Q04226 (TAF11_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription initiation factor TFIID subunit 11

Alternative name(s):
TAFII-40
Short name=TAFII40
TBP-associated factor 11
TBP-associated factor 40 kDa
Short name=P40

Gene names

Name:	TAF11
Synonyms:	TAF40
Ordered Locus Names:	YML015C
ORF Names:	YM9571.03C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. Ref.5 Ref.6 Ref.7 Ref.8 Ref.9
Subunit structure	TAF11 heterodimerizes with TAF13, but they do not seem to form a heterotetramer like TAF6/TAF9. The 1.2 MDa TFIID complex is composed of TATA binding protein (TBP) and the 14 TBP-associated factors (one copy of each TAF1, TAF2, TAF3, TAF7, TAF8, TAF11, TAF13, two copies of each TAF4, TAF5, TAF6, TAF9, TAF10, TAF12, and three copies of TAF14), ranging in size from 17 to 150 kDa. Ref.6
Subcellular location	Nucleus.
Sequence similarities	Belongs to the TAF11 family. Contains 1 histone-fold domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	RNA polymerase II transcriptional preinitiation complex assembly Inferred from mutant phenotype. Source: SGD regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	transcription factor TFIID complex Inferred from direct assay Ref.6. Source: SGD
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro chromatin binding Inferred from direct assay. Source: SGD protein binding Inferred from physical interaction Ref.6. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TAF10	Q12030	5	EBI-18884,EBI-18889
TAF13	P11747	5	EBI-18884,EBI-18897

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	Transcription initiation factor TFIID subunit 11		PRO_0000118907
Regions
	Domain	131 – 329	199	Histone-fold
Amino acid modifications
	Modified residue	238	1	Phosphoserine Ref.11

Sequences

	Sequence		Length	Mass (Da)
	Q04226 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: E9A538EE89488F46	FASTA	346	40,624
	10 20 30 40 50 60 MTEPQGPLDT IPKVNYPPIL TIANYFSTKQ MIDQVISEDQ DYVTWKLQNL RTGGTSINNQ 70 80 90 100 110 120 LNKYPKYKYQ KTRINQQDPD SINKVPENLI FPQDILQQQT QNSNYEDTNT NEDENEKLAQ 130 140 150 160 170 180 DEQFKLLVTN LDKDQTNRFE VFHRTSLNKT QVKKLASTVA NQTISENIRV FLQAVGKIYA 190 200 210 220 230 240 GEIIELAMIV KNKWLTSQMC IEFDKRTKIG YKLKKYLKKL TFSIIENQQY KQDYQSDSVP 250 260 270 280 290 300 EDEPDFYFDD EEVDKRETTL GNSLLQSKSL QQSDHNSQDL KLQLIEQYNK LVLQFNKLDV 310 320 330 340 SIEKYNNSPL LPEHIREAWR LYRLQSDTLP NAYWRTQGEG QGSMFR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of an essential Saccharomyces cerevisiae gene, TAF40, which encodes yTAFII40, an RNA polymerase II-specific TATA-binding protein-associated factor." Klebanow E.R., Poon D., Zhou S., Weil P.A. J. Biol. Chem. 272:9436-9442(1997) [PubMed: 9083082] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 29-46; 125-144; 255-267 AND 323-335.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. , Skelton J., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:90-93(1997) [PubMed: 9169872] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[5]	"Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family." Birck C., Poch O., Romier C., Ruff M., Mengus G., Lavigne A.C., Davidson I., Moras D. Cell 94:239-249(1998) [PubMed: 9695952] [Abstract] Cited for: FUNCTION, TAF-TAF INTERACTION THROUGH HISTONE-FOLD DOMAIN.
[6]	"Identification of two novel TAF subunits of the yeast Saccharomyces cerevisiae TFIID complex." Sanders S.L., Weil P.A. J. Biol. Chem. 275:13895-13900(2000) [PubMed: 10788514] [Abstract] Cited for: FUNCTION, SUBUNIT.
[7]	"The histone fold is a key structural motif of transcription factor TFIID." Gangloff Y.G., Romier C., Thuault S., Werten S., Davidson I. Trends Biochem. Sci. 26:250-257(2001) [PubMed: 11295558] [Abstract] Cited for: FUNCTION, HISTONE-FOLD DOMAIN CHARACTERIZATION.
[8]	"Molecular characterization of Saccharomyces cerevisiae TFIID." Sanders S.L., Garbett K.A., Weil P.A. Mol. Cell. Biol. 22:6000-6013(2002) [PubMed: 12138208] [Abstract] Cited for: FUNCTION, TFIID STOICHIOMETRY.
[9]	"Multi-protein complexes in eukaryotic gene transcription." Martinez E. Plant Mol. Biol. 50:925-947(2002) [PubMed: 12516863] [Abstract] Cited for: FUNCTION.
[10]	"Mapping histone fold TAFs within yeast TFIID." Leurent C., Sanders S.L., Ruhlmann C., Mallouh V., Weil P.A., Kirschner D.B., Tora L., Schultz P. EMBO J. 21:3424-3433(2002) [PubMed: 12093743] [Abstract] Cited for: 3D-STRUCTURE, ELECTRON MICROSCOPY OF TFIID.
[11]	"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H. Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed: 17563356] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U85960 Genomic DNA. Translation: AAB46715.1. Z49810 Genomic DNA. Translation: CAA89937.1. AY692911 Genomic DNA. Translation: AAT92930.1. BK006946 Genomic DNA. Translation: DAA09883.1.
PIR	S55104.
RefSeq	NP_013697.1. NM_001182373.1.
3D structure databases
ProteinModelPortal	Q04226.
SMR	Q04226. Positions 131-195.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1686N.
IntAct	Q04226. 17 interactions.
MINT	MINT-405924.
STRING	Q04226.
Proteomic databases
PeptideAtlas	Q04226.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YML015C; YML015C; YML015C.
GeneID	854993.
KEGG	sce:YML015C.
NMPDR	fig|4932.3.peg.4738.
Organism-specific databases
CYGD	YML015c.
SGD	S000004477. TAF11.
Phylogenomic databases
eggNOG	fuNOG13156.
HOGENOM	HBG203364.
OMA	NEDQEYV.
OrthoDB	EOG4Z0FFX.
Gene expression databases
ArrayExpress	Q04226.
Genevestigator	Q04226.
GermOnline	YML015C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR009072. Histone-fold. IPR006809. TAFII28. [Graphical view]
Gene3D	G3DSA:1.10.20.10. Histone-fold. 2 hits.
KO	K03135.
PANTHER	PTHR13218. TAFII28. 1 hit.
Pfam	PF04719. TAFII28. 1 hit. [Graphical view]
SUPFAM	SSF47113. Histone-fold. 1 hit.
ProtoNet	Search...
Other
NextBio	978136.

Entry information

Entry name

TAF11_YEAST

Accession

Primary (citable) accession number: Q04226
Secondary accession number(s): D6VZF9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	December 14, 2011
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program