Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q04305

- UTP15_YEAST

UniProt

Q04305 - UTP15_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

U3 small nucleolar RNA-associated protein 15

Gene

UTP15

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs).2 Publications

GO - Molecular functioni

  1. snoRNA binding Source: SGD

GO - Biological processi

  1. maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  2. positive regulation of transcription from RNA polymerase I promoter Source: SGD
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing, Transcription

Enzyme and pathway databases

BioCyciYEAST:G3O-32793-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 15
Short name:
U3 snoRNA-associated protein 15
Alternative name(s):
U three protein 15
U3 protein 15 required for transcription
t-UTP15
Gene namesi
Name:UTP15
Ordered Locus Names:YMR093W
ORF Names:YM9582.18
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR093w.
SGDiS000004699. UTP15.

Subcellular locationi

Nucleusnucleolus 2 Publications
Note: Associated with ribosomal chromatin, even in the absence of transcription.

GO - Cellular componenti

  1. nucleolus Source: SGD
  2. rDNA heterochromatin Source: SGD
  3. small-subunit processome Source: SGD
  4. t-UTP complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513U3 small nucleolar RNA-associated protein 15PRO_0000051328Add
BLAST

Proteomic databases

MaxQBiQ04305.
PaxDbiQ04305.
PeptideAtlasiQ04305.

Expressioni

Gene expression databases

GenevestigatoriQ04305.

Interactioni

Subunit structurei

Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. In the absence of snoRNA3, forms a complex with other t-UTPs. This complex can associate with pre-18S ribosomal RNAs.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
UTP8P532764EBI-28183,EBI-23301
UTP9P388824EBI-28183,EBI-24892

Protein-protein interaction databases

BioGridi35268. 78 interactions.
DIPiDIP-1962N.
IntActiQ04305. 35 interactions.
MINTiMINT-406079.
STRINGi4932.YMR093W.

Structurei

3D structure databases

ProteinModelPortaliQ04305.
SMRiQ04305. Positions 32-365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati37 – 7842WD 1Add
BLAST
Repeati79 – 11840WD 2Add
BLAST
Repeati124 – 16239WD 3Add
BLAST
Repeati166 – 20641WD 4Add
BLAST
Repeati210 – 24738WD 5Add
BLAST
Repeati250 – 29445WD 6Add
BLAST

Sequence similaritiesi

Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00390000004228.
HOGENOMiHOG000185028.
InParanoidiQ04305.
KOiK14549.
OMAiQFEGHTK.
OrthoDBiEOG7K6Q48.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR018983. U3_snoRNA-assocProt_15_C.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF09384. UTP15_C. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04305-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTARPRIIT SKAPLLPQQT TPEQRYWRQY TSAQLVKEHN SVTHISFNPQ
60 70 80 90 100
HPHDFAVTSS TRVQIFSSRT RQVIKTFSRF KDVVYSASFR SDGKLLCAGD
110 120 130 140 150
ATGLVSVYDS YNPRTILLSI NASTHPTHVT KFHTQDNKIL ATASDDRVTR
160 170 180 190 200
LWDISNAYEP QLELTGATDY VRTLSFIPAA PHLVATGSYD GLIRLYDTRS
210 220 230 240 250
SGSTPIYSLN HDQPVENVIA VSPTQIVSCG GNNFKVWDLT SNKKLYERGN
260 270 280 290 300
FNKAVTCLDY VENFDSPMQS ALIASSLDGH VKVFDPLDNF QVKFGWKFSG
310 320 330 340 350
PVLSCAVSPS TAQGNRHLVA GLSSGLLAIR TKKKEKRSSD KENAPASFNK
360 370 380 390 400
NAKSNNFQRM MRGSEYQGDQ EHIIHNDKVR SQRRMRAFER NINQFKWSEA
410 420 430 440 450
LDNAFVPGMA KELTLTVLQE LRKRGKVRVA LYGRDESTLE PLLNWCLKGI
460 470 480 490 500
EDVRSASIVA DWVAVVLELY GNTLESSPVL QELMIDLKTK VRHEIHKSKE
510
AQRIEGMLQL LTS
Length:513
Mass (Da):57,686
Last modified:November 1, 1997 - v1
Checksum:i2B74BA8BD496C8DA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49259 Genomic DNA. Translation: CAA89240.1.
BK006946 Genomic DNA. Translation: DAA09990.1.
PIRiS54469.
RefSeqiNP_013811.1. NM_001182593.1.

Genome annotation databases

EnsemblFungiiYMR093W; YMR093W; YMR093W.
GeneIDi855118.
KEGGisce:YMR093W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49259 Genomic DNA. Translation: CAA89240.1 .
BK006946 Genomic DNA. Translation: DAA09990.1 .
PIRi S54469.
RefSeqi NP_013811.1. NM_001182593.1.

3D structure databases

ProteinModelPortali Q04305.
SMRi Q04305. Positions 32-365.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35268. 78 interactions.
DIPi DIP-1962N.
IntActi Q04305. 35 interactions.
MINTi MINT-406079.
STRINGi 4932.YMR093W.

Proteomic databases

MaxQBi Q04305.
PaxDbi Q04305.
PeptideAtlasi Q04305.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR093W ; YMR093W ; YMR093W .
GeneIDi 855118.
KEGGi sce:YMR093W.

Organism-specific databases

CYGDi YMR093w.
SGDi S000004699. UTP15.

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00390000004228.
HOGENOMi HOG000185028.
InParanoidi Q04305.
KOi K14549.
OMAi QFEGHTK.
OrthoDBi EOG7K6Q48.

Enzyme and pathway databases

BioCyci YEAST:G3O-32793-MONOMER.

Miscellaneous databases

NextBioi 978467.
PROi Q04305.

Gene expression databases

Genevestigatori Q04305.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR018983. U3_snoRNA-assocProt_15_C.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF09384. UTP15_C. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view ]
SMARTi SM00320. WD40. 6 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: FUNCTION, INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU PROCESSOME BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components."
    Gallagher J.E.G., Dunbar D.A., Granneman S., Mitchell B.M., Osheim Y., Beyer A.L., Baserga S.J.
    Genes Dev. 18:2506-2517(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN COMPLEX WITH OTHER T-UTPS, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiUTP15_YEAST
AccessioniPrimary (citable) accession number: Q04305
Secondary accession number(s): D6VZR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 358 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3