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Protein

Protein BTG2

Gene

Btg2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors. Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-6804115. TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BTG2
Alternative name(s):
BTG family member 2
NGF-inducible protein TIS21
Gene namesi
Name:Btg2
Synonyms:Tis21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:108384. Btg2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001438051 – 158Protein BTG2Add BLAST158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei147Phosphoserine; by MAPK1 and MAPK3By similarity1
Modified residuei149Phosphoserine; by MAPK14By similarity1

Post-translational modificationi

Phosphorylated at Ser-147 by MAPK1/ERK2 and MAPK3/ERK1, and at Ser-149 by MAPK14, leading to PIN1-binding and mitochondrial depolarization.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ04211.
PRIDEiQ04211.

PTM databases

iPTMnetiQ04211.
PhosphoSitePlusiQ04211.

Expressioni

Inductioni

By nerve growth factor and tumors promoters.1 Publication

Gene expression databases

BgeeiENSMUSG00000020423.
CleanExiMM_BTG2.
ExpressionAtlasiQ04211. baseline and differential.
GenevisibleiQ04211. MM.

Interactioni

Subunit structurei

Interacts with PRKCABP. Interacts with CNOT7 and CNOT8; indicative for an association with the CCR4-NOT complex. Interacts with PIN1, inducing mitochondrial depolarization (By similarity).By similarity

Protein-protein interaction databases

BioGridi198398. 3 interactors.
DIPiDIP-41601N.
IntActiQ04211. 1 interactor.
MINTiMINT-1517995.
STRINGi10090.ENSMUSP00000020692.

Structurei

Secondary structure

1158
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 28Combined sources19
Helixi32 – 50Combined sources19
Turni59 – 62Combined sources4
Helixi63 – 66Combined sources4
Beta strandi68 – 73Combined sources6
Helixi76 – 84Combined sources9
Helixi89 – 95Combined sources7
Beta strandi98 – 105Combined sources8
Beta strandi108 – 114Combined sources7
Beta strandi120 – 124Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DJNX-ray2.20B8-125[»]
ProteinModelPortaliQ04211.
SMRiQ04211.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ04211.

Family & Domainsi

Sequence similaritiesi

Belongs to the BTG family.Curated

Phylogenomic databases

eggNOGiKOG4006. Eukaryota.
ENOG410ZZC0. LUCA.
GeneTreeiENSGT00550000074461.
HOGENOMiHOG000290200.
HOVERGENiHBG004907.
InParanoidiQ04211.
KOiK14443.
OMAiMLTCKNQ.
OrthoDBiEOG091G0RS0.
PhylomeDBiQ04211.
TreeFamiTF105272.

Family and domain databases

InterProiIPR002087. Anti_prolifrtn.
IPR033328. BTG2.
[Graphical view]
PANTHERiPTHR22978:SF29. PTHR22978:SF29. 1 hit.
PfamiPF07742. BTG. 1 hit.
[Graphical view]
PRINTSiPR00310. ANTIPRLFBTG1.
SMARTiSM00099. btg1. 1 hit.
[Graphical view]
SUPFAMiSSF160696. SSF160696. 1 hit.
PROSITEiPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04211-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHGKRTDML PEIAAAVGFL SSLLRTRGCV SEQRLKVFSR ALQDALTDHY
60 70 80 90 100
KHHWFPEKPS KGSGYRCIRI NHKMDPIISK VASQIGLSQP QLHRLLPSEL
110 120 130 140 150
TLWVDPYEVS YRIGEDGSIC VLYEEAPVAA SYGLLTCKNQ MMLGRSSPSK

NYVMAVSS
Length:158
Mass (Da):17,682
Last modified:February 1, 1994 - v1
Checksum:i5B91563BAE4CB74C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64292 Genomic DNA. Translation: AAA40449.1.
CCDSiCCDS15302.1.
PIRiA40761.
RefSeqiNP_031596.1. NM_007570.2.
UniGeneiMm.392646.

Genome annotation databases

EnsembliENSMUST00000020692; ENSMUSP00000020692; ENSMUSG00000020423.
GeneIDi12227.
KEGGimmu:12227.
UCSCiuc007cre.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64292 Genomic DNA. Translation: AAA40449.1.
CCDSiCCDS15302.1.
PIRiA40761.
RefSeqiNP_031596.1. NM_007570.2.
UniGeneiMm.392646.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DJNX-ray2.20B8-125[»]
ProteinModelPortaliQ04211.
SMRiQ04211.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198398. 3 interactors.
DIPiDIP-41601N.
IntActiQ04211. 1 interactor.
MINTiMINT-1517995.
STRINGi10090.ENSMUSP00000020692.

PTM databases

iPTMnetiQ04211.
PhosphoSitePlusiQ04211.

Proteomic databases

PaxDbiQ04211.
PRIDEiQ04211.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020692; ENSMUSP00000020692; ENSMUSG00000020423.
GeneIDi12227.
KEGGimmu:12227.
UCSCiuc007cre.1. mouse.

Organism-specific databases

CTDi7832.
MGIiMGI:108384. Btg2.

Phylogenomic databases

eggNOGiKOG4006. Eukaryota.
ENOG410ZZC0. LUCA.
GeneTreeiENSGT00550000074461.
HOGENOMiHOG000290200.
HOVERGENiHBG004907.
InParanoidiQ04211.
KOiK14443.
OMAiMLTCKNQ.
OrthoDBiEOG091G0RS0.
PhylomeDBiQ04211.
TreeFamiTF105272.

Enzyme and pathway databases

ReactomeiR-MMU-6804115. TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.

Miscellaneous databases

ChiTaRSiBtg2. mouse.
EvolutionaryTraceiQ04211.
PROiQ04211.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020423.
CleanExiMM_BTG2.
ExpressionAtlasiQ04211. baseline and differential.
GenevisibleiQ04211. MM.

Family and domain databases

InterProiIPR002087. Anti_prolifrtn.
IPR033328. BTG2.
[Graphical view]
PANTHERiPTHR22978:SF29. PTHR22978:SF29. 1 hit.
PfamiPF07742. BTG. 1 hit.
[Graphical view]
PRINTSiPR00310. ANTIPRLFBTG1.
SMARTiSM00099. btg1. 1 hit.
[Graphical view]
SUPFAMiSSF160696. SSF160696. 1 hit.
PROSITEiPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBTG2_MOUSE
AccessioniPrimary (citable) accession number: Q04211
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.