UniProtKB - Q04226 (TAF11_YEAST)
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Protein
Transcription initiation factor TFIID subunit 11
Gene
TAF11
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.5 Publications
GO - Molecular functioni
- chromatin binding Source: SGD
- protein heterodimerization activity Source: InterPro
- transcription coactivator activity Source: GO_Central
- transcription factor binding Source: GO_Central
GO - Biological processi
- regulation of transcription, DNA-templated Source: UniProtKB-KW
- RNA polymerase II transcriptional preinitiation complex assembly Source: SGD
- transcription by RNA polymerase II Source: SGD
Keywordsi
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | YEAST:G3O-32619-MONOMER. |
Reactomei | R-SCE-674695. RNA Polymerase II Pre-transcription Events. R-SCE-73776. RNA Polymerase II Promoter Escape. R-SCE-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening. R-SCE-75953. RNA Polymerase II Transcription Initiation. R-SCE-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance. |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription initiation factor TFIID subunit 11Alternative name(s): TAFII-40 Short name: TAFII40 TBP-associated factor 11 TBP-associated factor 40 kDa Short name: P40 |
Gene namesi | Name:TAF11 Synonyms:TAF40 Ordered Locus Names:YML015C ORF Names:YM9571.03C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YML015C. |
SGDi | S000004477. TAF11. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000118907 | 1 – 346 | Transcription initiation factor TFIID subunit 11Add BLAST | 346 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 236 | PhosphoserineCombined sources | 1 | |
Modified residuei | 238 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q04226. |
PaxDbi | Q04226. |
PRIDEi | Q04226. |
PTM databases
iPTMneti | Q04226. |
Interactioni
Subunit structurei
TAF11 heterodimerizes with TAF13, but they do not seem to form a heterotetramer like TAF6/TAF9. The 1.2 MDa TFIID complex is composed of TATA binding protein (TBP) and the 14 TBP-associated factors (one copy of each TAF1, TAF2, TAF3, TAF7, TAF8, TAF11, TAF13, two copies of each TAF4, TAF5, TAF6, TAF9, TAF10, TAF12, and three copies of TAF14), ranging in size from 17 to 150 kDa.1 Publication
Binary interactionsi
GO - Molecular functioni
- protein heterodimerization activity Source: InterPro
- transcription factor binding Source: GO_Central
Protein-protein interaction databases
BioGridi | 35154. 266 interactors. |
DIPi | DIP-1686N. |
IntActi | Q04226. 18 interactors. |
MINTi | Q04226. |
STRINGi | 4932.YML015C. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 131 – 329 | Histone-foldAdd BLAST | 199 |
Sequence similaritiesi
Belongs to the TAF11 family.Curated
Phylogenomic databases
GeneTreei | ENSGT00390000013228. |
HOGENOMi | HOG000000748. |
InParanoidi | Q04226. |
KOi | K03135. |
OMAi | FEVFHRT. |
OrthoDBi | EOG092C50DB. |
Family and domain databases
CDDi | cd08048. TAF11. 1 hit. |
Gene3Di | 1.10.20.10. 1 hit. |
InterProi | View protein in InterPro IPR009072. Histone-fold. IPR006809. TAFII28. |
PANTHERi | PTHR13218. PTHR13218. 1 hit. |
Pfami | View protein in Pfam PF04719. TAFII28. 1 hit. |
SUPFAMi | SSF47113. SSF47113. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q04226-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTEPQGPLDT IPKVNYPPIL TIANYFSTKQ MIDQVISEDQ DYVTWKLQNL
60 70 80 90 100
RTGGTSINNQ LNKYPKYKYQ KTRINQQDPD SINKVPENLI FPQDILQQQT
110 120 130 140 150
QNSNYEDTNT NEDENEKLAQ DEQFKLLVTN LDKDQTNRFE VFHRTSLNKT
160 170 180 190 200
QVKKLASTVA NQTISENIRV FLQAVGKIYA GEIIELAMIV KNKWLTSQMC
210 220 230 240 250
IEFDKRTKIG YKLKKYLKKL TFSIIENQQY KQDYQSDSVP EDEPDFYFDD
260 270 280 290 300
EEVDKRETTL GNSLLQSKSL QQSDHNSQDL KLQLIEQYNK LVLQFNKLDV
310 320 330 340
SIEKYNNSPL LPEHIREAWR LYRLQSDTLP NAYWRTQGEG QGSMFR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U85960 Genomic DNA. Translation: AAB46715.1. Z49810 Genomic DNA. Translation: CAA89937.1. AY692911 Genomic DNA. Translation: AAT92930.1. BK006946 Genomic DNA. Translation: DAA09883.1. |
PIRi | S55104. |
RefSeqi | NP_013697.1. NM_001182373.1. |
Genome annotation databases
EnsemblFungii | YML015C; YML015C; YML015C. |
GeneIDi | 854993. |
KEGGi | sce:YML015C. |
Similar proteinsi
Entry informationi
Entry namei | TAF11_YEAST | |
Accessioni | Q04226Primary (citable) accession number: Q04226 Secondary accession number(s): D6VZF9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | March 28, 2018 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |