Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Lactobacillus gasseri (strain ATCC 33323 / DSM 20243 / JCM 1131 / NCIMB 11718 / AM63)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei288Proton donorUniRule annotation1
Active sitei309UniRule annotation1
Active sitei423UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181
UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:LGAS_1256
OrganismiLactobacillus gasseri (strain ATCC 33323 / DSM 20243 / JCM 1131 / NCIMB 11718 / AM63)
Taxonomic identifieri324831 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000139791 – 447Glucose-6-phosphate isomeraseAdd BLAST447

Structurei

3D structure databases

ProteinModelPortaliQ042K0
SMRiQ042K0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QYV Bacteria
COG0166 LUCA
HOGENOMiHOG000100403
KOiK01810
OMAiVERCKAM

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q042K0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKVVHFDAS KLTPFVHENE LKEMQAMVTA ADQELREGTG AGSDFRGWID
60 70 80 90 100
LPINYDKDEF DRIKKAAKKI QNDSEVLVGI GIGGSYLGAQ ASIEFLNSSF
110 120 130 140 150
YGREKEKYPT VVFCGNSLSG SYLYDLLEWL GDKDFSINII SKSGTTTEPS
160 170 180 190 200
IAFRVLKDKL IKKYGKEEAA KRIYATTDRA KGALKTEADA EGYEEFVVPD
210 220 230 240 250
DIGGRFSVLS AVGLLPIAVA GGDIDAMMKG AADARAAYTD PDVSKDNPYQ
260 270 280 290 300
YAALRNILYR KGYTTELLEN YEPSLRMFGE WWKQLMGESE GKDQKGIYPS
310 320 330 340 350
SANFTTDLHS LGQYIQEGRR NLMETVIRVE SPEHDVTIPD DKENLDQLNF
360 370 380 390 400
LSGKTMNYVN DRAYEGVVLA HTDGGVPVMT VDIENQSAHT LGYLIYWFEL
410 420 430 440
AVGISGYLNG INPFNQPGVE SYKRNMFGLL NKPGYEDLHD DLTKRLK
Length:447
Mass (Da):49,857
Last modified:November 14, 2006 - v1
Checksum:i057047AA3002205C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000413 Genomic DNA Translation: ABJ60622.1
RefSeqiWP_003647059.1, NZ_BALQ01000002.1

Genome annotation databases

EnsemblBacteriaiABJ60622; ABJ60622; LGAS_1256
GeneIDi29638653
KEGGilga:LGAS_1256

Similar proteinsi

Entry informationi

Entry nameiG6PI_LACGA
AccessioniPrimary (citable) accession number: Q042K0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: March 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health