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Q04370

- PEX12_YEAST

UniProt

Q04370 - PEX12_YEAST

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Protein

Peroxisome assembly protein 12

Gene
PEX12, YMR026C, YM9711.16C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Required for protein import into peroxisomes By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri334 – 37340RING-type; degenerateAdd
BLAST

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. ubiquitin-protein transferase activity Source: SGD
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. protein import into peroxisome matrix Source: SGD
  2. protein ubiquitination Source: GOC
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-32731-MONOMER.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome assembly protein 12
Alternative name(s):
Peroxin-12
Gene namesi
Name:PEX12
Ordered Locus Names:YMR026C
ORF Names:YM9711.16C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR026c.
SGDiS000004628. PEX12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei270 – 28617Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of peroxisomal membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399Peroxisome assembly protein 12PRO_0000218617Add
BLAST

Proteomic databases

MaxQBiQ04370.
PaxDbiQ04370.
PeptideAtlasiQ04370.

Expressioni

Gene expression databases

GenevestigatoriQ04370.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PEX10Q0556812EBI-2077297,EBI-13194
PEX13P806676EBI-2077297,EBI-13206

Protein-protein interaction databases

BioGridi35198. 96 interactions.
DIPiDIP-7940N.
IntActiQ04370. 9 interactions.
MINTiMINT-737262.
STRINGi4932.YMR026C.

Structurei

3D structure databases

ProteinModelPortaliQ04370.

Family & Domainsi

Sequence similaritiesi

Belongs to the pex2/pex10/pex12 family.

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiNOG328872.
GeneTreeiENSGT00390000016209.
HOGENOMiHOG000038427.
KOiK13345.
OMAiDEDIPRP.
OrthoDBiEOG73BVP8.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR017375. PEX12.
IPR006845. Pex_N.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR12888. PTHR12888. 1 hit.
PfamiPF04757. Pex2_Pex12. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04370-1 [UniParc]FASTAAdd to Basket

« Hide

MSFYSNLPSA GQSSRGSSTS GRNGVGLEPL YPTIFEIMSS QEIDSLLPAS    50
IRYLLANHLV ANFPNRYTLR LNKYFFEWFQ AIKGFVEWYH LKTYNSTFID 100
RFYGLQLFSS RDRNLALTQC LNPKGQSEWP QGLQLNQQQK SVIFLEKIIL 150
PYITAKLDEI LEKISMNNIF SSDETENKWP KRAFLRIYPF IKKLLALSNL 200
LVKLLFLTKR TGSVSLLQYL FKIEYTTVRP LSSELSGLKE TKGMDNRLRK 250
TNISSIFALM QGQLSIIPRF LTFMGSQFFP TFIFVLRVYQ WWTTQDMTTK 300
LQKRVNDLDE DIPRPPFSSH SDKTEDKEGV SEACPVCEKT VQNPCVLETG 350
YVACYPCAIS YLVNNEGHCP VTNKKLLGCT YNKHTNKWEV VTGIRKLLI 399
Length:399
Mass (Da):45,992
Last modified:November 1, 1997 - v1
Checksum:i98E6300C2CBFA16A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371I → T in AAT93085. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49211 Genomic DNA. Translation: CAA89129.1.
AY693066 Genomic DNA. Translation: AAT93085.1.
BK006946 Genomic DNA. Translation: DAA09924.1.
PIRiS54028.
RefSeqiNP_013739.1. NM_001182522.1.

Genome annotation databases

EnsemblFungiiYMR026C; YMR026C; YMR026C.
GeneIDi855041.
KEGGisce:YMR026C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49211 Genomic DNA. Translation: CAA89129.1 .
AY693066 Genomic DNA. Translation: AAT93085.1 .
BK006946 Genomic DNA. Translation: DAA09924.1 .
PIRi S54028.
RefSeqi NP_013739.1. NM_001182522.1.

3D structure databases

ProteinModelPortali Q04370.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35198. 96 interactions.
DIPi DIP-7940N.
IntActi Q04370. 9 interactions.
MINTi MINT-737262.
STRINGi 4932.YMR026C.

Protein family/group databases

TCDBi 3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Proteomic databases

MaxQBi Q04370.
PaxDbi Q04370.
PeptideAtlasi Q04370.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR026C ; YMR026C ; YMR026C .
GeneIDi 855041.
KEGGi sce:YMR026C.

Organism-specific databases

CYGDi YMR026c.
SGDi S000004628. PEX12.

Phylogenomic databases

eggNOGi NOG328872.
GeneTreei ENSGT00390000016209.
HOGENOMi HOG000038427.
KOi K13345.
OMAi DEDIPRP.
OrthoDBi EOG73BVP8.

Enzyme and pathway databases

BioCyci YEAST:G3O-32731-MONOMER.

Miscellaneous databases

NextBioi 978262.
PROi Q04370.

Gene expression databases

Genevestigatori Q04370.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR017375. PEX12.
IPR006845. Pex_N.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
PANTHERi PTHR12888. PTHR12888. 1 hit.
Pfami PF04757. Pex2_Pex12. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPEX12_YEAST
AccessioniPrimary (citable) accession number: Q04370
Secondary accession number(s): D6VZK0, Q6B1L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 907 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

Similar proteinsi