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Protein

Sister chromatid cohesion protein PDS5

Gene

PDS5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the establishment and maintenance of sister chromatid cohesion at centromere proximal and distal regions during S phase. Also required for chromosomal condensation.2 Publications

Miscellaneous

Present with 7720 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • structural molecule activity Source: SGD

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • double-strand break repair Source: SGD
  • meiotic cell cycle Source: SGD
  • mitotic chromosome condensation Source: SGD
  • mitotic sister chromatid cohesion Source: SGD
  • synapsis Source: SGD

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-32778-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Sister chromatid cohesion protein PDS5
Alternative name(s):
Precocious dissociation of sisters protein 5
Gene namesi
Name:PDS5
Ordered Locus Names:YMR076C
ORF Names:YM9582.01C, YM9916.15C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR076C
SGDiS000004681 PDS5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000582801 – 1277Sister chromatid cohesion protein PDS5Add BLAST1277

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1231PhosphoserineCombined sources1
Modified residuei1233PhosphoserineCombined sources1

Post-translational modificationi

Acetylated by ECO1.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ04264
PaxDbiQ04264
PRIDEiQ04264

PTM databases

iPTMnetiQ04264

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35251, 365 interactors
DIPiDIP-6799N
IntActiQ04264, 31 interactors
MINTiQ04264
STRINGi4932.YMR076C

Structurei

Secondary structure

11277
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi19 – 21Combined sources3
Helixi25 – 41Combined sources17
Beta strandi44 – 47Combined sources4
Helixi53 – 58Combined sources6
Helixi62 – 65Combined sources4
Helixi70 – 87Combined sources18
Helixi95 – 113Combined sources19
Helixi120 – 132Combined sources13
Helixi136 – 141Combined sources6
Helixi145 – 157Combined sources13
Helixi165 – 167Combined sources3
Helixi168 – 180Combined sources13
Helixi187 – 199Combined sources13
Helixi215 – 226Combined sources12
Helixi228 – 247Combined sources20
Helixi254 – 272Combined sources19
Helixi274 – 279Combined sources6
Helixi281 – 288Combined sources8
Helixi293 – 306Combined sources14
Helixi315 – 318Combined sources4
Helixi320 – 327Combined sources8
Helixi328 – 331Combined sources4
Helixi335 – 343Combined sources9
Helixi345 – 351Combined sources7
Helixi358 – 366Combined sources9
Helixi372 – 384Combined sources13
Helixi387 – 393Combined sources7
Helixi397 – 405Combined sources9
Helixi406 – 408Combined sources3
Helixi412 – 431Combined sources20
Beta strandi437 – 439Combined sources3
Helixi440 – 446Combined sources7
Helixi449 – 455Combined sources7
Helixi456 – 459Combined sources4
Helixi462 – 475Combined sources14
Helixi483 – 495Combined sources13
Helixi499 – 526Combined sources28
Helixi527 – 529Combined sources3
Turni530 – 532Combined sources3
Beta strandi535 – 539Combined sources5
Helixi540 – 555Combined sources16
Helixi561 – 574Combined sources14
Helixi577 – 587Combined sources11
Helixi593 – 607Combined sources15
Helixi626 – 640Combined sources15
Beta strandi643 – 646Combined sources4
Helixi648 – 653Combined sources6
Helixi662 – 678Combined sources17
Turni680 – 682Combined sources3
Helixi683 – 690Combined sources8
Helixi692 – 696Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5FRPX-ray2.90A/B1-701[»]
5FRRX-ray5.80A/B1-701[»]
5FRSX-ray4.07A1-701[»]
ProteinModelPortaliQ04264
SMRiQ04264
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati393 – 429HEATAdd BLAST37

Sequence similaritiesi

Belongs to the PDS5 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000012488
HOGENOMiHOG000248675
InParanoidiQ04264
KOiK11267
OMAiYVFSAHF
OrthoDBiEOG092C2MZ0

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 6 hits

Sequencei

Sequence statusi: Complete.

Q04264-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKGAVTKLK FNSPIISTSD QLISTNELLD RLKALHEELA SLDQDNTDLT
60 70 80 90 100
GLDKYRDALV SRKLLKHKDV GIRAFTACCL SDILRLYAPD APYTDAQLTD
110 120 130 140 150
IFKLVLSQFE QLGDQENGYH IQQTYLITKL LEYRSIVLLA DLPSSNNLLI
160 170 180 190 200
ELFHIFYDPN KSFPARLFNV IGGILGEVIS EFDSVPLEVL RLIFNKFLTY
210 220 230 240 250
NPNEIPEGLN VTSDCGYEVS LILCDTYSNR MSRHLTKYYS EIIHEATNDD
260 270 280 290 300
NNSRLLTVVV KLHKLVLRLW ETVPELINAV IGFIYHELSS ENELFRKEAT
310 320 330 340 350
KLIGQILTSY SDLNFVSTHS DTFKAWISKI ADISPDVRVE WTESIPQIIA
360 370 380 390 400
TREDISKELN QALAKTFIDS DPRVRRTSVM IFNKVPVTEI WKNITNKAIY
410 420 430 440 450
TSLLHLAREK HKEVRELCIN TMAKFYSNSL NEIERTYQNK EIWEIIDTIP
460 470 480 490 500
STLYNLYYIN DLNINEQVDS VIFEYLLPFE PDNDKRVHRL LTVLSHFDKK
510 520 530 540 550
AFTSFFAFNA RQIKISFAIS KYIDFSKFLN NQESMSSSQG PIVMNKYNQT
560 570 580 590 600
LQWLASGLSD STKAIDALET IKQFNDERIF YLLNACVTND IPFLTFKNCY
610 620 630 640 650
NELVSKLQTP GLFKKYNIST GASIMPRDIA KVIQILLFRA SPIIYNVSNI
660 670 680 690 700
SVLLNLSNNS DAKQLDLKRR ILDDISKVNP TLFKDQIRTL KTIIKDLDDP
710 720 730 740 750
DAEKNDNLSL EEALKTLYKA SKTLKDQVDF DDTFFFTKLY DFAVESKPEI
760 770 780 790 800
TKYATKLIAL SPKAEETLKK IKIRILPLDL QKDKYFTSHI IVLMEIFKKF
810 820 830 840 850
PHVLNDDSTD IISYLIKEVL LSNQVVGDSK KEIDWVEDSL LSDTKYSAIG
860 870 880 890 900
NKVFTLKLFT NKLRSIAPDV PRDELAESFT EKTMKLFFYL IASGGELISE
910 920 930 940 950
FNKEFYPTPS NYQTKLRCVA GIQVLKLARI SNLNNFIKPS DIIKLINLVE
960 970 980 990 1000
DESLPVRKTF LEQLKDYVAN ELISIKFLPL VFFTAYEPDV ELKTTTKIWI
1010 1020 1030 1040 1050
NFTFGLKSFK KGTIFERALP RLIHAIAHHP DIVGGLDSEG DAYLNALTTA
1060 1070 1080 1090 1100
IDYLLFYFDS IAAQENFSLL YYLSERVKNY QDKLVEDEID EEEGPQKEEA
1110 1120 1130 1140 1150
PKKHRPYGQK MYIIGELSQM ILLNLKEKKN WQHSAYPGKL NLPSDLFKPF
1160 1170 1180 1190 1200
ATVQEAQLSF KTYIPESLTE KIQNNIKAKI GRILHTSQTQ RQRLQKRLLA
1210 1220 1230 1240 1250
HENNESQKKK KKVHHARSQA DDEEGDGDRE SDSDDDSYSP SNKNETKKGH
1260 1270
ENIVMKKLRV RKEVDYKDDE DDDIEMT
Length:1,277
Mass (Da):147,041
Last modified:November 1, 1997 - v1
Checksum:i9DF40A5274FD9623
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49259 Genomic DNA Translation: CAA89222.1
Z48952 Genomic DNA Translation: CAA88801.1
BK006946 Genomic DNA Translation: DAA09974.1
PIRiS54451
RefSeqiNP_013793.1, NM_001182575.1

Genome annotation databases

EnsemblFungiiYMR076C; YMR076C; YMR076C
GeneIDi855099
KEGGisce:YMR076C

Similar proteinsi

Entry informationi

Entry nameiPDS5_YEAST
AccessioniPrimary (citable) accession number: Q04264
Secondary accession number(s): D6VZQ0, Q04780
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health