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Q04305 (UTP15_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
U3 small nucleolar RNA-associated protein 15

Short name=U3 snoRNA-associated protein 15
Alternative name(s):
U three protein 15
U3 protein 15 required for transcription
t-UTP15
Gene names
Name:UTP15
Ordered Locus Names:YMR093W
ORF Names:YM9582.18
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs). Ref.3 Ref.5

Subunit structure

Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. In the absence of snoRNA3, forms a complex with other t-UTPs. This complex can associate with pre-18S ribosomal RNAs. Ref.3 Ref.5

Subcellular location

Nucleusnucleolus. Note: Associated with ribosomal chromatin, even in the absence of transcription. Ref.3 Ref.5

Miscellaneous

Present with 358 molecules/cell in log phase SD medium.

Sequence similarities

Contains 6 WD repeats.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

UTP8P532764EBI-28183,EBI-23301
UTP9P388824EBI-28183,EBI-24892

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 513513U3 small nucleolar RNA-associated protein 15
PRO_0000051328

Regions

Repeat37 – 7842WD 1
Repeat79 – 11840WD 2
Repeat124 – 16239WD 3
Repeat166 – 20641WD 4
Repeat210 – 24738WD 5
Repeat250 – 29445WD 6

Sequences

Sequence LengthMass (Da)Tools
Q04305 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 2B74BA8BD496C8DA

FASTA51357,686
        10         20         30         40         50         60 
MSTARPRIIT SKAPLLPQQT TPEQRYWRQY TSAQLVKEHN SVTHISFNPQ HPHDFAVTSS 

        70         80         90        100        110        120 
TRVQIFSSRT RQVIKTFSRF KDVVYSASFR SDGKLLCAGD ATGLVSVYDS YNPRTILLSI 

       130        140        150        160        170        180 
NASTHPTHVT KFHTQDNKIL ATASDDRVTR LWDISNAYEP QLELTGATDY VRTLSFIPAA 

       190        200        210        220        230        240 
PHLVATGSYD GLIRLYDTRS SGSTPIYSLN HDQPVENVIA VSPTQIVSCG GNNFKVWDLT 

       250        260        270        280        290        300 
SNKKLYERGN FNKAVTCLDY VENFDSPMQS ALIASSLDGH VKVFDPLDNF QVKFGWKFSG 

       310        320        330        340        350        360 
PVLSCAVSPS TAQGNRHLVA GLSSGLLAIR TKKKEKRSSD KENAPASFNK NAKSNNFQRM 

       370        380        390        400        410        420 
MRGSEYQGDQ EHIIHNDKVR SQRRMRAFER NINQFKWSEA LDNAFVPGMA KELTLTVLQE 

       430        440        450        460        470        480 
LRKRGKVRVA LYGRDESTLE PLLNWCLKGI EDVRSASIVA DWVAVVLELY GNTLESSPVL 

       490        500        510 
QELMIDLKTK VRHEIHKSKE AQRIEGMLQL LTS 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis."
Dragon F., Gallagher J.E.G., Compagnone-Post P.A., Mitchell B.M., Porwancher K.A., Wehner K.A., Wormsley S., Settlage R.E., Shabanowitz J., Osheim Y., Beyer A.L., Hunt D.F., Baserga S.J.
Nature 417:967-970(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU PROCESSOME BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components."
Gallagher J.E.G., Dunbar D.A., Granneman S., Mitchell B.M., Osheim Y., Beyer A.L., Baserga S.J.
Genes Dev. 18:2506-2517(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, IDENTIFICATION IN COMPLEX WITH OTHER T-UTPS, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z49259 Genomic DNA. Translation: CAA89240.1.
BK006946 Genomic DNA. Translation: DAA09990.1.
PIRS54469.
RefSeqNP_013811.1. NM_001182593.1.

3D structure databases

ProteinModelPortalQ04305.
SMRQ04305. Positions 32-365.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35268. 77 interactions.
DIPDIP-1962N.
IntActQ04305. 35 interactions.
MINTMINT-406079.
STRING4932.YMR093W.

Proteomic databases

PaxDbQ04305.
PeptideAtlasQ04305.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYMR093W; YMR093W; YMR093W.
GeneID855118.
KEGGsce:YMR093W.

Organism-specific databases

CYGDYMR093w.
SGDS000004699. UTP15.

Phylogenomic databases

eggNOGCOG2319.
GeneTreeENSGT00390000004228.
HOGENOMHOG000185028.
KOK14549.
OMAQFEGHTK.
OrthoDBEOG7K6Q48.

Enzyme and pathway databases

BioCycYEAST:G3O-32793-MONOMER.

Gene expression databases

GenevestigatorQ04305.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
InterProIPR018983. U3_snoRNA-assocProt_15_C.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF09384. UTP15_C. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
PROSITEPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio978467.
PROQ04305.

Entry information

Entry nameUTP15_YEAST
AccessionPrimary (citable) accession number: Q04305
Secondary accession number(s): D6VZR6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families