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Q04370

- PEX12_YEAST

UniProt

Q04370 - PEX12_YEAST

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Protein

Peroxisome assembly protein 12

Gene

PEX12

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Required for protein import into peroxisomes.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri334 – 37340RING-type; degenerateAdd
BLAST

GO - Molecular functioni

  1. ubiquitin-protein transferase activity Source: SGD
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. protein import into peroxisome matrix Source: SGD
  2. protein ubiquitination Source: GOC
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-32731-MONOMER.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome assembly protein 12
Alternative name(s):
Peroxin-12
Gene namesi
Name:PEX12
Ordered Locus Names:YMR026C
ORF Names:YM9711.16C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR026c.
SGDiS000004628. PEX12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei270 – 28617HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of peroxisomal membrane Source: SGD
  2. peroxisomal importomer complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399Peroxisome assembly protein 12PRO_0000218617Add
BLAST

Proteomic databases

MaxQBiQ04370.
PaxDbiQ04370.
PeptideAtlasiQ04370.

Expressioni

Gene expression databases

GenevestigatoriQ04370.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PEX10Q0556812EBI-2077297,EBI-13194
PEX13P806676EBI-2077297,EBI-13206

Protein-protein interaction databases

BioGridi35198. 96 interactions.
DIPiDIP-7940N.
IntActiQ04370. 9 interactions.
MINTiMINT-737262.
STRINGi4932.YMR026C.

Structurei

3D structure databases

ProteinModelPortaliQ04370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pex2/pex10/pex12 family.Curated
Contains 1 RING-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri334 – 37340RING-type; degenerateAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiNOG328872.
GeneTreeiENSGT00390000016209.
HOGENOMiHOG000038427.
InParanoidiQ04370.
KOiK13345.
OMAiDEDIPRP.
OrthoDBiEOG73BVP8.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR017375. PEX12.
IPR006845. Pex_N.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR12888. PTHR12888. 1 hit.
PfamiPF04757. Pex2_Pex12. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04370-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFYSNLPSA GQSSRGSSTS GRNGVGLEPL YPTIFEIMSS QEIDSLLPAS
60 70 80 90 100
IRYLLANHLV ANFPNRYTLR LNKYFFEWFQ AIKGFVEWYH LKTYNSTFID
110 120 130 140 150
RFYGLQLFSS RDRNLALTQC LNPKGQSEWP QGLQLNQQQK SVIFLEKIIL
160 170 180 190 200
PYITAKLDEI LEKISMNNIF SSDETENKWP KRAFLRIYPF IKKLLALSNL
210 220 230 240 250
LVKLLFLTKR TGSVSLLQYL FKIEYTTVRP LSSELSGLKE TKGMDNRLRK
260 270 280 290 300
TNISSIFALM QGQLSIIPRF LTFMGSQFFP TFIFVLRVYQ WWTTQDMTTK
310 320 330 340 350
LQKRVNDLDE DIPRPPFSSH SDKTEDKEGV SEACPVCEKT VQNPCVLETG
360 370 380 390
YVACYPCAIS YLVNNEGHCP VTNKKLLGCT YNKHTNKWEV VTGIRKLLI
Length:399
Mass (Da):45,992
Last modified:November 1, 1997 - v1
Checksum:i98E6300C2CBFA16A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371I → T in AAT93085. (PubMed:17322287)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49211 Genomic DNA. Translation: CAA89129.1.
AY693066 Genomic DNA. Translation: AAT93085.1.
BK006946 Genomic DNA. Translation: DAA09924.1.
PIRiS54028.
RefSeqiNP_013739.1. NM_001182522.1.

Genome annotation databases

EnsemblFungiiYMR026C; YMR026C; YMR026C.
GeneIDi855041.
KEGGisce:YMR026C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49211 Genomic DNA. Translation: CAA89129.1 .
AY693066 Genomic DNA. Translation: AAT93085.1 .
BK006946 Genomic DNA. Translation: DAA09924.1 .
PIRi S54028.
RefSeqi NP_013739.1. NM_001182522.1.

3D structure databases

ProteinModelPortali Q04370.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35198. 96 interactions.
DIPi DIP-7940N.
IntActi Q04370. 9 interactions.
MINTi MINT-737262.
STRINGi 4932.YMR026C.

Protein family/group databases

TCDBi 3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Proteomic databases

MaxQBi Q04370.
PaxDbi Q04370.
PeptideAtlasi Q04370.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR026C ; YMR026C ; YMR026C .
GeneIDi 855041.
KEGGi sce:YMR026C.

Organism-specific databases

CYGDi YMR026c.
SGDi S000004628. PEX12.

Phylogenomic databases

eggNOGi NOG328872.
GeneTreei ENSGT00390000016209.
HOGENOMi HOG000038427.
InParanoidi Q04370.
KOi K13345.
OMAi DEDIPRP.
OrthoDBi EOG73BVP8.

Enzyme and pathway databases

BioCyci YEAST:G3O-32731-MONOMER.

Miscellaneous databases

NextBioi 978262.
PROi Q04370.

Gene expression databases

Genevestigatori Q04370.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR017375. PEX12.
IPR006845. Pex_N.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
PANTHERi PTHR12888. PTHR12888. 1 hit.
Pfami PF04757. Pex2_Pex12. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPEX12_YEAST
AccessioniPrimary (citable) accession number: Q04370
Secondary accession number(s): D6VZK0, Q6B1L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 907 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3