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Q04279

- SEG1_YEAST

UniProt

Q04279 - SEG1_YEAST

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Protein

Eisosome protein SEG1

Gene

SEG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Important for the biogenesis of eisosomes, large cytoplasmic protein assemblies that localize to specialized domains on the plasma membrane to cluster specific proteins at sites of membrane invaginations. Required for efficient incorporation of the eisosome component PIL1 into eisosomes.1 Publication

GO - Biological processi

  1. eisosome assembly Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-32786-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Eisosome protein SEG1
Alternative name(s):
Stability of eisosomes guaranteed protein 1
Gene namesi
Name:SEG1
Ordered Locus Names:YMR086W
ORF Names:YM9582.10
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR086w.
SGDiS000004692. SEG1.

Subcellular locationi

Cell membrane 3 Publications; Peripheral membrane protein 3 Publications; Cytoplasmic side 3 Publications
Note: Localizes to eisosomes.

GO - Cellular componenti

  1. eisosome Source: SGD
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 960960Eisosome protein SEG1PRO_0000203284Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei48 – 481Phosphoserine1 Publication
Modified residuei220 – 2201Phosphoserine1 Publication
Modified residuei235 – 2351Phosphoserine1 Publication
Modified residuei238 – 2381Phosphoserine1 Publication
Modified residuei319 – 3191Phosphoserine1 Publication
Modified residuei339 – 3391Phosphoserine1 Publication
Modified residuei352 – 3521Phosphoserine3 Publications
Modified residuei434 – 4341Phosphoserine1 Publication
Modified residuei461 – 4611Phosphoserine2 Publications
Modified residuei467 – 4671Phosphothreonine1 Publication
Modified residuei630 – 6301Phosphoserine1 Publication
Modified residuei675 – 6751Phosphothreonine2 Publications
Modified residuei758 – 7581Phosphoserine1 Publication
Modified residuei816 – 8161Phosphoserine3 Publications
Modified residuei818 – 8181Phosphoserine3 Publications
Modified residuei855 – 8551Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ04279.
PaxDbiQ04279.
PRIDEiQ04279.

Expressioni

Gene expression databases

GenevestigatoriQ04279.

Interactioni

Subunit structurei

Component of eisosomes, large cytoplasmic protein assemblies that localize to specialized domains termed MCCs on the plasma membrane.1 Publication

Protein-protein interaction databases

BioGridi35261. 37 interactions.
DIPiDIP-6346N.
IntActiQ04279. 3 interactions.
MINTiMINT-2492235.
STRINGi4932.YMR086W.

Structurei

3D structure databases

ProteinModelPortaliQ04279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi941 – 96020Lys-rich (basic, sufficient to bind lipids, important for targeting the protein to the plasma membrane in small buds)Add
BLAST

Sequence similaritiesi

Belongs to the SEG1 family.Curated

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00530000067521.
InParanoidiQ04279.
OMAiPNIFANI.
OrthoDBiEOG7B05SF.

Sequencei

Sequence statusi: Complete.

Q04279-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFRRRTTAPE MEQADPTAVA AAASIGKLLM KKGNQSDNEQ RPTYRSASMT
60 70 80 90 100
NLRKPSAPKR MSSISSISSE SRRSDGKGRP GKINSLTQRS SMGKGDSLNS
110 120 130 140 150
PLTKEPQHKT RSHNRTSSLP NQRGQQSRNS SGLQRQKSKT HQRISYDEAQ
160 170 180 190 200
RTFKDFGGPQ ARGILTGQHR TENPSGSIPL RTTRKYIPGP NGLVAIEVPV
210 220 230 240 250
EKPSNANTSK LLRRSNSAHS ALNARNGSLL RKKVSQESLH SQPKKTSSLG
260 270 280 290 300
NTSSTQAKKG QKAVQERNLA KKHPINSNVP LIETQVREET DQELKLDNSN
310 320 330 340 350
SSESETVVNS ENNLEKPSSL NIEKDDLSKL IHENIELESF IEEKGKEKPL
360 370 380 390 400
NSDQEDVFIS EKTVKGDVQW PKNNRQASTL EKTFNYDNEE KREGNKPVAE
410 420 430 440 450
HPLPEAEVDD KSVEQLNNIS SSGSYSAQGS VENSKPENGN KNLENDTTSS
460 470 480 490 500
PTQDLDEKSR SIEEKDTLEG TESSKKVEKP DNCCEKISGA NTSSKKGNVG
510 520 530 540 550
DTKDEFFDTV EESDQKTSKS NSSKNTDHSN QTEPTPSLAQ YLRTSNTYLS
560 570 580 590 600
RKNQSKQAEQ EKFHKPEAPM VPVTKVVTPI KSALKKSSGS SNHDSSMYSD
610 620 630 640 650
NSPANGAYLS LTTAENTRLN AQMTMSDSVS RRASLKRSSI KRPQSVGQFR
660 670 680 690 700
SIRSNSPSPP EKINNKRHSA IPLGTPEKGK PKRNSVMASL SKNSQQIQEP
710 720 730 740 750
ASVYESNGPN KPKNQINKNI KRGSQIAQNN KPSTKDMNSI LYPKEPPPRK
760 770 780 790 800
SSFEKTRSNE SHLGFKKLSL RNGNFEEALS ESYNGQASQN STNVNRTDTA
810 820 830 840 850
QEFFKYLGHS SRFADSDSED ESQFFNQGPS KYNTETEGNK TSGNKNSNGG
860 870 880 890 900
NGAFSLFKSK SKQKENNVVS PGVSSPNHTT TDPAITSKKV DKKFSGLSLR
910 920 930 940 950
AASEAEPAKN SNPSMTNRLR FSSNPENGES RLPQAQEVSV TKEKKGSFGK
960
KLKKIFGRKK
Length:960
Mass (Da):105,874
Last modified:November 1, 1997 - v1
Checksum:i05A4FA27129DB09B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti167 – 1671G → E in AAT92595. (PubMed:17322287)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49259 Genomic DNA. Translation: CAA89232.1.
AY692576 Genomic DNA. Translation: AAT92595.1.
BK006946 Genomic DNA. Translation: DAA09983.1.
PIRiS54461.
RefSeqiNP_013803.1. NM_001182586.1.

Genome annotation databases

EnsemblFungiiYMR086W; YMR086W; YMR086W.
GeneIDi855110.
KEGGisce:YMR086W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49259 Genomic DNA. Translation: CAA89232.1 .
AY692576 Genomic DNA. Translation: AAT92595.1 .
BK006946 Genomic DNA. Translation: DAA09983.1 .
PIRi S54461.
RefSeqi NP_013803.1. NM_001182586.1.

3D structure databases

ProteinModelPortali Q04279.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35261. 37 interactions.
DIPi DIP-6346N.
IntActi Q04279. 3 interactions.
MINTi MINT-2492235.
STRINGi 4932.YMR086W.

Proteomic databases

MaxQBi Q04279.
PaxDbi Q04279.
PRIDEi Q04279.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR086W ; YMR086W ; YMR086W .
GeneIDi 855110.
KEGGi sce:YMR086W.

Organism-specific databases

CYGDi YMR086w.
SGDi S000004692. SEG1.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00530000067521.
InParanoidi Q04279.
OMAi PNIFANI.
OrthoDBi EOG7B05SF.

Enzyme and pathway databases

BioCyci YEAST:G3O-32786-MONOMER.

Miscellaneous databases

NextBioi 978446.

Gene expression databases

Genevestigatori Q04279.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION.
  5. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-352; SER-816 AND SER-818, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  6. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48; SER-235; SER-238; THR-675 AND SER-758, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-352; SER-461; SER-816 AND SER-818, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Unifying fluorescence microscopy and mass spectrometry for studying protein complexes in cells."
    Deng C., Xiong X., Krutchinsky A.N.
    Mol. Cell. Proteomics 8:1413-1423(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-220; SER-319; SER-339; SER-352; SER-434; SER-461; THR-467; SER-630; THR-675; SER-816; SER-818 AND SER-855, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Membrane compartment occupied by Can1 (MCC) and eisosome subdomains of the fungal plasma membrane."
    Douglas L.M., Wang H.X., Li L., Konopka J.B.
    Membranes 1:394-411(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE NAME.
  11. Cited for: FUNCTION, SUBCELLULAR LOCATION, SUBUNIT.

Entry informationi

Entry nameiSEG1_YEAST
AccessioniPrimary (citable) accession number: Q04279
Secondary accession number(s): D6VZQ9, Q6B304
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3