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Q04341 (MIC14_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial intermembrane space cysteine motif-containing protein MIC14
Alternative name(s):
Mitochondrial intermembrane space cysteine motif-containing protein of 14 kDa
Gene names
Name:MIC14
Ordered Locus Names:YDR031W
ORF Names:YD9673.01
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length121 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Mitochondrion intermembrane space. Cytoplasm. Nucleus. Note: Imported into mitochondrion intermembrane space through the MIA pathway. Ref.3 Ref.4

Sequence similarities

Contains 2 CHCH domains.

Sequence caution

The sequence CAA98853.1 differs from that shown. Reason: Frameshift at position 117.

Ontologies

Keywords
   Cellular componentCytoplasm
Mitochondrion
Nucleus
   DomainRepeat
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaerobic respiration

Inferred from mutant phenotype PubMed 19703468. Source: SGD

   Cellular_componentmitochondrial intermembrane space

Inferred from direct assay Ref.4. Source: SGD

nucleus

Inferred from direct assay Ref.3. Source: SGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 121121Mitochondrial intermembrane space cysteine motif-containing protein MIC14
PRO_0000242621

Regions

Domain10 – 5142CHCH 1
Domain56 – 10045CHCH 2

Amino acid modifications

Disulfide bond63 ↔ 97 By similarity
Disulfide bond73 ↔ 87 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q04341 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 9502632E07FC7916

FASTA12113,866
        10         20         30         40         50         60 
MSDILDEIVI EDVVANCPQE FLQYHKCIRD NEENPGKCKD GRMILSTCIR EKVPSVKSIM 

        70         80         90        100        110        120 
SECSEPMKKY DQCIRDNMGT RTINENCLGF LQDLRKCAEL QVKNKNIKPS INGVNLELIK 


D

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. expand/collapse author list , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]"Novel mitochondrial intermembrane space proteins as substrates of the MIA import pathway."
Gabriel K., Milenkovic D., Chacinska A., Mueller J., Guiard B., Pfanner N., Meisinger C.
J. Mol. Biol. 365:612-620(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z68196 Genomic DNA. Translation: CAA92368.1.
Z74327 Genomic DNA. Translation: CAA98853.1. Frameshift.
BK006938 Genomic DNA. Translation: DAA11875.1.
PIRS67845.
RefSeqNP_010314.4. NM_001180339.3.

3D structure databases

ProteinModelPortalQ04341.
SMRQ04341. Positions 8-100.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-5131N.
IntActQ04341. 1 interaction.
MINTMINT-2928259.
STRING4932.YDR031W.

Proteomic databases

PaxDbQ04341.
PeptideAtlasQ04341.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYDR031W; YDR031W; YDR031W.
GeneID851595.
KEGGsce:YDR031W.
sce:YDR034C-D.

Organism-specific databases

CYGDYDR031w.
SGDS000002438. MIC14.

Phylogenomic databases

eggNOGNOG281388.
HOGENOMHOG000065961.
OMAYEACLKM.
OrthoDBEOG4XD71V.

Enzyme and pathway databases

ReactomeREACT_118590. Mitochondrial Protein Import (yeast).
REACT_85873. Metabolism of proteins.

Gene expression databases

GenevestigatorQ04341.
GermOnlineYDR031W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR010625. CHCH.
IPR016611. UCP013232.
[Graphical view]
PfamPF06747. CHCH. 1 hit.
[Graphical view]
PIRSFPIRSF013232. UCP013232. 1 hit.
ProtoNetSearch...

Other

NextBio969081.

Entry information

Entry nameMIC14_YEAST
AccessionPrimary (citable) accession number: Q04341
Secondary accession number(s): D6VS15, Q07789
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 1, 1996
Last modified: May 1, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome IV

Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents