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Protein

Transcription initiation factor TFIID subunit 11

Gene

TAF11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.5 Publications

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • RNA polymerase II transcriptional preinitiation complex assembly Source: SGD
  • transcription from RNA polymerase II promoter Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-32619-MONOMER.
ReactomeiR-SCE-674695. RNA Polymerase II Pre-transcription Events.
R-SCE-73776. RNA Polymerase II Promoter Escape.
R-SCE-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-SCE-75953. RNA Polymerase II Transcription Initiation.
R-SCE-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 11
Alternative name(s):
TAFII-40
Short name:
TAFII40
TBP-associated factor 11
TBP-associated factor 40 kDa
Short name:
P40
Gene namesi
Name:TAF11
Synonyms:TAF40
Ordered Locus Names:YML015C
ORF Names:YM9571.03C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YML015C.
SGDiS000004477. TAF11.

Subcellular locationi

GO - Cellular componenti

  • transcription factor TFIID complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Transcription initiation factor TFIID subunit 11PRO_0000118907Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei236 – 2361PhosphoserineCombined sources
Modified residuei238 – 2381PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ04226.

PTM databases

iPTMnetiQ04226.

Interactioni

Subunit structurei

TAF11 heterodimerizes with TAF13, but they do not seem to form a heterotetramer like TAF6/TAF9. The 1.2 MDa TFIID complex is composed of TATA binding protein (TBP) and the 14 TBP-associated factors (one copy of each TAF1, TAF2, TAF3, TAF7, TAF8, TAF11, TAF13, two copies of each TAF4, TAF5, TAF6, TAF9, TAF10, TAF12, and three copies of TAF14), ranging in size from 17 to 150 kDa.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TAF10Q120305EBI-18884,EBI-18889
TAF13P117475EBI-18884,EBI-18897

GO - Molecular functioni

Protein-protein interaction databases

BioGridi35154. 28 interactions.
DIPiDIP-1686N.
IntActiQ04226. 19 interactions.
MINTiMINT-405924.

Structurei

3D structure databases

ProteinModelPortaliQ04226.
SMRiQ04226. Positions 131-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini131 – 329199Histone-foldAdd
BLAST

Sequence similaritiesi

Belongs to the TAF11 family.Curated
Contains 1 histone-fold domain.Curated

Phylogenomic databases

GeneTreeiENSGT00390000013228.
HOGENOMiHOG000000748.
InParanoidiQ04226.
KOiK03135.
OMAiNEDQEYV.
OrthoDBiEOG70KH18.

Family and domain databases

Gene3Di1.10.20.10. 2 hits.
InterProiIPR009072. Histone-fold.
IPR006809. TAFII28.
[Graphical view]
PANTHERiPTHR13218. PTHR13218. 2 hits.
PfamiPF04719. TAFII28. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04226-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEPQGPLDT IPKVNYPPIL TIANYFSTKQ MIDQVISEDQ DYVTWKLQNL
60 70 80 90 100
RTGGTSINNQ LNKYPKYKYQ KTRINQQDPD SINKVPENLI FPQDILQQQT
110 120 130 140 150
QNSNYEDTNT NEDENEKLAQ DEQFKLLVTN LDKDQTNRFE VFHRTSLNKT
160 170 180 190 200
QVKKLASTVA NQTISENIRV FLQAVGKIYA GEIIELAMIV KNKWLTSQMC
210 220 230 240 250
IEFDKRTKIG YKLKKYLKKL TFSIIENQQY KQDYQSDSVP EDEPDFYFDD
260 270 280 290 300
EEVDKRETTL GNSLLQSKSL QQSDHNSQDL KLQLIEQYNK LVLQFNKLDV
310 320 330 340
SIEKYNNSPL LPEHIREAWR LYRLQSDTLP NAYWRTQGEG QGSMFR
Length:346
Mass (Da):40,624
Last modified:November 1, 1997 - v1
Checksum:iE9A538EE89488F46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85960 Genomic DNA. Translation: AAB46715.1.
Z49810 Genomic DNA. Translation: CAA89937.1.
AY692911 Genomic DNA. Translation: AAT92930.1.
BK006946 Genomic DNA. Translation: DAA09883.1.
PIRiS55104.
RefSeqiNP_013697.1. NM_001182373.1.

Genome annotation databases

EnsemblFungiiYML015C; YML015C; YML015C.
GeneIDi854993.
KEGGisce:YML015C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85960 Genomic DNA. Translation: AAB46715.1.
Z49810 Genomic DNA. Translation: CAA89937.1.
AY692911 Genomic DNA. Translation: AAT92930.1.
BK006946 Genomic DNA. Translation: DAA09883.1.
PIRiS55104.
RefSeqiNP_013697.1. NM_001182373.1.

3D structure databases

ProteinModelPortaliQ04226.
SMRiQ04226. Positions 131-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35154. 28 interactions.
DIPiDIP-1686N.
IntActiQ04226. 19 interactions.
MINTiMINT-405924.

PTM databases

iPTMnetiQ04226.

Proteomic databases

MaxQBiQ04226.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYML015C; YML015C; YML015C.
GeneIDi854993.
KEGGisce:YML015C.

Organism-specific databases

EuPathDBiFungiDB:YML015C.
SGDiS000004477. TAF11.

Phylogenomic databases

GeneTreeiENSGT00390000013228.
HOGENOMiHOG000000748.
InParanoidiQ04226.
KOiK03135.
OMAiNEDQEYV.
OrthoDBiEOG70KH18.

Enzyme and pathway databases

BioCyciYEAST:G3O-32619-MONOMER.
ReactomeiR-SCE-674695. RNA Polymerase II Pre-transcription Events.
R-SCE-73776. RNA Polymerase II Promoter Escape.
R-SCE-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-SCE-75953. RNA Polymerase II Transcription Initiation.
R-SCE-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Miscellaneous databases

PROiQ04226.

Family and domain databases

Gene3Di1.10.20.10. 2 hits.
InterProiIPR009072. Histone-fold.
IPR006809. TAFII28.
[Graphical view]
PANTHERiPTHR13218. PTHR13218. 2 hits.
PfamiPF04719. TAFII28. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of an essential Saccharomyces cerevisiae gene, TAF40, which encodes yTAFII40, an RNA polymerase II-specific TATA-binding protein-associated factor."
    Klebanow E.R., Poon D., Zhou S., Weil P.A.
    J. Biol. Chem. 272:9436-9442(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 29-46; 125-144; 255-267 AND 323-335.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family."
    Birck C., Poch O., Romier C., Ruff M., Mengus G., Lavigne A.C., Davidson I., Moras D.
    Cell 94:239-249(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TAF-TAF INTERACTION THROUGH HISTONE-FOLD DOMAIN.
  6. "Identification of two novel TAF subunits of the yeast Saccharomyces cerevisiae TFIID complex."
    Sanders S.L., Weil P.A.
    J. Biol. Chem. 275:13895-13900(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT.
  7. "The histone fold is a key structural motif of transcription factor TFIID."
    Gangloff Y.G., Romier C., Thuault S., Werten S., Davidson I.
    Trends Biochem. Sci. 26:250-257(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, HISTONE-FOLD DOMAIN CHARACTERIZATION.
  8. "Molecular characterization of Saccharomyces cerevisiae TFIID."
    Sanders S.L., Garbett K.A., Weil P.A.
    Mol. Cell. Biol. 22:6000-6013(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TFIID STOICHIOMETRY.
  9. "Multi-protein complexes in eukaryotic gene transcription."
    Martinez E.
    Plant Mol. Biol. 50:925-947(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. Cited for: 3D-STRUCTURE, ELECTRON MICROSCOPY OF TFIID.
  11. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-236 AND SER-238, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTAF11_YEAST
AccessioniPrimary (citable) accession number: Q04226
Secondary accession number(s): D6VZF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 6, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.