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Protein

Protein BTG2

Gene

Btg2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors. Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth (By similarity).By similarity

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: MGI
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. associative learning Source: MGI
  3. cellular response to DNA damage stimulus Source: MGI
  4. central nervous system neuron development Source: MGI
  5. dentate gyrus development Source: MGI
  6. negative regulation of apoptotic process Source: MGI
  7. negative regulation of cell proliferation Source: UniProtKB
  8. negative regulation of neural precursor cell proliferation Source: MGI
  9. negative regulation of neuron apoptotic process Source: Ensembl
  10. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  11. negative regulation of translation Source: UniProtKB
  12. neuron differentiation Source: MGI
  13. neuron projection development Source: MGI
  14. positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Source: MGI
  15. protein methylation Source: MGI
  16. response to electrical stimulus Source: Ensembl
  17. response to mechanical stimulus Source: Ensembl
  18. response to organic cyclic compound Source: Ensembl
  19. response to peptide hormone Source: Ensembl
  20. skeletal muscle cell differentiation Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BTG2
Alternative name(s):
BTG family member 2
NGF-inducible protein TIS21
Gene namesi
Name:Btg2
Synonyms:Tis21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:108384. Btg2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 158158Protein BTG2PRO_0000143805Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei147 – 1471Phosphoserine; by MAPK1 and MAPK3By similarity
Modified residuei149 – 1491Phosphoserine; by MAPK14By similarity

Post-translational modificationi

Phosphorylated at Ser-147 by MAPK1/ERK2 and MAPK3/ERK1, and at Ser-149 by MAPK14, leading to PIN1-binding and mitochondrial depolarization.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ04211.
PRIDEiQ04211.

PTM databases

PhosphoSiteiQ04211.

Expressioni

Inductioni

By nerve growth factor and tumors promoters.1 Publication

Gene expression databases

BgeeiQ04211.
CleanExiMM_BTG2.
ExpressionAtlasiQ04211. baseline and differential.
GenevestigatoriQ04211.

Interactioni

Subunit structurei

Interacts with PRKCABP. Interacts with CNOT7 and CNOT8; indicative for an asscociation with the CCR4-NOT complex. Interacts with PIN1, inducing mitochondrial depolarization (By similarity).By similarity

Protein-protein interaction databases

BioGridi198398. 3 interactions.
IntActiQ04211. 1 interaction.
MINTiMINT-1517995.
STRINGi10090.ENSMUSP00000020692.

Structurei

Secondary structure

1
158
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi10 – 2819Combined sources
Helixi32 – 5019Combined sources
Turni59 – 624Combined sources
Helixi63 – 664Combined sources
Beta strandi68 – 736Combined sources
Helixi76 – 849Combined sources
Helixi89 – 957Combined sources
Beta strandi98 – 1058Combined sources
Beta strandi108 – 1147Combined sources
Beta strandi120 – 1245Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DJNX-ray2.20B8-125[»]
ProteinModelPortaliQ04211.
SMRiQ04211. Positions 8-125.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ04211.

Family & Domainsi

Sequence similaritiesi

Belongs to the BTG family.Curated

Phylogenomic databases

eggNOGiNOG287298.
HOGENOMiHOG000290200.
HOVERGENiHBG004907.
InParanoidiQ04211.
KOiK14443.
OMAiMLTCKNQ.
OrthoDBiEOG72RN0S.
PhylomeDBiQ04211.
TreeFamiTF105272.

Family and domain databases

InterProiIPR002087. Anti_prolifrtn.
[Graphical view]
PfamiPF07742. BTG. 1 hit.
[Graphical view]
PRINTSiPR00310. ANTIPRLFBTG1.
SMARTiSM00099. btg1. 1 hit.
[Graphical view]
PROSITEiPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04211-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHGKRTDML PEIAAAVGFL SSLLRTRGCV SEQRLKVFSR ALQDALTDHY
60 70 80 90 100
KHHWFPEKPS KGSGYRCIRI NHKMDPIISK VASQIGLSQP QLHRLLPSEL
110 120 130 140 150
TLWVDPYEVS YRIGEDGSIC VLYEEAPVAA SYGLLTCKNQ MMLGRSSPSK

NYVMAVSS
Length:158
Mass (Da):17,682
Last modified:February 1, 1994 - v1
Checksum:i5B91563BAE4CB74C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64292 Genomic DNA. Translation: AAA40449.1.
CCDSiCCDS15302.1.
PIRiA40761.
RefSeqiNP_031596.1. NM_007570.2.
UniGeneiMm.392646.

Genome annotation databases

EnsembliENSMUST00000020692; ENSMUSP00000020692; ENSMUSG00000020423.
GeneIDi12227.
KEGGimmu:12227.
UCSCiuc007cre.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64292 Genomic DNA. Translation: AAA40449.1.
CCDSiCCDS15302.1.
PIRiA40761.
RefSeqiNP_031596.1. NM_007570.2.
UniGeneiMm.392646.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DJNX-ray2.20B8-125[»]
ProteinModelPortaliQ04211.
SMRiQ04211. Positions 8-125.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198398. 3 interactions.
IntActiQ04211. 1 interaction.
MINTiMINT-1517995.
STRINGi10090.ENSMUSP00000020692.

PTM databases

PhosphoSiteiQ04211.

Proteomic databases

PaxDbiQ04211.
PRIDEiQ04211.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020692; ENSMUSP00000020692; ENSMUSG00000020423.
GeneIDi12227.
KEGGimmu:12227.
UCSCiuc007cre.1. mouse.

Organism-specific databases

CTDi7832.
MGIiMGI:108384. Btg2.

Phylogenomic databases

eggNOGiNOG287298.
HOGENOMiHOG000290200.
HOVERGENiHBG004907.
InParanoidiQ04211.
KOiK14443.
OMAiMLTCKNQ.
OrthoDBiEOG72RN0S.
PhylomeDBiQ04211.
TreeFamiTF105272.

Miscellaneous databases

ChiTaRSiBtg2. mouse.
EvolutionaryTraceiQ04211.
NextBioi280639.
PROiQ04211.
SOURCEiSearch...

Gene expression databases

BgeeiQ04211.
CleanExiMM_BTG2.
ExpressionAtlasiQ04211. baseline and differential.
GenevestigatoriQ04211.

Family and domain databases

InterProiIPR002087. Anti_prolifrtn.
[Graphical view]
PfamiPF07742. BTG. 1 hit.
[Graphical view]
PRINTSiPR00310. ANTIPRLFBTG1.
SMARTiSM00099. btg1. 1 hit.
[Graphical view]
PROSITEiPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure and expression of TIS21, a primary response gene induced by growth factors and tumor promoters."
    Fletcher B.S., Lim R.W., Varnum B.C., Kujubu D.A., Koski R.A., Herschman H.R.
    J. Biol. Chem. 266:14511-14518(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.

Entry informationi

Entry nameiBTG2_MOUSE
AccessioniPrimary (citable) accession number: Q04211
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: February 4, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.