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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Lactobacillus gasseri (strain ATCC 33323 / DSM 20243 / JCM 1131 / NCIMB 11718 / AM63)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. no protein annotated in this organism
  4. Enolase 1 (eno1), Enolase 2 (eno2)
  5. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36SubstrateUniRule annotation1
Binding sitei119SubstrateUniRule annotation1
Binding sitei159SubstrateUniRule annotation1
Binding sitei214ATPUniRule annotation1
Binding sitei301ATP; via carbonyl oxygenUniRule annotation1
Binding sitei332ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi359 – 362ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:LGAS_1307
OrganismiLactobacillus gasseri (strain ATCC 33323 / DSM 20243 / JCM 1131 / NCIMB 11718 / AM63)
Taxonomic identifieri324831 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000096221 – 403Phosphoglycerate kinaseAdd BLAST403

Proteomic databases

PRIDEiQ042F2

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ042F2
SMRiQ042F2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 23Substrate bindingUniRule annotation3
Regioni59 – 62Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
HOGENOMiHOG000227108
KOiK00927
OMAiDMIFDIG

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 2 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q042F2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLIVSDLD LKGKKVLVRV DFNVPIKNGV IGDDNRIVAA LPTIKYIIEH
60 70 80 90 100
GGKAILLSHL GRVKSDADKK ELSLRPVAER LSELLKKPVT FVPENEGKEV
110 120 130 140 150
EETIDKMKDG DVIVLENTRF QDIDNDFGKR ESKNDPKLGE YWASLGDVFV
160 170 180 190 200
NDAFGTAHRS HASNVGIATA MKKAGKPAAA GFLLEKEIKF LGDAVENPVH
210 220 230 240 250
PFVTILGGAK VSDKIGVIEN LIPKSDHILI GGGMAYTFLA AQGHKIGKSL
260 270 280 290 300
FEADKVELAK ELLAKAGDKI VLPVDNVAAT EFSNDAPHEV VGDDIPDNEM
310 320 330 340 350
GLDIGPKTVE KFRDILKDAK TVVWNGPMGA FEMPNYAEGT LEVGRALADL
360 370 380 390 400
KDAVTIIGGG DSTAAAKQLG IAPKISHIST GGGASLNYLE GKELPGIACV

SDK
Length:403
Mass (Da):43,043
Last modified:November 14, 2006 - v1
Checksum:iABE1068F1CFDCE44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000413 Genomic DNA Translation: ABJ60670.1
RefSeqiWP_003647013.1, NZ_BALQ01000002.1

Genome annotation databases

EnsemblBacteriaiABJ60670; ABJ60670; LGAS_1307
GeneIDi29639293
KEGGilga:LGAS_1307

Similar proteinsi

Entry informationi

Entry nameiPGK_LACGA
AccessioniPrimary (citable) accession number: Q042F2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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