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Q04279

- SEG1_YEAST

UniProt

Q04279 - SEG1_YEAST

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Protein
Eisosome protein SEG1
Gene
SEG1, YMR086W, YM9582.10
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Important for the biogenesis of eisosomes, large cytoplasmic protein assemblies that localize to specialized domains on the plasma membrane to cluster specific proteins at sites of membrane invaginations. Required for efficient incorporation of the eisosome component PIL1 into eisosomes.

GO - Biological processi

  1. eisosome assembly Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-32786-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Eisosome protein SEG1
Alternative name(s):
Stability of eisosomes guaranteed protein 1
Gene namesi
Name:SEG1
Ordered Locus Names:YMR086W
ORF Names:YM9582.10
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR086w.
SGDiS000004692. SEG1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. eisosome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 960960Eisosome protein SEG1
PRO_0000203284Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei48 – 481Phosphoserine1 Publication
Modified residuei220 – 2201Phosphoserine1 Publication
Modified residuei235 – 2351Phosphoserine1 Publication
Modified residuei238 – 2381Phosphoserine1 Publication
Modified residuei319 – 3191Phosphoserine1 Publication
Modified residuei339 – 3391Phosphoserine1 Publication
Modified residuei352 – 3521Phosphoserine3 Publications
Modified residuei434 – 4341Phosphoserine1 Publication
Modified residuei461 – 4611Phosphoserine2 Publications
Modified residuei467 – 4671Phosphothreonine1 Publication
Modified residuei630 – 6301Phosphoserine1 Publication
Modified residuei675 – 6751Phosphothreonine2 Publications
Modified residuei758 – 7581Phosphoserine1 Publication
Modified residuei816 – 8161Phosphoserine3 Publications
Modified residuei818 – 8181Phosphoserine3 Publications
Modified residuei855 – 8551Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ04279.
PaxDbiQ04279.
PRIDEiQ04279.

Expressioni

Gene expression databases

GenevestigatoriQ04279.

Interactioni

Subunit structurei

Component of eisosomes, large cytoplasmic protein assemblies that localize to specialized domains termed MCCs on the plasma membrane.

Protein-protein interaction databases

BioGridi35261. 37 interactions.
DIPiDIP-6346N.
IntActiQ04279. 3 interactions.
MINTiMINT-2492235.
STRINGi4932.YMR086W.

Structurei

3D structure databases

ProteinModelPortaliQ04279.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi941 – 96020Lys-rich (basic, sufficient to bind lipids, important for targeting the protein to the plasma membrane in small buds)
Add
BLAST

Sequence similaritiesi

Belongs to the SEG1 family.

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00530000067521.
OMAiPNIFANI.
OrthoDBiEOG7B05SF.

Sequencei

Sequence statusi: Complete.

Q04279-1 [UniParc]FASTAAdd to Basket

« Hide

MFRRRTTAPE MEQADPTAVA AAASIGKLLM KKGNQSDNEQ RPTYRSASMT    50
NLRKPSAPKR MSSISSISSE SRRSDGKGRP GKINSLTQRS SMGKGDSLNS 100
PLTKEPQHKT RSHNRTSSLP NQRGQQSRNS SGLQRQKSKT HQRISYDEAQ 150
RTFKDFGGPQ ARGILTGQHR TENPSGSIPL RTTRKYIPGP NGLVAIEVPV 200
EKPSNANTSK LLRRSNSAHS ALNARNGSLL RKKVSQESLH SQPKKTSSLG 250
NTSSTQAKKG QKAVQERNLA KKHPINSNVP LIETQVREET DQELKLDNSN 300
SSESETVVNS ENNLEKPSSL NIEKDDLSKL IHENIELESF IEEKGKEKPL 350
NSDQEDVFIS EKTVKGDVQW PKNNRQASTL EKTFNYDNEE KREGNKPVAE 400
HPLPEAEVDD KSVEQLNNIS SSGSYSAQGS VENSKPENGN KNLENDTTSS 450
PTQDLDEKSR SIEEKDTLEG TESSKKVEKP DNCCEKISGA NTSSKKGNVG 500
DTKDEFFDTV EESDQKTSKS NSSKNTDHSN QTEPTPSLAQ YLRTSNTYLS 550
RKNQSKQAEQ EKFHKPEAPM VPVTKVVTPI KSALKKSSGS SNHDSSMYSD 600
NSPANGAYLS LTTAENTRLN AQMTMSDSVS RRASLKRSSI KRPQSVGQFR 650
SIRSNSPSPP EKINNKRHSA IPLGTPEKGK PKRNSVMASL SKNSQQIQEP 700
ASVYESNGPN KPKNQINKNI KRGSQIAQNN KPSTKDMNSI LYPKEPPPRK 750
SSFEKTRSNE SHLGFKKLSL RNGNFEEALS ESYNGQASQN STNVNRTDTA 800
QEFFKYLGHS SRFADSDSED ESQFFNQGPS KYNTETEGNK TSGNKNSNGG 850
NGAFSLFKSK SKQKENNVVS PGVSSPNHTT TDPAITSKKV DKKFSGLSLR 900
AASEAEPAKN SNPSMTNRLR FSSNPENGES RLPQAQEVSV TKEKKGSFGK 950
KLKKIFGRKK 960
Length:960
Mass (Da):105,874
Last modified:November 1, 1997 - v1
Checksum:i05A4FA27129DB09B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti167 – 1671G → E in AAT92595. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49259 Genomic DNA. Translation: CAA89232.1.
AY692576 Genomic DNA. Translation: AAT92595.1.
BK006946 Genomic DNA. Translation: DAA09983.1.
PIRiS54461.
RefSeqiNP_013803.1. NM_001182586.1.

Genome annotation databases

EnsemblFungiiYMR086W; YMR086W; YMR086W.
GeneIDi855110.
KEGGisce:YMR086W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49259 Genomic DNA. Translation: CAA89232.1 .
AY692576 Genomic DNA. Translation: AAT92595.1 .
BK006946 Genomic DNA. Translation: DAA09983.1 .
PIRi S54461.
RefSeqi NP_013803.1. NM_001182586.1.

3D structure databases

ProteinModelPortali Q04279.
ModBasei Search...

Protein-protein interaction databases

BioGridi 35261. 37 interactions.
DIPi DIP-6346N.
IntActi Q04279. 3 interactions.
MINTi MINT-2492235.
STRINGi 4932.YMR086W.

Proteomic databases

MaxQBi Q04279.
PaxDbi Q04279.
PRIDEi Q04279.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR086W ; YMR086W ; YMR086W .
GeneIDi 855110.
KEGGi sce:YMR086W.

Organism-specific databases

CYGDi YMR086w.
SGDi S000004692. SEG1.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00530000067521.
OMAi PNIFANI.
OrthoDBi EOG7B05SF.

Enzyme and pathway databases

BioCyci YEAST:G3O-32786-MONOMER.

Miscellaneous databases

NextBioi 978446.

Gene expression databases

Genevestigatori Q04279.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION.
  5. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-352; SER-816 AND SER-818, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  6. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48; SER-235; SER-238; THR-675 AND SER-758, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-352; SER-461; SER-816 AND SER-818, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Unifying fluorescence microscopy and mass spectrometry for studying protein complexes in cells."
    Deng C., Xiong X., Krutchinsky A.N.
    Mol. Cell. Proteomics 8:1413-1423(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-220; SER-319; SER-339; SER-352; SER-434; SER-461; THR-467; SER-630; THR-675; SER-816; SER-818 AND SER-855, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Membrane compartment occupied by Can1 (MCC) and eisosome subdomains of the fungal plasma membrane."
    Douglas L.M., Wang H.X., Li L., Konopka J.B.
    Membranes 1:394-411(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE NAME.
  11. Cited for: FUNCTION, SUBCELLULAR LOCATION, SUBUNIT.

Entry informationi

Entry nameiSEG1_YEAST
AccessioniPrimary (citable) accession number: Q04279
Secondary accession number(s): D6VZQ9, Q6B304
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

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