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Protein

Peroxisome assembly protein 12

Gene

PEX12

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for protein import into peroxisomes.By similarity

Miscellaneous

Present with 907 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri334 – 373RING-type; degenerateAdd BLAST40

GO - Molecular functioni

GO - Biological processi

  • protein import into peroxisome matrix Source: SGD
  • protein monoubiquitination Source: SGD

Keywordsi

Biological processProtein transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-32731-MONOMER
ReactomeiR-SCE-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-SCE-9033241 Peroxisomal protein import

Protein family/group databases

TCDBi3.A.20.1.5 the peroxisomal protein importer (ppi) family

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome assembly protein 12
Alternative name(s):
Peroxin-12
Gene namesi
Name:PEX12
Ordered Locus Names:YMR026C
ORF Names:YM9711.16C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR026C
SGDiS000004628 PEX12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei270 – 286HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002186171 – 399Peroxisome assembly protein 12Add BLAST399

Proteomic databases

MaxQBiQ04370
PaxDbiQ04370
PRIDEiQ04370

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi35198, 214 interactors
ComplexPortaliCPX-1903 Pex2/Pex10/Pex12 ubiquitin ligase complex
DIPiDIP-7940N
IntActiQ04370, 11 interactors
MINTiQ04370
STRINGi4932.YMR026C

Structurei

3D structure databases

ProteinModelPortaliQ04370
SMRiQ04370
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pex2/pex10/pex12 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri334 – 373RING-type; degenerateAdd BLAST40

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00390000016209
HOGENOMiHOG000038427
InParanoidiQ04370
KOiK13345
OMAiLFDKTPY
OrthoDBiEOG092C44FF

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR017375 PEX12
IPR006845 Pex_N
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR12888 PTHR12888, 1 hit
PfamiView protein in Pfam
PF04757 Pex2_Pex12, 1 hit
PIRSFiPIRSF038074 Peroxisome_assembly_p12, 1 hit

Sequencei

Sequence statusi: Complete.

Q04370-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFYSNLPSA GQSSRGSSTS GRNGVGLEPL YPTIFEIMSS QEIDSLLPAS
60 70 80 90 100
IRYLLANHLV ANFPNRYTLR LNKYFFEWFQ AIKGFVEWYH LKTYNSTFID
110 120 130 140 150
RFYGLQLFSS RDRNLALTQC LNPKGQSEWP QGLQLNQQQK SVIFLEKIIL
160 170 180 190 200
PYITAKLDEI LEKISMNNIF SSDETENKWP KRAFLRIYPF IKKLLALSNL
210 220 230 240 250
LVKLLFLTKR TGSVSLLQYL FKIEYTTVRP LSSELSGLKE TKGMDNRLRK
260 270 280 290 300
TNISSIFALM QGQLSIIPRF LTFMGSQFFP TFIFVLRVYQ WWTTQDMTTK
310 320 330 340 350
LQKRVNDLDE DIPRPPFSSH SDKTEDKEGV SEACPVCEKT VQNPCVLETG
360 370 380 390
YVACYPCAIS YLVNNEGHCP VTNKKLLGCT YNKHTNKWEV VTGIRKLLI
Length:399
Mass (Da):45,992
Last modified:November 1, 1997 - v1
Checksum:i98E6300C2CBFA16A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37I → T in AAT93085 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49211 Genomic DNA Translation: CAA89129.1
AY693066 Genomic DNA Translation: AAT93085.1
BK006946 Genomic DNA Translation: DAA09924.1
PIRiS54028
RefSeqiNP_013739.1, NM_001182522.1

Genome annotation databases

EnsemblFungiiYMR026C; YMR026C; YMR026C
GeneIDi855041
KEGGisce:YMR026C

Similar proteinsi

Entry informationi

Entry nameiPEX12_YEAST
AccessioniPrimary (citable) accession number: Q04370
Secondary accession number(s): D6VZK0, Q6B1L4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 20, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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