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Protein

Ribosome assembly protein RRB1

Gene

RRB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in regulation of L3 expression and stability and plays a role in early 60S ribosomal subunit assembly. May be required for proper assembly of pre-ribosomal particles during early ribosome biogenesis, presumably by targeting L3 onto the 35S precursor rRNA.

GO - Molecular functioni

  • unfolded protein binding Source: SGD

GO - Biological processi

  • ribosome biogenesis Source: SGD
  • rRNA processing Source: UniProtKB-KW

Keywordsi

Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-32824-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome assembly protein RRB1
Gene namesi
Name:RRB1
Ordered Locus Names:YMR131C
ORF Names:YM9553.07C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:YMR131C
SGDiS000004738 RRB1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512021 – 511Ribosome assembly protein RRB1Add BLAST511

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ04225
PaxDbiQ04225
PRIDEiQ04225

PTM databases

iPTMnetiQ04225

Interactioni

Subunit structurei

Associates with ribosomal protein L3.

GO - Molecular functioni

  • unfolded protein binding Source: SGD

Protein-protein interaction databases

BioGridi35308, 109 interactors
DIPiDIP-6263N
IntActiQ04225, 8 interactors
MINTiQ04225
STRINGi4932.YMR131C

Structurei

3D structure databases

ProteinModelPortaliQ04225
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati319 – 359WD 1Add BLAST41
Repeati364 – 404WD 2Add BLAST41
Repeati415 – 455WD 3Add BLAST41
Repeati477 – 510WD 4Add BLAST34

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00550000075124
HOGENOMiHOG000036730
InParanoidiQ04225
KOiK14848
OMAiCLSFDII
OrthoDBiEOG092C21T4

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR022052 Histone-bd_RBBP4_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12265 CAF1C_H4-bd, 1 hit
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q04225-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKRSIEVNE EQDRVVSAKT ESHSVPAIPA SEEQDAPKND LEEQLSDEFD
60 70 80 90 100
SDGEIIEIDG DDEINDEDDL RKKQEEAETL VQKDQSEGNK EKIQELYLPH
110 120 130 140 150
MSRPLGPDEV LEADPTVYEM LHNVNMPWPC LTLDVIPDTL GSERRNYPQS
160 170 180 190 200
ILLTTATQSS RKKENELMVL ALSNLAKTLL KDDNEGEDDE EDDEDDVDPV
210 220 230 240 250
IENENIPLRD TTNRLKVSPF AISNQEVLTA TMSENGDVYI YNLAPQSKAF
260 270 280 290 300
STPGYQIPKS AKRPIHTVKN HGNVEGYGLD WSPLIKTGAL LSGDCSGQIY
310 320 330 340 350
FTQRHTSRWV TDKQPFTVSN NKSIEDIQWS RTESTVFATA GCDGYIRIWD
360 370 380 390 400
TRSKKHKPAI SVKASNTDVN VISWSDKIGY LLASGDDNGT WGVWDLRQFT
410 420 430 440 450
PSNADAVQPV AQYDFHKGAI TSIAFNPLDE SIVAVGSEDN TVTLWDLSVE
460 470 480 490 500
ADDEEIKQQA AETKELQEIP PQLLFVHWQK EVKDVKWHKQ IPGCLVSTGT
510
DGLNVWKTIS V
Length:511
Mass (Da):57,261
Last modified:November 1, 1997 - v1
Checksum:i1D18CE3C60BAFF30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48622 Genomic DNA Translation: CAA88556.1
BK006946 Genomic DNA Translation: DAA10028.1
PIRiS53061
RefSeqiNP_013850.1, NM_001182632.1

Genome annotation databases

EnsemblFungiiYMR131C; YMR131C; YMR131C
GeneIDi855161
KEGGisce:YMR131C

Similar proteinsi

Entry informationi

Entry nameiRRB1_YEAST
AccessioniPrimary (citable) accession number: Q04225
Secondary accession number(s): D6VZV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

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