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Protein

D-arabinose 1-dehydrogenase

Gene

ARA2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-arabinose + NAD+ = D-arabinono-1,4-lactone + NADH.

Kineticsi

  1. KM=0.78 mM for D-arabinose1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Active sitei58Proton donorBy similarity1
    Sitei86Lowers pKa of active site TyrBy similarity1
    Binding sitei124SubstrateSequence analysis1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Nucleotide bindingi221 – 287NADSequence analysisAdd BLAST67

    GO - Molecular functioni

    GO - Biological processi

    • dehydro-D-arabinono-1,4-lactone biosynthetic process Source: SGD

    Keywordsi

    Molecular functionOxidoreductase
    LigandNAD

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER3O-32
    YEAST:MONOMER3O-32
    BRENDAi1.1.1.116 984
    SABIO-RKiQ04212

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D-arabinose 1-dehydrogenase (EC:1.1.1.116)
    Alternative name(s):
    NAD(+)-specific D-arabinose dehydrogenase
    Gene namesi
    Name:ARA2
    Ordered Locus Names:YMR041C
    ORF Names:YM9532.06C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    Proteomesi
    • UP000002311 Componenti: Chromosome XIII

    Organism-specific databases

    EuPathDBiFungiDB:YMR041C
    SGDiS000004644 ARA2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000703721 – 335D-arabinose 1-dehydrogenaseAdd BLAST335

    Proteomic databases

    MaxQBiQ04212
    PaxDbiQ04212
    PRIDEiQ04212

    PTM databases

    iPTMnetiQ04212

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SPT16P325583EBI-28073,EBI-4334

    Protein-protein interaction databases

    BioGridi3521327 interactors.
    DIPiDIP-4506N
    IntActiQ04212 3 interactors.
    MINTiQ04212
    STRINGi4932.YMR041C

    Structurei

    3D structure databases

    ProteinModelPortaliQ04212
    SMRiQ04212
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    GeneTreeiENSGT00390000005890
    HOGENOMiHOG000250267
    InParanoidiQ04212
    KOiK00062
    OMAiICTKVGR
    OrthoDBiEOG092C4M0R

    Family and domain databases

    CDDicd06660 Aldo_ket_red, 1 hit
    Gene3Di3.20.20.1001 hit
    InterProiView protein in InterPro
    IPR023210 NADP_OxRdtase_dom
    IPR036812 NADP_OxRdtase_dom_sf
    PfamiView protein in Pfam
    PF00248 Aldo_ket_red, 1 hit
    SUPFAMiSSF51430 SSF51430, 1 hit

    Sequencei

    Sequence statusi: Complete.

    Q04212-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MVNEKVNPFD LASVSPLVLG GAILNQQYTD EPESIPLEDI IKYAFSHGIN
    60 70 80 90 100
    AIDTSPYYGP SEVLYGRALS NLRNEFPRDT YFICTKVGRI GAEEFNYSRD
    110 120 130 140 150
    FVRFSVHRSC ERLHTTYLDL VYLHDVEFVK FPDILEALKE LRTLKNKGVI
    160 170 180 190 200
    KNFGISGYPI DFITWLAEYC STEESDIGSL DAVLSYCNLN LQNNKLLNFR
    210 220 230 240 250
    ERLLRNAKLK MVCNASILSM SLLRSQETRQ FHPCSHELRE CASQAAKYCQ
    260 270 280 290 300
    EQNVDLADLA TRYAISEWVG KGPVVLGVSS MEELKLALDN YEIVKSNGNR
    310 320 330
    LSSKDGQLVE YIQKNIFKEH FNEEWSSGIP HPEMI
    Length:335
    Mass (Da):38,220
    Last modified:November 1, 1997 - v1
    Checksum:iCC7FA464FFAE6ED7
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB237161 Genomic DNA Translation: BAE93049.1
    Z48502 Genomic DNA Translation: CAA88407.1
    BK006946 Genomic DNA Translation: DAA09940.1
    PIRiS52890
    RefSeqiNP_013755.1, NM_001182538.1

    Genome annotation databases

    EnsemblFungiiYMR041C; YMR041C; YMR041C
    GeneIDi855057
    KEGGisce:YMR041C

    Similar proteinsi

    Entry informationi

    Entry nameiARA2_YEAST
    AccessioniPrimary (citable) accession number: Q04212
    Secondary accession number(s): D6VZL6, Q1XGQ6
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: March 28, 2018
    This is version 124 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome