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UniProtKB - Q04226 (TAF11_YEAST)

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Protein

Transcription initiation factor TFIID subunit 11

Gene

TAF11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.5 Publications

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • RNA polymerase II transcriptional preinitiation complex assembly Source: SGD
  • transcription from RNA polymerase II promoter Source: SGD
Complete GO annotation...

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-32619-MONOMER.
ReactomeiR-SCE-674695. RNA Polymerase II Pre-transcription Events.
R-SCE-73776. RNA Polymerase II Promoter Escape.
R-SCE-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-SCE-75953. RNA Polymerase II Transcription Initiation.
R-SCE-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 11
Alternative name(s):
TAFII-40
Short name:
TAFII40
TBP-associated factor 11
TBP-associated factor 40 kDa
Short name:
P40
Gene namesi
Name:TAF11
Synonyms:TAF40
Ordered Locus Names:YML015C
ORF Names:YM9571.03C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YML015C.
SGDiS000004477. TAF11.

Subcellular locationi

GO - Cellular componenti

  • transcription factor TFIID complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001189071 – 346Transcription initiation factor TFIID subunit 11Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei236PhosphoserineCombined sources1
Modified residuei238PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ04226.
PRIDEiQ04226.

PTM databases

iPTMnetiQ04226.

Interactioni

Subunit structurei

TAF11 heterodimerizes with TAF13, but they do not seem to form a heterotetramer like TAF6/TAF9. The 1.2 MDa TFIID complex is composed of TATA binding protein (TBP) and the 14 TBP-associated factors (one copy of each TAF1, TAF2, TAF3, TAF7, TAF8, TAF11, TAF13, two copies of each TAF4, TAF5, TAF6, TAF9, TAF10, TAF12, and three copies of TAF14), ranging in size from 17 to 150 kDa.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Complete GO annotation...

Protein-protein interaction databases

BioGridi35154. 264 interactors.
DIPiDIP-1686N.
IntActiQ04226. 19 interactors.
MINTiMINT-405924.
STRINGi4932.YML015C.

Structurei

3D structure databases

ProteinModelPortaliQ04226.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 329Histone-foldAdd BLAST199

Sequence similaritiesi

Belongs to the TAF11 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000013228.
HOGENOMiHOG000000748.
InParanoidiQ04226.
KOiK03135.
OMAiFEVFHRT.
OrthoDBiEOG092C50DB.

Family and domain databases

CDDicd08048. TAF11. 1 hit.
InterProiView protein in InterPro
IPR009072. Histone-fold.
IPR006809. TAFII28.
PANTHERiPTHR13218. PTHR13218. 1 hit.
PfamiView protein in Pfam
PF04719. TAFII28. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04226-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEPQGPLDT IPKVNYPPIL TIANYFSTKQ MIDQVISEDQ DYVTWKLQNL 
        60         70         80         90        100
RTGGTSINNQ LNKYPKYKYQ KTRINQQDPD SINKVPENLI FPQDILQQQT 
       110        120        130        140        150
QNSNYEDTNT NEDENEKLAQ DEQFKLLVTN LDKDQTNRFE VFHRTSLNKT 
       160        170        180        190        200
QVKKLASTVA NQTISENIRV FLQAVGKIYA GEIIELAMIV KNKWLTSQMC 
       210        220        230        240        250
IEFDKRTKIG YKLKKYLKKL TFSIIENQQY KQDYQSDSVP EDEPDFYFDD 
       260        270        280        290        300
EEVDKRETTL GNSLLQSKSL QQSDHNSQDL KLQLIEQYNK LVLQFNKLDV 
       310        320        330        340 
SIEKYNNSPL LPEHIREAWR LYRLQSDTLP NAYWRTQGEG QGSMFR
Length:346
Mass (Da):40,624
Last modified:November 1, 1997 - v1
Checksum:iE9A538EE89488F46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85960 Genomic DNA. Translation: AAB46715.1.
Z49810 Genomic DNA. Translation: CAA89937.1.
AY692911 Genomic DNA. Translation: AAT92930.1.
BK006946 Genomic DNA. Translation: DAA09883.1.
PIRiS55104.
RefSeqiNP_013697.1. NM_001182373.1.

Genome annotation databases

EnsemblFungiiYML015C; YML015C; YML015C.
GeneIDi854993.
KEGGisce:YML015C.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTAF11_YEAST
AccessioniPrimary (citable) accession number: Q04226
Secondary accession number(s): D6VZF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 5, 2017
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names