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Q04364 (YMP8_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
TPR repeat-containing protein YMR018W
Gene names
Ordered Locus Names:YMR018W
ORF Names:YM9711.06
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length514 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Unknown, but in contrast to the closely related PEX5, it is not involved in the binding of type-1 peroxisome-targeting sequences (PTS1) nor in peroxisome biogenesis or fatty acid oxidation.

Subunit structure

Interacts according to large scale protein interaction studies with TLG1 Potential. Ref.5

Sequence similarities

Belongs to the peroxisomal targeting signal receptor family.

Contains 8 TPR repeats.

Ontologies

Keywords
   DomainRepeat
TPR repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 514514TPR repeat-containing protein YMR018W
PRO_0000106320

Regions

Repeat174 – 20734TPR 1
Repeat218 – 25235TPR 2
Repeat254 – 28633TPR 3
Repeat288 – 32033TPR 4
Repeat326 – 35934TPR 5
Repeat360 – 39334TPR 6
Repeat394 – 42734TPR 7
Repeat429 – 46133TPR 8

Experimental info

Sequence conflict91T → P in AAT92739. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q04364 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 8A1302220602B64A

FASTA51459,065
        10         20         30         40         50         60 
MNEVTCSITG DNPIHKINNG LGLKWNNLGK FSDFQTNDSA ARDARTIDYI FTNCQTGSSI 

        70         80         90        100        110        120 
GKIDFRAALP ADKSQHSGVS EKEFSRLENQ WSKEFSCFPK NKNADVTKPS RNKHEKRSAN 

       130        140        150        160        170        180 
LHNRYFAQYY STAYQQNRIY PCRISYNEHS SVSNGWEFQF KSIENQLLNE LKIENNVEEK 

       190        200        210        220        230        240 
TVGYEYVAEY EETIDFMHML SSVPQTYQFL KSNIYITERD PYKIGCVLMD NGSNLNEVVM 

       250        260        270        280        290        300 
AFEAAISQDP SHINAWLKLG IVNFENESES NGELALRNCL NLDPNNTIAL ENLAIHHINQ 

       310        320        330        340        350        360 
QNESESLKLF HKWILSKFSK VFQPSAGENK DSINKIPKKA HLAHILESLL NMGIEKKDQY 

       370        380        390        400        410        420 
DIYSVLSILY YSDQKIKQSQ KCLEFLLLEK PNNGTIWNRY GAILANTKSY HSAINAYNKC 

       430        440        450        460        470        480 
KQLRPNFTRV RYNLAIAYMN KGDYVKASKM LIEVILLRSK GYEHNKAKMQ NKFMQNLKNA 

       490        500        510 
LIASKNFDSL DLINGSHNTE SLISTLKAIY NKMD 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Identification of PEX5p-related novel peroxisome-targeting signal 1 (PTS1)-binding proteins in mammals."
Amery L., Sano H., Mannaerts G.P., Snider J., Van Looy J., Fransen M., Van Veldhoven P.P.
Biochem. J. 357:635-646(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: LACK OF INVOLVEMENT IN PTS1 IMPORT.
[5]"A comprehensive two-hybrid analysis to explore the yeast protein interactome."
Ito T., Chiba T., Ozawa R., Yoshida M., Hattori M., Sakaki Y.
Proc. Natl. Acad. Sci. U.S.A. 98:4569-4574(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TLG1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z49211 Genomic DNA. Translation: CAA89120.1.
AY692720 Genomic DNA. Translation: AAT92739.1.
BK006946 Genomic DNA. Translation: DAA09916.1.
PIRS54019.
RefSeqNP_013731.1. NM_001182514.1.

3D structure databases

ProteinModelPortalQ04364.
SMRQ04364. Positions 234-461.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35189. 8 interactions.
DIPDIP-4510N.
IntActQ04364. 2 interactions.
MINTMINT-490324.
STRING4932.YMR018W.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYMR018W; YMR018W; YMR018W.
GeneID855032.
KEGGsce:YMR018W.

Organism-specific databases

CYGDYMR018w.
SGDS000004620. YMR018W.

Phylogenomic databases

eggNOGCOG0457.
GeneTreeENSGT00390000013941.
OMAITEHEVE.
OrthoDBEOG76QFSC.

Enzyme and pathway databases

BioCycYEAST:G3O-32724-MONOMER.

Gene expression databases

GenevestigatorQ04364.

Family and domain databases

Gene3D1.25.40.10. 2 hits.
InterProIPR024111. PTS1R_family.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERPTHR10130. PTHR10130. 1 hit.
SMARTSM00028. TPR. 3 hits.
[Graphical view]
PROSITEPS50005. TPR. 4 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio978236.

Entry information

Entry nameYMP8_YEAST
AccessionPrimary (citable) accession number: Q04364
Secondary accession number(s): D6VZJ2, Q6B2L0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families