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Protein

dTDP-glucose 4,6-dehydratase

Gene

LGAS_1136

Organism
Lactobacillus gasseri (strain ATCC 33323 / DSM 20243 / JCM 1131 / NCIMB 11718 / AM63)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O.UniRule annotation

Cofactori

NAD(+)UniRule annotation

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. dTDP-glucose 4,6-dehydratase activity Source: UniProtKB-EC

GO - Biological processi

  1. nucleotide-sugar metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported

Enzyme and pathway databases

BioCyciLGAS324831:GHTY-1136-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
dTDP-glucose 4,6-dehydrataseUniRule annotation (EC:4.2.1.46UniRule annotation)
Gene namesi
Ordered Locus Names:LGAS_1136Imported
OrganismiLactobacillus gasseri (strain ATCC 33323 / DSM 20243 / JCM 1131 / NCIMB 11718 / AM63)Imported
Taxonomic identifieri324831 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000664: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi324831.LGAS_1136.

Structurei

3D structure databases

ProteinModelPortaliQ042W5.
SMRiQ042W5. Positions 15-341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1088.
HOGENOMiHOG000168006.
KOiK01710.
OMAiHSSAVWA.
OrthoDBiEOG6PZXCX.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR005888. dTDP_Gluc_deHydtase.
IPR001509. Epimerase_deHydtase_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR10366:SF41. PTHR10366:SF41. 1 hit.
PfamiPF01370. Epimerase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01181. dTDP_gluc_dehyt. 1 hit.

Sequencei

Sequence statusi: Complete.

Q042W5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYTSYELKN IWRNNMKVIV TGGAGFIGSN FIFYMLKKHP DYEIICLDSL
60 70 80 90 100
TYAGNLSTLK DVMDNPNFKF VKLDIRDREG VYKLFEEEKP DVVVNFAAES
110 120 130 140 150
HVDRSIENPE IFLETNIIGT SVLMDACRKY GIKRFHQVST DEVYGDLPLD
160 170 180 190 200
RPDLFFHEDT PLHTSSPYSS SKASADLLVG AYGRTFHLPV TISRCSNNYG
210 220 230 240 250
PYQFPEKLIP LMIQRALNNE KLPVYGDGKN VRDWLYVEDH CKAIDLILEK
260 270 280 290 300
GTPGEVYNIG GHNEMHNIDI VKLICDYLDK PYSLIEHVTD RKGHDRRYAI
310 320 330 340 350
DPEKIHNELG WLPETMFKDG IKKTIQWYLD NKEWWENIIS GDYQNYYDEM
360
YGKKQVLDKD
Length:360
Mass (Da):41,842
Last modified:November 14, 2006 - v1
Checksum:i78BE1D55D1DA9860
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000413 Genomic DNA. Translation: ABJ60507.1.
RefSeqiWP_003648672.1. NC_008530.1.
YP_814945.1. NC_008530.1.

Genome annotation databases

EnsemblBacteriaiABJ60507; ABJ60507; LGAS_1136.
GeneIDi4439634.
KEGGilga:LGAS_1136.
PATRICi22230436. VBILacGas62225_1125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000413 Genomic DNA. Translation: ABJ60507.1.
RefSeqiWP_003648672.1. NC_008530.1.
YP_814945.1. NC_008530.1.

3D structure databases

ProteinModelPortaliQ042W5.
SMRiQ042W5. Positions 15-341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi324831.LGAS_1136.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ60507; ABJ60507; LGAS_1136.
GeneIDi4439634.
KEGGilga:LGAS_1136.
PATRICi22230436. VBILacGas62225_1125.

Phylogenomic databases

eggNOGiCOG1088.
HOGENOMiHOG000168006.
KOiK01710.
OMAiHSSAVWA.
OrthoDBiEOG6PZXCX.

Enzyme and pathway databases

BioCyciLGAS324831:GHTY-1136-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR005888. dTDP_Gluc_deHydtase.
IPR001509. Epimerase_deHydtase_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR10366:SF41. PTHR10366:SF41. 1 hit.
PfamiPF01370. Epimerase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01181. dTDP_gluc_dehyt. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33323 / DSM 20243 / JCM 1131 / NCIMB 11718 / AM63Imported.

Entry informationi

Entry nameiQ042W5_LACGA
AccessioniPrimary (citable) accession number: Q042W5
Entry historyi
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: March 4, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.