Q042W5 (Q042W5_LACGA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
dTDP-glucose 4,6-dehydratase RuleBase RU004473
EC=4.2.1.46 RuleBase RU004473

Gene names

Ordered Locus Names:

LGAS_1136

Organism

Lactobacillus gasseri (strain ATCC 33323 / DSM 20243) [Complete proteome] [HAMAP] EMBL ABJ60507.1

Taxonomic identifier

324831 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Lactobacillaceae › Lactobacillus › Lactobacillus gasseri

Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O. RuleBase RU004473
Cofactor	NAD By similarity. RuleBase RU004473
Sequence similarities	Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily. RuleBase RU004473

Ontologies

Keywords
Molecular function	Lyase RuleBase RU004473 EMBL ABJ60507.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	nucleotide-sugar metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	coenzyme binding Inferred from electronic annotation. Source: InterPro dTDP-glucose 4,6-dehydratase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q042W5 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: 78BE1D55D1DA9860	FASTA	360	41,842
	10 20 30 40 50 60 MLYTSYELKN IWRNNMKVIV TGGAGFIGSN FIFYMLKKHP DYEIICLDSL TYAGNLSTLK 70 80 90 100 110 120 DVMDNPNFKF VKLDIRDREG VYKLFEEEKP DVVVNFAAES HVDRSIENPE IFLETNIIGT 130 140 150 160 170 180 SVLMDACRKY GIKRFHQVST DEVYGDLPLD RPDLFFHEDT PLHTSSPYSS SKASADLLVG 190 200 210 220 230 240 AYGRTFHLPV TISRCSNNYG PYQFPEKLIP LMIQRALNNE KLPVYGDGKN VRDWLYVEDH 250 260 270 280 290 300 CKAIDLILEK GTPGEVYNIG GHNEMHNIDI VKLICDYLDK PYSLIEHVTD RKGHDRRYAI 310 320 330 340 350 360 DPEKIHNELG WLPETMFKDG IKKTIQWYLD NKEWWENIIS GDYQNYYDEM YGKKQVLDKD

References

[1]

"Comparative genomics of the lactic acid bacteria." Makarova K., Slesarev A., Wolf Y., Sorokin A., Mirkin B., Koonin E., Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V., Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M., Hawkins T. , Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A., Baldwin K., Lee J.H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W., Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y., Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J., Hutkins R., O'Sullivan D., Steele J., Unlu G., Saier M., Klaenhammer T., Richardson P., Kozyavkin S., Weimer B., Mills D. Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33323 / DSM 20243.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000413 Genomic DNA. Translation: ABJ60507.1.
RefSeq	YP_814945.1. NC_008530.1.
3D structure databases
ProteinModelPortal	Q042W5.
SMR	Q042W5. Positions 15-341.
ModBase	Search...
Protein-protein interaction databases
STRING	324831.LGAS_1136.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABJ60507; ABJ60507; LGAS_1136.
GeneID	4439634.
KEGG	lga:LGAS_1136.
PATRIC	22230436. VBILacGas62225_1125.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1088.
HOGENOM	HOG000168006.
KO	K01710.
OMA	FLETNII.
ProtClustDB	CLSK2522321.
Enzyme and pathway databases
BioCyc	LGAS324831:GHTY-1211-MONOMER.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR005888. dTDP_Gluc_deHydtase. IPR001509. Epimerase_deHydtase. IPR016040. NAD(P)-bd_dom. [Graphical view]
PANTHER	PTHR10366:SF41. PTHR10366:SF41. 1 hit.
Pfam	PF01370. Epimerase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01181. dTDP_gluc_dehyt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q042W5_LACGA

Accession

Primary (citable) accession number: Q042W5

Entry history

Integrated into UniProtKB/TrEMBL:	November 14, 2006
Last sequence update:	November 14, 2006
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)