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Q04213 (IOC4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ISWI one complex protein 4
Gene names
Name:IOC4
Ordered Locus Names:YMR044W
ORF Names:YM9532.09
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length475 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Functions as component of the ISW1B complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW1B complex acts within coding regions to control the amount of RNA polymerase II released into productive elongation and to coordinate elongation with termination and pre-mRNA processing. Ref.3 Ref.6

Subunit structure

Component of the ISW1B complex, which at least consists of ISW1, IOC2 and IOC4. Ref.6

Subcellular location

Nucleus Ref.4.

Miscellaneous

Present with 5820 molecules/cell in log phase SD medium.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 475475ISWI one complex protein 4
PRO_0000203276

Regions

Compositional bias74 – 774Poly-Glu
Compositional bias186 – 19510Poly-Glu
Compositional bias243 – 2519Poly-Glu

Amino acid modifications

Modified residue21Phosphoserine Ref.8
Modified residue91Phosphothreonine Ref.8
Modified residue651Phosphoserine Ref.8
Modified residue731Phosphoserine Ref.7 Ref.8 Ref.9
Modified residue2421Phosphoserine Ref.7 Ref.8 Ref.9

Sequences

Sequence LengthMass (Da)Tools
Q04213 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: DFD6189E81178060

FASTA47555,427
        10         20         30         40         50         60 
MSEAIFQPTD IVLAKVKGFS AWPAMIIPNE LIPDNILKTK PVSVHKGKSG SDKKANEDID 

        70         80         90        100        110        120 
ADMESEARDR EQSEEEEDIE DFGESEANPE KFIIYTPVLK FRKNDTLKST YCVKFFCDDS 

       130        140        150        160        170        180 
YIWVKPMDMK ILTSEDCRKW LSGKQRKNKK LIPAYEMAMR GKNGIDIWEF VEYGSYGKPD 

       190        200        210        220        230        240 
EEEYVEEEEE ENEPEKKAIR PTRSSSRQRQ KRASETEKSE GGNSNKRKRV TRSTRQQAID 

       250        260        270        280        290        300 
ASEEEEEEEE EKVQEAVRKR PQRTKTKKVV VSKTKPNPKT KAKKEKPKPP KPIKYHFEDD 

       310        320        330        340        350        360 
EDWSIVGLGP QDLSIEKTMD PIAKKLSQKK NLEKHVEIKL DLEDKLAGIN KLLCDVLCSA 

       370        380        390        400        410        420 
INQAVSIKDD FEIILDELQI ALDTRGSRNE FITIFQSNNS LLLNFRILFN LRKRELNKWD 

       430        440        450        460        470 
LWDRFQDIFK HIYSYQFIPD TEDWQLEQNM EIEEMDREKP SFSEDVKEEE SKVGA 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Isw1 chromatin remodeling ATPase coordinates transcription elongation and termination by RNA polymerase II."
Morillon A., Karabetsou N., O'Sullivan J., Kent N., Proudfoot N., Mellor J.
Cell 115:425-435(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION OF THE ISW1B COMPLEX.
[4]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"Yeast Isw1p forms two separable complexes in vivo."
Vary J.C. Jr., Gangaraju V.K., Qin J., Landel C.C., Kooperberg C., Bartholomew B., Tsukiyama T.
Mol. Cell. Biol. 23:80-91(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE ISW1B COMPLEX, FUNCTION OF THE ISW1B COMPLEX.
[7]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73 AND SER-242, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: ADR376.
[8]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; THR-9; SER-65; SER-73 AND SER-242, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73 AND SER-242, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z48502 Genomic DNA. Translation: CAA88410.1.
BK006946 Genomic DNA. Translation: DAA09943.1.
PIRS52893.
RefSeqNP_013758.1. NM_001182541.1.

3D structure databases

ProteinModelPortalQ04213.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35217. 104 interactions.
DIPDIP-876N.
IntActQ04213. 9 interactions.
MINTMINT-2734846.
STRING4932.YMR044W.

Proteomic databases

MaxQBQ04213.
PaxDbQ04213.
PeptideAtlasQ04213.
PRIDEQ04213.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYMR044W; YMR044W; YMR044W.
GeneID855061.
KEGGsce:YMR044W.

Organism-specific databases

CYGDYMR044w.
SGDS000004647. IOC4.

Phylogenomic databases

eggNOGNOG74166.
HOGENOMHOG000113087.
OMAWEFVEYG.
OrthoDBEOG7NGQPK.

Enzyme and pathway databases

BioCycYEAST:G3O-32749-MONOMER.

Gene expression databases

GenevestigatorQ04213.

Family and domain databases

InterProIPR000313. PWWP_dom.
[Graphical view]
PfamPF00855. PWWP. 1 hit.
[Graphical view]
SMARTSM00293. PWWP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio978318.

Entry information

Entry nameIOC4_YEAST
AccessionPrimary (citable) accession number: Q04213
Secondary accession number(s): D6VZL9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 14, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD