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Protein

DNA-directed RNA polymerase III subunit RPC10

Gene

RPC11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Involved in Pol III transcription reinitiation and RNA cleavage during transcription termination.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri5 – 29C4-typeSequence analysisAdd BLAST25
Zinc fingeri65 – 108TFIIS-typePROSITE-ProRule annotationAdd BLAST44

GO - Molecular functioni

GO - Biological processi

  • mRNA cleavage Source: InterPro
  • termination of RNA polymerase III transcription Source: SGD
  • tRNA transcription by RNA polymerase III Source: SGD

Keywordsi

Biological processTranscription
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-29658-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase III subunit RPC10
Short name:
RNA polymerase III subunit C10
Alternative name(s):
DNA-directed RNA polymerases III 12.5 kDa polypeptide
RNA polymerase III subunit C11
Gene namesi
Name:RPC11
Ordered Locus Names:YDR045C
ORF Names:YD9609.01C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR045C
SGDiS000002452 RPC11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001214781 – 110DNA-directed RNA polymerase III subunit RPC10Add BLAST110

Proteomic databases

MaxQBiQ04307
PaxDbiQ04307
PRIDEiQ04307

Interactioni

Subunit structurei

Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.

Protein-protein interaction databases

BioGridi32100, 273 interactors
DIPiDIP-887N
IntActiQ04307, 6 interactors
MINTiQ04307
STRINGi4932.YDR045C

Structurei

Secondary structure

1110
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni6 – 8Combined sources3
Beta strandi13 – 20Combined sources8
Beta strandi22 – 25Combined sources4
Beta strandi27 – 30Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QT1X-ray4.30I85-110[»]
5FJ8electron microscopy3.90I1-110[»]
5FJ9electron microscopy4.60I1-110[»]
5FJAelectron microscopy4.65I1-110[»]
6EU0electron microscopy4.00I1-110[»]
6EU1electron microscopy3.40I1-110[»]
6EU2electron microscopy3.40I1-110[»]
6EU3electron microscopy3.30I1-110[»]
6F40electron microscopy3.70I1-110[»]
6F41electron microscopy4.30I1-110[»]
6F42electron microscopy5.50I1-110[»]
6F44electron microscopy4.20I1-110[»]
ProteinModelPortaliQ04307
SMRiQ04307
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri5 – 29C4-typeSequence analysisAdd BLAST25
Zinc fingeri65 – 108TFIIS-typePROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00550000075071
HOGENOMiHOG000228131
InParanoidiQ04307
KOiK03019
OMAiMEFCDEC
OrthoDBiEOG092C5UXV

Family and domain databases

CDDicd10509 Zn-ribbon_RPC11, 1 hit
InterProiView protein in InterPro
IPR019761 DNA-dir_RNA_pol-M_15_CS
IPR001529 DNA-dir_RNA_pol_M/15kDasu
IPR012164 Rpa12/Rpb9/Rpc10/TFS
IPR034014 Zn_ribbon_RPC11_C
IPR001222 Znf_TFIIS
PfamiView protein in Pfam
PF02150 RNA_POL_M_15KD, 1 hit
PF01096 TFIIS_C, 1 hit
PIRSFiPIRSF005586 RNApol_RpoM, 1 hit
SMARTiView protein in SMART
SM00661 RPOL9, 1 hit
SM00440 ZnF_C2C2, 1 hit
PROSITEiView protein in PROSITE
PS01030 RNA_POL_M_15KD, 1 hit
PS51133 ZF_TFIIS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q04307-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSFCPSCNN MLLITSGDSG VYTLACRSCP YEFPIEGIEI YDRKKLPRKE
60 70 80 90 100
VDDVLGGGWD NVDQTKTQCP NYDTCGGESA YFFQLQIRSA DEPMTTFYKC
110
VNCGHRWKEN
Length:110
Mass (Da):12,513
Last modified:November 1, 1996 - v1
Checksum:iE4AA802EC9F92230
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF108188 Genomic DNA Translation: AAD12060.1
Z49209 Genomic DNA Translation: CAA89076.1
AY557636 Genomic DNA Translation: AAS55962.1
AY899253 mRNA Translation: AAX83938.1
BK006938 Genomic DNA Translation: DAA11893.1
PIRiS54031
RefSeqiNP_010330.1, NM_001180353.1

Genome annotation databases

EnsemblFungiiYDR045C; YDR045C; YDR045C
GeneIDi851615
KEGGisce:YDR045C

Similar proteinsi

Entry informationi

Entry nameiRPC10_YEAST
AccessioniPrimary (citable) accession number: Q04307
Secondary accession number(s): D6VS33, Q2VQW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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