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Q04233

- GIS4_YEAST

UniProt

Q04233 - GIS4_YEAST

Protein

Protein GIS4

Gene

GIS4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    May be involved in the Ras/cAMP signaling pathway.1 Publication

    GO - Biological processi

    1. cellular ion homeostasis Source: SGD
    2. intracellular signal transduction Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32611-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein GIS4
    Gene namesi
    Name:GIS4
    Ordered Locus Names:YML006C
    ORF Names:YM9571.13C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYML006c.
    SGDiS000004465. GIS4.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 774774Protein GIS4PRO_0000087498Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei165 – 1651Phosphoserine1 Publication
    Modified residuei304 – 3041Phosphoserine1 Publication
    Modified residuei616 – 6161Phosphoserine1 Publication
    Modified residuei622 – 6221Phosphoserine2 Publications
    Modified residuei707 – 7071Phosphoserine1 Publication
    Modified residuei720 – 7201Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ04233.
    PaxDbiQ04233.

    Expressioni

    Gene expression databases

    GenevestigatoriQ04233.

    Interactioni

    Protein-protein interaction databases

    BioGridi35164. 62 interactions.
    DIPiDIP-1334N.
    IntActiQ04233. 12 interactions.
    MINTiMINT-384235.
    STRINGi4932.YML006C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04233.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi147 – 1526Poly-Asn
    Compositional biasi183 – 20321Thr-richAdd
    BLAST
    Compositional biasi329 – 35830Ser-richAdd
    BLAST
    Compositional biasi340 – 34910Poly-Ser
    Compositional biasi353 – 3586Poly-Ser
    Compositional biasi576 – 58914Asp-richAdd
    BLAST

    Phylogenomic databases

    eggNOGiNOG45211.
    HOGENOMiHOG000000749.
    OMAiKILFYTM.
    OrthoDBiEOG72ZCPP.

    Sequencei

    Sequence statusi: Complete.

    Q04233-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQKSVRVGDY FDNDDNGLWS WYLTNLRLGD FEELIGNQLK YTLLKRFLNS    50
    HFYGDNNISA RPNKKILLVS IPENVHEDIS ILEIFLKDYF HLEKLEHIQI 100
    SKLTHSHCYN HENHYLLTDN LNNFQDPTFL EFASTSWQVQ KNSKALNNNN 150
    RNSIPPPTIS SSKASNGKLE SNVSDDQWSN INTQTSTATR TNTNTRTLTS 200
    PDTVDINVTS VNSQSNNNDT PQDNENEVDE EDATSSIVLN FSHSRTVDSK 250
    PNRLPKIFPS YTNEDYTPSH SEIMSIDSFA GEDVSSTYPG QDLSLTTARR 300
    EDESGQDEVE DHYSRVSHDL GDESIDQASY SMESSVSYTS YSSSSNSSSA 350
    HYSLSSSSRG NPKRENIDHT NATYVSELSS ITSSIDNLTT STTPEEEDNL 400
    IHHNYDAQGY GSGEDDGEEV YDDEDLSSSD YSVLSILPSI SICDSLGYFR 450
    LVLQSILIQD PDTKEIFTAI RQSNNKPTMA SVTDDWLLYD SNFSMNNLQI 500
    LTLQDLLDIK RSFPKILFYT MVIVTNSGKQ VEEEFKNPNY DNREGISKEQ 550
    PLDSELSLTN DPQQYFPTAY NNGYNDYIDD EDDEDDGDDA SLSEQSGPQM 600
    YIPTRMESNV TTAHRSIRTV NSIGEWAFNR HNSVTKIDKS NSNELDNSKT 650
    GESTVLSSEP HPMTQLSNSN TTSSNFSHSL KTKNSHKPNS KGNNESNSKN 700
    ELKKIKSSIN AMSAVERSKS LPLPTLLKSL SGIDNPTHAT NKDRKRWKFQ 750
    MNRFKNHKNS GSAGTDKSQR CAIM 774
    Length:774
    Mass (Da):87,140
    Last modified:November 1, 1997 - v1
    Checksum:iC7E837AA7001E241
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49810 Genomic DNA. Translation: CAA89946.1.
    BK006946 Genomic DNA. Translation: DAA09893.1.
    PIRiS55113.
    RefSeqiNP_013708.1. NM_001182361.1.

    Genome annotation databases

    EnsemblFungiiYML006C; YML006C; YML006C.
    GeneIDi855006.
    KEGGisce:YML006C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49810 Genomic DNA. Translation: CAA89946.1 .
    BK006946 Genomic DNA. Translation: DAA09893.1 .
    PIRi S55113.
    RefSeqi NP_013708.1. NM_001182361.1.

    3D structure databases

    ProteinModelPortali Q04233.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35164. 62 interactions.
    DIPi DIP-1334N.
    IntActi Q04233. 12 interactions.
    MINTi MINT-384235.
    STRINGi 4932.YML006C.

    Proteomic databases

    MaxQBi Q04233.
    PaxDbi Q04233.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YML006C ; YML006C ; YML006C .
    GeneIDi 855006.
    KEGGi sce:YML006C.

    Organism-specific databases

    CYGDi YML006c.
    SGDi S000004465. GIS4.

    Phylogenomic databases

    eggNOGi NOG45211.
    HOGENOMi HOG000000749.
    OMAi KILFYTM.
    OrthoDBi EOG72ZCPP.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32611-MONOMER.

    Miscellaneous databases

    NextBioi 978166.

    Gene expression databases

    Genevestigatori Q04233.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Yeast genes GIS1-4: multicopy suppressors of the Gal- phenotype of snf1 mig1 srb8/10/11 cells."
      Balciunas D., Ronne H.
      Mol. Gen. Genet. 262:589-599(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-622; SER-707 AND SER-720, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165; SER-304; SER-616 AND SER-622, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGIS4_YEAST
    AccessioniPrimary (citable) accession number: Q04233
    Secondary accession number(s): D6VZG9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 222 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3