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Protein

CUE domain-containing protein CUE4

Gene

CUE4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 1850 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BioCyciYEAST:G3O-32685-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
CUE domain-containing protein CUE4
Alternative name(s):
Coupling of ubiquitin conjugation to ER degradation protein 4
Gene namesi
Name:CUE4
Ordered Locus Names:YML101C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YML101C.
SGDiS000004568. CUE4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002032441 – 117CUE domain-containing protein CUE4Add BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki37Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei48PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ04201.
PRIDEiQ04201.

PTM databases

iPTMnetiQ04201.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi35042. 62 interactors.
DIPiDIP-4525N.
IntActiQ04201. 8 interactors.
MINTiMINT-512819.
STRINGi4932.YML101C.

Structurei

3D structure databases

ProteinModelPortaliQ04201.
SMRiQ04201.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 116CUEPROSITE-ProRule annotationAdd BLAST43

Domaini

The CUE domain binds ubiquitin, which may facilitate intramolecular monoubiquitination.

Phylogenomic databases

InParanoidiQ04201.
OrthoDBiEOG092C5I2D.

Family and domain databases

InterProiView protein in InterPro
IPR003892. CUE.
PfamiView protein in Pfam
PF02845. CUE. 1 hit.
SMARTiView protein in SMART
SM00546. CUE. 1 hit.
PROSITEiView protein in PROSITE
PS51140. CUE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04201-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGSTIVFIL TMVCLFVYTV KHRGAKQVPS RTVQDAKPAP SVATNDPSPE
60 70 80 90 100
PVPSAPEERV ARLNRHGSDR KRAVNSDMVE IVMTMAPHVP QEKVVQDLRN
110
TGSIEHTMEN IFAGKLD
Length:117
Mass (Da):12,893
Last modified:November 1, 1997 - v1
Checksum:iEC50D817C4B66947
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80835 Genomic DNA. Translation: CAA56796.1.
BK006946 Genomic DNA. Translation: DAA09797.1.
PIRiS47448.
RefSeqiNP_013607.1. NM_001182462.1.

Genome annotation databases

EnsemblFungiiYML101C; YML101C; YML101C.
GeneIDi854871.
KEGGisce:YML101C.

Similar proteinsi

Entry informationi

Entry nameiCUE4_YEAST
AccessioniPrimary (citable) accession number: Q04201
Secondary accession number(s): D6W0I3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 27, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names