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Protein

TPR repeat-containing protein YMR018W

Gene

YMR018W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Unknown, but in contrast to the closely related PEX5, it is not involved in the binding of type-1 peroxisome-targeting sequences (PTS1) nor in peroxisome biogenesis or fatty acid oxidation.

Enzyme and pathway databases

BioCyciYEAST:G3O-32724-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
TPR repeat-containing protein YMR018W
Gene namesi
Ordered Locus Names:YMR018W
ORF Names:YM9711.06
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome XIII

Organism-specific databases

CYGDiYMR018w.
EuPathDBiFungiDB:YMR018W.
SGDiS000004620. YMR018W.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514TPR repeat-containing protein YMR018WPRO_0000106320Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriQ04364.

Interactioni

Subunit structurei

Interacts according to large scale protein interaction studies with TLG1.Curated

Protein-protein interaction databases

BioGridi35189. 8 interactions.
DIPiDIP-4510N.
IntActiQ04364. 2 interactions.
MINTiMINT-490324.
STRINGi4932.YMR018W.

Structurei

3D structure databases

ProteinModelPortaliQ04364.
SMRiQ04364. Positions 234-461.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati174 – 20734TPR 1Add
BLAST
Repeati218 – 25235TPR 2Add
BLAST
Repeati254 – 28633TPR 3Add
BLAST
Repeati288 – 32033TPR 4Add
BLAST
Repeati326 – 35934TPR 5Add
BLAST
Repeati360 – 39334TPR 6Add
BLAST
Repeati394 – 42734TPR 7Add
BLAST
Repeati429 – 46133TPR 8Add
BLAST

Sequence similaritiesi

Contains 8 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG0457.
GeneTreeiENSGT00390000013941.
InParanoidiQ04364.
OrthoDBiEOG76QFSC.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR024111. PTS1R_family.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10130. PTHR10130. 1 hit.
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
PROSITEiPS50005. TPR. 4 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04364-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEVTCSITG DNPIHKINNG LGLKWNNLGK FSDFQTNDSA ARDARTIDYI
60 70 80 90 100
FTNCQTGSSI GKIDFRAALP ADKSQHSGVS EKEFSRLENQ WSKEFSCFPK
110 120 130 140 150
NKNADVTKPS RNKHEKRSAN LHNRYFAQYY STAYQQNRIY PCRISYNEHS
160 170 180 190 200
SVSNGWEFQF KSIENQLLNE LKIENNVEEK TVGYEYVAEY EETIDFMHML
210 220 230 240 250
SSVPQTYQFL KSNIYITERD PYKIGCVLMD NGSNLNEVVM AFEAAISQDP
260 270 280 290 300
SHINAWLKLG IVNFENESES NGELALRNCL NLDPNNTIAL ENLAIHHINQ
310 320 330 340 350
QNESESLKLF HKWILSKFSK VFQPSAGENK DSINKIPKKA HLAHILESLL
360 370 380 390 400
NMGIEKKDQY DIYSVLSILY YSDQKIKQSQ KCLEFLLLEK PNNGTIWNRY
410 420 430 440 450
GAILANTKSY HSAINAYNKC KQLRPNFTRV RYNLAIAYMN KGDYVKASKM
460 470 480 490 500
LIEVILLRSK GYEHNKAKMQ NKFMQNLKNA LIASKNFDSL DLINGSHNTE
510
SLISTLKAIY NKMD
Length:514
Mass (Da):59,065
Last modified:November 1, 1997 - v1
Checksum:i8A1302220602B64A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91T → P in AAT92739 (PubMed:17322287).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49211 Genomic DNA. Translation: CAA89120.1.
AY692720 Genomic DNA. Translation: AAT92739.1.
BK006946 Genomic DNA. Translation: DAA09916.1.
PIRiS54019.
RefSeqiNP_013731.1. NM_001182514.1.

Genome annotation databases

EnsemblFungiiYMR018W; YMR018W; YMR018W.
GeneIDi855032.
KEGGisce:YMR018W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49211 Genomic DNA. Translation: CAA89120.1.
AY692720 Genomic DNA. Translation: AAT92739.1.
BK006946 Genomic DNA. Translation: DAA09916.1.
PIRiS54019.
RefSeqiNP_013731.1. NM_001182514.1.

3D structure databases

ProteinModelPortaliQ04364.
SMRiQ04364. Positions 234-461.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35189. 8 interactions.
DIPiDIP-4510N.
IntActiQ04364. 2 interactions.
MINTiMINT-490324.
STRINGi4932.YMR018W.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR018W; YMR018W; YMR018W.
GeneIDi855032.
KEGGisce:YMR018W.

Organism-specific databases

CYGDiYMR018w.
EuPathDBiFungiDB:YMR018W.
SGDiS000004620. YMR018W.

Phylogenomic databases

eggNOGiCOG0457.
GeneTreeiENSGT00390000013941.
InParanoidiQ04364.
OrthoDBiEOG76QFSC.

Enzyme and pathway databases

BioCyciYEAST:G3O-32724-MONOMER.

Miscellaneous databases

NextBioi978236.
PROiQ04364.

Gene expression databases

GenevestigatoriQ04364.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR024111. PTS1R_family.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10130. PTHR10130. 1 hit.
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
PROSITEiPS50005. TPR. 4 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Identification of PEX5p-related novel peroxisome-targeting signal 1 (PTS1)-binding proteins in mammals."
    Amery L., Sano H., Mannaerts G.P., Snider J., Van Looy J., Fransen M., Van Veldhoven P.P.
    Biochem. J. 357:635-646(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: LACK OF INVOLVEMENT IN PTS1 IMPORT.
  5. "A comprehensive two-hybrid analysis to explore the yeast protein interactome."
    Ito T., Chiba T., Ozawa R., Yoshida M., Hattori M., Sakaki Y.
    Proc. Natl. Acad. Sci. U.S.A. 98:4569-4574(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TLG1.

Entry informationi

Entry nameiYMP8_YEAST
AccessioniPrimary (citable) accession number: Q04364
Secondary accession number(s): D6VZJ2, Q6B2L0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 27, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.