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Q042A7 (PPNK_LACGA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable inorganic polyphosphate/ATP-NAD kinase

Short name=Poly(P)/ATP NAD kinase
EC=2.7.1.23
Gene names
Name:ppnK
Ordered Locus Names:LGAS_1353
OrganismLactobacillus gasseri (strain ATCC 33323 / DSM 20243) [Complete proteome] [HAMAP]
Taxonomic identifier324831 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267Probable inorganic polyphosphate/ATP-NAD kinase HAMAP-Rule MF_00361
PRO_1000005417

Sequences

Sequence LengthMass (Da)Tools
Q042A7 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: BE844344E91E927D

FASTA26730,356
        10         20         30         40         50         60 
MKVALVYNEK VETLAVVKAL EKLLDSRKIE IDPENPDVVI TIGGDGTLIS GFHKYQNLVD 

        70         80         90        100        110        120 
QIRFIGVHTG HLGFYTDWRN FEIGKMVDNL TKKQPSSASY PLLELIITTG SGEKKKLLAL 

       130        140        150        160        170        180 
NEATIKRVSK TLKADVYIRD QFFESFKGDG LCVSTPTGST AYSKSLGGAV IHPRLKALQM 

       190        200        210        220        230        240 
TEIASINNRV FRTLSSPIVI APDEWITIKP ESDDHYVVTY DGYEFNHKHI KKIEYRISQH 

       250        260 
VIRFDKYQHT HFWNRVEDAF IGQPKNK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000413 Genomic DNA. Translation: ABJ60715.1.
RefSeqYP_815153.1. NC_008530.1.

3D structure databases

ProteinModelPortalQ042A7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING324831.LGAS_1353.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ60715; ABJ60715; LGAS_1353.
GeneID4439439.
KEGGlga:LGAS_1353.
PATRIC22230877. VBILacGas62225_1342.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000275803.
KOK00858.
OMAWDRVEDA.
OrthoDBEOG6PZXDR.
ProtClustDBPRK04885.

Enzyme and pathway databases

BioCycLGAS324831:GHTY-1353-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK_prd.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry namePPNK_LACGA
AccessionPrimary (citable) accession number: Q042A7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families