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Q04370 (PEX12_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peroxisome assembly protein 12
Alternative name(s):
Peroxin-12
Gene names
Name:PEX12
Ordered Locus Names:YMR026C
ORF Names:YM9711.16C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length399 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for protein import into peroxisomes By similarity.

Subcellular location

Peroxisome membrane; Single-pass membrane protein Potential.

Miscellaneous

Present with 907 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the pex2/pex10/pex12 family.

Contains 1 RING-type zinc finger.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PEX10Q0556812EBI-2077297,EBI-13194
PEX13P806676EBI-2077297,EBI-13206

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 399399Peroxisome assembly protein 12
PRO_0000218617

Regions

Transmembrane270 – 28617Helical; Potential
Zinc finger334 – 37340RING-type; degenerate

Experimental info

Sequence conflict371I → T in AAT93085. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q04370 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 98E6300C2CBFA16A

FASTA39945,992
        10         20         30         40         50         60 
MSFYSNLPSA GQSSRGSSTS GRNGVGLEPL YPTIFEIMSS QEIDSLLPAS IRYLLANHLV 

        70         80         90        100        110        120 
ANFPNRYTLR LNKYFFEWFQ AIKGFVEWYH LKTYNSTFID RFYGLQLFSS RDRNLALTQC 

       130        140        150        160        170        180 
LNPKGQSEWP QGLQLNQQQK SVIFLEKIIL PYITAKLDEI LEKISMNNIF SSDETENKWP 

       190        200        210        220        230        240 
KRAFLRIYPF IKKLLALSNL LVKLLFLTKR TGSVSLLQYL FKIEYTTVRP LSSELSGLKE 

       250        260        270        280        290        300 
TKGMDNRLRK TNISSIFALM QGQLSIIPRF LTFMGSQFFP TFIFVLRVYQ WWTTQDMTTK 

       310        320        330        340        350        360 
LQKRVNDLDE DIPRPPFSSH SDKTEDKEGV SEACPVCEKT VQNPCVLETG YVACYPCAIS 

       370        380        390 
YLVNNEGHCP VTNKKLLGCT YNKHTNKWEV VTGIRKLLI 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z49211 Genomic DNA. Translation: CAA89129.1.
AY693066 Genomic DNA. Translation: AAT93085.1.
BK006946 Genomic DNA. Translation: DAA09924.1.
PIRS54028.
RefSeqNP_013739.1. NM_001182522.1.

3D structure databases

ProteinModelPortalQ04370.
SMRQ04370. Positions 332-378.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35198. 96 interactions.
DIPDIP-7940N.
IntActQ04370. 9 interactions.
MINTMINT-737262.
STRING4932.YMR026C.

Protein family/group databases

TCDB3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Proteomic databases

PaxDbQ04370.
PeptideAtlasQ04370.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYMR026C; YMR026C; YMR026C.
GeneID855041.
KEGGsce:YMR026C.

Organism-specific databases

CYGDYMR026c.
SGDS000004628. PEX12.

Phylogenomic databases

eggNOGNOG328872.
GeneTreeENSGT00390000016209.
HOGENOMHOG000038427.
KOK13345.
OMAKRGRCPI.
OrthoDBEOG73BVP8.

Enzyme and pathway databases

BioCycYEAST:G3O-32731-MONOMER.

Gene expression databases

GenevestigatorQ04370.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR017375. PEX12.
IPR006845. Pex_N.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERPTHR12888. PTHR12888. 1 hit.
PfamPF04757. Pex2_Pex12. 1 hit.
[Graphical view]
SMARTSM00184. RING. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio978262.
PROQ04370.

Entry information

Entry namePEX12_YEAST
AccessionPrimary (citable) accession number: Q04370
Secondary accession number(s): D6VZK0, Q6B1L4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families