TAF11

Functionⁱ

Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.5 Publications

GO - Molecular functionⁱ

chromatin binding
Source: SGD
Inferred from direct assayⁱ
- 10818000
protein heterodimerization activity Source: InterPro
transcription coactivator activity Source: GO_Central
transcription factor binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transcription, Transcription regulation

Biological process

Transcription, Transcription regulation

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-32619-MONOMER.
Reactomeⁱ	R-SCE-674695. RNA Polymerase II Pre-transcription Events. R-SCE-73776. RNA Polymerase II Promoter Escape. R-SCE-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening. R-SCE-75953. RNA Polymerase II Transcription Initiation. R-SCE-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription initiation factor TFIID subunit 11 Alternative name(s): TAFII-40 Short name: TAFII40 TBP-associated factor 11 TBP-associated factor 40 kDa Short name: P40
Gene namesⁱ	Name:TAF11 Synonyms:TAF40 Ordered Locus Names:YML015C ORF Names:YM9571.03C
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome XIII

Organism-specific databases

EuPathDBⁱ	FungiDB:YML015C.
Saccharomyces Genome Database More...SGDⁱ	S000004477. TAF11.

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000118907	1 – 346	Transcription initiation factor TFIID subunit 11Add BLAST		346

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	236	PhosphoserineCombined sources		1
Modified residueⁱ	238	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q04226.
PaxDbⁱ	Q04226.
PRIDEⁱ	Q04226.

PTM databases

iPTMnetⁱ	Q04226.

iPTMnetⁱ

Q04226.

Interactionⁱ

Subunit structureⁱ

TAF11 heterodimerizes with TAF13, but they do not seem to form a heterotetramer like TAF6/TAF9. The 1.2 MDa TFIID complex is composed of TATA binding protein (TBP) and the 14 TBP-associated factors (one copy of each TAF1, TAF2, TAF3, TAF7, TAF8, TAF11, TAF13, two copies of each TAF4, TAF5, TAF6, TAF9, TAF10, TAF12, and three copies of TAF14), ranging in size from 17 to 150 kDa.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
TAF10	Q12030	5	EBI-18884,EBI-18889
TAF12	Q03761	8	EBI-18884,EBI-35097
TAF13	P11747	4	EBI-18884,EBI-18897
TAF3	Q12297	3	EBI-18884,EBI-36697
TAF4	P50105	4	EBI-18884,EBI-11231
TAF5	P38129	12	EBI-18884,EBI-18868
TAF6	P53040	5	EBI-18884,EBI-18876
TAF9	Q05027	10	EBI-18884,EBI-27500

Show more details

GO - Molecular functionⁱ

protein heterodimerization activity Source: InterPro
transcription factor binding Source: GO_Central

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	35154. 266 interactors.
Database of interacting proteins More...DIPⁱ	DIP-1686N.
IntActⁱ	Q04226. 18 interactors.
Molecular INTeraction database More...MINTⁱ	Q04226.
STRINGⁱ	4932.YML015C.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q04226.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	131 – 329	Histone-foldAdd BLAST		199

Sequence similaritiesⁱ

Belongs to the TAF11 family.Curated

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013228.
HOGENOMⁱ	HOG000000748.
InParanoidⁱ	Q04226.
KEGG Orthology (KO) More...KOⁱ	K03135.
OMAⁱ	FEVFHRT.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C50DB.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08048. TAF11. 1 hit.
Gene3Dⁱ	1.10.20.10. 1 hit.
InterProⁱ	View protein in InterPro IPR009072. Histone-fold. IPR006809. TAFII28.
PANTHERⁱ	PTHR13218. PTHR13218. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04719. TAFII28. 1 hit.
SUPFAMⁱ	SSF47113. SSF47113. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q04226-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTEPQGPLDT IPKVNYPPIL TIANYFSTKQ MIDQVISEDQ DYVTWKLQNL 
        60         70         80         90        100
RTGGTSINNQ LNKYPKYKYQ KTRINQQDPD SINKVPENLI FPQDILQQQT 
       110        120        130        140        150
QNSNYEDTNT NEDENEKLAQ DEQFKLLVTN LDKDQTNRFE VFHRTSLNKT 
       160        170        180        190        200
QVKKLASTVA NQTISENIRV FLQAVGKIYA GEIIELAMIV KNKWLTSQMC 
       210        220        230        240        250
IEFDKRTKIG YKLKKYLKKL TFSIIENQQY KQDYQSDSVP EDEPDFYFDD 
       260        270        280        290        300
EEVDKRETTL GNSLLQSKSL QQSDHNSQDL KLQLIEQYNK LVLQFNKLDV 
       310        320        330        340 
SIEKYNNSPL LPEHIREAWR LYRLQSDTLP NAYWRTQGEG QGSMFR

Length:346

Mass (Da):40,624

Last modified:November 1, 1997 - v1

Checksum:ⁱE9A538EE89488F46

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U85960 Genomic DNA. Translation: AAB46715.1. Z49810 Genomic DNA. Translation: CAA89937.1. AY692911 Genomic DNA. Translation: AAT92930.1. BK006946 Genomic DNA. Translation: DAA09883.1.
PIRⁱ	S55104.
NCBI Reference Sequences More...RefSeqⁱ	NP_013697.1. NM_001182373.1.

Genome annotation databases

EnsemblFungiⁱ	YML015C; YML015C; YML015C.
GeneIDⁱ	854993.
KEGGⁱ	sce:YML015C.

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q04226	G2WK37 A6ZM47 N1P035 A0A250WEX2	Saccharomyces cerevisiae (strain Kyokai no. 7 / NBRC 101557) (Baker's yeast) Saccharomyces cerevisiae (strain YJM789) (Baker's yeast) Saccharomyces cerevisiae (strain CEN.PK113-7D) (Baker's yeast) Saccharomyces cerevisiae (Baker's yeast)	346	UniRef100_Q04226	Cluster: Transcription initiation factor TFIID subunit 11	5

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q04226	G2WK37 A6ZM47 N1P035 A0A250WEX2 J8Q476 C7GLD3 B3LLN7 B5VPB0 E7QJ16 C8ZEI9 +3	Saccharomyces cerevisiae (strain Kyokai no. 7 / NBRC 101557) (Baker's yeast) Saccharomyces cerevisiae (strain YJM789) (Baker's yeast) Saccharomyces cerevisiae (strain CEN.PK113-7D) (Baker's yeast) Saccharomyces cerevisiae (Baker's yeast) Saccharomyces arboricola (strain H-6 / AS 2.3317 / CBS 10644) (Yeast) Saccharomyces cerevisiae (strain JAY291) (Baker's yeast) Saccharomyces cerevisiae (strain RM11-1a) (Baker's yeast) Saccharomyces cerevisiae (strain AWRI1631) (Baker's yeast) Saccharomyces cerevisiae (strain Zymaflore VL3) (Baker's yeast) Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) (Baker's yeast) And more	346	UniRef90_Q04226	Cluster: Transcription initiation factor TFIID subunit 11	14

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q04226	G2WK37 A6ZM47 N1P035 A0A250WEX2 J8Q476 E7QJ16 A0A0L8VJY1 A0A0L8RD17 C7GLD3 B3LLN7 +12	Saccharomyces cerevisiae (strain Kyokai no. 7 / NBRC 101557) (Baker's yeast) Saccharomyces cerevisiae (strain YJM789) (Baker's yeast) Saccharomyces cerevisiae (strain CEN.PK113-7D) (Baker's yeast) Saccharomyces cerevisiae (Baker's yeast) Saccharomyces arboricola (strain H-6 / AS 2.3317 / CBS 10644) (Yeast) Saccharomyces cerevisiae (strain Zymaflore VL3) (Baker's yeast) Saccharomyces sp. 'boulardii' Saccharomyces eubayanus (Yeast) Saccharomyces cerevisiae (strain JAY291) (Baker's yeast) Saccharomyces cerevisiae (strain RM11-1a) (Baker's yeast) And more	346	UniRef50_Q04226	Cluster: Transcription initiation factor TFIID subunit 11	23

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U85960 Genomic DNA. Translation: AAB46715.1. Z49810 Genomic DNA. Translation: CAA89937.1. AY692911 Genomic DNA. Translation: AAT92930.1. BK006946 Genomic DNA. Translation: DAA09883.1.
PIRⁱ	S55104.
NCBI Reference Sequences More...RefSeqⁱ	NP_013697.1. NM_001182373.1.

3D structure databases

ProteinModelPortalⁱ	Q04226.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	35154. 266 interactors.
Database of interacting proteins More...DIPⁱ	DIP-1686N.
IntActⁱ	Q04226. 18 interactors.
Molecular INTeraction database More...MINTⁱ	Q04226.
STRINGⁱ	4932.YML015C.

PTM databases

iPTMnetⁱ	Q04226.

iPTMnetⁱ

Q04226.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q04226.
PaxDbⁱ	Q04226.
PRIDEⁱ	Q04226.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YML015C; YML015C; YML015C.
GeneIDⁱ	854993.
KEGGⁱ	sce:YML015C.

Organism-specific databases

EuPathDBⁱ	FungiDB:YML015C.
Saccharomyces Genome Database More...SGDⁱ	S000004477. TAF11.

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013228.
HOGENOMⁱ	HOG000000748.
InParanoidⁱ	Q04226.
KEGG Orthology (KO) More...KOⁱ	K03135.
OMAⁱ	FEVFHRT.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C50DB.

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-32619-MONOMER.
Reactomeⁱ	R-SCE-674695. RNA Polymerase II Pre-transcription Events. R-SCE-73776. RNA Polymerase II Promoter Escape. R-SCE-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening. R-SCE-75953. RNA Polymerase II Transcription Initiation. R-SCE-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q04226.

PROⁱ

PR:Q04226.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08048. TAF11. 1 hit.
Gene3Dⁱ	1.10.20.10. 1 hit.
InterProⁱ	View protein in InterPro IPR009072. Histone-fold. IPR006809. TAFII28.
PANTHERⁱ	PTHR13218. PTHR13218. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04719. TAFII28. 1 hit.
SUPFAMⁱ	SSF47113. SSF47113. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TAF11_YEAST
Accessionⁱ	Q04226Primary (citable) accession number: Q04226 Secondary accession number(s): D6VZF9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1997
	Last modified:	March 28, 2018
	This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB

UniParc

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Supporting data

UniProtKB - Q04226 (TAF11_YEAST)

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Transcription initiation factor TFIID subunit 11

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ