Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q04205

- TENS_CHICK

UniProt

Q04205 - TENS_CHICK

Protein

Tensin

Gene

TNS

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May be involved in cell migration, fibrillar adhesion formation, cartilage development and in linking signal transduction pathways to the cytoskeleton.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tensin
    Gene namesi
    Name:TNS
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. adherens junction Source: UniProtKB-SubCell
    2. cell surface Source: UniProtKB-SubCell
    3. cytoplasm Source: UniProtKB-KW
    4. cytoskeleton Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 17441744TensinPRO_0000215901Add
    BLAST

    Post-translational modificationi

    Tyrosine phosphorylated.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ04205.

    Expressioni

    Tissue specificityi

    Heart, gizzard, lung and skeletal muscle.

    Interactioni

    Subunit structurei

    Binds to actin filaments and interacts with phosphotyrosine-containing proteins.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BCAR1P569452EBI-2607590,EBI-702093From a different organism.

    Protein-protein interaction databases

    DIPiDIP-56927N.
    IntActiQ04205. 1 interaction.

    Structurei

    Secondary structure

    1
    1744
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi1607 – 161913
    Helixi1623 – 163513
    Beta strandi1644 – 16518
    Beta strandi1654 – 16629
    Beta strandi1667 – 16715
    Helixi1672 – 16743
    Beta strandi1675 – 16806
    Beta strandi1686 – 16883
    Beta strandi1690 – 16934
    Beta strandi1695 – 17039
    Beta strandi1706 – 17094
    Beta strandi1712 – 17198
    Helixi1726 – 173712

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1WVHX-ray1.50A1605-1738[»]
    2GJYNMR-A1605-1744[»]
    ProteinModelPortaliQ04205.
    SMRiQ04205. Positions 1605-1744.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ04205.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini58 – 230173Phosphatase tensin-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini235 – 361127C2 tensin-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini1472 – 1581110SH2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C2 tensin-type domain.PROSITE-ProRule annotation
    Contains 1 phosphatase tensin-type domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiCOG2453.
    HOGENOMiHOG000060090.
    HOVERGENiHBG060186.
    InParanoidiQ04205.
    KOiK18080.
    PhylomeDBiQ04205.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProiIPR000008. C2_dom.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR013625. PTB.
    IPR006020. PTB/PI_dom.
    IPR000980. SH2.
    IPR014020. Tensin_C2-dom.
    IPR029023. Tensin_lipid_phosphatase_dom.
    [Graphical view]
    PfamiPF08416. PTB. 1 hit.
    PF10409. PTEN_C2. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view]
    SMARTiSM00462. PTB. 1 hit.
    SM00252. SH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 1 hit.
    SSF52799. SSF52799. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEiPS51182. C2_TENSIN. 1 hit.
    PS51181. PPASE_TENSIN. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04205-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFGSVMNQA ATPCSPAVNY ELPSPGQSIT KQVDTPDATR SPRGGQAHCK     50
    ASRSMSVTAA MESSCELDLV YITERIIAVS YPSTAEEQSF RSNLREVAHM 100
    LKSKHGDNYV LFNLSERRHD ISKLHPKVLD FGWPDLHTPA LEKICSICKA 150
    MDTWLNAAAH NVVVLHNKGN RGRLGVVVAA YMHYSNISAS ADQALDRFAM 200
    KRFYEDKVVP VGQPSQKRYI HYFSGLLSGS IKMNNKPLFL HHVIMHGIPN 250
    FESKGGCRPF LKIYQAMQPV YTSGIYNVQG DSQTGICITI EPGLLLKGDI 300
    LLKCYHKKFR SPTRDVIFRV QFHTCAVHDL DIVFGKEDLD EAFRDERFPE 350
    YGKVEFVFSY GPEKIQGMEH LENGPSVSVD YNTSDPLIRW DSYENFNIQR 400
    EDSAEGTWAE PALPGKHLEK EVGHTQGPLD GSLYAKVKKK DSLHGSIGAV 450
    NTARLPLSAA PNHVEHTLSV SSDSGNSTAS TKTDRTDEPG APGAPTGHAV 500
    LSPEEKRDVD RLLVGFGLES AAPMHNHAPG PAPARLPAGP GRHVVPAQVH 550
    VNGAGTPLLA ERETDILDDE LPNQDGHSVG SLGTLSSLDG TTTASEAGFH 600
    EAPRVGSLSS LPNGPASYNG AEKMLKEGLY EAEPLSNGAY PYSNQNTLMG 650
    HHLRDPLAHL RPSRSAQEHL AGYPQRQPAS ASPAWLQPPV PQPYLYGYDL 700
    PSAHRSQSFP AVGTAKYEAN LALPQAPARS TSSREAVQRG LNSWQQQGGS 750
    RPPSQLHDGG LESHSPSLSS CSPQPSPLQP MPPHSHSMPE FPRAPSRREI 800
    EQSIEALDVL MLDLAPSVHK SQSVPSAATR QDKPAAMLSS LSAQRLSGHY 850
    AQPTPQVVQP RSFGTSVGTD PLAKPYSPGP LVPAARSTAE PDYTVHEYRE 900
    TYTPYSYQPV PEPRSYGSAP ASILPLSASY SPAGSQQLLV SSPPSPTAPA 950
    QSQLPHKGLE SYEDLSRSGE EPLNLEGLVA HRVAGVQSRE KSPEESTVPA 1000
    RRRTPSDSHY EKSSPEPGSP RSPTVLSPEV VSTIAANPGG RPKEPHLHSY 1050
    KEAFEEMESA SPSSLTSGGV RSPPGLAKTP LSALGLKPHN PADILLHPVG 1100
    ELEGEAGADS EEEPRSYVES VARTATTGRA GNLPAAQPVG LEVPARNGAF 1150
    GNSFTVPSPV STSSPIHSVD GASLRSYPSE GSPHGTVTPP HAVAETAYRS 1200
    PMVSQTPSAH SSYQTSSPSS FQAGTLGSPY ASPDYPDGRG GFQPDPQARQ 1250
    QPQVSVVGVH ALPGSPRTLH RTVATNTPPS PGFGRRAANP AVASVPGSPG 1300
    LGRHTVSPHA PPGSPSLARH QMAAVPPGSP MYGYSSPEER RPTLSRQSSA 1350
    SGYQPPSTPS FPVSPAYYPG TSTPHSSSPD SAAYRQGSPT PQPALPEKRR 1400
    MSAGERSNSL PNYATVNGKA SSPLSSGMSS PSSGSAVAFS HTLPDFSKFS 1450
    MPDISPETRA NVKFVQDTSK YWYKPDISRE QAIALLKDRE PGAFIIRDSH 1500
    SFRGAYGLAM KVASPPPTVM QQNKKGDITN ELVRHFLIET SPRGVKLKGC 1550
    PNEPNFGCLS ALVYQHSIMP LALPCKLVIP DRDPMEEKKD AASTTNSATD 1600
    LLKQGAACNV LFINSVEMES LTGPQAISKA VAETLVADPT PTATIVHFKV 1650
    SAQGITLTDN QRKLFFRRHY PLNTVTFCDL DPQERKWTKT DGSGPAKLFG 1700
    FVARKQGSTT DNVCHLFAEL DPDQPAAAIV NFVSRVMLGS GQKR 1744
    Length:1,744
    Mass (Da):187,214
    Last modified:November 1, 1997 - v2
    Checksum:i5C3C8B6211935524
    GO

    Sequence cautioni

    The sequence AAA73949.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAA79215.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti49 – 491C → R in AAA73949. (PubMed:7896874)Curated
    Sequence conflicti49 – 491C → R in CAA79215. (PubMed:7896874)Curated
    Sequence conflicti61 – 611M → T in AAA73949. (PubMed:7896874)Curated
    Sequence conflicti61 – 611M → T in CAA79215. (PubMed:7896874)Curated
    Sequence conflicti88 – 881Q → PR in AAA49087. 1 PublicationCurated
    Sequence conflicti404 – 4041A → T in AAA73949. (PubMed:7896874)Curated
    Sequence conflicti404 – 4041A → T in CAA79215. (PubMed:7896874)Curated
    Sequence conflicti452 – 4521T → A in AAA73949. (PubMed:7896874)Curated
    Sequence conflicti452 – 4521T → A in CAA79215. (PubMed:7896874)Curated
    Sequence conflicti508 – 5092DV → EL in AAA73949. (PubMed:7896874)Curated
    Sequence conflicti508 – 5092DV → EL in CAA79215. (PubMed:7896874)Curated
    Sequence conflicti522 – 5221A → P in AAA73949. (PubMed:7896874)Curated
    Sequence conflicti522 – 5221A → P in CAA79215. (PubMed:7896874)Curated
    Sequence conflicti664 – 6641R → A(PubMed:7896874)Curated
    Sequence conflicti666 – 6661A → T(PubMed:7896874)Curated
    Sequence conflicti875 – 8751P → A in AAA73949. (PubMed:7896874)Curated
    Sequence conflicti875 – 8751P → A in CAA79215. (PubMed:7896874)Curated
    Sequence conflicti909 – 9091P → T in AAA73949. (PubMed:7896874)Curated
    Sequence conflicti909 – 9091P → T in CAA79215. (PubMed:7896874)Curated
    Sequence conflicti1102 – 111312Missing1 PublicationCuratedAdd
    BLAST
    Sequence conflicti1240 – 12401G → A in AAA73949. (PubMed:7896874)Curated
    Sequence conflicti1240 – 12401G → A in CAA79215. (PubMed:7896874)Curated
    Sequence conflicti1480 – 14801E → D in AAA73949. (PubMed:7896874)Curated
    Sequence conflicti1480 – 14801E → D in CAA79215. (PubMed:7896874)Curated
    Sequence conflicti1711 – 17111D → E in AAA73949. (PubMed:7896874)Curated
    Sequence conflicti1711 – 17111D → E in CAA79215. (PubMed:7896874)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M96625 mRNA. Translation: AAA59053.1.
    L06662 mRNA. Translation: AAA73949.1. Different initiation.
    Z18529 mRNA. Translation: CAA79215.1. Different initiation.
    M74165 mRNA. Translation: AAA49087.1.
    X66286 mRNA. Translation: CAA46992.1.
    PIRiA54970.
    A57075.
    S27939.
    RefSeqiNP_990786.1. NM_205455.1.
    UniGeneiGga.4128.

    Genome annotation databases

    GeneIDi396439.
    KEGGigga:396439.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M96625 mRNA. Translation: AAA59053.1 .
    L06662 mRNA. Translation: AAA73949.1 . Different initiation.
    Z18529 mRNA. Translation: CAA79215.1 . Different initiation.
    M74165 mRNA. Translation: AAA49087.1 .
    X66286 mRNA. Translation: CAA46992.1 .
    PIRi A54970.
    A57075.
    S27939.
    RefSeqi NP_990786.1. NM_205455.1.
    UniGenei Gga.4128.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1WVH X-ray 1.50 A 1605-1738 [» ]
    2GJY NMR - A 1605-1744 [» ]
    ProteinModelPortali Q04205.
    SMRi Q04205. Positions 1605-1744.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-56927N.
    IntActi Q04205. 1 interaction.

    Proteomic databases

    PaxDbi Q04205.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396439.
    KEGGi gga:396439.

    Organism-specific databases

    CTDi 7145.

    Phylogenomic databases

    eggNOGi COG2453.
    HOGENOMi HOG000060090.
    HOVERGENi HBG060186.
    InParanoidi Q04205.
    KOi K18080.
    PhylomeDBi Q04205.

    Miscellaneous databases

    EvolutionaryTracei Q04205.
    NextBioi 20816480.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    3.30.505.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProi IPR000008. C2_dom.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR013625. PTB.
    IPR006020. PTB/PI_dom.
    IPR000980. SH2.
    IPR014020. Tensin_C2-dom.
    IPR029023. Tensin_lipid_phosphatase_dom.
    [Graphical view ]
    Pfami PF08416. PTB. 1 hit.
    PF10409. PTEN_C2. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view ]
    SMARTi SM00462. PTB. 1 hit.
    SM00252. SH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 1 hit.
    SSF52799. SSF52799. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEi PS51182. C2_TENSIN. 1 hit.
    PS51181. PPASE_TENSIN. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of chick cardiac muscle tensin. Full-length cDNA sequence, expression, and characterization."
      Lo S.H., An Q., Bao S., Wong W.K., Liu Y., Janmey P.A., Hartwig J.H., Chen L.B.
      J. Biol. Chem. 269:22310-22319(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    2. "Molecular cloning, expression, and mapping of the high affinity actin-capping domain of chicken cardiac tensin."
      Chuang J.Z., Lin D.C., Lin S.
      J. Cell Biol. 128:1095-1109(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    3. Chen L.B.
      Submitted (AUG-1991) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Modulation of tensin and vimentin expression in chick embryo developing cartilage and cultured differentiating chondrocytes."
      van de Werken R., Gennari M., Tavella S., Bet P., Molina F., Lin S., Cancedda R., Castagnola P.
      Eur. J. Biochem. 217:781-790(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1469-1744.
      Tissue: Embryonic chondrocyte and Embryonic heart.
    5. "Presence of an SH2 domain in the actin-binding protein tensin."
      Davis S., Lu M.L., Lo S.H., Lin S., Butler J.A., Druker B.J., Roberts T.M., An Q., Chen L.B.
      Science 252:712-715(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: DOMAIN SH2.

    Entry informationi

    Entry nameiTENS_CHICK
    AccessioniPrimary (citable) accession number: Q04205
    Secondary accession number(s): Q91007, Q92011
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3