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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Lactobacillus gasseri (strain ATCC 33323 / DSM 20243 / JCM 1131 / NCIMB 11718 / AM63)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei288 – 2881Proton donorUniRule annotation
Active sitei309 – 3091UniRule annotation
Active sitei423 – 4231UniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciLGAS324831:GHTY-1256-MONOMER.
UniPathwayiUPA00109; UER00181.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:LGAS_1256
OrganismiLactobacillus gasseri (strain ATCC 33323 / DSM 20243 / JCM 1131 / NCIMB 11718 / AM63)
Taxonomic identifieri324831 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000664: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447Glucose-6-phosphate isomerasePRO_1000013979Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi324831.LGAS_1256.

Structurei

3D structure databases

ProteinModelPortaliQ042K0.
SMRiQ042K0. Positions 5-446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000100403.
KOiK01810.
OMAiSFIIPDD.
OrthoDBiEOG64R61J.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q042K0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKVVHFDAS KLTPFVHENE LKEMQAMVTA ADQELREGTG AGSDFRGWID
60 70 80 90 100
LPINYDKDEF DRIKKAAKKI QNDSEVLVGI GIGGSYLGAQ ASIEFLNSSF
110 120 130 140 150
YGREKEKYPT VVFCGNSLSG SYLYDLLEWL GDKDFSINII SKSGTTTEPS
160 170 180 190 200
IAFRVLKDKL IKKYGKEEAA KRIYATTDRA KGALKTEADA EGYEEFVVPD
210 220 230 240 250
DIGGRFSVLS AVGLLPIAVA GGDIDAMMKG AADARAAYTD PDVSKDNPYQ
260 270 280 290 300
YAALRNILYR KGYTTELLEN YEPSLRMFGE WWKQLMGESE GKDQKGIYPS
310 320 330 340 350
SANFTTDLHS LGQYIQEGRR NLMETVIRVE SPEHDVTIPD DKENLDQLNF
360 370 380 390 400
LSGKTMNYVN DRAYEGVVLA HTDGGVPVMT VDIENQSAHT LGYLIYWFEL
410 420 430 440
AVGISGYLNG INPFNQPGVE SYKRNMFGLL NKPGYEDLHD DLTKRLK
Length:447
Mass (Da):49,857
Last modified:November 14, 2006 - v1
Checksum:i057047AA3002205C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000413 Genomic DNA. Translation: ABJ60622.1.
RefSeqiYP_815060.1. NC_008530.1.

Genome annotation databases

EnsemblBacteriaiABJ60622; ABJ60622; LGAS_1256.
GeneIDi4439546.
KEGGilga:LGAS_1256.
PATRICi22230683. VBILacGas62225_1246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000413 Genomic DNA. Translation: ABJ60622.1.
RefSeqiYP_815060.1. NC_008530.1.

3D structure databases

ProteinModelPortaliQ042K0.
SMRiQ042K0. Positions 5-446.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi324831.LGAS_1256.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ60622; ABJ60622; LGAS_1256.
GeneIDi4439546.
KEGGilga:LGAS_1256.
PATRICi22230683. VBILacGas62225_1246.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000100403.
KOiK01810.
OMAiSFIIPDD.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
UPA00138.
BioCyciLGAS324831:GHTY-1256-MONOMER.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33323 / DSM 20243 / JCM 1131 / NCIMB 11718 / AM63.

Entry informationi

Entry nameiG6PI_LACGA
AccessioniPrimary (citable) accession number: Q042K0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: January 7, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.