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Protein

Protein-glutamate O-methyltransferase

Gene

YMR027W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

O-methyltransferase that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues.By similarity

Catalytic activityi

S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate methyl ester.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei259S-adenosyl-L-methionineBy similarity1
Binding sitei292S-adenosyl-L-methionineBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciYEAST:G3O-32732-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamate O-methyltransferaseBy similarity (EC:2.1.1.-By similarity)
Gene namesi
Ordered Locus Names:YMR027W
ORF Names:YM9711.17
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR027W.
SGDiS000004629. YMR027W.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002032711 – 470Protein-glutamate O-methyltransferaseAdd BLAST470

Proteomic databases

MaxQBiQ04371.
PRIDEiQ04371.

Interactioni

Protein-protein interaction databases

BioGridi35199. 13 interactors.
IntActiQ04371. 4 interactors.
MINTiMINT-627372.

Structurei

Secondary structure

1470
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi15 – 21Combined sources7
Helixi23 – 39Combined sources17
Beta strandi44 – 46Combined sources3
Helixi47 – 68Combined sources22
Helixi77 – 82Combined sources6
Helixi88 – 95Combined sources8
Beta strandi103 – 105Combined sources3
Helixi106 – 123Combined sources18
Turni125 – 129Combined sources5
Helixi134 – 142Combined sources9
Helixi145 – 167Combined sources23
Helixi175 – 190Combined sources16
Helixi191 – 193Combined sources3
Helixi196 – 199Combined sources4
Helixi204 – 208Combined sources5
Helixi210 – 220Combined sources11
Beta strandi223 – 226Combined sources4
Helixi228 – 240Combined sources13
Beta strandi248 – 252Combined sources5
Helixi258 – 272Combined sources15
Beta strandi277 – 286Combined sources10
Turni289 – 291Combined sources3
Helixi295 – 306Combined sources12
Turni308 – 310Combined sources3
Helixi319 – 336Combined sources18
Beta strandi339 – 344Combined sources6
Helixi346 – 349Combined sources4
Helixi354 – 356Combined sources3
Beta strandi363 – 365Combined sources3
Helixi366 – 373Combined sources8
Beta strandi377 – 382Combined sources6
Helixi383 – 391Combined sources9
Helixi402 – 405Combined sources4
Helixi407 – 410Combined sources4
Beta strandi416 – 421Combined sources6
Helixi434 – 443Combined sources10
Beta strandi444 – 446Combined sources3
Helixi450 – 455Combined sources6
Beta strandi456 – 458Combined sources3
Beta strandi460 – 465Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PT1X-ray1.77A1-470[»]
5BY0X-ray1.80A1-470[»]
5F13X-ray2.39A/B/C1-470[»]
ProteinModelPortaliQ04371.
SMRiQ04371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARMT1 family.Curated

Phylogenomic databases

GeneTreeiENSGT00530000064023.
HOGENOMiHOG000172710.
InParanoidiQ04371.
OMAiWAKFDIF.
OrthoDBiEOG092C2H3M.

Family and domain databases

InterProiIPR002791. DUF89.
[Graphical view]
PfamiPF01937. DUF89. 1 hit.
[Graphical view]
SUPFAMiSSF111321. SSF111321. 2 hits.

Sequencei

Sequence statusi: Complete.

Q04371-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIPGRFMTI DKGTFGEYTA STRWPIIIQN AIDDLSKHQE TEKSNGTKFE
60 70 80 90 100
QGEVIKKELK EFRQEIIDRV PLRPFTEEEI KIANVPLSFN EYLKKHPEVN
110 120 130 140 150
WGAVEWLFSE VYLYRRVNVL FQRQCEWAKF DIFNRLKQST FESSFYGVVE
160 170 180 190 200
LALRYENLLP QLREMKQNPG NEIDDILKVL FKEFIEISLW GNATDLSLLT
210 220 230 240 250
NATLEDIKSI QGAKARAASE SKIVVNDTEK AWEVLTKARA DANSREIRVD
260 270 280 290 300
FVLDNSGFEL YADLMLAAFL LQSGLATKCI FHAKDIPYMV SDVMLKDFDI
310 320 330 340 350
LVHDLRDREF FPSGEPSTKE SRALDLFAGE MEKFVSSGKI EFREDSFWTT
360 370 380 390 400
ELDYWNLDAN ETKYHGSILH KDLQKSNLVI FKGDLNYRKL TGDRKWPRTT
410 420 430 440 450
KWETAIGPLA TNGITSLSLR TCKADVQVAL PEGLDAKLSQ EWEKENPGRG
460 470
SWWCCSGKWA VICFCSGIHK
Length:470
Mass (Da):54,129
Last modified:November 1, 1997 - v1
Checksum:iC71DC2833CF85D5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49211 Genomic DNA. Translation: CAA89130.1.
BK006946 Genomic DNA. Translation: DAA09925.1.
PIRiS54029.
RefSeqiNP_013740.1. NM_001182523.1.

Genome annotation databases

EnsemblFungiiYMR027W; YMR027W; YMR027W.
GeneIDi855042.
KEGGisce:YMR027W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49211 Genomic DNA. Translation: CAA89130.1.
BK006946 Genomic DNA. Translation: DAA09925.1.
PIRiS54029.
RefSeqiNP_013740.1. NM_001182523.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PT1X-ray1.77A1-470[»]
5BY0X-ray1.80A1-470[»]
5F13X-ray2.39A/B/C1-470[»]
ProteinModelPortaliQ04371.
SMRiQ04371.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35199. 13 interactors.
IntActiQ04371. 4 interactors.
MINTiMINT-627372.

Proteomic databases

MaxQBiQ04371.
PRIDEiQ04371.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR027W; YMR027W; YMR027W.
GeneIDi855042.
KEGGisce:YMR027W.

Organism-specific databases

EuPathDBiFungiDB:YMR027W.
SGDiS000004629. YMR027W.

Phylogenomic databases

GeneTreeiENSGT00530000064023.
HOGENOMiHOG000172710.
InParanoidiQ04371.
OMAiWAKFDIF.
OrthoDBiEOG092C2H3M.

Enzyme and pathway databases

BioCyciYEAST:G3O-32732-MONOMER.

Miscellaneous databases

PROiQ04371.

Family and domain databases

InterProiIPR002791. DUF89.
[Graphical view]
PfamiPF01937. DUF89. 1 hit.
[Graphical view]
SUPFAMiSSF111321. SSF111321. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiARMT1_YEAST
AccessioniPrimary (citable) accession number: Q04371
Secondary accession number(s): D6VZK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6190 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.