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Q04205

- TENS_CHICK

UniProt

Q04205 - TENS_CHICK

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Protein

Tensin

Gene
TNS
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in cell migration, fibrillar adhesion formation, cartilage development and in linking signal transduction pathways to the cytoskeleton.

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tensin
Gene namesi
Name:TNS
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. adherens junction Source: UniProtKB-SubCell
  2. cell surface Source: UniProtKB-SubCell
  3. cytoplasm Source: UniProtKB-KW
  4. cytoskeleton Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17441744TensinPRO_0000215901Add
BLAST

Post-translational modificationi

Tyrosine phosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ04205.

Expressioni

Tissue specificityi

Heart, gizzard, lung and skeletal muscle.

Interactioni

Subunit structurei

Binds to actin filaments and interacts with phosphotyrosine-containing proteins.

Binary interactionsi

WithEntry#Exp.IntActNotes
BCAR1P569452EBI-2607590,EBI-702093From a different organism.

Protein-protein interaction databases

IntActiQ04205. 1 interaction.

Structurei

Secondary structure

1
1744
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1607 – 161913
Helixi1623 – 163513
Beta strandi1644 – 16518
Beta strandi1654 – 16629
Beta strandi1667 – 16715
Helixi1672 – 16743
Beta strandi1675 – 16806
Beta strandi1686 – 16883
Beta strandi1690 – 16934
Beta strandi1695 – 17039
Beta strandi1706 – 17094
Beta strandi1712 – 17198
Helixi1726 – 173712

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WVHX-ray1.50A1605-1738[»]
2GJYNMR-A1605-1744[»]
ProteinModelPortaliQ04205.
SMRiQ04205. Positions 1605-1744.

Miscellaneous databases

EvolutionaryTraceiQ04205.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 230173Phosphatase tensin-typeAdd
BLAST
Domaini235 – 361127C2 tensin-typeAdd
BLAST
Domaini1472 – 1581110SH2Add
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiCOG2453.
HOGENOMiHOG000060090.
HOVERGENiHBG060186.
InParanoidiQ04205.
KOiK18080.
PhylomeDBiQ04205.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR014020. Tensin_C2-dom.
IPR029023. Tensin_lipid_phosphatase_dom.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF10409. PTEN_C2. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04205-1 [UniParc]FASTAAdd to Basket

« Hide

MDFGSVMNQA ATPCSPAVNY ELPSPGQSIT KQVDTPDATR SPRGGQAHCK     50
ASRSMSVTAA MESSCELDLV YITERIIAVS YPSTAEEQSF RSNLREVAHM 100
LKSKHGDNYV LFNLSERRHD ISKLHPKVLD FGWPDLHTPA LEKICSICKA 150
MDTWLNAAAH NVVVLHNKGN RGRLGVVVAA YMHYSNISAS ADQALDRFAM 200
KRFYEDKVVP VGQPSQKRYI HYFSGLLSGS IKMNNKPLFL HHVIMHGIPN 250
FESKGGCRPF LKIYQAMQPV YTSGIYNVQG DSQTGICITI EPGLLLKGDI 300
LLKCYHKKFR SPTRDVIFRV QFHTCAVHDL DIVFGKEDLD EAFRDERFPE 350
YGKVEFVFSY GPEKIQGMEH LENGPSVSVD YNTSDPLIRW DSYENFNIQR 400
EDSAEGTWAE PALPGKHLEK EVGHTQGPLD GSLYAKVKKK DSLHGSIGAV 450
NTARLPLSAA PNHVEHTLSV SSDSGNSTAS TKTDRTDEPG APGAPTGHAV 500
LSPEEKRDVD RLLVGFGLES AAPMHNHAPG PAPARLPAGP GRHVVPAQVH 550
VNGAGTPLLA ERETDILDDE LPNQDGHSVG SLGTLSSLDG TTTASEAGFH 600
EAPRVGSLSS LPNGPASYNG AEKMLKEGLY EAEPLSNGAY PYSNQNTLMG 650
HHLRDPLAHL RPSRSAQEHL AGYPQRQPAS ASPAWLQPPV PQPYLYGYDL 700
PSAHRSQSFP AVGTAKYEAN LALPQAPARS TSSREAVQRG LNSWQQQGGS 750
RPPSQLHDGG LESHSPSLSS CSPQPSPLQP MPPHSHSMPE FPRAPSRREI 800
EQSIEALDVL MLDLAPSVHK SQSVPSAATR QDKPAAMLSS LSAQRLSGHY 850
AQPTPQVVQP RSFGTSVGTD PLAKPYSPGP LVPAARSTAE PDYTVHEYRE 900
TYTPYSYQPV PEPRSYGSAP ASILPLSASY SPAGSQQLLV SSPPSPTAPA 950
QSQLPHKGLE SYEDLSRSGE EPLNLEGLVA HRVAGVQSRE KSPEESTVPA 1000
RRRTPSDSHY EKSSPEPGSP RSPTVLSPEV VSTIAANPGG RPKEPHLHSY 1050
KEAFEEMESA SPSSLTSGGV RSPPGLAKTP LSALGLKPHN PADILLHPVG 1100
ELEGEAGADS EEEPRSYVES VARTATTGRA GNLPAAQPVG LEVPARNGAF 1150
GNSFTVPSPV STSSPIHSVD GASLRSYPSE GSPHGTVTPP HAVAETAYRS 1200
PMVSQTPSAH SSYQTSSPSS FQAGTLGSPY ASPDYPDGRG GFQPDPQARQ 1250
QPQVSVVGVH ALPGSPRTLH RTVATNTPPS PGFGRRAANP AVASVPGSPG 1300
LGRHTVSPHA PPGSPSLARH QMAAVPPGSP MYGYSSPEER RPTLSRQSSA 1350
SGYQPPSTPS FPVSPAYYPG TSTPHSSSPD SAAYRQGSPT PQPALPEKRR 1400
MSAGERSNSL PNYATVNGKA SSPLSSGMSS PSSGSAVAFS HTLPDFSKFS 1450
MPDISPETRA NVKFVQDTSK YWYKPDISRE QAIALLKDRE PGAFIIRDSH 1500
SFRGAYGLAM KVASPPPTVM QQNKKGDITN ELVRHFLIET SPRGVKLKGC 1550
PNEPNFGCLS ALVYQHSIMP LALPCKLVIP DRDPMEEKKD AASTTNSATD 1600
LLKQGAACNV LFINSVEMES LTGPQAISKA VAETLVADPT PTATIVHFKV 1650
SAQGITLTDN QRKLFFRRHY PLNTVTFCDL DPQERKWTKT DGSGPAKLFG 1700
FVARKQGSTT DNVCHLFAEL DPDQPAAAIV NFVSRVMLGS GQKR 1744
Length:1,744
Mass (Da):187,214
Last modified:November 1, 1997 - v2
Checksum:i5C3C8B6211935524
GO

Sequence cautioni

The sequence AAA73949.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAA79215.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 491C → R in AAA73949. 1 Publication
Sequence conflicti49 – 491C → R in CAA79215. 1 Publication
Sequence conflicti61 – 611M → T in AAA73949. 1 Publication
Sequence conflicti61 – 611M → T in CAA79215. 1 Publication
Sequence conflicti88 – 881Q → PR in AAA49087. 1 Publication
Sequence conflicti404 – 4041A → T in AAA73949. 1 Publication
Sequence conflicti404 – 4041A → T in CAA79215. 1 Publication
Sequence conflicti452 – 4521T → A in AAA73949. 1 Publication
Sequence conflicti452 – 4521T → A in CAA79215. 1 Publication
Sequence conflicti508 – 5092DV → EL in AAA73949. 1 Publication
Sequence conflicti508 – 5092DV → EL in CAA79215. 1 Publication
Sequence conflicti522 – 5221A → P in AAA73949. 1 Publication
Sequence conflicti522 – 5221A → P in CAA79215. 1 Publication
Sequence conflicti664 – 6641R → A1 Publication
Sequence conflicti666 – 6661A → T1 Publication
Sequence conflicti875 – 8751P → A in AAA73949. 1 Publication
Sequence conflicti875 – 8751P → A in CAA79215. 1 Publication
Sequence conflicti909 – 9091P → T in AAA73949. 1 Publication
Sequence conflicti909 – 9091P → T in CAA79215. 1 Publication
Sequence conflicti1102 – 111312Missing1 PublicationAdd
BLAST
Sequence conflicti1240 – 12401G → A in AAA73949. 1 Publication
Sequence conflicti1240 – 12401G → A in CAA79215. 1 Publication
Sequence conflicti1480 – 14801E → D in AAA73949. 1 Publication
Sequence conflicti1480 – 14801E → D in CAA79215. 1 Publication
Sequence conflicti1711 – 17111D → E in AAA73949. 1 Publication
Sequence conflicti1711 – 17111D → E in CAA79215. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M96625 mRNA. Translation: AAA59053.1.
L06662 mRNA. Translation: AAA73949.1. Different initiation.
Z18529 mRNA. Translation: CAA79215.1. Different initiation.
M74165 mRNA. Translation: AAA49087.1.
X66286 mRNA. Translation: CAA46992.1.
PIRiA54970.
A57075.
S27939.
RefSeqiNP_990786.1. NM_205455.1.
UniGeneiGga.4128.

Genome annotation databases

GeneIDi396439.
KEGGigga:396439.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M96625 mRNA. Translation: AAA59053.1 .
L06662 mRNA. Translation: AAA73949.1 . Different initiation.
Z18529 mRNA. Translation: CAA79215.1 . Different initiation.
M74165 mRNA. Translation: AAA49087.1 .
X66286 mRNA. Translation: CAA46992.1 .
PIRi A54970.
A57075.
S27939.
RefSeqi NP_990786.1. NM_205455.1.
UniGenei Gga.4128.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1WVH X-ray 1.50 A 1605-1738 [» ]
2GJY NMR - A 1605-1744 [» ]
ProteinModelPortali Q04205.
SMRi Q04205. Positions 1605-1744.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q04205. 1 interaction.

Proteomic databases

PaxDbi Q04205.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396439.
KEGGi gga:396439.

Organism-specific databases

CTDi 7145.

Phylogenomic databases

eggNOGi COG2453.
HOGENOMi HOG000060090.
HOVERGENi HBG060186.
InParanoidi Q04205.
KOi K18080.
PhylomeDBi Q04205.

Miscellaneous databases

EvolutionaryTracei Q04205.
NextBioi 20816480.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR000008. C2_dom.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR014020. Tensin_C2-dom.
IPR029023. Tensin_lipid_phosphatase_dom.
[Graphical view ]
Pfami PF08416. PTB. 1 hit.
PF10409. PTEN_C2. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view ]
SMARTi SM00462. PTB. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEi PS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of chick cardiac muscle tensin. Full-length cDNA sequence, expression, and characterization."
    Lo S.H., An Q., Bao S., Wong W.K., Liu Y., Janmey P.A., Hartwig J.H., Chen L.B.
    J. Biol. Chem. 269:22310-22319(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "Molecular cloning, expression, and mapping of the high affinity actin-capping domain of chicken cardiac tensin."
    Chuang J.Z., Lin D.C., Lin S.
    J. Cell Biol. 128:1095-1109(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  3. Chen L.B.
    Submitted (AUG-1991) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Modulation of tensin and vimentin expression in chick embryo developing cartilage and cultured differentiating chondrocytes."
    van de Werken R., Gennari M., Tavella S., Bet P., Molina F., Lin S., Cancedda R., Castagnola P.
    Eur. J. Biochem. 217:781-790(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1469-1744.
    Tissue: Embryonic chondrocyte and Embryonic heart.
  5. "Presence of an SH2 domain in the actin-binding protein tensin."
    Davis S., Lu M.L., Lo S.H., Lin S., Butler J.A., Druker B.J., Roberts T.M., An Q., Chen L.B.
    Science 252:712-715(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAIN SH2.

Entry informationi

Entry nameiTENS_CHICK
AccessioniPrimary (citable) accession number: Q04205
Secondary accession number(s): Q91007, Q92011
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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