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Protein

Sister chromatid cohesion protein PDS5

Gene

PDS5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential for the establishment and maintenance of sister chromatid cohesion at centromere proximal and distal regions during S phase. Also required for chromosomal condensation.2 Publications

GO - Molecular functioni

  • structural molecule activity Source: SGD

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • double-strand break repair Source: SGD
  • meiotic nuclear division Source: SGD
  • mitotic chromosome condensation Source: SGD
  • mitotic sister chromatid cohesion Source: SGD
  • synapsis Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-32778-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sister chromatid cohesion protein PDS5
Alternative name(s):
Precocious dissociation of sisters protein 5
Gene namesi
Name:PDS5
Ordered Locus Names:YMR076C
ORF Names:YM9582.01C, YM9916.15C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR076C.
SGDiS000004681. PDS5.

Subcellular locationi

GO - Cellular componenti

  • condensed nuclear chromosome Source: SGD
  • cytosol Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12771277Sister chromatid cohesion protein PDS5PRO_0000058280Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1231 – 12311PhosphoserineCombined sources
Modified residuei1233 – 12331PhosphoserineCombined sources

Post-translational modificationi

Acetylated by ECO1.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ04264.
PeptideAtlasiQ04264.

PTM databases

iPTMnetiQ04264.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SMC1P329082EBI-13077,EBI-17402

Protein-protein interaction databases

BioGridi35251. 55 interactions.
DIPiDIP-6799N.
IntActiQ04264. 13 interactions.
MINTiMINT-650430.

Structurei

Secondary structure

1
1277
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi19 – 213Combined sources
Helixi25 – 4117Combined sources
Beta strandi44 – 474Combined sources
Helixi53 – 586Combined sources
Helixi62 – 654Combined sources
Helixi70 – 8718Combined sources
Helixi95 – 11319Combined sources
Helixi120 – 13213Combined sources
Helixi136 – 1416Combined sources
Helixi145 – 15713Combined sources
Helixi165 – 1673Combined sources
Helixi168 – 18013Combined sources
Helixi187 – 19913Combined sources
Helixi215 – 22612Combined sources
Helixi228 – 24720Combined sources
Helixi254 – 27219Combined sources
Helixi274 – 2796Combined sources
Helixi281 – 2888Combined sources
Helixi293 – 30614Combined sources
Helixi315 – 3184Combined sources
Helixi320 – 3278Combined sources
Helixi328 – 3314Combined sources
Helixi335 – 3439Combined sources
Helixi345 – 3517Combined sources
Helixi358 – 3669Combined sources
Helixi372 – 38413Combined sources
Helixi387 – 3937Combined sources
Helixi397 – 4059Combined sources
Helixi406 – 4083Combined sources
Helixi412 – 43120Combined sources
Beta strandi437 – 4393Combined sources
Helixi440 – 4467Combined sources
Helixi449 – 4557Combined sources
Helixi456 – 4594Combined sources
Helixi462 – 47514Combined sources
Helixi483 – 49513Combined sources
Helixi499 – 52628Combined sources
Helixi527 – 5293Combined sources
Turni530 – 5323Combined sources
Beta strandi535 – 5395Combined sources
Helixi540 – 55516Combined sources
Helixi561 – 57414Combined sources
Helixi577 – 58711Combined sources
Helixi593 – 60715Combined sources
Helixi626 – 64015Combined sources
Beta strandi643 – 6464Combined sources
Helixi648 – 6536Combined sources
Helixi662 – 67817Combined sources
Turni680 – 6823Combined sources
Helixi683 – 6908Combined sources
Helixi692 – 6965Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5FRPX-ray2.90A/B1-701[»]
5FRRX-ray5.80A/B1-701[»]
5FRSX-ray4.07A1-701[»]
ProteinModelPortaliQ04264.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati393 – 42937HEATAdd
BLAST

Sequence similaritiesi

Belongs to the PDS5 family.Curated
Contains 1 HEAT repeat.Curated

Phylogenomic databases

GeneTreeiENSGT00390000012488.
HOGENOMiHOG000248675.
InParanoidiQ04264.
KOiK11267.
OMAiDMDQEHV.
OrthoDBiEOG79KPPR.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 6 hits.

Sequencei

Sequence statusi: Complete.

Q04264-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKGAVTKLK FNSPIISTSD QLISTNELLD RLKALHEELA SLDQDNTDLT
60 70 80 90 100
GLDKYRDALV SRKLLKHKDV GIRAFTACCL SDILRLYAPD APYTDAQLTD
110 120 130 140 150
IFKLVLSQFE QLGDQENGYH IQQTYLITKL LEYRSIVLLA DLPSSNNLLI
160 170 180 190 200
ELFHIFYDPN KSFPARLFNV IGGILGEVIS EFDSVPLEVL RLIFNKFLTY
210 220 230 240 250
NPNEIPEGLN VTSDCGYEVS LILCDTYSNR MSRHLTKYYS EIIHEATNDD
260 270 280 290 300
NNSRLLTVVV KLHKLVLRLW ETVPELINAV IGFIYHELSS ENELFRKEAT
310 320 330 340 350
KLIGQILTSY SDLNFVSTHS DTFKAWISKI ADISPDVRVE WTESIPQIIA
360 370 380 390 400
TREDISKELN QALAKTFIDS DPRVRRTSVM IFNKVPVTEI WKNITNKAIY
410 420 430 440 450
TSLLHLAREK HKEVRELCIN TMAKFYSNSL NEIERTYQNK EIWEIIDTIP
460 470 480 490 500
STLYNLYYIN DLNINEQVDS VIFEYLLPFE PDNDKRVHRL LTVLSHFDKK
510 520 530 540 550
AFTSFFAFNA RQIKISFAIS KYIDFSKFLN NQESMSSSQG PIVMNKYNQT
560 570 580 590 600
LQWLASGLSD STKAIDALET IKQFNDERIF YLLNACVTND IPFLTFKNCY
610 620 630 640 650
NELVSKLQTP GLFKKYNIST GASIMPRDIA KVIQILLFRA SPIIYNVSNI
660 670 680 690 700
SVLLNLSNNS DAKQLDLKRR ILDDISKVNP TLFKDQIRTL KTIIKDLDDP
710 720 730 740 750
DAEKNDNLSL EEALKTLYKA SKTLKDQVDF DDTFFFTKLY DFAVESKPEI
760 770 780 790 800
TKYATKLIAL SPKAEETLKK IKIRILPLDL QKDKYFTSHI IVLMEIFKKF
810 820 830 840 850
PHVLNDDSTD IISYLIKEVL LSNQVVGDSK KEIDWVEDSL LSDTKYSAIG
860 870 880 890 900
NKVFTLKLFT NKLRSIAPDV PRDELAESFT EKTMKLFFYL IASGGELISE
910 920 930 940 950
FNKEFYPTPS NYQTKLRCVA GIQVLKLARI SNLNNFIKPS DIIKLINLVE
960 970 980 990 1000
DESLPVRKTF LEQLKDYVAN ELISIKFLPL VFFTAYEPDV ELKTTTKIWI
1010 1020 1030 1040 1050
NFTFGLKSFK KGTIFERALP RLIHAIAHHP DIVGGLDSEG DAYLNALTTA
1060 1070 1080 1090 1100
IDYLLFYFDS IAAQENFSLL YYLSERVKNY QDKLVEDEID EEEGPQKEEA
1110 1120 1130 1140 1150
PKKHRPYGQK MYIIGELSQM ILLNLKEKKN WQHSAYPGKL NLPSDLFKPF
1160 1170 1180 1190 1200
ATVQEAQLSF KTYIPESLTE KIQNNIKAKI GRILHTSQTQ RQRLQKRLLA
1210 1220 1230 1240 1250
HENNESQKKK KKVHHARSQA DDEEGDGDRE SDSDDDSYSP SNKNETKKGH
1260 1270
ENIVMKKLRV RKEVDYKDDE DDDIEMT
Length:1,277
Mass (Da):147,041
Last modified:November 1, 1997 - v1
Checksum:i9DF40A5274FD9623
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49259 Genomic DNA. Translation: CAA89222.1.
Z48952 Genomic DNA. Translation: CAA88801.1.
BK006946 Genomic DNA. Translation: DAA09974.1.
PIRiS54451.
RefSeqiNP_013793.1. NM_001182575.1.

Genome annotation databases

EnsemblFungiiYMR076C; YMR076C; YMR076C.
GeneIDi855099.
KEGGisce:YMR076C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49259 Genomic DNA. Translation: CAA89222.1.
Z48952 Genomic DNA. Translation: CAA88801.1.
BK006946 Genomic DNA. Translation: DAA09974.1.
PIRiS54451.
RefSeqiNP_013793.1. NM_001182575.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5FRPX-ray2.90A/B1-701[»]
5FRRX-ray5.80A/B1-701[»]
5FRSX-ray4.07A1-701[»]
ProteinModelPortaliQ04264.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35251. 55 interactions.
DIPiDIP-6799N.
IntActiQ04264. 13 interactions.
MINTiMINT-650430.

PTM databases

iPTMnetiQ04264.

Proteomic databases

MaxQBiQ04264.
PeptideAtlasiQ04264.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR076C; YMR076C; YMR076C.
GeneIDi855099.
KEGGisce:YMR076C.

Organism-specific databases

EuPathDBiFungiDB:YMR076C.
SGDiS000004681. PDS5.

Phylogenomic databases

GeneTreeiENSGT00390000012488.
HOGENOMiHOG000248675.
InParanoidiQ04264.
KOiK11267.
OMAiDMDQEHV.
OrthoDBiEOG79KPPR.

Enzyme and pathway databases

BioCyciYEAST:G3O-32778-MONOMER.

Miscellaneous databases

NextBioi978417.
PROiQ04264.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 6 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Pds5p is an essential chromosomal protein required for both sister chromatid cohesion and condensation in Saccharomyces cerevisiae."
    Hartman T., Stead K., Koshland D., Guacci V.
    J. Cell Biol. 151:613-626(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  4. "Pds5 cooperates with cohesin in maintaining sister chromatid cohesion."
    Panizza S., Tanaka T., Hochwagen A., Eisenhaber F., Nasmyth K.
    Curr. Biol. 10:1557-1564(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Eco1 is a novel acetyltransferase that can acetylate proteins involved in cohesion."
    Ivanov D., Schleiffer A., Eisenhaber F., Mechtler K., Haering C.H., Nasmyth K.
    Curr. Biol. 12:323-328(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1231 AND SER-1233, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPDS5_YEAST
AccessioniPrimary (citable) accession number: Q04264
Secondary accession number(s): D6VZQ0, Q04780
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 11, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 7720 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.