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Q04211 (BTG2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein BTG2
Alternative name(s):
BTG family member 2
NGF-inducible protein TIS21
Gene names
Name:Btg2
Synonyms:Tis21
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length158 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenyltion in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors. Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth By similarity.

Subunit structure

Interacts with PRKCABP. Interacts with CNOT7 and CNOT8; indicative for an asscociation with the CCR4-NOT complex. Interacts with PIN1, inducing mitochondrial depolarization By similarity.

Induction

By nerve growth factor and tumors promoters. Ref.1

Post-translational modification

Phosphorylated at Ser-147 by MAPK1/ERK2 and MAPK3/ERK1, and at Ser-149 by MAPK14, leading to PIN1-binding and mitochondrial depolarization By similarity.

Sequence similarities

Belongs to the BTG family.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   PTMPhosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processanterior/posterior pattern specification

Inferred from mutant phenotype PubMed 15542835. Source: MGI

associative learning

Inferred from mutant phenotype PubMed 20020054. Source: MGI

cellular response to DNA damage stimulus

Inferred from electronic annotation. Source: Ensembl

central nervous system neuron development

Inferred from mutant phenotype PubMed 20020054. Source: MGI

dentate gyrus development

Inferred from mutant phenotype PubMed 20020054. Source: MGI

negative regulation of cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of neural precursor cell proliferation

Inferred from mutant phenotype PubMed 20020054. Source: MGI

negative regulation of neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of translation

Inferred from sequence or structural similarity. Source: UniProtKB

neuron projection development

Inferred from electronic annotation. Source: Ensembl

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

Inferred from electronic annotation. Source: Ensembl

protein methylation

Inferred from direct assay PubMed 8663146. Source: MGI

response to electrical stimulus

Inferred from electronic annotation. Source: Ensembl

response to mechanical stimulus

Inferred from electronic annotation. Source: Ensembl

response to organic cyclic compound

Inferred from electronic annotation. Source: Ensembl

response to peptide hormone

Inferred from electronic annotation. Source: Ensembl

skeletal muscle cell differentiation

Inferred from mutant phenotype PubMed 22147266. Source: MGI

   Molecular_functionRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

Inferred from electronic annotation. Source: Ensembl

protein binding

Inferred from physical interaction PubMed 15542835PubMed 8663146. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 158158Protein BTG2
PRO_0000143805

Amino acid modifications

Modified residue1471Phosphoserine; by MAPK1 and MAPK3 By similarity
Modified residue1491Phosphoserine; by MAPK14 By similarity

Secondary structure

.................... 158
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q04211 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 5B91563BAE4CB74C

FASTA15817,682
        10         20         30         40         50         60 
MSHGKRTDML PEIAAAVGFL SSLLRTRGCV SEQRLKVFSR ALQDALTDHY KHHWFPEKPS 

        70         80         90        100        110        120 
KGSGYRCIRI NHKMDPIISK VASQIGLSQP QLHRLLPSEL TLWVDPYEVS YRIGEDGSIC 

       130        140        150 
VLYEEAPVAA SYGLLTCKNQ MMLGRSSPSK NYVMAVSS 

« Hide

References

[1]"Structure and expression of TIS21, a primary response gene induced by growth factors and tumor promoters."
Fletcher B.S., Lim R.W., Varnum B.C., Kujubu D.A., Koski R.A., Herschman H.R.
J. Biol. Chem. 266:14511-14518(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M64292 Genomic DNA. Translation: AAA40449.1.
CCDSCCDS15302.1.
PIRA40761.
RefSeqNP_031596.1. NM_007570.2.
UniGeneMm.392646.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3DJNX-ray2.20B8-125[»]
ProteinModelPortalQ04211.
SMRQ04211. Positions 8-125.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198398. 3 interactions.
IntActQ04211. 1 interaction.
MINTMINT-1517995.
STRING10090.ENSMUSP00000020692.

PTM databases

PhosphoSiteQ04211.

Proteomic databases

PaxDbQ04211.
PRIDEQ04211.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020692; ENSMUSP00000020692; ENSMUSG00000020423.
GeneID12227.
KEGGmmu:12227.
UCSCuc007cre.1. mouse.

Organism-specific databases

CTD7832.
MGIMGI:108384. Btg2.

Phylogenomic databases

eggNOGNOG287298.
HOGENOMHOG000290200.
HOVERGENHBG004907.
InParanoidQ04211.
KOK14443.
OMANAFANIR.
OrthoDBEOG72RN0S.
PhylomeDBQ04211.
TreeFamTF105272.

Gene expression databases

ArrayExpressQ04211.
BgeeQ04211.
CleanExMM_BTG2.
GenevestigatorQ04211.

Family and domain databases

InterProIPR002087. Anti_prolifrtn.
[Graphical view]
PfamPF07742. BTG. 1 hit.
[Graphical view]
PRINTSPR00310. ANTIPRLFBTG1.
SMARTSM00099. btg1. 1 hit.
[Graphical view]
PROSITEPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSBTG2. mouse.
EvolutionaryTraceQ04211.
NextBio280639.
PROQ04211.
SOURCESearch...

Entry information

Entry nameBTG2_MOUSE
AccessionPrimary (citable) accession number: Q04211
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot