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Protein

Tensin

Gene

TNS

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in cell migration, fibrillar adhesion formation, cartilage development and in linking signal transduction pathways to the cytoskeleton.

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tensin
Gene namesi
Name:TNS
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002159011 – 1744TensinAdd BLAST1744

Post-translational modificationi

Tyrosine phosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ04205.

Expressioni

Tissue specificityi

Heart, gizzard, lung and skeletal muscle.

Interactioni

Subunit structurei

Binds to actin filaments and interacts with phosphotyrosine-containing proteins.

Binary interactionsi

WithEntry#Exp.IntActNotes
BCAR1P569452EBI-2607590,EBI-702093From a different organism.

Protein-protein interaction databases

DIPiDIP-56927N.
IntActiQ04205. 1 interactor.
STRINGi9031.ENSGALP00000018665.

Structurei

Secondary structure

11744
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1607 – 1619Combined sources13
Helixi1623 – 1635Combined sources13
Beta strandi1644 – 1651Combined sources8
Beta strandi1654 – 1662Combined sources9
Beta strandi1667 – 1671Combined sources5
Helixi1672 – 1674Combined sources3
Beta strandi1675 – 1680Combined sources6
Beta strandi1686 – 1688Combined sources3
Beta strandi1690 – 1693Combined sources4
Beta strandi1695 – 1703Combined sources9
Beta strandi1706 – 1709Combined sources4
Beta strandi1712 – 1719Combined sources8
Helixi1726 – 1737Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WVHX-ray1.50A1605-1738[»]
2GJYNMR-A1605-1744[»]
ProteinModelPortaliQ04205.
SMRiQ04205.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ04205.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 230Phosphatase tensin-typePROSITE-ProRule annotationAdd BLAST173
Domaini235 – 361C2 tensin-typePROSITE-ProRule annotationAdd BLAST127
Domaini1472 – 1581SH2PROSITE-ProRule annotationAdd BLAST110

Sequence similaritiesi

Contains 1 C2 tensin-type domain.PROSITE-ProRule annotation
Contains 1 phosphatase tensin-type domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG1930. Eukaryota.
KOG2283. Eukaryota.
COG2453. LUCA.
HOGENOMiHOG000060090.
HOVERGENiHBG060186.
InParanoidiQ04205.
KOiK18080.
PhylomeDBiQ04205.

Family and domain databases

CDDicd01213. PTB_tensin. 1 hit.
Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR014020. Tensin_C2-dom.
IPR029023. Tensin_lipid_phosphatase_dom.
IPR033929. Tensin_PTB.
IPR003595. Tyr_Pase_cat.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF10409. PTEN_C2. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
SM01326. PTEN_C2. 1 hit.
SM00404. PTPc_motif. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04205-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFGSVMNQA ATPCSPAVNY ELPSPGQSIT KQVDTPDATR SPRGGQAHCK
60 70 80 90 100
ASRSMSVTAA MESSCELDLV YITERIIAVS YPSTAEEQSF RSNLREVAHM
110 120 130 140 150
LKSKHGDNYV LFNLSERRHD ISKLHPKVLD FGWPDLHTPA LEKICSICKA
160 170 180 190 200
MDTWLNAAAH NVVVLHNKGN RGRLGVVVAA YMHYSNISAS ADQALDRFAM
210 220 230 240 250
KRFYEDKVVP VGQPSQKRYI HYFSGLLSGS IKMNNKPLFL HHVIMHGIPN
260 270 280 290 300
FESKGGCRPF LKIYQAMQPV YTSGIYNVQG DSQTGICITI EPGLLLKGDI
310 320 330 340 350
LLKCYHKKFR SPTRDVIFRV QFHTCAVHDL DIVFGKEDLD EAFRDERFPE
360 370 380 390 400
YGKVEFVFSY GPEKIQGMEH LENGPSVSVD YNTSDPLIRW DSYENFNIQR
410 420 430 440 450
EDSAEGTWAE PALPGKHLEK EVGHTQGPLD GSLYAKVKKK DSLHGSIGAV
460 470 480 490 500
NTARLPLSAA PNHVEHTLSV SSDSGNSTAS TKTDRTDEPG APGAPTGHAV
510 520 530 540 550
LSPEEKRDVD RLLVGFGLES AAPMHNHAPG PAPARLPAGP GRHVVPAQVH
560 570 580 590 600
VNGAGTPLLA ERETDILDDE LPNQDGHSVG SLGTLSSLDG TTTASEAGFH
610 620 630 640 650
EAPRVGSLSS LPNGPASYNG AEKMLKEGLY EAEPLSNGAY PYSNQNTLMG
660 670 680 690 700
HHLRDPLAHL RPSRSAQEHL AGYPQRQPAS ASPAWLQPPV PQPYLYGYDL
710 720 730 740 750
PSAHRSQSFP AVGTAKYEAN LALPQAPARS TSSREAVQRG LNSWQQQGGS
760 770 780 790 800
RPPSQLHDGG LESHSPSLSS CSPQPSPLQP MPPHSHSMPE FPRAPSRREI
810 820 830 840 850
EQSIEALDVL MLDLAPSVHK SQSVPSAATR QDKPAAMLSS LSAQRLSGHY
860 870 880 890 900
AQPTPQVVQP RSFGTSVGTD PLAKPYSPGP LVPAARSTAE PDYTVHEYRE
910 920 930 940 950
TYTPYSYQPV PEPRSYGSAP ASILPLSASY SPAGSQQLLV SSPPSPTAPA
960 970 980 990 1000
QSQLPHKGLE SYEDLSRSGE EPLNLEGLVA HRVAGVQSRE KSPEESTVPA
1010 1020 1030 1040 1050
RRRTPSDSHY EKSSPEPGSP RSPTVLSPEV VSTIAANPGG RPKEPHLHSY
1060 1070 1080 1090 1100
KEAFEEMESA SPSSLTSGGV RSPPGLAKTP LSALGLKPHN PADILLHPVG
1110 1120 1130 1140 1150
ELEGEAGADS EEEPRSYVES VARTATTGRA GNLPAAQPVG LEVPARNGAF
1160 1170 1180 1190 1200
GNSFTVPSPV STSSPIHSVD GASLRSYPSE GSPHGTVTPP HAVAETAYRS
1210 1220 1230 1240 1250
PMVSQTPSAH SSYQTSSPSS FQAGTLGSPY ASPDYPDGRG GFQPDPQARQ
1260 1270 1280 1290 1300
QPQVSVVGVH ALPGSPRTLH RTVATNTPPS PGFGRRAANP AVASVPGSPG
1310 1320 1330 1340 1350
LGRHTVSPHA PPGSPSLARH QMAAVPPGSP MYGYSSPEER RPTLSRQSSA
1360 1370 1380 1390 1400
SGYQPPSTPS FPVSPAYYPG TSTPHSSSPD SAAYRQGSPT PQPALPEKRR
1410 1420 1430 1440 1450
MSAGERSNSL PNYATVNGKA SSPLSSGMSS PSSGSAVAFS HTLPDFSKFS
1460 1470 1480 1490 1500
MPDISPETRA NVKFVQDTSK YWYKPDISRE QAIALLKDRE PGAFIIRDSH
1510 1520 1530 1540 1550
SFRGAYGLAM KVASPPPTVM QQNKKGDITN ELVRHFLIET SPRGVKLKGC
1560 1570 1580 1590 1600
PNEPNFGCLS ALVYQHSIMP LALPCKLVIP DRDPMEEKKD AASTTNSATD
1610 1620 1630 1640 1650
LLKQGAACNV LFINSVEMES LTGPQAISKA VAETLVADPT PTATIVHFKV
1660 1670 1680 1690 1700
SAQGITLTDN QRKLFFRRHY PLNTVTFCDL DPQERKWTKT DGSGPAKLFG
1710 1720 1730 1740
FVARKQGSTT DNVCHLFAEL DPDQPAAAIV NFVSRVMLGS GQKR
Length:1,744
Mass (Da):187,214
Last modified:November 1, 1997 - v2
Checksum:i5C3C8B6211935524
GO

Sequence cautioni

The sequence AAA73949 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA79215 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49C → R in AAA73949 (PubMed:7896874).Curated1
Sequence conflicti49C → R in CAA79215 (PubMed:7896874).Curated1
Sequence conflicti61M → T in AAA73949 (PubMed:7896874).Curated1
Sequence conflicti61M → T in CAA79215 (PubMed:7896874).Curated1
Sequence conflicti88Q → PR in AAA49087 (Ref. 3) Curated1
Sequence conflicti404A → T in AAA73949 (PubMed:7896874).Curated1
Sequence conflicti404A → T in CAA79215 (PubMed:7896874).Curated1
Sequence conflicti452T → A in AAA73949 (PubMed:7896874).Curated1
Sequence conflicti452T → A in CAA79215 (PubMed:7896874).Curated1
Sequence conflicti508 – 509DV → EL in AAA73949 (PubMed:7896874).Curated2
Sequence conflicti508 – 509DV → EL in CAA79215 (PubMed:7896874).Curated2
Sequence conflicti522A → P in AAA73949 (PubMed:7896874).Curated1
Sequence conflicti522A → P in CAA79215 (PubMed:7896874).Curated1
Sequence conflicti664R → A (PubMed:7896874).Curated1
Sequence conflicti666A → T (PubMed:7896874).Curated1
Sequence conflicti875P → A in AAA73949 (PubMed:7896874).Curated1
Sequence conflicti875P → A in CAA79215 (PubMed:7896874).Curated1
Sequence conflicti909P → T in AAA73949 (PubMed:7896874).Curated1
Sequence conflicti909P → T in CAA79215 (PubMed:7896874).Curated1
Sequence conflicti1102 – 1113Missing (Ref. 3) CuratedAdd BLAST12
Sequence conflicti1240G → A in AAA73949 (PubMed:7896874).Curated1
Sequence conflicti1240G → A in CAA79215 (PubMed:7896874).Curated1
Sequence conflicti1480E → D in AAA73949 (PubMed:7896874).Curated1
Sequence conflicti1480E → D in CAA79215 (PubMed:7896874).Curated1
Sequence conflicti1711D → E in AAA73949 (PubMed:7896874).Curated1
Sequence conflicti1711D → E in CAA79215 (PubMed:7896874).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96625 mRNA. Translation: AAA59053.1.
L06662 mRNA. Translation: AAA73949.1. Different initiation.
Z18529 mRNA. Translation: CAA79215.1. Different initiation.
M74165 mRNA. Translation: AAA49087.1.
X66286 mRNA. Translation: CAA46992.1.
PIRiA54970.
A57075.
S27939.
RefSeqiNP_990786.1. NM_205455.1.
UniGeneiGga.4128.

Genome annotation databases

GeneIDi396439.
KEGGigga:396439.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96625 mRNA. Translation: AAA59053.1.
L06662 mRNA. Translation: AAA73949.1. Different initiation.
Z18529 mRNA. Translation: CAA79215.1. Different initiation.
M74165 mRNA. Translation: AAA49087.1.
X66286 mRNA. Translation: CAA46992.1.
PIRiA54970.
A57075.
S27939.
RefSeqiNP_990786.1. NM_205455.1.
UniGeneiGga.4128.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WVHX-ray1.50A1605-1738[»]
2GJYNMR-A1605-1744[»]
ProteinModelPortaliQ04205.
SMRiQ04205.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-56927N.
IntActiQ04205. 1 interactor.
STRINGi9031.ENSGALP00000018665.

Proteomic databases

PaxDbiQ04205.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396439.
KEGGigga:396439.

Organism-specific databases

CTDi7145.

Phylogenomic databases

eggNOGiKOG1930. Eukaryota.
KOG2283. Eukaryota.
COG2453. LUCA.
HOGENOMiHOG000060090.
HOVERGENiHBG060186.
InParanoidiQ04205.
KOiK18080.
PhylomeDBiQ04205.

Miscellaneous databases

EvolutionaryTraceiQ04205.
PROiQ04205.

Family and domain databases

CDDicd01213. PTB_tensin. 1 hit.
Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR014020. Tensin_C2-dom.
IPR029023. Tensin_lipid_phosphatase_dom.
IPR033929. Tensin_PTB.
IPR003595. Tyr_Pase_cat.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF10409. PTEN_C2. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
SM01326. PTEN_C2. 1 hit.
SM00404. PTPc_motif. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTENS_CHICK
AccessioniPrimary (citable) accession number: Q04205
Secondary accession number(s): Q91007, Q92011
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.