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Protein

Protein BTG2

Gene

Btg2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors. Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • associative learning Source: MGI
  • cellular response to DNA damage stimulus Source: MGI
  • central nervous system neuron development Source: MGI
  • dentate gyrus development Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of neural precursor cell proliferation Source: MGI
  • negative regulation of neuron apoptotic process Source: Ensembl
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • negative regulation of translation Source: UniProtKB
  • neuron differentiation Source: MGI
  • neuron projection development Source: MGI
  • positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Source: MGI
  • protein methylation Source: MGI
  • response to electrical stimulus Source: Ensembl
  • response to mechanical stimulus Source: Ensembl
  • response to organic cyclic compound Source: Ensembl
  • response to peptide hormone Source: Ensembl
  • skeletal muscle cell differentiation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BTG2
Alternative name(s):
BTG family member 2
NGF-inducible protein TIS21
Gene namesi
Name:Btg2
Synonyms:Tis21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:108384 Btg2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001438051 – 158Protein BTG2Add BLAST158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei147Phosphoserine; by MAPK1 and MAPK3By similarity1
Modified residuei149Phosphoserine; by MAPK14By similarity1

Post-translational modificationi

Phosphorylated at Ser-147 by MAPK1/ERK2 and MAPK3/ERK1, and at Ser-149 by MAPK14, leading to PIN1-binding and mitochondrial depolarization.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ04211
PRIDEiQ04211

PTM databases

iPTMnetiQ04211
PhosphoSitePlusiQ04211

Expressioni

Inductioni

By nerve growth factor and tumors promoters.1 Publication

Gene expression databases

BgeeiENSMUSG00000020423
CleanExiMM_BTG2
ExpressionAtlasiQ04211 baseline and differential
GenevisibleiQ04211 MM

Interactioni

Subunit structurei

Interacts with PRKCABP. Interacts with CNOT7 and CNOT8; indicative for an association with the CCR4-NOT complex. Interacts with PIN1, inducing mitochondrial depolarization (By similarity).By similarity

Protein-protein interaction databases

BioGridi198398, 3 interactors
DIPiDIP-41601N
IntActiQ04211, 2 interactors
MINTiQ04211
STRINGi10090.ENSMUSP00000020692

Structurei

Secondary structure

1158
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 28Combined sources19
Helixi32 – 50Combined sources19
Turni59 – 62Combined sources4
Helixi63 – 66Combined sources4
Beta strandi68 – 73Combined sources6
Helixi76 – 84Combined sources9
Helixi89 – 95Combined sources7
Beta strandi98 – 105Combined sources8
Beta strandi108 – 114Combined sources7
Beta strandi120 – 124Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DJNX-ray2.20B8-125[»]
ProteinModelPortaliQ04211
SMRiQ04211
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ04211

Family & Domainsi

Sequence similaritiesi

Belongs to the BTG family.Curated

Phylogenomic databases

eggNOGiKOG4006 Eukaryota
ENOG410ZZC0 LUCA
GeneTreeiENSGT00550000074461
HOGENOMiHOG000290200
HOVERGENiHBG004907
InParanoidiQ04211
KOiK14443
OMAiPSKNYIM
OrthoDBiEOG091G0RS0
PhylomeDBiQ04211
TreeFamiTF105272

Family and domain databases

Gene3Di1.20.120.1120, 1 hit
InterProiView protein in InterPro
IPR002087 Anti_prolifrtn
IPR036054 BTG-like_sf
IPR033328 BTG2
PANTHERiPTHR22978:SF29 PTHR22978:SF29, 1 hit
PfamiView protein in Pfam
PF07742 BTG, 1 hit
PRINTSiPR00310 ANTIPRLFBTG1
SMARTiView protein in SMART
SM00099 btg1, 1 hit
SUPFAMiSSF160696 SSF160696, 1 hit
PROSITEiView protein in PROSITE
PS00960 BTG_1, 1 hit
PS01203 BTG_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q04211-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHGKRTDML PEIAAAVGFL SSLLRTRGCV SEQRLKVFSR ALQDALTDHY
60 70 80 90 100
KHHWFPEKPS KGSGYRCIRI NHKMDPIISK VASQIGLSQP QLHRLLPSEL
110 120 130 140 150
TLWVDPYEVS YRIGEDGSIC VLYEEAPVAA SYGLLTCKNQ MMLGRSSPSK

NYVMAVSS
Length:158
Mass (Da):17,682
Last modified:February 1, 1994 - v1
Checksum:i5B91563BAE4CB74C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64292 Genomic DNA Translation: AAA40449.1
CCDSiCCDS15302.1
PIRiA40761
RefSeqiNP_031596.1, NM_007570.2
UniGeneiMm.392646

Genome annotation databases

EnsembliENSMUST00000020692; ENSMUSP00000020692; ENSMUSG00000020423
GeneIDi12227
KEGGimmu:12227
UCSCiuc007cre.1 mouse

Similar proteinsi

Entry informationi

Entry nameiBTG2_MOUSE
AccessioniPrimary (citable) accession number: Q04211
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: March 28, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health