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Q04211

- BTG2_MOUSE

UniProt

Q04211 - BTG2_MOUSE

Protein

Protein BTG2

Gene

Btg2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenyltion in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors. Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. associative learning Source: MGI
    3. cellular response to DNA damage stimulus Source: Ensembl
    4. central nervous system neuron development Source: MGI
    5. dentate gyrus development Source: MGI
    6. negative regulation of cell proliferation Source: UniProtKB
    7. negative regulation of neural precursor cell proliferation Source: MGI
    8. negative regulation of neuron apoptotic process Source: Ensembl
    9. negative regulation of translation Source: UniProtKB
    10. neuron projection development Source: Ensembl
    11. positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Source: Ensembl
    12. protein methylation Source: MGI
    13. response to electrical stimulus Source: Ensembl
    14. response to mechanical stimulus Source: Ensembl
    15. response to organic cyclic compound Source: Ensembl
    16. response to peptide hormone Source: Ensembl
    17. skeletal muscle cell differentiation Source: MGI

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein BTG2
    Alternative name(s):
    BTG family member 2
    NGF-inducible protein TIS21
    Gene namesi
    Name:Btg2
    Synonyms:Tis21
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:108384. Btg2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 158158Protein BTG2PRO_0000143805Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei147 – 1471Phosphoserine; by MAPK1 and MAPK3By similarity
    Modified residuei149 – 1491Phosphoserine; by MAPK14By similarity

    Post-translational modificationi

    Phosphorylated at Ser-147 by MAPK1/ERK2 and MAPK3/ERK1, and at Ser-149 by MAPK14, leading to PIN1-binding and mitochondrial depolarization.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ04211.
    PRIDEiQ04211.

    PTM databases

    PhosphoSiteiQ04211.

    Expressioni

    Inductioni

    By nerve growth factor and tumors promoters.1 Publication

    Gene expression databases

    ArrayExpressiQ04211.
    BgeeiQ04211.
    CleanExiMM_BTG2.
    GenevestigatoriQ04211.

    Interactioni

    Subunit structurei

    Interacts with PRKCABP. Interacts with CNOT7 and CNOT8; indicative for an asscociation with the CCR4-NOT complex. Interacts with PIN1, inducing mitochondrial depolarization By similarity.By similarity

    Protein-protein interaction databases

    BioGridi198398. 3 interactions.
    IntActiQ04211. 1 interaction.
    MINTiMINT-1517995.
    STRINGi10090.ENSMUSP00000020692.

    Structurei

    Secondary structure

    1
    158
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi10 – 2819
    Helixi32 – 5019
    Turni59 – 624
    Helixi63 – 664
    Beta strandi68 – 736
    Helixi76 – 849
    Helixi89 – 957
    Beta strandi98 – 1058
    Beta strandi108 – 1147
    Beta strandi120 – 1245

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3DJNX-ray2.20B8-125[»]
    ProteinModelPortaliQ04211.
    SMRiQ04211. Positions 8-125.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ04211.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the BTG family.Curated

    Phylogenomic databases

    eggNOGiNOG287298.
    HOGENOMiHOG000290200.
    HOVERGENiHBG004907.
    InParanoidiQ04211.
    KOiK14443.
    OMAiNAFANIR.
    OrthoDBiEOG72RN0S.
    PhylomeDBiQ04211.
    TreeFamiTF105272.

    Family and domain databases

    InterProiIPR002087. Anti_prolifrtn.
    [Graphical view]
    PfamiPF07742. BTG. 1 hit.
    [Graphical view]
    PRINTSiPR00310. ANTIPRLFBTG1.
    SMARTiSM00099. btg1. 1 hit.
    [Graphical view]
    PROSITEiPS00960. BTG_1. 1 hit.
    PS01203. BTG_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04211-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHGKRTDML PEIAAAVGFL SSLLRTRGCV SEQRLKVFSR ALQDALTDHY    50
    KHHWFPEKPS KGSGYRCIRI NHKMDPIISK VASQIGLSQP QLHRLLPSEL 100
    TLWVDPYEVS YRIGEDGSIC VLYEEAPVAA SYGLLTCKNQ MMLGRSSPSK 150
    NYVMAVSS 158
    Length:158
    Mass (Da):17,682
    Last modified:February 1, 1994 - v1
    Checksum:i5B91563BAE4CB74C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64292 Genomic DNA. Translation: AAA40449.1.
    CCDSiCCDS15302.1.
    PIRiA40761.
    RefSeqiNP_031596.1. NM_007570.2.
    UniGeneiMm.392646.

    Genome annotation databases

    EnsembliENSMUST00000020692; ENSMUSP00000020692; ENSMUSG00000020423.
    GeneIDi12227.
    KEGGimmu:12227.
    UCSCiuc007cre.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64292 Genomic DNA. Translation: AAA40449.1 .
    CCDSi CCDS15302.1.
    PIRi A40761.
    RefSeqi NP_031596.1. NM_007570.2.
    UniGenei Mm.392646.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3DJN X-ray 2.20 B 8-125 [» ]
    ProteinModelPortali Q04211.
    SMRi Q04211. Positions 8-125.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198398. 3 interactions.
    IntActi Q04211. 1 interaction.
    MINTi MINT-1517995.
    STRINGi 10090.ENSMUSP00000020692.

    PTM databases

    PhosphoSitei Q04211.

    Proteomic databases

    PaxDbi Q04211.
    PRIDEi Q04211.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020692 ; ENSMUSP00000020692 ; ENSMUSG00000020423 .
    GeneIDi 12227.
    KEGGi mmu:12227.
    UCSCi uc007cre.1. mouse.

    Organism-specific databases

    CTDi 7832.
    MGIi MGI:108384. Btg2.

    Phylogenomic databases

    eggNOGi NOG287298.
    HOGENOMi HOG000290200.
    HOVERGENi HBG004907.
    InParanoidi Q04211.
    KOi K14443.
    OMAi NAFANIR.
    OrthoDBi EOG72RN0S.
    PhylomeDBi Q04211.
    TreeFami TF105272.

    Miscellaneous databases

    ChiTaRSi BTG2. mouse.
    EvolutionaryTracei Q04211.
    NextBioi 280639.
    PROi Q04211.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q04211.
    Bgeei Q04211.
    CleanExi MM_BTG2.
    Genevestigatori Q04211.

    Family and domain databases

    InterProi IPR002087. Anti_prolifrtn.
    [Graphical view ]
    Pfami PF07742. BTG. 1 hit.
    [Graphical view ]
    PRINTSi PR00310. ANTIPRLFBTG1.
    SMARTi SM00099. btg1. 1 hit.
    [Graphical view ]
    PROSITEi PS00960. BTG_1. 1 hit.
    PS01203. BTG_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and expression of TIS21, a primary response gene induced by growth factors and tumor promoters."
      Fletcher B.S., Lim R.W., Varnum B.C., Kujubu D.A., Koski R.A., Herschman H.R.
      J. Biol. Chem. 266:14511-14518(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.

    Entry informationi

    Entry nameiBTG2_MOUSE
    AccessioniPrimary (citable) accession number: Q04211
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3