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Q04305

- UTP15_YEAST

UniProt

Q04305 - UTP15_YEAST

Protein

U3 small nucleolar RNA-associated protein 15

Gene

UTP15

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs).2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. snoRNA binding Source: SGD

    GO - Biological processi

    1. maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
    2. positive regulation of transcription from RNA polymerase I promoter Source: SGD
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    Ribosome biogenesis, rRNA processing, Transcription

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32793-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    U3 small nucleolar RNA-associated protein 15
    Short name:
    U3 snoRNA-associated protein 15
    Alternative name(s):
    U three protein 15
    U3 protein 15 required for transcription
    t-UTP15
    Gene namesi
    Name:UTP15
    Ordered Locus Names:YMR093W
    ORF Names:YM9582.18
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYMR093w.
    SGDiS000004699. UTP15.

    Subcellular locationi

    Nucleusnucleolus 2 Publications
    Note: Associated with ribosomal chromatin, even in the absence of transcription.

    GO - Cellular componenti

    1. nucleolus Source: SGD
    2. rDNA heterochromatin Source: SGD
    3. small-subunit processome Source: SGD
    4. t-UTP complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 513513U3 small nucleolar RNA-associated protein 15PRO_0000051328Add
    BLAST

    Proteomic databases

    MaxQBiQ04305.
    PaxDbiQ04305.
    PeptideAtlasiQ04305.

    Expressioni

    Gene expression databases

    GenevestigatoriQ04305.

    Interactioni

    Subunit structurei

    Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. In the absence of snoRNA3, forms a complex with other t-UTPs. This complex can associate with pre-18S ribosomal RNAs.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    UTP8P532764EBI-28183,EBI-23301
    UTP9P388824EBI-28183,EBI-24892

    Protein-protein interaction databases

    BioGridi35268. 77 interactions.
    DIPiDIP-1962N.
    IntActiQ04305. 35 interactions.
    MINTiMINT-406079.
    STRINGi4932.YMR093W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04305.
    SMRiQ04305. Positions 32-365.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati37 – 7842WD 1Add
    BLAST
    Repeati79 – 11840WD 2Add
    BLAST
    Repeati124 – 16239WD 3Add
    BLAST
    Repeati166 – 20641WD 4Add
    BLAST
    Repeati210 – 24738WD 5Add
    BLAST
    Repeati250 – 29445WD 6Add
    BLAST

    Sequence similaritiesi

    Contains 6 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    GeneTreeiENSGT00390000004228.
    HOGENOMiHOG000185028.
    KOiK14549.
    OMAiQFEGHTK.
    OrthoDBiEOG7K6Q48.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR018983. U3_snoRNA-assocProt_15_C.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF09384. UTP15_C. 1 hit.
    PF00400. WD40. 2 hits.
    [Graphical view]
    SMARTiSM00320. WD40. 6 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 2 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04305-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTARPRIIT SKAPLLPQQT TPEQRYWRQY TSAQLVKEHN SVTHISFNPQ    50
    HPHDFAVTSS TRVQIFSSRT RQVIKTFSRF KDVVYSASFR SDGKLLCAGD 100
    ATGLVSVYDS YNPRTILLSI NASTHPTHVT KFHTQDNKIL ATASDDRVTR 150
    LWDISNAYEP QLELTGATDY VRTLSFIPAA PHLVATGSYD GLIRLYDTRS 200
    SGSTPIYSLN HDQPVENVIA VSPTQIVSCG GNNFKVWDLT SNKKLYERGN 250
    FNKAVTCLDY VENFDSPMQS ALIASSLDGH VKVFDPLDNF QVKFGWKFSG 300
    PVLSCAVSPS TAQGNRHLVA GLSSGLLAIR TKKKEKRSSD KENAPASFNK 350
    NAKSNNFQRM MRGSEYQGDQ EHIIHNDKVR SQRRMRAFER NINQFKWSEA 400
    LDNAFVPGMA KELTLTVLQE LRKRGKVRVA LYGRDESTLE PLLNWCLKGI 450
    EDVRSASIVA DWVAVVLELY GNTLESSPVL QELMIDLKTK VRHEIHKSKE 500
    AQRIEGMLQL LTS 513
    Length:513
    Mass (Da):57,686
    Last modified:November 1, 1997 - v1
    Checksum:i2B74BA8BD496C8DA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49259 Genomic DNA. Translation: CAA89240.1.
    BK006946 Genomic DNA. Translation: DAA09990.1.
    PIRiS54469.
    RefSeqiNP_013811.1. NM_001182593.1.

    Genome annotation databases

    EnsemblFungiiYMR093W; YMR093W; YMR093W.
    GeneIDi855118.
    KEGGisce:YMR093W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49259 Genomic DNA. Translation: CAA89240.1 .
    BK006946 Genomic DNA. Translation: DAA09990.1 .
    PIRi S54469.
    RefSeqi NP_013811.1. NM_001182593.1.

    3D structure databases

    ProteinModelPortali Q04305.
    SMRi Q04305. Positions 32-365.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35268. 77 interactions.
    DIPi DIP-1962N.
    IntActi Q04305. 35 interactions.
    MINTi MINT-406079.
    STRINGi 4932.YMR093W.

    Proteomic databases

    MaxQBi Q04305.
    PaxDbi Q04305.
    PeptideAtlasi Q04305.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YMR093W ; YMR093W ; YMR093W .
    GeneIDi 855118.
    KEGGi sce:YMR093W.

    Organism-specific databases

    CYGDi YMR093w.
    SGDi S000004699. UTP15.

    Phylogenomic databases

    eggNOGi COG2319.
    GeneTreei ENSGT00390000004228.
    HOGENOMi HOG000185028.
    KOi K14549.
    OMAi QFEGHTK.
    OrthoDBi EOG7K6Q48.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32793-MONOMER.

    Miscellaneous databases

    NextBioi 978467.
    PROi Q04305.

    Gene expression databases

    Genevestigatori Q04305.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR018983. U3_snoRNA-assocProt_15_C.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF09384. UTP15_C. 1 hit.
    PF00400. WD40. 2 hits.
    [Graphical view ]
    SMARTi SM00320. WD40. 6 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 2 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: FUNCTION, INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU PROCESSOME BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components."
      Gallagher J.E.G., Dunbar D.A., Granneman S., Mitchell B.M., Osheim Y., Beyer A.L., Baserga S.J.
      Genes Dev. 18:2506-2517(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN COMPLEX WITH OTHER T-UTPS, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiUTP15_YEAST
    AccessioniPrimary (citable) accession number: Q04305
    Secondary accession number(s): D6VZR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 358 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3