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Q04370

- PEX12_YEAST

UniProt

Q04370 - PEX12_YEAST

Protein

Peroxisome assembly protein 12

Gene

PEX12

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Required for protein import into peroxisomes.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri334 – 37340RING-type; degenerateAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. ubiquitin-protein transferase activity Source: SGD
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein import into peroxisome matrix Source: SGD
    2. protein ubiquitination Source: GOC

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32731-MONOMER.

    Protein family/group databases

    TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisome assembly protein 12
    Alternative name(s):
    Peroxin-12
    Gene namesi
    Name:PEX12
    Ordered Locus Names:YMR026C
    ORF Names:YM9711.16C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYMR026c.
    SGDiS000004628. PEX12.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of peroxisomal membrane Source: SGD

    Keywords - Cellular componenti

    Membrane, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 399399Peroxisome assembly protein 12PRO_0000218617Add
    BLAST

    Proteomic databases

    MaxQBiQ04370.
    PaxDbiQ04370.
    PeptideAtlasiQ04370.

    Expressioni

    Gene expression databases

    GenevestigatoriQ04370.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PEX10Q0556812EBI-2077297,EBI-13194
    PEX13P806676EBI-2077297,EBI-13206

    Protein-protein interaction databases

    BioGridi35198. 96 interactions.
    DIPiDIP-7940N.
    IntActiQ04370. 9 interactions.
    MINTiMINT-737262.
    STRINGi4932.YMR026C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04370.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei270 – 28617HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pex2/pex10/pex12 family.Curated
    Contains 1 RING-type zinc finger.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri334 – 37340RING-type; degenerateAdd
    BLAST

    Keywords - Domaini

    Transmembrane, Transmembrane helix, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG328872.
    GeneTreeiENSGT00390000016209.
    HOGENOMiHOG000038427.
    KOiK13345.
    OMAiDEDIPRP.
    OrthoDBiEOG73BVP8.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR017375. PEX12.
    IPR006845. Pex_N.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PANTHERiPTHR12888. PTHR12888. 1 hit.
    PfamiPF04757. Pex2_Pex12. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04370-1 [UniParc]FASTAAdd to Basket

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    MSFYSNLPSA GQSSRGSSTS GRNGVGLEPL YPTIFEIMSS QEIDSLLPAS    50
    IRYLLANHLV ANFPNRYTLR LNKYFFEWFQ AIKGFVEWYH LKTYNSTFID 100
    RFYGLQLFSS RDRNLALTQC LNPKGQSEWP QGLQLNQQQK SVIFLEKIIL 150
    PYITAKLDEI LEKISMNNIF SSDETENKWP KRAFLRIYPF IKKLLALSNL 200
    LVKLLFLTKR TGSVSLLQYL FKIEYTTVRP LSSELSGLKE TKGMDNRLRK 250
    TNISSIFALM QGQLSIIPRF LTFMGSQFFP TFIFVLRVYQ WWTTQDMTTK 300
    LQKRVNDLDE DIPRPPFSSH SDKTEDKEGV SEACPVCEKT VQNPCVLETG 350
    YVACYPCAIS YLVNNEGHCP VTNKKLLGCT YNKHTNKWEV VTGIRKLLI 399
    Length:399
    Mass (Da):45,992
    Last modified:November 1, 1997 - v1
    Checksum:i98E6300C2CBFA16A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti37 – 371I → T in AAT93085. (PubMed:17322287)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49211 Genomic DNA. Translation: CAA89129.1.
    AY693066 Genomic DNA. Translation: AAT93085.1.
    BK006946 Genomic DNA. Translation: DAA09924.1.
    PIRiS54028.
    RefSeqiNP_013739.1. NM_001182522.1.

    Genome annotation databases

    EnsemblFungiiYMR026C; YMR026C; YMR026C.
    GeneIDi855041.
    KEGGisce:YMR026C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49211 Genomic DNA. Translation: CAA89129.1 .
    AY693066 Genomic DNA. Translation: AAT93085.1 .
    BK006946 Genomic DNA. Translation: DAA09924.1 .
    PIRi S54028.
    RefSeqi NP_013739.1. NM_001182522.1.

    3D structure databases

    ProteinModelPortali Q04370.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35198. 96 interactions.
    DIPi DIP-7940N.
    IntActi Q04370. 9 interactions.
    MINTi MINT-737262.
    STRINGi 4932.YMR026C.

    Protein family/group databases

    TCDBi 3.A.20.1.5. the peroxisomal protein importer (ppi) family.

    Proteomic databases

    MaxQBi Q04370.
    PaxDbi Q04370.
    PeptideAtlasi Q04370.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YMR026C ; YMR026C ; YMR026C .
    GeneIDi 855041.
    KEGGi sce:YMR026C.

    Organism-specific databases

    CYGDi YMR026c.
    SGDi S000004628. PEX12.

    Phylogenomic databases

    eggNOGi NOG328872.
    GeneTreei ENSGT00390000016209.
    HOGENOMi HOG000038427.
    KOi K13345.
    OMAi DEDIPRP.
    OrthoDBi EOG73BVP8.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32731-MONOMER.

    Miscellaneous databases

    NextBioi 978262.
    PROi Q04370.

    Gene expression databases

    Genevestigatori Q04370.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR017375. PEX12.
    IPR006845. Pex_N.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    PANTHERi PTHR12888. PTHR12888. 1 hit.
    Pfami PF04757. Pex2_Pex12. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPEX12_YEAST
    AccessioniPrimary (citable) accession number: Q04370
    Secondary accession number(s): D6VZK0, Q6B1L4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 907 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3