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Q04213

- IOC4_YEAST

UniProt

Q04213 - IOC4_YEAST

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Protein

ISWI one complex protein 4

Gene
IOC4, YMR044W, YM9532.09
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Functions as component of the ISW1B complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW1B complex acts within coding regions to control the amount of RNA polymerase II released into productive elongation and to coordinate elongation with termination and pre-mRNA processing.2 Publications

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. chromatin remodeling Source: SGD
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-32749-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ISWI one complex protein 4
Gene namesi
Name:IOC4
Ordered Locus Names:YMR044W
ORF Names:YM9532.09
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR044w.
SGDiS000004647. IOC4.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. Isw1b complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475ISWI one complex protein 4PRO_0000203276Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21Phosphoserine1 Publication
Modified residuei9 – 91Phosphothreonine1 Publication
Modified residuei65 – 651Phosphoserine1 Publication
Modified residuei73 – 731Phosphoserine3 Publications
Modified residuei242 – 2421Phosphoserine3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ04213.
PaxDbiQ04213.
PeptideAtlasiQ04213.
PRIDEiQ04213.

Expressioni

Gene expression databases

GenevestigatoriQ04213.

Interactioni

Subunit structurei

Component of the ISW1B complex, which at least consists of ISW1, IOC2 and IOC4.1 Publication

Protein-protein interaction databases

BioGridi35217. 104 interactions.
DIPiDIP-876N.
IntActiQ04213. 9 interactions.
MINTiMINT-2734846.
STRINGi4932.YMR044W.

Structurei

3D structure databases

ProteinModelPortaliQ04213.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi74 – 774Poly-Glu
Compositional biasi186 – 19510Poly-Glu
Compositional biasi243 – 2519Poly-Glu

Phylogenomic databases

eggNOGiNOG74166.
HOGENOMiHOG000113087.
OMAiWEFVEYG.
OrthoDBiEOG7NGQPK.

Family and domain databases

InterProiIPR000313. PWWP_dom.
[Graphical view]
PfamiPF00855. PWWP. 1 hit.
[Graphical view]
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04213-1 [UniParc]FASTAAdd to Basket

« Hide

MSEAIFQPTD IVLAKVKGFS AWPAMIIPNE LIPDNILKTK PVSVHKGKSG    50
SDKKANEDID ADMESEARDR EQSEEEEDIE DFGESEANPE KFIIYTPVLK 100
FRKNDTLKST YCVKFFCDDS YIWVKPMDMK ILTSEDCRKW LSGKQRKNKK 150
LIPAYEMAMR GKNGIDIWEF VEYGSYGKPD EEEYVEEEEE ENEPEKKAIR 200
PTRSSSRQRQ KRASETEKSE GGNSNKRKRV TRSTRQQAID ASEEEEEEEE 250
EKVQEAVRKR PQRTKTKKVV VSKTKPNPKT KAKKEKPKPP KPIKYHFEDD 300
EDWSIVGLGP QDLSIEKTMD PIAKKLSQKK NLEKHVEIKL DLEDKLAGIN 350
KLLCDVLCSA INQAVSIKDD FEIILDELQI ALDTRGSRNE FITIFQSNNS 400
LLLNFRILFN LRKRELNKWD LWDRFQDIFK HIYSYQFIPD TEDWQLEQNM 450
EIEEMDREKP SFSEDVKEEE SKVGA 475
Length:475
Mass (Da):55,427
Last modified:November 1, 1997 - v1
Checksum:iDFD6189E81178060
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z48502 Genomic DNA. Translation: CAA88410.1.
BK006946 Genomic DNA. Translation: DAA09943.1.
PIRiS52893.
RefSeqiNP_013758.1. NM_001182541.1.

Genome annotation databases

EnsemblFungiiYMR044W; YMR044W; YMR044W.
GeneIDi855061.
KEGGisce:YMR044W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z48502 Genomic DNA. Translation: CAA88410.1 .
BK006946 Genomic DNA. Translation: DAA09943.1 .
PIRi S52893.
RefSeqi NP_013758.1. NM_001182541.1.

3D structure databases

ProteinModelPortali Q04213.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35217. 104 interactions.
DIPi DIP-876N.
IntActi Q04213. 9 interactions.
MINTi MINT-2734846.
STRINGi 4932.YMR044W.

Proteomic databases

MaxQBi Q04213.
PaxDbi Q04213.
PeptideAtlasi Q04213.
PRIDEi Q04213.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR044W ; YMR044W ; YMR044W .
GeneIDi 855061.
KEGGi sce:YMR044W.

Organism-specific databases

CYGDi YMR044w.
SGDi S000004647. IOC4.

Phylogenomic databases

eggNOGi NOG74166.
HOGENOMi HOG000113087.
OMAi WEFVEYG.
OrthoDBi EOG7NGQPK.

Enzyme and pathway databases

BioCyci YEAST:G3O-32749-MONOMER.

Miscellaneous databases

NextBioi 978318.

Gene expression databases

Genevestigatori Q04213.

Family and domain databases

InterProi IPR000313. PWWP_dom.
[Graphical view ]
Pfami PF00855. PWWP. 1 hit.
[Graphical view ]
SMARTi SM00293. PWWP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Isw1 chromatin remodeling ATPase coordinates transcription elongation and termination by RNA polymerase II."
    Morillon A., Karabetsou N., O'Sullivan J., Kent N., Proudfoot N., Mellor J.
    Cell 115:425-435(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE ISW1B COMPLEX.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION IN THE ISW1B COMPLEX, FUNCTION OF THE ISW1B COMPLEX.
  7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73 AND SER-242, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; THR-9; SER-65; SER-73 AND SER-242, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73 AND SER-242, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiIOC4_YEAST
AccessioniPrimary (citable) accession number: Q04213
Secondary accession number(s): D6VZL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 14, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 5820 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

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