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Q04213

- IOC4_YEAST

UniProt

Q04213 - IOC4_YEAST

Protein

ISWI one complex protein 4

Gene

IOC4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Functions as component of the ISW1B complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW1B complex acts within coding regions to control the amount of RNA polymerase II released into productive elongation and to coordinate elongation with termination and pre-mRNA processing.2 Publications

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. chromatin remodeling Source: SGD
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32749-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ISWI one complex protein 4
    Gene namesi
    Name:IOC4
    Ordered Locus Names:YMR044W
    ORF Names:YM9532.09
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYMR044w.
    SGDiS000004647. IOC4.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. Isw1b complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 475475ISWI one complex protein 4PRO_0000203276Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21Phosphoserine1 Publication
    Modified residuei9 – 91Phosphothreonine1 Publication
    Modified residuei65 – 651Phosphoserine1 Publication
    Modified residuei73 – 731Phosphoserine3 Publications
    Modified residuei242 – 2421Phosphoserine3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ04213.
    PaxDbiQ04213.
    PeptideAtlasiQ04213.
    PRIDEiQ04213.

    Expressioni

    Gene expression databases

    GenevestigatoriQ04213.

    Interactioni

    Subunit structurei

    Component of the ISW1B complex, which at least consists of ISW1, IOC2 and IOC4.1 Publication

    Protein-protein interaction databases

    BioGridi35217. 104 interactions.
    DIPiDIP-876N.
    IntActiQ04213. 9 interactions.
    MINTiMINT-2734846.
    STRINGi4932.YMR044W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04213.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi74 – 774Poly-Glu
    Compositional biasi186 – 19510Poly-Glu
    Compositional biasi243 – 2519Poly-Glu

    Phylogenomic databases

    eggNOGiNOG74166.
    HOGENOMiHOG000113087.
    OMAiWEFVEYG.
    OrthoDBiEOG7NGQPK.

    Family and domain databases

    InterProiIPR000313. PWWP_dom.
    [Graphical view]
    PfamiPF00855. PWWP. 1 hit.
    [Graphical view]
    SMARTiSM00293. PWWP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04213-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEAIFQPTD IVLAKVKGFS AWPAMIIPNE LIPDNILKTK PVSVHKGKSG    50
    SDKKANEDID ADMESEARDR EQSEEEEDIE DFGESEANPE KFIIYTPVLK 100
    FRKNDTLKST YCVKFFCDDS YIWVKPMDMK ILTSEDCRKW LSGKQRKNKK 150
    LIPAYEMAMR GKNGIDIWEF VEYGSYGKPD EEEYVEEEEE ENEPEKKAIR 200
    PTRSSSRQRQ KRASETEKSE GGNSNKRKRV TRSTRQQAID ASEEEEEEEE 250
    EKVQEAVRKR PQRTKTKKVV VSKTKPNPKT KAKKEKPKPP KPIKYHFEDD 300
    EDWSIVGLGP QDLSIEKTMD PIAKKLSQKK NLEKHVEIKL DLEDKLAGIN 350
    KLLCDVLCSA INQAVSIKDD FEIILDELQI ALDTRGSRNE FITIFQSNNS 400
    LLLNFRILFN LRKRELNKWD LWDRFQDIFK HIYSYQFIPD TEDWQLEQNM 450
    EIEEMDREKP SFSEDVKEEE SKVGA 475
    Length:475
    Mass (Da):55,427
    Last modified:November 1, 1997 - v1
    Checksum:iDFD6189E81178060
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48502 Genomic DNA. Translation: CAA88410.1.
    BK006946 Genomic DNA. Translation: DAA09943.1.
    PIRiS52893.
    RefSeqiNP_013758.1. NM_001182541.1.

    Genome annotation databases

    EnsemblFungiiYMR044W; YMR044W; YMR044W.
    GeneIDi855061.
    KEGGisce:YMR044W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48502 Genomic DNA. Translation: CAA88410.1 .
    BK006946 Genomic DNA. Translation: DAA09943.1 .
    PIRi S52893.
    RefSeqi NP_013758.1. NM_001182541.1.

    3D structure databases

    ProteinModelPortali Q04213.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35217. 104 interactions.
    DIPi DIP-876N.
    IntActi Q04213. 9 interactions.
    MINTi MINT-2734846.
    STRINGi 4932.YMR044W.

    Proteomic databases

    MaxQBi Q04213.
    PaxDbi Q04213.
    PeptideAtlasi Q04213.
    PRIDEi Q04213.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YMR044W ; YMR044W ; YMR044W .
    GeneIDi 855061.
    KEGGi sce:YMR044W.

    Organism-specific databases

    CYGDi YMR044w.
    SGDi S000004647. IOC4.

    Phylogenomic databases

    eggNOGi NOG74166.
    HOGENOMi HOG000113087.
    OMAi WEFVEYG.
    OrthoDBi EOG7NGQPK.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32749-MONOMER.

    Miscellaneous databases

    NextBioi 978318.

    Gene expression databases

    Genevestigatori Q04213.

    Family and domain databases

    InterProi IPR000313. PWWP_dom.
    [Graphical view ]
    Pfami PF00855. PWWP. 1 hit.
    [Graphical view ]
    SMARTi SM00293. PWWP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Isw1 chromatin remodeling ATPase coordinates transcription elongation and termination by RNA polymerase II."
      Morillon A., Karabetsou N., O'Sullivan J., Kent N., Proudfoot N., Mellor J.
      Cell 115:425-435(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF THE ISW1B COMPLEX.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. Cited for: IDENTIFICATION IN THE ISW1B COMPLEX, FUNCTION OF THE ISW1B COMPLEX.
    7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73 AND SER-242, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; THR-9; SER-65; SER-73 AND SER-242, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73 AND SER-242, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiIOC4_YEAST
    AccessioniPrimary (citable) accession number: Q04213
    Secondary accession number(s): D6VZL9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 5820 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3