic activityi

S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate methyl ester.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei259 – 2591S-adenosyl-L-methionineBy similarity
Binding sitei292 – 2921S-adenosyl-L-methionineBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciYEAST:G3O-32732-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamate O-methyltransferaseBy similarity (EC:2.1.1.-By similarity)
Gene namesi
Ordered Locus Names:YMR027W
ORF Names:YM9711.17
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR027W.
SGDiS000004629. YMR027W.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 470470Protein-glutamate O-methyltransferasePRO_0000203271Add
BLAST

Proteomic databases

MaxQBiQ04371.

Interactioni

Protein-protein interaction databases

BioGridi35199. 13 interactions.
IntActiQ04371. 4 interactions.
MINTiMINT-627372.

Structurei

Secondary structure

1
470
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi15 – 217Combined sources
Helixi23 – 3917Combined sources
Beta strandi44 – 463Combined sources
Helixi47 – 6822Combined sources
Helixi77 – 826Combined sources
Helixi88 – 958Combined sources
Beta strandi103 – 1053Combined sources
Helixi106 – 12318Combined sources
Turni125 – 1295Combined sources
Helixi134 – 1429Combined sources
Helixi145 – 16723Combined sources
Helixi175 – 19016Combined sources
Helixi191 – 1933Combined sources
Helixi196 – 1994Combined sources
Helixi204 – 2085Combined sources
Helixi210 – 22011Combined sources
Beta strandi223 – 2264Combined sources
Helixi228 – 24013Combined sources
Beta strandi248 – 2525Combined sources
Helixi258 – 27215Combined sources
Beta strandi277 – 28610Combined sources
Turni289 – 2913Combined sources
Helixi295 – 30612Combined sources
Turni308 – 3103Combined sources
Helixi319 – 33618Combined sources
Beta strandi339 – 3446Combined sources
Helixi346 – 3494Combined sources
Helixi354 – 3563Combined sources
Beta strandi363 – 3653Combined sources
Helixi366 – 3738Combined sources
Beta strandi377 – 3826Combined sources
Helixi383 – 3919Combined sources
Helixi402 – 4054Combined sources
Helixi407 – 4104Combined sources
Beta strandi416 – 4216Combined sources
Helixi434 – 44310Combined sources
Beta strandi444 – 4463Combined sources
Helixi450 – 4556Combined sources
Beta strandi456 – 4583Combined sources
Beta strandi460 – 4656Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3PT1X-ray1.77A1-470[»]
5BY0X-ray1.80A1-470[»]
5F13X-ray2.39A/B/C1-470[»]
ProteinModelPortaliQ04371.
SMRiQ04371. Positions 1-468.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARMT1 family.Curated

Phylogenomic databases

GeneTreeiENSGT00530000064023.
HOGENOMiHOG000172710.
InParanoidiQ04371.
OMAiWAKFDIF.
OrthoDBiEOG092C2H3M.

Family and domain databases

InterProiIPR002791. DUF89.
[Graphical view]
PfamiPF01937. DUF89. 1 hit.
[Graphical view]
SUPFAMiSSF111321. SSF111321. 2 hits.

Sequencei

Sequence statusi: Complete.

Q04371-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIPGRFMTI DKGTFGEYTA STRWPIIIQN AIDDLSKHQE TEKSNGTKFE
60 70 80 90 100
QGEVIKKELK EFRQEIIDRV PLRPFTEEEI KIANVPLSFN EYLKKHPEVN
110 120 130 140 150
WGAVEWLFSE VYLYRRVNVL FQRQCEWAKF DIFNRLKQST FESSFYGVVE
160 170 180 190 200
LALRYENLLP QLREMKQNPG NEIDDILKVL FKEFIEISLW GNATDLSLLT
210 220 230 240 250
NATLEDIKSI QGAKARAASE SKIVVNDTEK AWEVLTKARA DANSREIRVD
260 270 280 290 300
FVLDNSGFEL YADLMLAAFL LQSGLATKCI FHAKDIPYMV SDVMLKDFDI
310 320 330 340 350
LVHDLRDREF FPSGEPSTKE SRALDLFAGE MEKFVSSGKI EFREDSFWTT
360 370 380 390 400
ELDYWNLDAN ETKYHGSILH KDLQKSNLVI FKGDLNYRKL TGDRKWPRTT
410 420 430 440 450
KWETAIGPLA TNGITSLSLR TCKADVQVAL PEGLDAKLSQ EWEKENPGRG
460 470
SWWCCSGKWA VICFCSGIHK
Length:470
Mass (Da):54,129
Last modified:November 1, 1997 - v1
Checksum:iC71DC2833CF85D5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49211 Genomic DNA. Translation: CAA89130.1.
BK006946 Genomic DNA. Translation: DAA09925.1.
PIRiS54029.
RefSeqiNP_013740.1. NM_001182523.1.

Genome annotation databases

EnsemblFungiiYMR027W; YMR027W; YMR027W.
GeneIDi855042.
KEGGisce:YMR027W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49211 Genomic DNA. Translation: CAA89130.1.
BK006946 Genomic DNA. Translation: DAA09925.1.
PIRiS54029.
RefSeqiNP_013740.1. NM_001182523.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3PT1X-ray1.77A1-470[»]
5BY0X-ray1.80A1-470[»]
5F13X-ray2.39A/B/C1-470[»]
ProteinModelPortaliQ04371.
SMRiQ04371. Positions 1-468.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35199. 13 interactions.
IntActiQ04371. 4 interactions.
MINTiMINT-627372.

Proteomic databases

MaxQBiQ04371.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR027W; YMR027W; YMR027W.
GeneIDi855042.
KEGGisce:YMR027W.

Organism-specific databases

EuPathDBiFungiDB:YMR027W.
SGDiS000004629. YMR027W.

Phylogenomic databases

GeneTreeiENSGT00530000064023.
HOGENOMiHOG000172710.
InParanoidiQ04371.
OMAiWAKFDIF.
OrthoDBiEOG092C2H3M.

Enzyme and pathway databases

BioCyciYEAST:G3O-32732-MONOMER.

Miscellaneous databases

PROiQ04371.

Family and domain databases

InterProiIPR002791. DUF89.
[Graphical view]
PfamiPF01937. DUF89. 1 hit.
[Graphical view]
SUPFAMiSSF111321. SSF111321. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiARMT1_YEAST
AccessioniPrimary (citable) accession number: Q04371
Secondary accession number(s): D6VZK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6190 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.