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Protein

Ribosome assembly protein RRB1

Gene

RRB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in regulation of L3 expression and stability and plays a role in early 60S ribosomal subunit assembly. May be required for proper assembly of pre-ribosomal particles during early ribosome biogenesis, presumably by targeting L3 onto the 35S precursor rRNA.

GO - Molecular functioni

  • unfolded protein binding Source: SGD

GO - Biological processi

  • ribosome biogenesis Source: SGD
  • rRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-32824-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome assembly protein RRB1
Gene namesi
Name:RRB1
Ordered Locus Names:YMR131C
ORF Names:YM9553.07C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR131C.
SGDiS000004738. RRB1.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511Ribosome assembly protein RRB1PRO_0000051202Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei5 – 51PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ04225.

PTM databases

iPTMnetiQ04225.

Interactioni

Subunit structurei

Associates with ribosomal protein L3.

GO - Molecular functioni

  • unfolded protein binding Source: SGD

Protein-protein interaction databases

BioGridi35308. 36 interactions.
DIPiDIP-6263N.
IntActiQ04225. 8 interactions.
MINTiMINT-1168783.

Structurei

3D structure databases

ProteinModelPortaliQ04225.
SMRiQ04225. Positions 115-507.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati319 – 35941WD 1Add
BLAST
Repeati364 – 40441WD 2Add
BLAST
Repeati415 – 45541WD 3Add
BLAST
Repeati477 – 51034WD 4Add
BLAST

Sequence similaritiesi

Contains 4 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00550000075124.
HOGENOMiHOG000036730.
InParanoidiQ04225.
KOiK14848.
OMAiTYEMLHN.
OrthoDBiEOG092C21T4.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR022052. Histone-bd_RBBP4_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12265. CAF1C_H4-bd. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04225-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKRSIEVNE EQDRVVSAKT ESHSVPAIPA SEEQDAPKND LEEQLSDEFD
60 70 80 90 100
SDGEIIEIDG DDEINDEDDL RKKQEEAETL VQKDQSEGNK EKIQELYLPH
110 120 130 140 150
MSRPLGPDEV LEADPTVYEM LHNVNMPWPC LTLDVIPDTL GSERRNYPQS
160 170 180 190 200
ILLTTATQSS RKKENELMVL ALSNLAKTLL KDDNEGEDDE EDDEDDVDPV
210 220 230 240 250
IENENIPLRD TTNRLKVSPF AISNQEVLTA TMSENGDVYI YNLAPQSKAF
260 270 280 290 300
STPGYQIPKS AKRPIHTVKN HGNVEGYGLD WSPLIKTGAL LSGDCSGQIY
310 320 330 340 350
FTQRHTSRWV TDKQPFTVSN NKSIEDIQWS RTESTVFATA GCDGYIRIWD
360 370 380 390 400
TRSKKHKPAI SVKASNTDVN VISWSDKIGY LLASGDDNGT WGVWDLRQFT
410 420 430 440 450
PSNADAVQPV AQYDFHKGAI TSIAFNPLDE SIVAVGSEDN TVTLWDLSVE
460 470 480 490 500
ADDEEIKQQA AETKELQEIP PQLLFVHWQK EVKDVKWHKQ IPGCLVSTGT
510
DGLNVWKTIS V
Length:511
Mass (Da):57,261
Last modified:November 1, 1997 - v1
Checksum:i1D18CE3C60BAFF30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48622 Genomic DNA. Translation: CAA88556.1.
BK006946 Genomic DNA. Translation: DAA10028.1.
PIRiS53061.
RefSeqiNP_013850.1. NM_001182632.1.

Genome annotation databases

EnsemblFungiiYMR131C; YMR131C; YMR131C.
GeneIDi855161.
KEGGisce:YMR131C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48622 Genomic DNA. Translation: CAA88556.1.
BK006946 Genomic DNA. Translation: DAA10028.1.
PIRiS53061.
RefSeqiNP_013850.1. NM_001182632.1.

3D structure databases

ProteinModelPortaliQ04225.
SMRiQ04225. Positions 115-507.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35308. 36 interactions.
DIPiDIP-6263N.
IntActiQ04225. 8 interactions.
MINTiMINT-1168783.

PTM databases

iPTMnetiQ04225.

Proteomic databases

MaxQBiQ04225.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR131C; YMR131C; YMR131C.
GeneIDi855161.
KEGGisce:YMR131C.

Organism-specific databases

EuPathDBiFungiDB:YMR131C.
SGDiS000004738. RRB1.

Phylogenomic databases

GeneTreeiENSGT00550000075124.
HOGENOMiHOG000036730.
InParanoidiQ04225.
KOiK14848.
OMAiTYEMLHN.
OrthoDBiEOG092C21T4.

Enzyme and pathway databases

BioCyciYEAST:G3O-32824-MONOMER.

Miscellaneous databases

PROiQ04225.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR022052. Histone-bd_RBBP4_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12265. CAF1C_H4-bd. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRRB1_YEAST
AccessioniPrimary (citable) accession number: Q04225
Secondary accession number(s): D6VZV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.