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Q04211

- BTG2_MOUSE

UniProt

Q04211 - BTG2_MOUSE

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Protein

Protein BTG2

Gene
Btg2, Tis21
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenyltion in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors. Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth By similarity.

GO - Molecular functioni

  1. protein binding Source: MGI
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. associative learning Source: MGI
  3. cellular response to DNA damage stimulus Source: Ensembl
  4. central nervous system neuron development Source: MGI
  5. dentate gyrus development Source: MGI
  6. negative regulation of cell proliferation Source: UniProtKB
  7. negative regulation of neural precursor cell proliferation Source: MGI
  8. negative regulation of neuron apoptotic process Source: Ensembl
  9. negative regulation of translation Source: UniProtKB
  10. neuron projection development Source: Ensembl
  11. positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Source: Ensembl
  12. protein methylation Source: MGI
  13. response to electrical stimulus Source: Ensembl
  14. response to mechanical stimulus Source: Ensembl
  15. response to organic cyclic compound Source: Ensembl
  16. response to peptide hormone Source: Ensembl
  17. skeletal muscle cell differentiation Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BTG2
Alternative name(s):
BTG family member 2
NGF-inducible protein TIS21
Gene namesi
Name:Btg2
Synonyms:Tis21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:108384. Btg2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 158158Protein BTG2PRO_0000143805Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei147 – 1471Phosphoserine; by MAPK1 and MAPK3 By similarity
Modified residuei149 – 1491Phosphoserine; by MAPK14 By similarity

Post-translational modificationi

Phosphorylated at Ser-147 by MAPK1/ERK2 and MAPK3/ERK1, and at Ser-149 by MAPK14, leading to PIN1-binding and mitochondrial depolarization By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ04211.
PRIDEiQ04211.

PTM databases

PhosphoSiteiQ04211.

Expressioni

Inductioni

By nerve growth factor and tumors promoters.1 Publication

Gene expression databases

ArrayExpressiQ04211.
BgeeiQ04211.
CleanExiMM_BTG2.
GenevestigatoriQ04211.

Interactioni

Subunit structurei

Interacts with PRKCABP. Interacts with CNOT7 and CNOT8; indicative for an asscociation with the CCR4-NOT complex. Interacts with PIN1, inducing mitochondrial depolarization By similarity.

Protein-protein interaction databases

BioGridi198398. 3 interactions.
IntActiQ04211. 1 interaction.
MINTiMINT-1517995.
STRINGi10090.ENSMUSP00000020692.

Structurei

Secondary structure

1
158
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi10 – 2819
Helixi32 – 5019
Turni59 – 624
Helixi63 – 664
Beta strandi68 – 736
Helixi76 – 849
Helixi89 – 957
Beta strandi98 – 1058
Beta strandi108 – 1147
Beta strandi120 – 1245

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DJNX-ray2.20B8-125[»]
ProteinModelPortaliQ04211.
SMRiQ04211. Positions 8-125.

Miscellaneous databases

EvolutionaryTraceiQ04211.

Family & Domainsi

Sequence similaritiesi

Belongs to the BTG family.

Phylogenomic databases

eggNOGiNOG287298.
HOGENOMiHOG000290200.
HOVERGENiHBG004907.
InParanoidiQ04211.
KOiK14443.
OMAiNAFANIR.
OrthoDBiEOG72RN0S.
PhylomeDBiQ04211.
TreeFamiTF105272.

Family and domain databases

InterProiIPR002087. Anti_prolifrtn.
[Graphical view]
PfamiPF07742. BTG. 1 hit.
[Graphical view]
PRINTSiPR00310. ANTIPRLFBTG1.
SMARTiSM00099. btg1. 1 hit.
[Graphical view]
PROSITEiPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04211-1 [UniParc]FASTAAdd to Basket

« Hide

MSHGKRTDML PEIAAAVGFL SSLLRTRGCV SEQRLKVFSR ALQDALTDHY    50
KHHWFPEKPS KGSGYRCIRI NHKMDPIISK VASQIGLSQP QLHRLLPSEL 100
TLWVDPYEVS YRIGEDGSIC VLYEEAPVAA SYGLLTCKNQ MMLGRSSPSK 150
NYVMAVSS 158
Length:158
Mass (Da):17,682
Last modified:February 1, 1994 - v1
Checksum:i5B91563BAE4CB74C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64292 Genomic DNA. Translation: AAA40449.1.
CCDSiCCDS15302.1.
PIRiA40761.
RefSeqiNP_031596.1. NM_007570.2.
UniGeneiMm.392646.

Genome annotation databases

EnsembliENSMUST00000020692; ENSMUSP00000020692; ENSMUSG00000020423.
GeneIDi12227.
KEGGimmu:12227.
UCSCiuc007cre.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64292 Genomic DNA. Translation: AAA40449.1 .
CCDSi CCDS15302.1.
PIRi A40761.
RefSeqi NP_031596.1. NM_007570.2.
UniGenei Mm.392646.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3DJN X-ray 2.20 B 8-125 [» ]
ProteinModelPortali Q04211.
SMRi Q04211. Positions 8-125.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198398. 3 interactions.
IntActi Q04211. 1 interaction.
MINTi MINT-1517995.
STRINGi 10090.ENSMUSP00000020692.

PTM databases

PhosphoSitei Q04211.

Proteomic databases

PaxDbi Q04211.
PRIDEi Q04211.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020692 ; ENSMUSP00000020692 ; ENSMUSG00000020423 .
GeneIDi 12227.
KEGGi mmu:12227.
UCSCi uc007cre.1. mouse.

Organism-specific databases

CTDi 7832.
MGIi MGI:108384. Btg2.

Phylogenomic databases

eggNOGi NOG287298.
HOGENOMi HOG000290200.
HOVERGENi HBG004907.
InParanoidi Q04211.
KOi K14443.
OMAi NAFANIR.
OrthoDBi EOG72RN0S.
PhylomeDBi Q04211.
TreeFami TF105272.

Miscellaneous databases

ChiTaRSi BTG2. mouse.
EvolutionaryTracei Q04211.
NextBioi 280639.
PROi Q04211.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q04211.
Bgeei Q04211.
CleanExi MM_BTG2.
Genevestigatori Q04211.

Family and domain databases

InterProi IPR002087. Anti_prolifrtn.
[Graphical view ]
Pfami PF07742. BTG. 1 hit.
[Graphical view ]
PRINTSi PR00310. ANTIPRLFBTG1.
SMARTi SM00099. btg1. 1 hit.
[Graphical view ]
PROSITEi PS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure and expression of TIS21, a primary response gene induced by growth factors and tumor promoters."
    Fletcher B.S., Lim R.W., Varnum B.C., Kujubu D.A., Koski R.A., Herschman H.R.
    J. Biol. Chem. 266:14511-14518(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.

Entry informationi

Entry nameiBTG2_MOUSE
AccessioniPrimary (citable) accession number: Q04211
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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